Clinical trials: Whipple Procedure
Pancreaticoduodenectomy
Effect of Perioperative Neurostimulation in Patients Undergoing Whipple Operation (Pancreaticoduodenectomy) on Acute Postsurgical Inflammatory Response [ENSWAPI-trial]
The purpose of this clinical trial is to test whether electrical stimulation of the vagus nerve via a device placed on the top of the external ear can reduce the postoperative inflammatory reaction after Whipple's surgery…
- Trial name
- NCT05743530
- Testing
- TENS - transcutaneous electrical nerve stimulation
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Graz
Pancreaticoduodenectomy, Delayed Gastric Emptying
Comparison Between Pylorus-resecting and Preserving Pancreaticoduodenectomy on Delayed Gastric Emptying and Nutrition
Pylorus preserving pancreaticoduodenectomy has been standard procedure for periampullary benign and malignant disease. Delayed gastric emptying is one of most common complications after the procedure.
- Conditions
- Pancreaticoduodenectomy, Delayed Gastric Emptying, Nutrition
- Trial name
- NCT05314244
- Testing
- Pylorus resecting pancreaticoduodenectomy
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Duodenopancreatectomy
Economisation of Whipple Resection Using Electrosurgical Sealing Device
Including 89 randomised patient, the studies aim is to determine whether an economisation and/or improvement in terms of operating time, drainage fluid, blood loss, time of hospitalisation can be found using an electrosurgical…
- Trial name
- SEAL (NCT00850291)
- Where
- Germany
- Volunteers
- 89 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Closure of POPF After Pancreaticoduodenectomy
Route of Nutritional Support for Pancreatic Fistula
The aim of this study is to compare the closure rate of pancreatic fistula (PF) after pancreaticoduodenectomy (PD) under various types of nutrition.
- Trial name
- NCT01755260
- Testing
- Jejunostomy tube feeding
- Where
- 2 sites in Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Continuous Glucose Monitoring
Effects of Intraoperative Glycemic Management Strategies Assisted With RT-CGM on TIR and Postoperative Recovery
The purpose of this study is to investigate the effect of intraoperative blood glucose management based on real-time continuous glucose monitoring ( RT-CGM) on time in range (TIR) and postoperative recovery during…
- Trial name
- NCT06755788
- Testing
- RT-CGM, Control
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Peking Union Medical College Hospital
Pancreaticoduodenectomy
Three-Dimensional Vascular Reconstruction of the Pancreas on Multidetector Computed Tomography Images and Its Impact on Patients Undergoing Pancreaticoduodenectomy
Three-Dimensional Vascular Reconstruction of the Pancreas on Multi detector Computed Tomography images and its impact on patients undergoing Pancreatoduodenectomy - A Prospective Observational Study IPDA is difficult to identify…
- Trial name
- NCT05389917
- Testing
- Pancreaticoduodenectomy
- Volunteers
- 25 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Duodenal Neoplasm, Pancreatic Neoplasm
Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy
This phase II trial compares the effect of rectus sheath block with liposomal bupivacaine to thoracic epidural analgesia (TEA) on pain control in patients following surgical removal of all or part of the pancreas and duodenectomy…
- Trial name
- NCT06411795
- Testing
- Bupivacaine, Hydromorphone, Iopamidol
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pancreaticoduodenectomy, Pancreatic Fistula
Intravenous Human Albumin In Improving Pancreaticoduodenectomy Outcomes
Pancreaticoduodenectomy (PD), more commonly known as Whipple's surgery is the mainstay treatment for pancreatic head and periampullary cancer.
- Conditions
- Pancreaticoduodenectomy, Pancreatic Fistula, Delayed Gastric Emptying, Pancreatic Cancer
- Trial name
- NCT04418739
- Testing
- Human albumin
- Where
- Malaysia
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Pancreatic Surgery, Antibiotic Prophylaxis
Impact of Antibiotic Prophylaxis Change on Surgical Site Infections After Pancreaticoduodenectomy
Patients undergoing pancreaticoduodenectomy after preoperative biliary drainage are at increased risk of surgical site infections (SSI) due to bile colonization.
- Conditions
- Pancreatic Surgery, Antibiotic Prophylaxis, Surgical Site Infection (SSI), Surgical Site Infection Prevention
- Trial name
- ICADI (NCT07531420)
- Where
- France
- Volunteers
- 117 people
- Sponsor
- Central Hospital, Nancy, France
Pancreatic Cancer, Cholangiocarcinoma
Margin Status After Pancreaticoduodenectomy for Cancer
This multicentric prospective randomized controlled trial (RCT) compares the Leeds Pathology Protocol (LEEPP) with other "conventional" pathological protocol of PD specimen for periampullary cancer.
