Clinical trials: Whipple Procedure
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Trial of Early Versus Standard Drainage Removal After Pancreatic Resections
Despite a substantial decrease in postoperative mortality, morbidity after pancreatic resections is still high, even at high-volume centers.
- Conditions
- Pancreaticoduodenectomy, Distal Pancreatectomy, Pancreatic Fistula, Abdominal Abscess
- Trial name
- NCT00931554
- Testing
- Postoperative drain removal
- Where
- Italy
- Volunteers
- 114 people
- Sponsor
- Universita di Verona
Pancreatic Cancer
A Prospective Non-randomized Controlled Interventional Study on the Effect of Shouhui Tongbian Capsules Combined With Pancreatin Enteric-coated Capsules on Pancreatic Exocrine Function in Patients After Curative Resection for Pancreatic Cancer
Exploratory evaluation comparing the addition of Shouhui Constipation Capsules to standard pancreatic enzyme therapy for improving exocrine pancreatic function in patients after pancreaticoduodenectomy.
- Trial name
- NCT07557394
- Testing
- Shouhui Tongbian Capsules, Pancreatin Enteric-Coated Capsules
- Volunteers
- 80 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Pancreatic Fistula
Role of Octreotide in Preventing Pancreatic Fistula After Pancreaticoduodenectomy (PD) in Patients With Soft Pancreas
This randomized controlled trial (RCT) aims at assessing the influence of octreotide on pancreatic fistula or complications following pancreatoduodenectomy in patients with soft pancreas.
- Trial name
- PD (NCT01301222)
- Testing
- Inj. Octreotide
- Where
- India
- Volunteers
- 110 people
- Sponsor
- PVS Memorial Hospital
Pancreatic Cancer
Standard Versus Prolonged Antibiotic Prophylaxis After Pancreatoduodenectomy (SPARROW)
The goal of this multicenter randomized controlled trial is to evaluate the additional value of pre-emptive antibiotic treatment on clinically relevant organ/space surgical site infections (OSIs) in patients undergoing…
- Trial name
- SPARROW (NCT05784311)
- Testing
- Cefuroxime, Metronidazole
- Where
- 11 sites in Netherlands
- Volunteers
- 344 people
- Sponsor
- Leiden University Medical Center
Diabetes Mellitus, Glucose Intolerance
Effects of Pancreaticoduodenectomy on Glucose Metabolism
Pancreaticoduodenectomy (PD) involves removing the head of pancreas, duodenum, common bile duct, gall bladder, and/or distal stomach.
- Trial name
- NCT01388192
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Pancreatic Ductal Adenocarcinoma (mPDAC), Pancreatic Head Tumour
Immunoparalysis After Pancreaticoduodenectomy
By 2030, pancreatic adenocarcinoma could become the second leading cause of cancer-related death in France. To date, Pancreaticoduodenectomy (PD) is the standard treatment for resectable adenocarcinoma of the pancreatic head.
- Conditions
- Pancreatic Ductal Adenocarcinoma (mPDAC), Pancreatic Head Tumour, Pancreatic Fistula
- Trial name
- ImPaHLA (NCT07144917)
- Testing
- mHLA-DR analysis
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Pancreatoduodenectomy
Billroth II Versus Roux-en-Y for the Gastrojejunostomy in the Pancreatoduodenectomy
The purpose of this study is to compare the safety and superiority of Roux-Y versus Billroth II gastrojejunostomy reconstruction on delayed gastric emptying after pancreatoduodenectomy.
- Trial name
- NCT01984216
- Testing
- Roux-en-Y for the gastrojejunostomy reconstruction, Billroth II for the gastrojejunostomy reconstruction
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Fundacion Miguel Servet
Pancreatic Neoplasms
Safety and Feasibility Study of Enhanced Recovery in Pancreaticoduodenectomy
The purpose of this study is to assess the adherence to an enhanced recovery after surgery (ERAS) pathway and the impact of the ERAS protocol on postoperative short-term outcome in patients undergoing pancreaticoduodenectomy (PD).
- Trial name
- NCT01759706
- Testing
- Enhanced recovery after surgery protocol, Standard perioperative care, PONV prophylaxis with Ondansetron + Dexamethasone
- Where
- Italy
- Volunteers
- 123 people
- Sponsor
- Università Vita-Salute San Raffaele
Pancreatic Cancer, Adult, Prehabilitation
Prehab for Pancreatic Cancer Surgery
The goal of this clinical study is to test whether a structured prehabilitation program can be successfully used by adults with pancreatic cancer who are receiving chemotherapy before planned surgery.
- Trial name
- NCT07478185
- Testing
- Multimodal Prehabilitation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Massachusetts, Worcester
Pancreas Cancer, Periampullary Carcinoma
Role of Pre-operative CPET in Pancreatoduodenectomy
A clinical database has been prospectively maintained by the investigators, with details of pancreatic resections since January 2016.
