Clinical trials: Whipple Procedure
Pancreas Cancer, Pancreaticoduodenal Lymphadenopathy
Para-aortic Lymphnodes Removal During Upfront Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) associated with lymphadenectomy is the only curative option for patients affected by pancreatic ductal adenocarcinoma (PDAC).
- Conditions
- Pancreas Cancer, Pancreaticoduodenal Lymphadenopathy, Pancreas Adenocarcinoma
- Trial name
- PALN (NCT04571294)
- Testing
- removal of para-aortic lymphnodes (PALN)
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Humanitas Hospital, Italy
Hemoglobins, Albumins
Association Between Preoperative HALP and Immediate Postoperative Outcomes
Multiple inflammation-based prognostic scores have been developed for the prediction of perioperative morbidity and mortality following pancreaticoduodenectomy (PD).
- Conditions
- Hemoglobins, Albumins, Platelets, Lymphocytes
- Trial name
- NCT05506748
- Testing
- pantients undergoing pancreaticoduodenectomy
- Where
- Nepal
- Volunteers
- 22 people
- Sponsor
- Chitwan Medical College
Postoperative Complications, Postoperative Pancreatitis
Cortisone Treatment for the Prevention of Postoperative Pancreatitis and Pancreatitis-induced Complications After Pancreaticoduodenectomy and Distal Pancreatic Resection
The purpose of this randomized, placebo-controlled trial is to investigate whether postoperative pancreatitis and other immediate complications after pancreaticoduodenectomy or distal pancreatic resection may be reduced with…
- Trial name
- NCT01460615
- Testing
- Hydrocortisone
- Where
- Finland
- Sponsor
- Tampere University Hospital
Adenocarcinoma of Head of Pancreas, Cholangio Carcinoma
Pancreatic Head and Peri-ampullary Cancer Laparoscopic vs Open Surgical Treatment Trial (PLOT)
The aim of this study is to compare the two surgical approaches namely laparoscopic pancreatoduodenectomy and open pancreatoduodenectomy for management of periampullary and pancreatic head cancers in terms of parameters like…
- Conditions
- Adenocarcinoma of Head of Pancreas, Cholangio Carcinoma, Duodenal Adenocarcinoma, Carcinoma of Ampulla of Vater
- Trial name
- PLOT (NCT02081131)
- Testing
- Open surgery, Laparoscopic surgery
- Where
- India
- Volunteers
- 64 people
- Sponsor
- GEM Hospital & Research Center
Pancreatoduodenectomy
Outcome After Laparoscopic Versus Open Pancreaticoduodenectomy
Aim of the study : To determine the morbimortality of Laparoscopic pancreaticoduodenectomy (LPD) compared to the gold standard Open pancreaticoduodenectomy approach (OPD).
- Trial name
- PaMIvOP (NCT04381702)
- Testing
- Pancreatoduodenectomy
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Pancreas Neoplasm
Postoperative Outcomes After Partial Duodenopancreatectomy Versus Total Pancreatectomy
The goal of this observational study is to compare short-term outcomes after partial pancreatoduodenectomy and total pancreatectomy in adults undergoing elective surgery for pancreatic or periampullary neoplasms in Switzerland.
- Trial name
- NCT07831694
- Volunteers
- 3,602 people
- Sponsor
- Cantonal Hospital of St. Gallen
Periampullary Neoplasms, Pancreatic Cancer
Cohort Study on Nutritional, Metabolic, and Volumetric Assessment After Pancreaticoduodenectomy
Periampullary malignant neoplasms are among the most lethal gastrointestinal tumors. They are usually diagnosed at advanced stages and require complex surgical treatment.
- Conditions
- Periampullary Neoplasms, Pancreatic Cancer, Pancreaticoduodenectomy
- Trial name
- NCT07159672
- Testing
- Pancreaticoduodenectomy
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Marco Aurélio Ribeiro, PhD
Quality of Life, Diabetes Mellitus
The Comparison of Quality of Life in Patients With Pancreatogenic Diabetes After Pancreatectomy
Background: Pancreatogenic diabetes resulted from total pancreatectomy(TP) is one of the reason why this form of surgery technique is seldom performed.
- Conditions
- Quality of Life, Diabetes Mellitus, Pancreatectomy
- Trial name
- NCT02985502
- Testing
- pancreatogenic diabetes
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Pancreaticoduodenectomy, Hepatectomy
Acute Normovolemic Hemodilution Versus Standard Intraoperative Management in Patients Having Hepatic Resection and Pancreaticoduodenectomy
With a major liver or pancreas operation, there is a chance that one will require a transfusion of blood products (either red blood cells or plasma). This may be necessary during the operation or a few days after surgery.
