Clinical trials: Wide Local Excision
Clinical Stage IA Cutaneous Melanoma AJCC v8, Clinical Stage IB Cutaneous Melanoma AJCC v8
Narrow Excision Versus Wide Excision for the Treatment of Adults With Invasive Cutaneous Melanoma, ICEMAN Trial
This clinical trial compares the effect of a narrow surgical excision (removal) to a wide excision for the treatment of adults with invasive cutaneous melanoma.
- Trial name
- NCT06673095
- Testing
- Biospecimen Collection, Excision, Survey Administration
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- OHSU Knight Cancer Institute
Head and Neck Cancer
Oral Cancer With Wide Excision and Free Flap Reconstruction
A proactive speech-language pathologist program can be successfully established as part of the multidisciplinary care of patients with head and neck squamous cell carcinoma and improve patient quality of life.
- Trial name
- NCT03776578
- Testing
- swallow fuction and swallow training
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Sarcoma,Soft Tissue
Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO)
This trial will investigate the combination of two low-cost, non-toxic strategies to assess whether they can reduce the risk of acute major wound complications in soft tissue sarcoma of the lower extremity.
- Trial name
- CONCERTO (NCT06712433)
- Testing
- 2% intranasal mupirocin ointment, 4% chlorhexidine gluconate body cleanser
- Where
- United States
- Sponsor
- Adam Olson
Breast Cancer
The LightPath® and 68Ga-RM2 in Breast Cancer Study
This study is a prospective, open-label study to examine the performance of the LightPath® Imaging System using the PET tracer 68Ga-RM2 in patients scheduled for and/or undergoing wide local excision (WLE) with or without…
- Trial name
- NCT03731026
- Testing
- LightPath® Imaging System and 68Ga-RM2, 68Ga-RM2
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Lightpoint Medical Limited
Ductal Carcinoma in Situ of the Breast
Wide Excision Alone as Treatment for Ductal Carcinoma in Situ of The Breast
The purpose of this study is to determine if wide excision (surgical removal) alone is adequate treatment for small, grade 1 or 2 ductal carcinoma in situ (DCIS) of the breast.
- Trial name
- NCT00165256
- Testing
- Observation
- Where
- 2 sites in United States
- Volunteers
- 157 people
- Sponsor
- Dana-Farber Cancer Institute
Cutaneous Melanoma by AJCC V7 Stage
MelmarT Melanoma Margins Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma
Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe.
- Trial name
- MelMarT (NCT02385214)
- Testing
- Wide Local Excision = 1cm Margin, Wide Local Excision = 2cm Margin
- Where
- 20 sites in United States, Australia and 3 more
- Volunteers
- 400 people
- Sponsor
- Melanoma and Skin Cancer Trials Limited
Surgical Site Infection, Skin Cancer
Cyanoacrylate Skin Adhesive After Mohs Surgery or Wide Local Excision
This study will compare surgical site infection after linear repair with or without cyanoacrylate skin adhesive following Mohs micrographic surgery or wide local excision.
- Conditions
- Surgical Site Infection, Skin Cancer, Wound Healing
- Trial name
- NCT07844681
- Testing
- Cyanoacrylate Skin Adhesive, Fast Gut Running Epidermal Suture Closure, Vicryl Rapide Running Epidermal Suture Closure
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Minnesota
Cutaneous Melanoma, Stage II, Cutaneous Melanoma
Trial Comparing CPDMA Versus Standard Breadloafing in WLE Specimens of Stage 1-II Cutaneous Melanoma
The primary goal of this clinical trial is to is to compare the rate of positive peripheral margins in wide local excision (WLE) performed to allow for comprehensive peripheral and deep margin assessment (CPDMA) assessment versus…
- Conditions
- Cutaneous Melanoma, Stage II, Cutaneous Melanoma, Acral Melanoma
- Trial name
- NCT07869381
- Testing
- Wide Local Excision
- Where
- United States
- Volunteers
- 282 people
- Sponsor
- University of Nebraska
Pilonidal Sinus
Comparative Study Between Wide Local Excision and Minimal Excision of Pilonidal Sinus
Comparative study between wide local excision and minimal excision of pilonidal sinus
- Trial name
- NCT06021392
- Testing
- Z plasty and minimal excision of pilonidal sinus
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Abanoub emad fayez
Breast Cancer, Elderly Patient
A Prospective Cohort Study Comparing Disparity in Surgical Procedure (Wide Local Excision Only vs Any Other Surgery Procedures) Among the Elderly Breast Cancer Patients
The incidence and mortality rates of breast cancer are still increasing in both developing and developed countries. The number of women ≥70 years who are affected by breast cancer (BC) worldwide is also on the increase.
