Clinical trials: Whipple Procedure
Pancreatic Neoplasms, Biliary Tract Neoplasms
Duct-to-mucosa Versus Invagination for Pancreaticojejunostomy
The purpose of this study is to determine whether duct-to-mucosa is better than invagination in pancreaticojejunostomy after pancreaticoduodenectomy.
- Trial name
- NCT01695447
- Testing
- duct-to-mucosa, invagination, Internal stent
- Where
- China
- Volunteers
- 100 people
- Sponsor
- TingBo Liang
Pancreatic Fistula, Pancreatic Neoplasms
Treatment of the Pancreatic Stump With Neoprene®-Based Glue After High-risk Pancreatoduodenectomy
The study evaluates the safety and efficacy of Neoprene-based glue in the management of pancreatic stump after pancreatoduodenectomy (PD) in patients at high risk for pancreatic fistula and early neoplastic recurrence, compared…
- Conditions
- Pancreatic Fistula, Pancreatic Neoplasms, Postoperative Complications
- Trial name
- NCT03738787
- Testing
- Pancreatic duct occlusion with Neoprene, Pancreato-Jejunal anastomosis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Surgical Site Infection
Wound Protector Dual-ring Alexis® in Pancreaticoduodenectomy
Surgical site infection (SSI) is a leading cause of preventable morbidity and mortality in North America and worldwide. This condition has consistently been reported to account for up to 25% of all healthcare-associated…
- Trial name
- PALEXIS (NCT03820648)
- Testing
- Alexis, Standard 3M™ Steri-Drape 2
- Where
- Italy
- Volunteers
- 212 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pancreatic Carcinoma, Laparoscopic
Comparing Laparoscopic and Open Surgery for Pancreatic Carcinoma
Background: Pancreatic cancer (PC) is one of the most aggressive malignant neoplasms with poor outcomes. Pancreatoduodenectomy (PD) is the only curative treatment for PC.
- Conditions
- Pancreatic Carcinoma, Laparoscopic, Pancreaticoduodenectomy
- Trial name
- NCT03785743
- Testing
- TLPD Surgery, OPD Surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tongji Hospital
Pancreatic Fistula, Pancreaticoduodenectomy
Effect of Trans-Nasal Afferent Loop Decompression on Post-Pancreaticoduodenectomy Pancreatic Fistula
Postoperative pancreatic fistula (POPF) is a major complication and an important cause of mortality after pancreaticoduodenectomy (PD).
- Conditions
- Pancreatic Fistula, Pancreaticoduodenectomy, Complication of Surgical Procedure
- Trial name
- NCT04989868
- Testing
- Trans-Nasal Afferent Loop Decompression, Without Trans-Nasal Afferent Loop Decompression
- Where
- China
- Volunteers
- 299 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Postoperative Complications
Perioperative Fluid Therapy in Patients Undergoing Pancreaticoduodenectomy
Postoperative complication rates in patients undergoing pancreaticoduodenectomy remain high although the operation techniques have developed a lot in recent years.
- Trial name
- NCT04687826
- Testing
- Goal directed fluid therapy, Liberal fluid therapy
- Volunteers
- 168 people
- Sponsor
- Helsinki University Central Hospital
Whipple Operation
Dachengqi Decoction for Enhancing Early Gastrointestinal Recovery After Whipple Surgery
To investigate the clinical efficacy of the traditional Chinese medicine formula Dachengqi Decoction in promoting early gastrointestinal function recovery after Whipple surgery, and to evaluate its impact on postoperative…
- Trial name
- NCT06948474
- Testing
- Dachengqi decoction, modified gastrointestinal dual-lumen feeding tube, Normal Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 45 people
- Sponsor
- China-Japan Friendship Hospital
Pancreaticoduodenectomy
Effects of Immunonutrition in Patients Undergoing Pancreaticoduodenectomy
The purpose of this study is to determine whether immunonutrition is effective on surgical site infection and Th1/Th2/Th17 differentiation in patients undergoing pancreaticoduodenectomy
- Trial name
- NCT00668876
- Testing
- Oral IMPACT, Parenteral nutrition
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Chiba University
Pancreatic Cancer, Bile Duct Cancer
Randomized Controlled Trial on Pancreatic Stent Tube in Pancreaticoduodenectomy
The purpose of this study is to determine which stent type is effective in the decrease of postoperative stay and complications across pancreaticojejunostomy after pancreaticoduodenectomy.
- Conditions
- Pancreatic Cancer, Bile Duct Cancer, Ampullary Cancer, Pancreatitis
- Trial name
- NCT00628186
- Testing
- external drainage tube [polyethylene pancreatic drainage tube], internal drainage tube [polyethylene pancreatic drainage tube]
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Wakayama Medical University
Delayed Gastric Emptying
The Effect of taVNS on the Prognosis of Patients Undergoing Pancreatoduodenectomy
To explore the effects of transcutaneous auricular vagus nerve stimulation (taVNS) during the perioperative period on the incidence of delayed gastric emptying after pancreatoduodenectomy and its possible mechanisms.
- Trial name
- NCT06786923
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulator
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Affiliated Hospital of Nantong University
Pancreatic Fistula
Comparison of Feasibility Between Internal and External Pancreatic Drainage in Pancreaticoduodenectomy
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend pancreatic stent in pancreatojejunostomy.
