Clinical trials: Whipple Procedure
Pancreatic Fistula
A Multicenter Randomized Controlled Study of External Pancreatic Duct Stents in Pancreaticoduodenectomy
The prognostic value of external vs internal pancreatic duct stents after pancreaticoduodenectomy remains controversial. This study aimed to evaluate the benefits of external and internal stents using the Updated Alternative…
- Trial name
- NCT05725590
- Testing
- External pancreatic duct stent, Internal pancreatic duct stent
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreatic Cancer, Adult, Cephalic Duodenopancreatectomy
Effects of Peptamen 1.6 in Malnourished Patients (or at Risk) With Pancreatic Neoplasia Undergoing Cephalic Pancreaticoduodenectomy (CPD): A Mechanistic Study
Malnutrition is a common challenge in patients with pancreatic cancer undergoing cephalic pancreaticoduodenectomy (CPD), impacting postoperative recovery and overall prognosis.
- Trial name
- NCT06852014
- Testing
- Dietary Supplement: Experimental Treatment with nutritional suplement A + nutritional suplement B, Dietary Supplement: Dietary Supplement: Experimental Treatment with nutritional suplement B + nutritional suplement A
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Pancreatic Surgery, Prophylactic SBRT
Stereotactic Body Radiotherapy (SBRT) Induced Pancreatic Atrophy for Prevention of Post Operative Pancreatic Fistulae (POPF) After Pancreatoduodenectomy in Very High-Risk Patients (STEREOPANC)
STEREOPANC is a randomized, controlled, open label, multicenter study initiated by the Oulu HPB Study Group. Patients with a very high risk of B/C POPF (soft pancreas) scheduled for PD for any indication are recognized at a local…
- Conditions
- Pancreatic Surgery, Prophylactic SBRT, Pancreatic Leak
- Trial name
- STEREOPANC (NCT07884019)
- Testing
- Remnant pancreas SBRT
- Where
- 3 sites in Finland
- Volunteers
- 70 people
- Sponsor
- Oulu University Hospital
Wound Infection and Wound Healing
The Effect of a Local Injection of a Platelet Concentrate on Infection and Healing of Surgical Wounds
The purpose of this project is to investigate whether a combination of a local injection of platelet rich plasma (PRP) combined with a daily supplement of vitamin C, zinc, L-arginine, as well as high protein diet (1.5 g of…
- Trial name
- NCT02869204
- Testing
- Leucocyte - Platelet rich Plasma, Vitamin C, Zinc
- Volunteers
- 40 people
- Sponsor
- Jens Rikardt Andersen
Pancreaticoduodenectomy, Postoperative Pancreatic Fistula
Pancreatic Parenchymal Injection of N-butyl-2-cyanoacrylate
This randomized controlled trial investigates the safety and efficacy of injecting N-butyl-2- cyanoacrylate (Histoacryl®) into the pancreatic parenchyma during pancreaticoduodenectomy (PD) to enhance the security of the…
- Conditions
- Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Pancreas Cancer, Periampullary Cancer
- Trial name
- NBCA (NCT07230509)
- Testing
- Pancreatic parenchymal injection of N-butyl-2- cyanoacrylate(Histoacryl®)Injection Group., Standard Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Pancreatic Cancer, Pancreaticoduodenal; Fistula
Early Detection of Anastomotic Leakage by Microdialysis Catheters
Anastomotic leakage of the pancreatojejunostomy is often discovered with considerable delay, causing severe peritonitis, hemorrhage due to erosion of vessels, sepsis, and death.
- Conditions
- Pancreatic Cancer, Pancreaticoduodenal; Fistula, Pancreas; Fistula, Pancreatic Fistula
- Trial name
- NCT03627559
- Testing
- Pancreaticoduodenectomy microdialysis catheter analyses
- Volunteers
- 35 people
- Sponsor
- Oslo University Hospital
Pain, Postoperative
Erector Spinae Plane Block With Ropivacaine for Major Upper Abdominal Surgery
Prospective, single-centre, randomized, controlled, open-label, evaluator-blinded, superiority trial.
- Trial name
- NCT04702685
- Testing
- Ropivacaine
- Where
- Kazakhstan
- Volunteers
- 50 people
- Sponsor
- Nazarbayev University Medical Center
Pancreatic Cancer, Pancreatic Fistula
Anastomotic Techniques in Pancreaticoduodenectomy
There are two principal ways of draining the remnant of the pancreas back into the intestine after removal of the head of the pancreas for cancer. This can be performed either to the jejunum or to the stomach.
- Trial name
- PG/PJ (NCT00855985)
- Testing
- type of anastomosis after pancreaticoduodenectomy
- Where
- India
- Volunteers
- 312 people
- Sponsor
- Lakeshore Hospital
Pancreatic Fistula, Pancreas Cancer
Reinforced Pancreaticojejunostomy With or Without glubran2
Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend different techniques in pancreatojejunostomy.
- Conditions
- Pancreatic Fistula, Pancreas Cancer, Periampullary Carcinoma, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06756074
- Testing
- Reinforced pancreaticojejunostomy with tissue adhesive glue modified cyanoacrylate (glubran 2), Pancreaticojejunostomy without tissue adhesive glue modified cyanoacrylate (glubran 2)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Pancreaticoduodenectomy
Minimally Invasive Pancreatico-duodenectomy
Open pancreaticoduodenectomy (PD) is the standard treatment for a wide array of periampullary and pancreatic diseases including malignant and benign conditions.