- Conditions
- Breast Cancer, Elderly Patient, Wide Local Excision, Surgery
- Trial name
- NCT04426136
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Pilonidal Disease
Open Wide Excision Versus Minimal Surgery for Pilonidal Disease
In order to compare the early recurrence rates of pilonidal disease and overall patient satisfaction between procedures involving minimal and wide open excisions, we propose to perform a prospective, randomized clinical trial…
- Trial name
- NCT01241136
- Testing
- open wide-excision pilonidal cystectomy, minimal invasive pilonidal cystotomy
- Where
- United States
- Sponsor
- United States Naval Medical Center, Portsmouth
Breast Cancer
The LightPath® Breast Cancer Study
This study is a prospective, single arm, multi-centre study to evaluate the intra-operative use of the LightPath® Imaging System for the assessment of tumour margin status compared to hospital standard of care histopathology in…
- Trial name
- NCT02666079
- Testing
- LightPath® Imaging System.
- Where
- 5 sites in Poland, United Kingdom
- Volunteers
- 170 people
- Sponsor
- Lightpoint Medical Limited
Breast Cancer, Chronic Pain
Effect of Perioperative CBT on Chronic Persistent Postsurgical Pain Among Breast Cancer Patients
Chronic persistent post-surgical pain (CPSP) is defined as pain at or near the site of surgery persisting for 3 months or more after the date of surgery.
- Conditions
- Breast Cancer, Chronic Pain, Chronic Postsurgical Pain, Quality of Life
- Trial name
- NCT04924010
- Testing
- Cognitive Behavioural Therapy (CBT), Education and Mindfulness
- Where
- Ireland
- Volunteers
- 48 people
- Sponsor
- Mater Misericordiae University Hospital
Melanoma
WoW - Single- vs Two-staged Excisions of Thin Melanoma
The overall aim of this national, multicenter, prospective, randomized, and controlled study is to enhance the management of patients with thin melanoma (≤1 mm Breslow thickness).
- Trial name
- WoW (NCT06363591)
- Testing
- Surgery, No Surgery
- Where
- Sweden
- Volunteers
- 2,486 people
- Sponsor
- Vastra Gotaland Region
Hidradenitis Suppurativa, Wide Excision
Quality of Life After Wide Surgical Excision in Patients With Hidradenitis Suppurativa
Patients undergoing wide surgical excision of their hidradenitis suppurativa areas are asked by telephone about their quality of life by standard questionnaires (WHOQOL-BREF, DLQI, Skindex, MHF, FLQA-d) and their sexual function…
- Trial name
- NCT02593604
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Schleswig-Holstein
Pilonidal Abscess, Pilonidal Sinus With Abscess
De-roofing and Curettage vs WLE for Pilonidal Abscess
Pilonidal disease refers to a common disease affecting mostly young males. It may present as asymptomatic pits, acute and painful abscess formation, or chronic discharging sinuses.
- Conditions
- Pilonidal Abscess, Pilonidal Sinus With Abscess, Pilonidal Sinus Infected, Pilonidal Disease
- Trial name
- NCT03415347
- Testing
- Abscess de-roofing and curettage, Abscess wide local excision
- Volunteers
- 138 people
- Sponsor
- London North West Healthcare NHS Trust
Breast Cancer
A Prospective Comparative Study Between Oncoplastic Breast Surgery and Standard Wide Local Excision
The aim of this study is to asses the oncological safety of oncoplastic breast surgery, and its impact on patient satisfaction.
- Trial name
- NCT02923635
- Testing
- Standard wide local excision., oncoplastic breast surgery.
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Axillary Hidradenitis Suppurativa
Perforator Flaps for Axillary Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS) is a recurrent inflammatory disease (< 2 episode /6 months) with 1%-4% prevalence in Europe. Suppurating lesions are painful and involve one or more regions (axilla, genitofemoral, perineum, gluteal…
- Trial name
- HS-PAX (NCT03784313)
- Testing
- skin repair by axillary perforator flaps, skin repair by secondary wound healing
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Skin Cancer, Skin Wound
Preoperative Image-based Education Effect on Postoperative Satisfaction of Patients Undergoing First-time Dermatologic Surgery
This research study aims to understand whether visual and written education on wound appearance can improve patients' experience and understanding of what their wound will look like following dermatologic surgery.
- Trial name
- NCT05643755
- Testing
- Preoperative image-based education
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Melanoma
Multicenter Selective Lymphadenectomy Trial (MSLT)
Subjects must be diagnosed with melanoma. All subjects receive Wide Excision (WEX) of their melanoma. If the melanoma meets study requirements, the subject is randomized to receive either (1) no further surgical procedures as…
- Trial name
- NCT00275496
- Testing
- Sentinel Lymph Node Dissection, Complete Lymph Node Dissection, Wide Excision
- Volunteers
- 2,001 people
- Sponsor
- Saint John's Cancer Institute