Clinical trials: White Matter Injury
Spinal Cord Compression
White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord
White matter fiber tracking may provide a novel tool to assess the integrity of injured motor tracts in the cervical spine. It provides information about fiber directions which is not given by conventional MRI.
- Trial name
- NCT00280306
- Testing
- No interventions
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Spinal Cord Injury
Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury
As the spinal cord injured population ages, these individuals are being exposed to an increased prevalence of age-associated diseases, which coupled with the secondary complications of the injury may contribute to the reduced…
- Trial name
- NCT01984476
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Fetal Brain Injury
Quantification of Fetal Brains' Sulci Along Gestation
Gyrogenesis is an ontogenic process that transforms the smooth (lissencephalic) cortex toward its mature, convolved (gyrencephalic) state.
- Trial name
- NCT03168932
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Concussion, Brain
Diffusion Tensor Brain MRI in the Detection of Structural Abnormality of the White Substance in Concussion
Concussions in sports are a major public health problem because of their frequency, and are often underdiagnosed because of an unspecific clinical picture or sometimes masked by the concussion itself.
- Trial name
- COMMOTION (NCT06144359)
- Testing
- specific MRI Acquisition (Diffusion Tensor Imaging) at 3T
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Cerebral Palsy, Periventricular White Matter Abnormalities
Predicting Cerebral Palsy in Infants With White Matter Injury Using MRI
The goal of this study is to determin the MRI features associated with cerebral palsy and to develop prediction models of pediatric disorders by combining MRI with artificial intelligence.
- Trial name
- NCT06575283
- Testing
- No intervention will be performed in this cohort study
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Multiple Sclerosis, Cognitive Impairment
Early Cognitive Impairment in Multiple Sclerosis
Cognitive impairment is one of the symptoms of Multiple Sclerosis (MS), and it may occur during the first years of the disease. It usually affects attention, information processing speed and short term memory.
- Trial name
- CogniSEP (NCT01157728)
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myelinopathy
Association of Plasma Metabolomic Biomarkers with Chronic Ischemic White Matter Injury
The cases were screened according to the inclusion criteria, and after the patients signed the informed consent, the clinical data were collected, the imaging data were evaluated, and blood samples were taken for follow-up…
- Trial name
- WML (NCT06608251)
- Testing
- white matter lesion
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Stroke, Trauma
Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity
The goal of this preclinical study is to assess the effects of focused ultrasound stimulation to the cerebellum on brain dynamics and cognition in healthy volunteers aged 18 to 40.
- Conditions
- Stroke, Trauma, Cognition, Agency
- Trial name
- FUSCBM (NCT07389447)
- Testing
- Focused ultrasound, EEG
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Paraplegia, Spinal, Myelomeningocele
Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions
The purpose of this study is to use functional MRI (fMRI) and magnetic resonance (MR) diffusion tensor imaging (DTI) to investigate brain activation and white matter changes in patients with congenital (birth defect of the spinal…
- Trial name
- NCT01208584
- Testing
- fMRI, DTI
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Investigating Spinal Atrophy in Patients With Spinal Injury
Plasticity of Grey and White Matter in Response to Motor Skill Training in Healthy Individuals and Those With Spinal Cord Injury
We aim to investigate the effect of motor skill training of the upper and lower limbs on the function and structure of the CNS as measured by neuroimaging parameters sensitive to changes in tissue volume and density and the…
- Trial name
- NCT02148887
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Spinal Cord Injury
A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences
The general population is aging, today 12% of the United States population is older than 65 and it is estimated that by 2020 the number of people in the United States older than 65 will outnumber children younger than 5.
- Trial name
- NCT03023163
- Testing
- Longitudinal
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center