Clinical trials: Whipple Procedures
Pancreaticoduodenectomy, Malnutrition
Enteral vs. Oral Nutrition After Pancreatoduodenectomy
Patients suffering from pancreas cancer as well as patients with chronic pancreatitis or requiring pancreas surgery often are in a compromised nutritional status.
- Conditions
- Pancreaticoduodenectomy, Malnutrition, Postoperative Complications
- Trial name
- NUTRIWHI (NCT05042882)
- Testing
- Early enteral nutrition
- Where
- 3 sites in France, Switzerland
- Volunteers
- 144 people
- Sponsor
- University of Lausanne Hospitals
Acute Lung Injury, Chronic Obstructive Pulmonary Disease (COPD)
Imaging of Peri-operative (periOP) Lung Injury
The aim of study is to determine if 99mTc Annexin V-128 (AxV- 128/Tc) single photon emission computed tomography (SPECT)-computed tomography (CT) can detect perioperative lung injury.
- Trial name
- NCT02978885
- Testing
- SPECT-CT imaging, AxV-128/Tc, Whipple procedure
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Hospital Stay
Effect of Incentive Spirometer and Pursed Lip Breathing After Whipple Procedure.
Whipple procedure is one of the most complex surgeries among hepatobiliary surgeries. It has named as Pancreaticoduodenectomy. It can cause many PPCs. Lung volumes are reduced due to atelectasis and pneumonia.
- Trial name
- NCT06460584
- Testing
- Pursed Lip Breathing, Incentive Spirometer
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Duodenal Diverticulization, Pyloric Exclusion
National Retrospective Study of Duodenal Trauma
Duodenal injuries remain rare among abdominal trauma, concerning less than 5 % of cases. However, due to its central location, it is most commonly associated with multiple organs lesions, with the main three organs being the…
- Conditions
- Duodenal Diverticulization, Pyloric Exclusion, Gastrojejunostomy, Retrograde Duodenostomy
- Trial name
- TRAUMADUOD (NCT06058975)
- Testing
- Observational
- Where
- France
- Volunteers
- 135 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pancreatic Cancer, Periampullary Cancer
Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas
This is a single-center, randomized controlled trial comparing the efficacy of pancreaticojejunostomy with modified N-butyl-2-cyanoacrylate(Glubran® 2) versus standard pancreaticojejunostomy without cyanoacrylate in preventing…
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Duodenal Cancer, Cholangiocarcinoma
- Trial name
- NBCA-MS (NCT07155525)
- Testing
- Pancreaticojejunostomy with Modified N-Butyl-2-Cyanoacrylate (Glubran® 2), Standard(duct-to-mucosa) Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Minia University
Whipple Procedures, Pancreatic Cancer
Energy Expenditure and Nutrition After Pancreatic Surgery
This prospective observational cohort study examines the energy requirements and nutritional care of patients undergoing total or partial pancreatectomy for pancreatic tumors.
- Conditions
- Whipple Procedures, Pancreatic Cancer, Pancreaticoduodenectomy, Pancreatic Neoplasms
- Trial name
- NUTRI-PD (NCT07703813)
- Testing
- Pancreatectomy, Indirect calorimetry
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Evangelismos Hospital
Whipple Procedure
Whipple Procedure: A 5-year Clinical Experience in Tertiary Care Center
The study was conducted in tertiary care hospital of Lahore. Patient undergoing Whipple procedure were studied by compiling demographic details of the patients, common presenting symptoms, various indications for Whipple's…
- Trial name
- NCT03820583
- Testing
- Whipple Procedure
- Where
- Pakistan
- Volunteers
- 57 people
- Sponsor
- Services Hospital, Lahore
Whipple Procedure, Intraoperative Hemodynamic Management
MAP- Versus Cardiac Index-Guided Hemodynamic Management in Whipple Surgery
This prospective randomized study aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing pancreaticoduodenectomy.
- Trial name
- NCT07603336
- Testing
- Mean Arterial Pressure-Guided Hemodynamic Management, Cardiac Index-Guided Hemodynamic Management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Pancreatic Cancer
Correlation Between Complications After Pancreaticoduodenectomy and Microbiota
Pancreaticoduodenectomy is the most performed pancreatic surgery for malignant or premalignant tumors of the region of the head of the pancreas. Its post-operative morbidity is very high, over 40%.
