Clinical trials: White Spot Lesions
White Spot Lesion
Evaluation of Enamel Demineralization During Clear Aligner Orthodontic Treatment
Development of white spot lesions (enamel demineralization) will be evaluated quantitatively during clear aligner orthodontic treatment compared to conventional fixed appliances using quantitative light induced fluorescence (QLF)
- Trial name
- NCT04107012
- Testing
- Orthodontic treatment with clear aligner
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Dental Caries, White Spot Lesions
QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment
This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS…
- Conditions
- Dental Caries, White Spot Lesions, Caries Lesion Activity, Post-Orthodontic Enamel Demineralization
- Trial name
- NCT07608471
- Volunteers
- 30 people
- Sponsor
- Universidad El Bosque, Bogotá
Orthodontic Appliance Complication
Efficacy of a Novel Fluoride Varnish in Preventing WSL During/After Treatment With Fixed Orthodontic Appliances
The aim of the present study is to evaluate the efficacy of a novel fluoride varnish (NFV) in preventing white spot lesion development in adolescents during and after treatment with fixed orthodontic appliances.
- Trial name
- NCT03725020
- Testing
- Fluoride varnish
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Malmö University
White Spot Lesions
Fluoride Varnish for Treatment of White Spot Lesions
Study will look at ability of fluoride varnish to remineralize white spot enamel lesions that can occur around the edge of fixed orthodontic brackets.
- Trial name
- NCT01500187
- Testing
- Vanish Varnish, Pediagel
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
EFFICACY OF BIOMIN FLUORIDE VERSUS SODIUM FLUORIDE VARNISHES, WITH AND WITHOUT DIODE LASER ON WHITE SPOT LESIONS REMINERALIZATION IN PRIMARY TEETH.
The goal of this randomized controlled clinical trial is to assess and compare the remineralizing effect of Biomin fluoride varnish and conventional 5% sodium fluoride varnish (Duraphat), with and without adjunctive low-level…
- Trial name
- NCT07845110
- Testing
- BioMin® fluoride varnish: 5% NaF varnish incorporating bioactive glass (calcium/phosphate releasing)., (BioMin® + Diode Laser), (Duraphat varnish + Diode laser)
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Yassmin Mohamed
White Spot Lesion
Fluoride Controlled-release System for Initial Lesions of Caries
OBJECTIVE: To evaluate in vivo the efficacy of fluoride-containing dentifrice incorporated in a controlled-release system (F-CSL, patent pending) in the remineralization of white spot lesions of caries in caries-active…
- Trial name
- NCT05139966
- Testing
- Mouthwash Product
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
White Spot Lesion of Tooth, Tooth Color
Toothpastes With Different Contents and Tooth Color
This study aims to investigate the color tone and fluorescence changes that may occur during fixed orthodontic treatment with brackets in patients' teeth using toothpaste with different properties.
- Conditions
- White Spot Lesion of Tooth, Tooth Color, Dentistry, Orthodontic Appliances, Fixed
- Trial name
- NCT06833970
- Testing
- Colgate use, Curaprox use, ROCS use
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Taner OZTURK, DDS, MS
White Spot Lesions
Compare the Efficacy of the Remineralization Agents on the White Enamel Lesions
The purpose of this study is to determine whether Fluoride varnish + calcium (Clinpro White Varnish) and polipeptide solution (Curodont Repair) are effective in the treatment of remineralization therapy.
- Trial name
- NCT02341872
- Testing
- Clinpro White Varnish (fluoride + calcium varnish), Curodont Repair
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ege University
Tooth; Lesion, White Spot Lesions
Resin Infiltratration on the Sealing of Proximal Early Caries
Material for caries prevention dont have better results compared with non-operatory interventions.
- Trial name
- NCT01659463
- Testing
- ICON, instruction oral hygiene
- Where
- Brazil
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
White Spot Lesion
Effect of Poly Amido Amine Dendrimer, Nano-hydroxyapatite
Dental caries is a common oral disease. The process of caries formation is a cycle of remineralization and demineralization with various stages being either reversible or irreversible.
