Clinical trials: White Blood Cells
Eosinophilic Esophagitis
The Efficacy and Tolerability of 12-weeks Treatment With Almond and Buckwheat Based Formula in Pediatric Patients With Active EoE
Eosinophilic esophagitis (EoE) is a chronic, relapsing, immune-mediated esophageal disease. Clinical manifestations in infants and toddlers generally include vomiting, food refusal, choking with meals and, less commonly, failure…
- Trial name
- NCT05622214
- Testing
- Else nutrition formula
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Primary Immune-Deficiency (PID) Common Variable Immune Deficiency (CVID)
Severe PID With Lymphoproliferation and Neutropenia
The purpose of this study is to analyse the phenotype in a sub-population of adults with severe primary immunodeficiency with lymphoproliferation and neutropenia and to decipher the possible pathways involved, especially under…
- Trial name
- DICEP (NCT03427593)
- Testing
- FACS analyses, Target Sequencing by NGS ( Next-generation sequencing), Whole Exome Sequencing
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Immunosuppresion, Thrombocytopenia
Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia
Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder characterized by pancytopenia and a hypocellular bone marrow.
- Conditions
- Immunosuppresion, Thrombocytopenia, Pancytopenia, Neutropenia
- Trial name
- NCT00260689
- Testing
- Anti-thymocyte globulin (rabbit), Anti-thymocyte globulin (horse), Cyclosporine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Solid Tumors, Malignant Hemopathy
Nivestim® (Filgrastim) Tolerance in Patients Treated by Toxic Chemotherapeutic Agents
The main aim of the study is to assess the safety of Nivestim® treatment in patients treated with neutropenia-inducing chemotherapy for a malignant disease, solid tumor or a malignant hemopathy.
- Conditions
- Solid Tumors, Malignant Hemopathy, Chemotherapy-induced Febrile Neutropenia (FN)
- Trial name
- NCT01574235
- Testing
- Nivestim®
- Where
- 87 sites in France
- Volunteers
- 2,114 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Chronic Lymphocytic Leukemia
Ibrutinib and PD-1 Blockade in High Risk Lymphocytic Leukemia
The purpose of this study is to evaluate the impact of sequential overlapping treatment with PD-1 monoclonal antibody (mAb), pembrolizumab/MK-1375, followed by ibrutinib on endogenous immune function in previously untreated…
- Trial name
- NCT03514017
- Testing
- Pembrolizumab, Ibrutinib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Wound Infection
A Comparison of Surgical Preparations and Wound Infection Rates for Elective Cesarean Sections
The purpose of this study is to find out if chlorhexidine gluconate solution is better at reducing the rate of wound infection after cesarean section compared to povidone-iodine.
- Trial name
- NCT00528008
- Testing
- povidone-iodine solution, chlorhexidine gluconate
- Where
- Canada
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Eosinophilic Esophagitis
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine…
- Trial name
- NCT03822325
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Eosinophilic Esophagitis
Capsule Sponge Study in Eosinophilic Oesophagitis
Open pragmatic, descriptive single site study in adult patients with non-stenotic eosinophilic oesophagitis. To assess the clinical value of Capsule sponge in the assessment of treatment response in patients with known…
- Trial name
- Cosie (NCT06501274)
- Testing
- capsule sponge
- Where
- United Kingdom
- Volunteers
- 143 people
- Sponsor
- East and North Hertfordshire NHS Trust
Colorectal Cancer, Diarrhea
Biomarker-Guided Fluorouracil in Treating Patients With Colorectal Cancer Receiving Combination Chemotherapy
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, oxaliplatin, and leucovorin calcium, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Colorectal Cancer, Diarrhea, Neutropenia
- Trial name
- NCT01164215
- Testing
- fluorouracil, leucovorin, oxaliplatin
- Where
- 5 sites in United States
- Volunteers
- 76 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer
Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment
RATIONALE: Caspofungin acetate or amphotericin B liposomal may be effective in preventing or controlling fever and neutropenia caused by chemotherapy, bone marrow transplantation, or peripheral stem cell transplantation.
- Trial name
- NCT00008359
- Testing
- caspofungin acetate, liposomal amphotericin B
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lateral Epicondylitis (Tennis Elbow)
Platelet Rich Plasma Injection vs Percutaneous Tenotomy for Common Extensor Tendinopathy
This is a randomized control trial comparing the use of leukocyte rich platelet rich plasma injections to percutaneous tenotomy for the treatment of chronic common extensor tendinopathy.
