Clinical trials: White Matter Hyperintensity
Migraine
Prediction of WMH in Migraine Using a BOLD-CVR Map
Brain white matter hyperintensities (WMHs) are prevalent in migraineurs, of which the mechanism is still unclear. The investigators aimed to test the spatial association between areas with reduced cerebrovascular reactivity (CVR)…
- Trial name
- NCT03494673
- Testing
- BOLD MRI
- Where
- South Korea
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Alzheimer's Dementia
Cilostazol Augmentation Study in Dementia
The purpose of this study is to examine the effects of cilostazol augmentation in mild to moderate Alzheimer disease patients with subcortical white matter hyperintensities (WMHI) treated by donepezil.
- Trial name
- NCT01409564
- Testing
- Cilostazol
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Seoul National University Hospital
Neurological Impairments, Leukoencephalopathies
Hyperbaric Oxygen Treatment in Patients With White Matter Hyperintensities
The primary purpose of this study is to assess whether hyperbaric oxygen treatment improves neurological function in patients who exhibit white matter hyperintensities on MRI examination.
- Trial name
- NCT00497432
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- St. Luke's Hospital, Chesterfield, Missouri
Migraine, Small Vessel Ischemic Disease
A Study to Evaluate White Matter Hyperintensities in Migraine
The purpose of this research is to better understand brain white matter hyperintensities (WMH) in women with migraines
- Conditions
- Migraine, Small Vessel Ischemic Disease, Multiple Sclerosis
- Trial name
- NCT05112289
- Testing
- Brain Neuroimaging
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Leukoaraiosis, Magnetic Resonance Imaging
Leucoaraiosis and Multimodal MRI With Fingerprinting Technique
Leukoaraiosis (LA) corresponds to an alteration of the encephalic white matter, linked to chronic hypoxia. Its pathophysiology, which has been partially elucidated, is underpinned by chronic changes in the walls of small-caliber…
- Trial name
- LEUKOPRINT (NCT06181981)
- Testing
- MRI fingerprinting
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Lille Catholic University
White Matter Hyperintensity, Multiple Sclerosis
Evaluation of the Reproducibility of the Measurement of the QSM Signal (Quantitative Susceptibility Mapping)
Many central nervous system pathologies have an inflammatory component, often associated with an accumulation of disability and more severe tissue damage.
- Trial name
- ERESI (NCT04465448)
- Testing
- MRI
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Spinal Cord Injury
A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences
The general population is aging, today 12% of the United States population is older than 65 and it is estimated that by 2020 the number of people in the United States older than 65 will outnumber children younger than 5.
- Trial name
- NCT03023163
- Testing
- Longitudinal
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Mild Cognitive Impairment, Alzheimer Disease
White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease
This study focuses on assessing and measuring white matter hyperintensities in individuals with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease.
- Trial name
- NCT06179680
- Testing
- Magnetic Resonance Imaging
- Where
- Italy
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
White Matter Hyperintensity
Measuring Brain Health Using Low-Field Portable MRI
The purpose of this study is to develop a new grading scale and utilize automated segmentation for measurement of White Matter Hyperintensity (WMH) volume using a low field MRI.
- Trial name
- MR SCREEN (NCT06533631)
- Testing
- Portable low-field MRI (pMRI), 3T MRI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Cerebral Amyloid Angiopathy, Hypertensive Arteriopathy
Periventricular White Matter Hyperintensities in Cerebral Amyloid Angiopathy and Hypertensive Arteriopathy
White matter hyperintensities (WMH) are one of the small vessel disease-related MRI characteristics of both cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA).
- Trial name
- PVWMH (NCT05486897)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 315 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Mild Cognitive Impairment
A Computer-based Cognitive Stimulation in Mild Cognitive Impairment With White Matter Hyperintensities
This is a non-pharmacological study evaluating the impact of a computerized cognitive stimulation program on verbal learning and on the progression white matter hyperintensities in elderly with mild cognitive impairment.