- Trial name
- NCT05771077
- Testing
- Poly(Amidoamine) dendrimer
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Egymedicalpedia
Dental Caries, White Spot Lesion
A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome
The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in…
- Conditions
- Dental Caries, White Spot Lesion, Initial Caries, Incipient Enamel Caries
- Trial name
- Incipient (NCT06172764)
- Testing
- Vitamin D supplements along with behavioral modification, Topical fluoride application and Vitamin D supplements along with behavioral modification, Topical fluoride application along with behavioral modification
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Caries
Effect of CPP-ACP With/Without Fl on White Spot Lesion,Salivary pH and fl Release in High Caries Risk Patients
Effect of CPP-ACP pastes with/without Fluoride on White spot lesion progression, salivary pH and fluoride release in high caries risk Patients, over 3 month period using VistaCam, Digital pH meter and Selective ion electrode.
- Trial name
- NCT03656432
- Testing
- CPP-ACP paste
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Moringa Oleifera
Remineralization Efficacy of Moringa Oleifera Varnish Vs MI Varnish in Initial Carious Lesions Over 6 Months Follow Up: a Randomized Controlled Clinical Trial
This randomized clinical trial aimed to test the remineralization effect of laboratory prepared Moringa Oleifera based varnish compared to MI varnish (CPP-ACP) on incipient carious lesions.
- Trial name
- NCT06905379
- Testing
- Moringa Oleifera, Varnish
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesions, Dental Plaque
AI-Generated WhatsApp Reminders vs. No Reminders: Impact on Oral Health in Young Adults
This randomized controlled trial aims to evaluate the effectiveness of artificial intelligence-generated WhatsApp reminders on improving oral hygiene practices among individuals aged 20-40 years visiting the periodontal clinic at…
- Conditions
- White Spot Lesions, Dental Plaque, Oral Hygiene, Oral Health
- Trial name
- NCT06897033
- Testing
- Health education followed by AI-generated Whatsapp reminders, Oral Health Education
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion of Tooth
Effect of Diode Laser With Dye and Remineralizing Agent on Surface Area of White Spot Lesions by Using Digital Subtraction Radiograph Techniques.
The current study was conducted to compare effect of diode laser and perio green dye with reminerlizing agent on surface area white spot lesions by using digital subtraction radiographic techniques.
- Trial name
- NCT07818655
- Testing
- remin pro
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
White Spot Lesions
Remineralization Potential of Ginger and Rosemary Herbals Versus Sodium Fluoride in Treatment of White Spot Lesions
To evaluate the effectiveness of ginger and rosemary herbals versus sodium fluoride in remineralization of incipient enamel caries.
- Trial name
- NCT03990935
- Testing
- ginger and rosemary gel
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion
Effectiveness of Different Remineralizing Strategies on the Management of Early Carious Lesions in Primary Teeth
the primary aim of the study is remineralization of early carious lesions in primary teeth using different remineralizing agents of different remineralizing strategies when applied in an intensive mode.
- Trial name
- NCT06566833
- Testing
- self assmbling peptide p11-4 combined with 0.05% fluoride, Casein phosphopeptide amorphous calcium phosphate, 5% sodium fluoride varnish
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Tooth Crowding, Tooth; Lesion, White Spot Lesions
Comparison Of Different Orthodontic Aligner Systems Applied On Single Stage And Three Stage
Applying to the Orthodontics Department of the Faculty of Dentistry of Erciyes University for orthodontic treatment, a periodontally healthy 16-26 year-old periodontally healthy, non-congenital or congenital anomaly in the…
- Trial name
- NCT04678596
- Testing
- EonAligner, Clearfix
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Malaligned Teeth, Crowding of Teeth
Effect of Different Adhesive Systems on White Spot Lesions During Fixed Orthodontic Treatment
The primary goal of this study is to compare the number of white spot lesions during fixed appliance therapy between self-etch and one-step bonding systems.
- Trial name
- NCT07753512
- Testing
- Self-etch adhesive, One-Step Adhesive, Conventional Bonding Technique
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Orthodontic Appliance Complication
The Effect of Different Remineralizing Agents on White Spot Lesions and Dental Plaque During Orthodontic Retention
Dental caries is a decay process that breaks down the tooth. The earliest clinical signs of active dental caries is seen as 'white spot lesions' (WSLs).
- Trial name
- NCT04788550
- Testing
- Fluoridated toothpaste, fluoride varnish (5% sodium fluoride), CPP-ACP plus crème group
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Malaya