Clinical trials: White Blood Cells
Eosinophilic Asthma, Severe Asthma
Fasenra: An Asthma Study
The goal of this observational study is to learn more about the effectiveness of benralizumab (Fasenra, 30 mg every 8 weeks) in maintaining asthma control in people with severe eosinophilic asthma.
- Conditions
- Eosinophilic Asthma, Severe Asthma, Severe Eosinophilic Asthma, Asthma
- Trial name
- NCT07654842
- Testing
- Budesonide-albuterol, Benralizumab
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Endeavor Health
Esophagitis, Eosinophilic
Outcome of Children With Eosinophilic Esophagitis
The investigator would like to create a prospective cohort of patients in order to describe eosinophilic esophagitis with the specificities corresponding to our geographical territory, and to study their evolution at 3 months, 6…
- Trial name
- Obs-OE (NCT06190080)
- Testing
- Digestive endoscopy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Fondation Lenval
Immunologic Deficiency Syndrome, Agammaglobulinemia
Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency Patients
The objective of this study is to determine if the safety and tolerability of Immune Globulin Intravenous (Human), 10% caprylate/chromatography (IGIV-C)purified is similar when infused at two different infusion rates.
- Conditions
- Immunologic Deficiency Syndrome, Agammaglobulinemia, Severe Combined Immunodeficiency, Wiskott-Aldrich Syndrome
- Trial name
- NCT00220766
- Testing
- Immune Globulin Intravenous [Human], 10% Caprylate/Chromatography Purified, Dextrose, 5% in Water
- Where
- 13 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Grifols Therapeutics LLC
Neutropenia
A Phase II, Dose-finding Study of F-627 in Patients With Breast Cancer Receiving Myelotoxic Chemotherapy.
This was a randomized, open-label, active-controlled, dose-finding, phase II study to evaluate the efficacy and safety of 2 doses of F-627 compared to Filgrastim in women with breast cancer receiving myelotoxic chemotherapy.
- Trial name
- NCT02521441
- Testing
- F-627, Filgrastim
- Where
- China
- Volunteers
- 138 people
- Sponsor
- EVIVE Biotechnology
Neutropenia
Pegfilgrastim as Support to Advanced Breast Cancer Patients Receiving Chemotherapy
Physicians are conducting a clinical trial for patients with advanced breast cancer. Breast cancer can be treated with chemotherapy which can affect the bone marrow, where blood cells are produced.
- Trial name
- NCT00035594
- Testing
- pegfilgrastim
- Volunteers
- 928 people
- Sponsor
- Amgen
Food Allergy, Loeys-Dietz Syndrome
Natural History and Genetics of Food Allergy and Related Conditions
Background: About 15 million Americans have a food allergy. Because there are no cures or effective prevention or treatment for food allergies, researchers want to learn more about them.
- Conditions
- Food Allergy, Loeys-Dietz Syndrome, Atopic Dermatitis, Eosinophilic Esophagitis
- Trial name
- NCT02504853
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nosocomial Infection, Pneumonia
Pilot Study of the Utility of Empiric Antibiotic Therapy for Suspected ICU-Acquired Infection
Infection developing in the intensive care unit is a common complication of critical illness, but notoriously difficult to diagnose.
- Conditions
- Nosocomial Infection, Pneumonia, Systemic Inflammatory Response Syndrome, Critical Illness
- Trial name
- NCT00438269
- Testing
- Site-specific empiric regimens included: Meropenem, Piperacillin/tazobactam, Ciprofloxacin and cefazolin +/- metronidazole
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Canadian Critical Care Trials Group
Hematological Malignancies
Intrabone Infusion of Cord Blood in Adults With Hematological Malignancies
The purpose of this study is to evaluate the engraftment of donor hemopoiesis (proportion of transplanted patients with successful engraftment at day +42) in adult patients affected by high risk hematological malignancies after…
- Trial name
- IBCB (NCT00886522)
- Testing
- Intrabone cord blood infusion
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Eosinophilic Esophagitis (EoE)
A Study to Investigate the Efficacy and Safety of NSI-8226 in Adults With Eosinophilic Esophagitis
Phase 2 study to evaluate the safety, tolerability, PK, immunogenicity, and pharmacodynamics of solrikitug in adult participants with eosinophilic esophagitis.
- Trial name
- NCT06598462
- Testing
- Solrikitug Low Dose, Solrikitug Mid Dose, Solrikitug High Dose
- Where
- 73 sites in United States, Australia and 7 more
- Volunteers
- 184 people
- Sponsor
- Uniquity One (UNI)
Infectious Mononucleosis, Epstein-Barr Virus Infections
Study on Infectious Mononucleosis in Munich
This observational clinical study aims at the identification of novel biomarkers and causative factors of complicated and/or protracted Epstein-Barr virus-associated infectious mononucleosis (IM).