- Trial name
- NCT01023594
- Testing
- Pancreatic stent
- Where
- 8 sites in South Korea
- Volunteers
- 328 people
- Sponsor
- Seoul National University Hospital
Postoperative Pancreatic Fistula, Delayed Gastric Emptying
Pancreaticoduodenectomy With or Without Braun Enteroenterostomy: Comparison of Postoperative Pancreatic Fistula and Delayed Gastric Emptying
The investigators plan to perform a prospective randomized, head-to-head trial to test the hypothesis that the addition of Braun enteroenterostomy to standard pancreaticoduodenectomy (PD) reconstruction can decrease the rates of…
- Trial name
- NCT01481753
- Testing
- pancreaticoduodenectomy without Braun enteroenterostomy, Braun enteroenterostomy
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Johns Hopkins University
Pancreaticojuodenectomy
The Role of Intravenous Ferritin in Optimizing Postoperative Recovery Following Pancreaticoduodenectomy
Iron deficiency anemia is well known as a risk factor that worsens postoperative morbidity and patient prognosis. Several studies have shown that intravenous iron administration before surgery is effective in reducing the risk of…
- Trial name
- Ferritin (NCT06442111)
- Testing
- The intravenous ferritin group
- Volunteers
- 106 people
- Sponsor
- Seoul St. Mary's Hospital
Ampullary Carcinoma, Duodenal Adenocarcinoma
Modified Single-Incision Plus One-Port Versus Conventional Five-Port Laparoscopic Pancreaticoduodenectomy for Nonpancreatic Periampullary Adenocarcinomas
This multicenter, randomized, controlled, non-inferiority trial will compare modified single-incision plus one-port laparoscopic pancreaticoduodenectomy (mSILPD+1) with conventional five-port laparoscopic pancreaticoduodenectomy…
- Conditions
- Ampullary Carcinoma, Duodenal Adenocarcinoma, Distal Cholangiocarcinoma
- Trial name
- NCT07744087
- Testing
- Modified Single Incision plus one-port Laparoscopic Pancreaticoduodenectomy, Conventional Laparoscopic Pancreaticoduodenectomy
- Where
- 4 sites in China
- Volunteers
- 232 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Pancreaticoduodenectomy, Distal Pancreatectomy
Randomized Controlled Trial Comparing Closed-suction Drain Versus Passive Gravity Drain Following Pancreatic Resection
Pancreatic resection is the only potentially curative modality of treatment for pancreatic neoplasm. The mortality associated with this procedure decreased rapidly in the past decades.
- Trial name
- DRAPA (NCT01988519)
- Testing
- Closed gravity drain, closed suction drain
- Where
- 2 sites in Czechia
- Volunteers
- 223 people
- Sponsor
- University Hospital Hradec Kralove
Paralytic Ileus
Daikenchuto for Intestinal Dysmotility and Prevention of Postoperative Paralytic Ielus After Pancreaticoduodenectomy
A multicenter randomized-controlled trial of daikenchuto (TJ-100), a traditional Japanese herbal medicine (Kampo), to investigate its effect on intestinal dysmotility and for the prevention of postoperative paralytic ileus.
- Trial name
- JAPAN-PD (NCT01607307)
- Testing
- Oral/enteral TJ-100 solution
- Where
- 5 sites in Japan
- Volunteers
- 220 people
- Sponsor
- Wakayama Medical University
Pancreatic Cancer, Bile Duct Cancer
Effects of Preoperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy
The purpose of this study is to determine whether preoperative immunonutrition is effective on infectious complication and Th1/Th2 differentiation in patients with pancreaticoduodenectomy.
- Trial name
- EPIPD (NCT01256034)
- Testing
- Oral IMPACT
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Chiba University
Periampullary Cancer, Pancreatic Fistula
Complication of Pancreatic Fistula and Bleeding After Pancreaticoduodenectomy in Treatment Periampullary Cancer
This multi-site study will be done across Hepatobiliary and Pancreatic Surgery Department at Cho Ray Hospital and University and Pharmacy Center.
- Conditions
- Periampullary Cancer, Pancreatic Fistula, Bleeding
- Trial name
- PF (NCT04985071)
- Testing
- Pancreaticoduodenectomy
- Where
- Vietnam
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Vo Truong Quoc
Pancreatic Neoplasm
Evaluation of Difficulty Score for Robotic Pancreatoduodenectomy
Robotic pancreatoduodenectomy is the most complex surgery for a general surgeon and consequently a pancreatic surgeon can aspire to.
- Trial name
- NCT04662346
- Testing
- Difficulty score system for robotic pancreatoduodenectomy
- Where
- 2 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Pisa
Pancreaticoduodenectomy, ERAS
ERAS Program Implementation for MIPD
To evaluate the impact of an Enhanced Recovery After Surgery (ERAS) program on postoperative recovery in patients undergoing minimally invasive pancreatoduodenectomy (MIPD)
- Conditions
- Pancreaticoduodenectomy, ERAS, Minimally Invasive Surgery
- Trial name
- NCT07017361
- Testing
- Conventional, ERAS
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul National University Hospital