- Trial name
- NCT04384809
- Testing
- Leukocyte rich platelet rich plasma, Percutaneous Tenotomy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Inflammation, Brain
Control of Leukocyte Function
The protocol is to draw peripheral blood from healthy volunteers for in vitro studies. The aims of these in vitro studies are to determine the cellular and intracellular mechanisms by which hypertonic saline and ATP release…
- Trial name
- NCT03027232
- Testing
- No intervention (drugs) will be given. Purpose: collecting blood for in vitro studies
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Alveolar Socket Preservation
Connective Tissue Graft and Leucocyte - Platelet Rich Fibrin in Alveolar Ridge Preservation
The purpose of our randomized controlled clinical trial is to evaluate radiographic bone dimensional changes and soft tissue healing and thickness after teeth extraction and the implementation of alveolar ridge preservation (RAP)…
- Trial name
- NCT06663982
- Testing
- Connective tissue graft + L-PRF, L-PRF
- Volunteers
- 34 people
- Sponsor
- G. d'Annunzio University
Chemotherapy-Induced Neutropenia
Evaluation of the Food Effect on the Safety, Tolerability, PK of EC-18 After Oral Administration in Healthy Volunteers
A Randomized, Open-Label, Single -Dose, Crossover, Phase I Clinical Trial to Evaluate the Effect of Food on the Safety, Tolerability and Pharmacokinetics of EC-18 after Oral Administration in Healthy Volunteers
- Trial name
- NCT02700360
- Testing
- high-fat diet, EC-18
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Enzychem Lifesciences Corporation
Sepsis, Disseminated Intravascular Coagulation (DIC)
Fluorescent Leukocytes as a Marker of Early Sepsis/Severity
Sepsis is a medical emergency whose prognosis depends on the early identification of patients at risk of septic shock, but the tools available in the Emergency Department remain insufficient.
- Conditions
- Sepsis, Disseminated Intravascular Coagulation (DIC), Septic Shock
- Trial name
- FLAMES (NCT07585942)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Granulomatous Diseases (CGD) and Liver Lesions
Radiofrequency Ablation for Liver Abscesses From Chronic Granulomatous Disease
Background: Abscesses are a pocket of infection in an organ or tissue. Patients with a disease called chronic granulomatous disease (CGD) often develop these abscesses.
- Trial name
- NCT01851460
- Testing
- Cool-tip RF Ablation System
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Severe Eosinophilic Asthma
Mepolizumab: Real World Evidence Study for the Treatment of Severe Eosinophilic Asthma in Greece
A prospective multi-centre, non-interventional observational study, that will be conducted in several centers in Greece for a 2-year time period (completion date December 2020), to describe patient characteristics, medical…
- Trial name
- NCT04084613
- Volunteers
- 150 people
- Sponsor
- Attikon Hospital
Given Indication for Open Resection of Colorectal Cancer
Diagnostic Value of C-reactive Protein and White Blood Cell Counts for Early Detection of Inflammatory Complications After Open Resection of Colorectal Cancer
Although widely used, there is a lack of evidence concerning diagnostic value of C-reactive protein (CRP) and white blood cell counts (WBC) in the postoperative course.
- Trial name
- NCT01221324
- Volunteers
- 1,200 people
- Sponsor
- Cantonal Hospital of St. Gallen
Gingival Papillary Cratering
Efficacy of HA Gel Injection Versus Multilayer (L-PRF) in the Interdental Papilla Reconstruction
This research aims to investigate the effectiveness of non invasive application Hyaluronic acid gel injection versus minimally invasive surgical approach using multilayer L-PRF both clinically and radiographically as a suitable…
- Trial name
- NCT05953896
- Testing
- Hyaluronic acid gel, Multilayer L-PRF membranes
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aya Elleithy
Food Allergy, Eosinophilic Esophagitis
Molecular Basis of Food Allergy
The Study examines the molecular basis of food allergy. It explores the interaction between T cells, InKT cells, basophils and cytokines in the development of food allergy.
- Trial name
- NCT01832324
- Where
- United States
- Volunteers
- 5,300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
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