- Trial name
- IMMUC (NCT06002802)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technical University of Munich
Neutropenia
Hematological Effects of Atypical Antipsychotics (AAPs) in a Geriatric Population: What is the Role of 5-HT2 Receptors
White lineage abnormalities and in particular neutropenia and agranulocytosis are known and increasingly studied adverse effects of antipsychotics, particularly second generation.
- Trial name
- AAPs (NCT06107322)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Diabetes Mellitus, Type 2, Atherosclerosis
The Gene Expression Patterns in the Peripheral White Blood Cells of Type 2 Diabetic Patients
The investigators hypothesize that macrophages play a crucial role in the pathogenesis of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT00155922
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Eosinophilic Esophagitis
EoE Food Desensitization
This is a single-center, prospective, pilot clinical trial in which children ages 3-17 years with eosinophilic esophagitis (EoE) who have a known food that triggers EoE flares receive oral desensitization with that specific food…
- Trial name
- NCT02881372
- Testing
- Oral food desensitization
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Chemotherapy Associated Neutropenia, Breast Cancer
Phase III Study Comparing the Efficacy and Safety of EP2006 and Filgrastim
The study will assess the efficacy of EP2006 compared to Filgrastim with respect to the mean duration of severe neutropenia during treatment with myelosuppressive chemotherapy in breast cancer patients.
- Trial name
- PIONEER (NCT01519700)
- Testing
- EP2006, Filgrastim
- Where
- 26 sites in Czechia, Hungary and 4 more
- Volunteers
- 218 people
- Sponsor
- Sandoz
Breast Cancer
A Study to Evaluate the Efficacy, Safety and Immunogenicity of Leucostim® Versus Neupogen® in Breast Cancer Patients
A study to compare the efficacy, safety and immunogenicity of Leucostim® to those of Neupogen® in patients with breast cancer intended to be treated with TAC regimen as a myelosuppressive chemotherapy.
- Trial name
- NCT03343145
- Testing
- Leucostim 5µg/kg/day, Neupogen 5µg/kg/day
- Where
- Indonesia
- Volunteers
- 143 people
- Sponsor
- Dong-A ST Co., Ltd.
Hemolytic Disorders, Gallstones
The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders
It is well established that hemolytic diseases predispose patients to the development of pigment gallstones. Gallstones are noted in at least 5% of children under the age of 10 years, increasing to 40-50% in the second to fifth…
- Trial name
- NCT02472509
- Testing
- Ursodeoxycholic Acid
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Shaare Zedek Medical Center
Non-small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma
A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
Phase I Study of NT-175, an autologous T cell therapy product genetically engineered to express an HLA-A*02:01-restricted T cell receptor (TCR), targeting TP53 R175H mutant malignancies
- Conditions
- Non-small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, Colorectal Carcinoma, Pancreatic Adenocarcinoma
- Trial name
- NCT05877599
- Testing
- NT-175
- Where
- 20 sites in United States
- Volunteers
- 45 people
- Sponsor
- AstraZeneca
Sepsis (SMQ), Opportunistic Infections
Evaluation of Reporting of Antibody-Drug Conjugate Associated Sepsis-related Toxicities
Although antibody-drug conjugate(ADC) has proved effective in treating many cancers, few patients receiving ADC may experience rare but life-threatening sepsis-related toxicities such as sepsis and septic shock.
- Conditions
- Sepsis (SMQ), Opportunistic Infections, Agranulocytosis
- Trial name
- NCT05349383
- Testing
- Antibody-Drug Conjugate, Antineoplastic and immunomodulating agents other than Antibody-Drug Conjugate
- Where
- China
- Volunteers
- 24,618 people
- Sponsor
- Central South University
Eosinophilic Esophagitis, Eosinophilic Gastritis
Eosinophilic Gastrointestinal Disorders Patient Registry
The Eosinophilic Gastrointestinal Disorders (EGIDS) Registry is a longitudinal study that does not involve medical interventions, but serves as a record of demographics, characteristics of disease and treatment, utilization…
- Conditions
- Eosinophilic Esophagitis, Eosinophilic Gastritis, Eosinophilic Enteritis, Eosinophilic Colitis
- Trial name
- NCT01779154
- Where
- United States
- Sponsor
- Arkansas Children's Hospital Research Institute
Leukemia, Lymphoma
Donor Stem Cell Transplant Followed By Donor White Blood Cell Infusions in Treating Young Patients With Hematologic Cancer
RATIONALE: Giving chemotherapy before a donor peripheral blood stem cell transplant helps stop both the growth of cancer cells and the patient's immune system from rejecting the donor's stem cells.
- Trial name
- NCT00301860
- Testing
- anti-thymocyte globulin, filgrastim, therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, San Francisco
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