- Trial name
- NCT00200148
- Testing
- Normovolemic Hemodilution (ANH), Standard of care
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreaticoduodenectomy
Extended Retroperitoneal Lymphadenectomy and Nerve Plexus Clearance Versus Standard Lymphadenectomy in Pancreaticoduodenectomy
This clinical trial is about the survival benefit of extended lymphadenectomy and nerve clearance versus standard lymphadenectomy in pancreaticoduodenectomy of pancreatic adenocarcinoma，which is a…
- Trial name
- NCT03081351
- Testing
- extended lymphadenectomy and nerve clearance, standard lymphadenectomy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Zhongshan Hospital
Pancreatic Neoplasms, Pancreatic Fistula
Preoperative EUS Elastography for Pancreatic Texture and POPF Prediction After PD
This prospective study evaluates whether preoperative endoscopic ultrasound elastography (EUS-E) can predict pancreatic texture during surgery and risk of postoperative pancreatic fistula (POPF) in 100 patients undergoing…
- Trial name
- EUS-E (NCT07139236)
- Testing
- Preoperative Endoscopic Ultrasound Elastography (EUS Elastography)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Pancreatic Fistula
eXtended Antibiotic Prophylaxis for Intermediate- and High-risk Glands After Pancreatoduodenectomy to Reduce CR-POPF
The purpose of this clinical trial is to investigate if prolonged antibiotics after pancreatoduodenectomy can prevent the development of a pancreatic fistula and related complications.
- Trial name
- NCT05753735
- Testing
- Piperacillin/Tazobactam, Amoxicillin/ Clavulanic acid
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Case Comprehensive Cancer Center
Disease of Pancreatic Head or Periampullary Lesions to Require Pancreaticoduodenectomy
Predictive Risk Factors for Pancreatic Fistula Grade C After Pancreaticoduodenectomy
Pancreatic fistula (PF) grade C, defined by the International Study Group of Pancreatic Fistula (ISGPF) is associated with a life-threatening complication after pancreaticoduodenectomy(PD).
- Trial name
- NCT02322424
- Testing
- pancreaticoduodenectomy
- Where
- Taiwan
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Wakayama Medical University
Pancreatic Cancer, Common Bile Duct Diseases
A Prospective Study on the Safety and Efficacy of Robot-assisted Pancreaticoduodenectomy
Further studies are needed to investigate the prognosis and perioperative safety of patients undergoing robotic-assisted pancreaticoduodenectomy.
- Conditions
- Pancreatic Cancer, Common Bile Duct Diseases, Periampullary Carcinoma
- Trial name
- NCT05755594
- Testing
- Robot-assisted Pancreaticoduodenectomy
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of University of South China
Surgical Wound Infection, Pancreatic Neoplasms
The Use of Wound Protector in Whipple's Procedure With Intrabiliary Stent
Background: There are no published studies regarding the use of wound protectors in the context of surgical site infection (SSI) rates among patients receiving a pancreatoduodenectomy (Whipple) with preoperatively placed…
- Trial name
- NCT01836237
- Testing
- Alexis - a wound protector
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- University of Calgary
Pancreatic Neoplasms, Hypotension
Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia
This randomized clinical trial compares the hemodynamic effects of general anesthesia versus combined general anesthesia (thoracic epidural) in patients undergoing pancreatoduodenectomy.
- Conditions
- Pancreatic Neoplasms, Hypotension, Pancreatoduodenectomy
- Trial name
- NCT06953193
- Testing
- General Anesthesia, Combined General Anesthesia (Thoracic Epidural)
- Where
- Mexico
- Volunteers
- 206 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Pancreaticoduodenectomy
Learning Curve of Robotic Pancreatoduodenectomy
A few reports were focused on the RPD learning curve for surgeons with extensive experience in LPD. Therefore, this study aimed to investigate the number of cases required for such surgeons to overcome the learning curve for RPD…
- Trial name
- NCT06094465
- Testing
- Different phase of the learning curve of RPD
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Vomiting
Is Nasogastric Tube Necessary After Pancreaticoduodenectomy?
Nasogastric decompression was routinely used in most major intra-abdominal operations. Nasogastric tube intubation was thought to decrease postoperative ileus (nausea, vomiting, and gastric distension).
- Trial name
- NCT01991392
- Testing
- Nasogastric tube, No nasogastric tube
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Carcinoma, Pancreatic Ductal
Standard Versus Extended Lymphadenectomy in Pancreatoduodenectomy for Patients With Pancreatic Head Adenocarcinoma
The aim of this study is to determine whether the performance of extended lymphadenectomy in association with pancreatoduodenectomy improves the long-term survival in patients with pancreatic head ductal adenocarcinoma.Half of…
- Trial name
- NCT02928081
- Testing
- Extended lymphadenectomy, Standard lymphadenectomy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- West China Hospital
Resectable Pancreatic Cancer
Surgery Impact on Circulating Tumor DNA in Pancreatic Cancer
Pancreatic cancer represents the fourth cause of death by cancer in western countries. The only curative treatment is surgery but this one is possible only in 10 to 15 % of cases.
- Trial name
- ICAPAC (NCT03435536)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Toulouse