- Trial name
- WHIPPLES (NCT06068452)
- Where
- United Kingdom
- Volunteers
- 113 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Postoperative Complications
Biliary Externalization After Pancreaticoduodenectomy
Postoperative pancreatic fistula(POPF) is the most common complication of pancreaticoduodenectomy (PD). Sometimes POPF is associated with biliary fistula(BF), or "mixed" fistula.
- Trial name
- NCT04654299
- Testing
- External biliary stent
- Volunteers
- 128 people
- Sponsor
- Universidad de Extremadura
Pancreatoduodenectomy, Pain Management
Continous Infusion of Nefopam for Patients Undergoing Pancreatoduodenectomy
The goal of this clinical trial is to determine whether continuous nefopam administration, as part of a multimodal analgesia strategy, reduces opioid consumption and improves patient satisfaction after pancreatoduodenectomy.
- Conditions
- Pancreatoduodenectomy, Pain Management, Opioid Analgesia, Multimodal Analgesia
- Trial name
- NCT07423650
- Testing
- Nefopam 120mg/day infusion, Lidocaine Infusion, Peridural
- Where
- Romania
- Volunteers
- 93 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Pancreaticoduodenectomy
Observation of Perioperative Outcomes of Robotic Pancreaticoduodenectomy
This is a multi-site prospective, single arm, observational study examining the outcomes of robotic pancreaticoduodenectomy.
- Trial name
- NCT04171440
- Testing
- robotic pancreaticoduodenectomy
- Where
- 2 sites in United States
- Volunteers
- 91 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Surgical Site Infection, Pancreaticoduodenectomy
Association of Cephalosporin Resistance and Surgical Site Infections in Patients Undergoing Pancreaticoduodenectomy
Preoperative biliary drainage predisposes the bile to be contaminated with bacteria of the duodenum. These bacteria colonizing the bile are a potential source for surgical site infections after pancreaticoduodenectomy and many…
- Conditions
- Surgical Site Infection, Pancreaticoduodenectomy, Biliary Tract Infection Bacterial
- Trial name
- NCT05581017
- Testing
- Preoperative biliary drainage
- Where
- Finland
- Volunteers
- 376 people
- Sponsor
- Helsinki University Central Hospital
PDAC, Pancreatoduodenectomy
Mesopancreas Study in Pancreatic Cancer
After the Introduction of the pathological circumferential resection margin (CRM status by LEEPP Protocol), residual cancer (R1 resection) was most often found in the dorsal and medial resection margins.
- Conditions
- PDAC, Pancreatoduodenectomy, Margin, Resection, Surgery
- Trial name
- MESOPANC-01 (NCT05895214)
- Testing
- oncological relevance of the mesopancreas
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Postoperative Outcome, Whipple Procedures
Veno-arterial CO2 Pressure Difference to Arterio-venous O2 Difference Ratio & Blood Lactate Levels Are Predictors of Postoperative Outcome in Whipple Procedures
Whipple surgery is a complex abdominal procedure associated with a high risk of hemodynamic instability and splanchnic hypoperfusion leading to anastomotic leaks, delayed gastric emptying, and organ dysfunction Traditional…
- Trial name
- NCT07306845
- Testing
- predictors of postoperative outcome in Whipple Procedures
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Pancreatic Neoplasm, Pancreatic Periampullary Cancer
The Effect of Application of TachoSil® in Pancreatoduodenectomy
Fibrinogen/thrombin-coated collagen patch (TachoSil®) is known to have the effect of strengthening tissue anastomosis and promoting suturing to prevent leakage.
- Conditions
- Pancreatic Neoplasm, Pancreatic Periampullary Cancer, Pancreatic Bordeline Tumor
- Trial name
- NCT03269955
- Testing
- Fibrinogen/thrombin-coated collagen patch
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Asan Medical Center
Sarcopenia, Pancreatic Cancer
Preoperative Prehabilitation for Sarcopenic Patients Prior to Pancreatic Surgery for Cancer
Major digestive surgery is associated with a significant rate of postoperative complications. To improve postoperative outcome, efforts are focused on postoperative course leading to the concept of rehabilitation.
- Trial name
- PSOAS (NCT04469504)
- Testing
- Prehabilitation program, Oral Impact
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Delayed Gastric Emptying
Impact of Additional DJ (Duodenojejunostomy)-Pexy on Reduction in Delayed Gastric Emptying Following Pylorus-preserving Pancreaticoduodenectomy: A Prospective, Randomized Controlled Trial
Surgical resection in periampullary cancer using pancreaticoduodenectomy is the most important modality in the treatment. In the past, pancreaticoduodenectomy was associated with high morbidity and mortality.
- Trial name
- NCT02635399
- Testing
- PPPD (pylorus-preserving pancreaticoduodenectomy), PPPD (pylorus-preserving pancreaticoduodenectomy) with DJ-pexy
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Yonsei University
Pancreatic Fistula
External Pancreatic Stent in Pancreaticojejunostomy
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend pancreatic stent in pancreatojejunostomy.
- Trial name
- NCT06743516
- Testing
- Pancreaticojejunostomy with external stent, Pancreaticojejunostomy without external stent
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University