Clinical trials: White Matter Hyperintensity, open to volunteers
Ischemic Stroke, Acute, Blood Pressure Variability
Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic Stroke
This prospective observational cohort study examines whether blood pressure variability and nighttime blood pressure patterns, measured non-invasively over 72 hours with a cuffless ring-type wearable device, help predict recovery…
- Conditions
- Ischemic Stroke, Acute, Blood Pressure Variability, Cerebral Small Vessel Disease, White Matter Hyperintensity
- Trial name
- COMPASS (NCT07903922)
- Testing
- Cuffless ring-type continuous blood pressure monitor
- Where
- South Korea
- Volunteers
- 450 people
- Sponsor
- Minyoul Baik
Stroke, Ischemic, Small Vessel Cerebrovascular Disease
Antiplatelet Therapy and Endothelial-stabilizing Agents in Cerebral Small Vessel Diseases
Cerebral small vessel disease (cSVD) is a common accompaniment of aging. Recent small subcortical (or lacunar) infarcts (i.e. symptomatic cSVD) and white matter hyperintensities are typical cSVD lesions on neuroimaging.
- Conditions
- Stroke, Ischemic, Small Vessel Cerebrovascular Disease, White Matter Hyperintensity
- Trial name
- Athena-cSVD (NCT06715007)
- Testing
- Clopidogrel, Aspirin, Cilostazol + Isosorbide Mononitrate
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Ischemic Stroke, Hypertension
Imaging the Pathogenesis of Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI.
- Conditions
- Ischemic Stroke, Hypertension, Hyperlipidemias, Diabetes
- Trial name
- NCT05703386
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Cerebral Small Vessel Disease, Cognitive Impairment
Remote Ischemic Conditioning for Cognitive Impairment in Cerebral Small Vessel Disease
This randomized, double-blind, sham-controlled trial aims to evaluate the effect of remote ischemic conditioning (RIC) on cognitive function in patients with cerebral small vessel disease-related mild cognitive impairment.
- Trial name
- RIC-CSVD (NCT07317557)
- Testing
- Remote ischemic conditioning using IPC-906 device
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Mild Cognitive Impairment, Alzheimer Disease
White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease
This study focuses on assessing and measuring white matter hyperintensities in individuals with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease.
- Trial name
- NCT06179680
- Testing
- Magnetic Resonance Imaging
- Where
- Italy
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Cerebral Small Vessel Diseases, Dementia, Mixed
WHIte MAtter Hyperintensity Shape and Glymphatics
In a society with increased life expectancy, the economic, social and personal burden of dementia increases. Dementia is often caused by a combination of neurovascular and neurodegenerative diseases.
- Conditions
- Cerebral Small Vessel Diseases, Dementia, Mixed, Dementia, Vascular, Mild Cognitive Impairment
- Trial name
- WHIMAS (NCT06010511)
- Testing
- 3T MRI scan, 7T MRI scan, Neuropsychological assessment
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center