- Trial name
- LPD (NCT02807701)
- Testing
- Laparoscopic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Pancreatic Insufficiency
PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled Trial
After pancreas surgery, patients may develop pancreatic exocrine insufficiency (PEI). PEI can be treated with oral pancreatic enzyme replacement therapy (PERT).
- Trial name
- PERQ-UP (NCT05466838)
- Testing
- PERT at discharge, Standard of Care
- Where
- 6 sites in Canada
- Volunteers
- 166 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pancreatic Disease, Pancreatic Cancer
The Effectiveness of Adding Braun Anastomosis to Standard Child Reconstruction After Pancreatoduodenectomy
The goal of this clinical trial (REMBRANDT) is to evaluate the effectiveness of adding an extra connection (i.e. 'Braun anastomosis') after standard reconstruction in pancreatic head resection in reducing the incidence of delayed…
- Conditions
- Pancreatic Disease, Pancreatic Cancer, Delayed Gastric Emptying
- Trial name
- REMBRANDT (NCT05709197)
- Testing
- Braun anastomosis, Standard Child reconstruction
- Where
- 12 sites in Netherlands
- Volunteers
- 256 people
- Sponsor
- Radboud University Medical Center
Periampullary Cancer, Borderline Malignancy Tumor
The Effect of ERAS on Pancreaticoduodenectomy (v2.0)
Enhanced Recovery After Surgery (ERAS) is not a program that aims to reduce postoperative hospital stay, but the multimodal strategies that aim to attenuate the loss of, and improve the restoration of, functional capacity after…
- Trial name
- NCT06009224
- Testing
- ERAS perioperative management
- Where
- South Korea
- Volunteers
- 334 people
- Sponsor
- Asan Medical Center
Colon or Colorectal Resection, Partial or Total Gastrectomy
Development and Validation of a Predictive Score for Surgical Site Infections
More than 8 millions surgical interventions are carried out each year in France. Postoperative complications, in particular infectious, can occur in 10 to 60% of cases and are the cause of postoperative revision in 30% of cases…
- Conditions
- Colon or Colorectal Resection, Partial or Total Gastrectomy, Pancreaticoduodenectomy, Hepatectomy
- Trial name
- SPRED (NCT05523713)
- Testing
- Peripheral venous blood samples
- Where
- 4 sites in France
- Volunteers
- 283 people
- Sponsor
- Hopital Foch
Pancreatic Cancer, Periampullary Carcinoma
Evaluation of Preoperative Biliary Drainage Before Pancreatoduodenectomy
The purpose of this study is to evaluate the efficacy of preoperative biliary drainage (PBD) which is performed prior to pancreatoduodenectomy candidates with obstructive jaundice by observing the prevalence of drainage and…
- Trial name
- NCT01941342
- Testing
- Pancreatoduodenectomy, ENBD and Pancreatoduodenectomy, EBD and Pancreatoduodenectomy
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Southwest Hospital, China
Pancreas Cancer
Registry Study - Whipple at the Splenic Artery
The purpose of this study is to determine how effective Whipple at the Splenic Artery (WATSA).
- Trial name
- WATSA (NCT01155882)
- Testing
- Whipple at the Splenic Artery (WATSA)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Pancreaticoduodenectomy, Antibiotherapy
Postoperative Anti-infective Strategy Following Pancreaticoduodenectomy in Patients With Preoperative Biliary Stent
The main objective of the study is to compare 2 broad-spectrum antibiotic (Piperacillin / Tazobactam) treatment modalities, following pancreaticoduodenectomy in patients with preoperative biliary stent, to demonstrate the…
- Trial name
- FRENCH24 ANIS (NCT06123169)
- Testing
- Antibioprophylaxis (Piperacillin-tazobactam), 5 days Antibiotherapy (Piperacillin-tazobactam)
- Where
- France
- Volunteers
- 326 people
- Sponsor
- University Hospital, Rouen
Pancreas Neoplasm
The Neutrophil-to-Lymphocyte Ratio to Exclude Pancreatic Fistula
There is still no consensus on whether drain fluid amylase (DFA) level, C-reactive protein (CRP) level, or complex scores predict clinically relevant postoperative pancreatic fistula (CR-POPF).
- Trial name
- NLR (NCT04724551)
- Testing
- pancreatoduodenectomy (PD)
- Volunteers
- 648 people
- Sponsor
- Institut Paoli-Calmettes
Pancreatic Neoplasms; Periampullary Neoplasms
Enhanced Recovery After Minimally Invasive Pancreaticoduodenectomy
This prospective observational cohort study aims to improve the postoperative course after minimally invasive pancreaticoduodenectomy (MIP) with stented pancreaticogastrostomy (sPG) for pancreatic head or peri-ampullary…
- Trial name
- ERAMIP (NCT02671357)
- Testing
- ERAMIP
- Where
- Belgium
- Volunteers
- 210 people
- Sponsor
- University Hospital, Gasthuisberg
Pancreaticoduodenectomy, Drainage
Prospective Multicenter Trial of Early Versus Late Drain Removal After Pancreaticoduodenectomy
The aim of this randomized prospective multicenter study is to demonstrate the hypothesis that early removal of drain could reduce the incidence of major complications (grade 2-4) after pancreaticoduodenectomy (PD) , when…
- Trial name
- NCT03055676
- Testing
- Early drain removal, Late drain removal
- Where
- China
- Volunteers
- 319 people
- Sponsor
- Peking Union Medical College Hospital