- Conditions
- Pancreatic Cancer, Cholangiocarcinoma, Ampullary Cancer
- Trial name
- NCT03267966
- Testing
- Leeds Pathology Protocol (LEEPP)
- Volunteers
- 168 people
- Sponsor
- Campus Bio-Medico University
Pancreatic Cancer, Pancreas Cancer
Role of Proton Pump Inhibitors on the Postoperative Course Following Pancreaticoduodenectomy
The purpose of this study is to prospectively determine the effects of administering proton pump inhibitors (PPIs) following pancreaticoduodenectomy on postoperative outcomes.
- Conditions
- Pancreatic Cancer, Pancreas Cancer, Ampullary Cancer, Pancreas Neuroendocrine Tumor
- Trial name
- NCT05251233
- Testing
- Pantoprazole
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Washington University School of Medicine
Pancreas Cancer, Pancreatic Fistula
Validations of New cut-of for the Stratification of Postoperative Complications,Drains Management
Pancreatic fistula (PF) represents the Achille's heel of pancreatic surgery and is the main cause of postoperative morbidity since it can determine the onset of others complications such as abdominal abscesses, surgical wound…
- Trial name
- DALCUT (NCT04380506)
- Testing
- Surgical Drains Management
- Where
- Italy
- Volunteers
- 165 people
- Sponsor
- Campus Bio-Medico University
Auricular Acupoint Embedding, Pancreaticoduodenectomy
Ear Acupuncture Preventing Delayed Gastric Emptying.
Pancreatoduodenectomy is the preferred surgical method for periampullary diseases. The most common complication is gastric emptying disorder, which often greatly affects the quality of life of patients and prolongs the length of…
- Conditions
- Auricular Acupoint Embedding, Pancreaticoduodenectomy, Delayed Gastric Emptying
- Trial name
- NCT04118881
- Testing
- Ear Acupuncture
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Pancreatic Cancer, Pancreatic Anastomotic Leak
Pancreaticogastrostomy Versus Pancreaticojejunostomy in Reconstruction After Cephalic Duodenopancreatectomy
Pancreaticoduodenectomy is the standards surgical procedure for various malignant and benign disease of the pancreas and periampullariy region.
- Trial name
- PanAm (NCT01324856)
- Testing
- Pancreatico gastro anastomosis, Pancreaticojejuno anastomosis
- Where
- 4 sites in Serbia
- Volunteers
- 100 people
- Sponsor
- University of Belgrade
Digestive System Surgical Procedure, Pancreaticoduodenectomy
Impact of the Absence of Nasogastric Decompression After Pancreaticoduodenectomy
The use of nasogastric (NG) decompression after pancreaticoduodenectomy (PD) is a current practice. NG tube is associated with a high rate of morbidity including pulmonary morbidity, delayed gastric emptying and finally an…
- Trial name
- IPOD (NCT02594956)
- Testing
- no nasogastric tube, nasogastric tube
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Rennes University Hospital
Delayed Gastric Emptying, Postoperative Nausea and Vomiting
Intraoperative Pyloric Balloon Dilatation to Reduce Delayed Gastric Emptying After PPPD
Pylorus-preserving pancreatoduodenectomy (PPPD) is a standard surgical treatment for tumors of the pancreatic head and surrounding areas.
- Conditions
- Delayed Gastric Emptying, Postoperative Nausea and Vomiting, Gastric Emptying Time
- Trial name
- NCT07451392
- Testing
- Intraoperative Pyloric Balloon Dilatation
- Volunteers
- 70 people
- Sponsor
- Assiut University
Pancreas Neoplasm
Open Versus Laparoscopic Assisted Pancreaticoduodenectomy
Compare open and laparoscopic assisted pancreaticoduodenectomy regarding intraoprative blood loss, organ injury, completion of planned laparoscopic steps, duration and early post operative course of pain, hem stability, oral…
- Trial name
- NCT05463328
- Testing
- laparoscopic assisted pancreaticoduodenectomy, Open pancreaticduodenctomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Pancreatic Neoplasm
Prognostic Score To Predict Major Complications After Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) still carries a high rate of severe postoperative complications. No score is currently available to help identify the patient's surgical risk.
- Trial name
- NCT01278381
- Testing
- Pancreaticoduodenectomy
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Università Vita-Salute San Raffaele
Pancreas Cancer
Preoperative Stent Study
Randomized study comparing the effect of plastic stents to that of expandable metal stents as pre-operative drainage of the bile ducts prior to Whipple operation.
- Trial name
- NCT00501176
- Testing
- Plastic and metalic stent inserion
- Where
- Sweden
- Volunteers
- 92 people
- Sponsor
- Karolinska Institutet
Pancreatic Cancer Resectable, Pancreas Neoplasms
Antecolic Versus Retrocolic Gastrojejunostomy During Whipple's Procedure
Aim: This randomized clinical study aims to compare occurrence of DGE in patients undergoing either antecolic or retrocolic gastrojejunostomy following pancreaticoduodenectomy.
- Trial name
- NCT06914349
- Testing
- Antecolic gastrojejunostomy, Retrocolic gastrojejunostomy
- Where
- Greece
- Volunteers
- 76 people
- Sponsor
- University of Thessaly