- Trial name
- NCT03195816
- Testing
- Computerized Cognitive training
- Volunteers
- 90 people
- Sponsor
- Leila DJABELKHIR
Mild Cognitive Impairment
Cognitive Intervention in Mild Cognitive Impairment With or Without White Matter Hyperintensities
This is a non-pharmacological study evaluating the differential effects of a computerized cognitive stimulation program according to the existence or not of white matter hyperintensities in elderly with mild cognitive impairment.
- Trial name
- NCT03195803
- Testing
- Computerized Cognitive Stimulation
- Volunteers
- 51 people
- Sponsor
- Leila DJABELKHIR
Parkinson's Disease
A Retrospective Study of the Relationship Between White Matter Hyperintensities(WMHs) Within the Cholinergic Pathways and the Cognition of PD Patients After Bilateral STN DBS
To retrospectively investigate the relationship between the Cholinergic Pathways Hyperintensities Scale (CHIPS) score and the change of cognitive status of Parkinson's disease (PD) patients after bilateral subthalamic nucleus…
- Trial name
- NCT02071693
- Where
- China
- Volunteers
- 38 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Aging, Premature, Congenital Heart Disease
White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a Pilot Study
The study aims at investigating the role of cyanotic congenital heart disease (cCHD) on brain aging. The investigators assume that due to congenital and acquired cardiovascular abnormalities, cCHD patients could show radiologic…
- Conditions
- Aging, Premature, Congenital Heart Disease, White Matter Hyperintensities
- Trial name
- NCT03487302
- Testing
- Brain MRI, Neuropsychological test battery
- Where
- Italy
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Aged, Leukoaraiosis
The Relationship Between White Matter Hyperintensity With Cognition and Emotion
White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing…
- Trial name
- NCT02761148
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Encephalopathy, White Matter Hyperintensities
Effect of HBO on Functional Connectivity of Resting State Networks in Patients With Cerebral Small Vessel Disease
The purpose of this study is to extend our previous work, in which we demonstrated an increase in the internal and cross network connectivity of resting state neural networks in patients with cerebral small vessel disease by…
- Conditions
- Encephalopathy, White Matter Hyperintensities, Impaired Oxygen Delivery
- Trial name
- HBO (NCT02232958)
- Testing
- Hyperbaric Oxygen Treatment
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- St. Luke's Hospital, Chesterfield, Missouri
Mild Cognitive Impairment, White Matter Hyperintensity
Use of Gou-Teng to Treat Patients With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a pre-dementia condition commonly occurs in elderly people. As Hong Kong has become an aged society, the prevalence of dementia and MCI in Hong Kong has increased substantially in recent…
- Trial name
- NCT04532697
- Testing
- Uncaria Rhynchophylla (Gou-Teng)
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- Chinese University of Hong Kong
Cerebral Small Vessel Diseases
White Matter Hyperintensities Subtypes in Cerebral Small Vessel Disease : 7 Tesla Ultra-high Resolution Imaging MRI
Cerebral small vessel diseases (SVD) are a very frequent group of disorders all characterized by alterations of the structure and/or function of small arteries, veins and capillaries.
- Trial name
- SV7 (NCT04298866)
- Testing
- Experimental Arm
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dementia, Mixed, Dementia, Vascular
Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy
The STAREE-Mind imaging sub-study will examine the effect of statin treatment over a 4-year period, compared with placebo, on markers of brain health.
- Conditions
- Dementia, Mixed, Dementia, Vascular, Dementia of Alzheimer Type, Cognitive Decline
- Trial name
- STAREE-Mind (NCT05586750)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- 2 sites in Australia
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Monash University
Cerebral Small Vessel Diseases, Postmenopausal Symptoms
Effect of Menopause Hormone Therapy In Postmenopausal Women With CSVD And MCI
The objective of this clinical trial is to explore the efficacy of menopausal hormone therapy in early menopausal women with CSVD and MCI.
- Conditions
- Cerebral Small Vessel Diseases, Postmenopausal Symptoms, Mild Cognitive Impairment, White Matter Hyperintensity
- Trial name
- MIRACLE (NCT05982470)
- Testing
- Estradiol Gel, Progesterone Soft Capsule
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Beijing Tiantan Hospital