- Trial name
- COMPAMIC (NCT04931069)
- Testing
- Microbiota analysis
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Toulouse
Pancreatic Head Neoplasm, Delayed Gastric Emptying
Nasogastric Decompression Following Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) remains the gold-standard operation for peri-ampullary neoplasms. Traditionally, gastric decompression via nasogastric intubation has been employed postoperatively to prevent nausea, vomiting…
- Conditions
- Pancreatic Head Neoplasm, Delayed Gastric Emptying, Post Operative Ileus, Whipple Procedure
- Trial name
- whipple (NCT06413888)
- Testing
- pancreaticoduodenectomy
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Baylor College of Medicine
Terlipressin, Blood Loss
Terlipressin Infusion During Whipple Procedure: Effect on Blood Loss and Transfusion Needs
The present study aims to look at the effect of terlipressin infusion on blood loss and blood transfusion needs during Whipple procedure
- Trial name
- NCT03572088
- Testing
- Terlipressin, normal saline
- Volunteers
- 40 people
- Sponsor
- Assiut University
Postoperative Outcome, Whipple Procedures
Veno-arterial CO2 Pressure Difference to Arterio-venous O2 Difference Ratio & Blood Lactate Levels Are Predictors of Postoperative Outcome in Whipple Procedures
Whipple surgery is a complex abdominal procedure associated with a high risk of hemodynamic instability and splanchnic hypoperfusion leading to anastomotic leaks, delayed gastric emptying, and organ dysfunction Traditional…
- Trial name
- NCT07306845
- Testing
- predictors of postoperative outcome in Whipple Procedures
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Duodenopancreatectomy
Economisation of Whipple Resection Using Electrosurgical Sealing Device
Including 89 randomised patient, the studies aim is to determine whether an economisation and/or improvement in terms of operating time, drainage fluid, blood loss, time of hospitalisation can be found using an electrosurgical…
- Trial name
- SEAL (NCT00850291)
- Where
- Germany
- Volunteers
- 89 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pancreatic Cancer Resectable, Pancreas Neoplasms
Antecolic Versus Retrocolic Gastrojejunostomy During Whipple's Procedure
Aim: This randomized clinical study aims to compare occurrence of DGE in patients undergoing either antecolic or retrocolic gastrojejunostomy following pancreaticoduodenectomy.
- Trial name
- NCT06914349
- Testing
- Antecolic gastrojejunostomy, Retrocolic gastrojejunostomy
- Where
- Greece
- Volunteers
- 76 people
- Sponsor
- University of Thessaly
Pain, Postoperative
Erector Spinae Plane Block With Ropivacaine for Major Upper Abdominal Surgery
Prospective, single-centre, randomized, controlled, open-label, evaluator-blinded, superiority trial.
- Trial name
- NCT04702685
- Testing
- Ropivacaine
- Where
- Kazakhstan
- Volunteers
- 50 people
- Sponsor
- Nazarbayev University Medical Center
Pancreatic Cancer, Pancreatic Fistula
Anastomotic Techniques in Pancreaticoduodenectomy
There are two principal ways of draining the remnant of the pancreas back into the intestine after removal of the head of the pancreas for cancer. This can be performed either to the jejunum or to the stomach.
- Trial name
- PG/PJ (NCT00855985)
- Testing
- type of anastomosis after pancreaticoduodenectomy
- Where
- India
- Volunteers
- 312 people
- Sponsor
- Lakeshore Hospital
Pancreas Cancer
Registry Study - Whipple at the Splenic Artery
The purpose of this study is to determine how effective Whipple at the Splenic Artery (WATSA).
- Trial name
- WATSA (NCT01155882)
- Testing
- Whipple at the Splenic Artery (WATSA)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Pancreatoduodenectomy, Whipple Procedure
Antiseptic-Coated Sutures and Pancreatic Fistula Risk After Pancreatoduodenectomy
The purpose of this study is to determine if the use of antiseptic-coated sutures is better than the use of the standard sutures in preventing postoperative fistulas within 90 days after pancreatoduodenectomy.
- Trial name
- Triclosan (NCT07318493)
- Testing
- Standard (non-antiseptic coated) suture will be used., Triclosan/antiseptic -coated suture
- Where
- 3 sites in United States
- Volunteers
- 436 people
- Sponsor
- The Cleveland Clinic
Pancreatic Neoplasms, Bile Duct Carcinoma
Whipple Procedure: Standard of Care vs. Thunderbeat
The Whipple procedure is the standard method for therapy for cancerous tumors, inflammation, and stenosis (narrowing) near the head of the pancreas.
- Trial name
- NCT02204124
- Testing
- Thunderbeat, Standard of care scissors, ligatures, clips, and sutures
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Washington University School of Medicine
Esophageal Neoplasms, Stomach Neoplasms
The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery
Improvements to treatment strategies for patients with cancers of the upper gastrointestinal tract have produced a large population of people who remain free from cancer recurrence in the long term following treatment.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02381249
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland