Clinical trials: Withdrawal
Cocaine Withdrawal, Cocaine Smoking
Use of Intranasal Oxytocin During Detoxification of Crack Cocaine
This study investigated whether adding oxytocin nasal spray to usual inpatient treatment could reduce withdrawal, anxiety, and depressive symptoms in women hospitalized for cocaine detoxification.
- Conditions
- Cocaine Withdrawal, Cocaine Smoking, Cocaine-Related Disorders
- Trial name
- NCT04306354
- Testing
- Oxytocin nasal spray, Conventional Inpatient Treatment
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
TBI (Traumatic Brain Injury), Concussion, Brain
Growth Hormone Replacement Therapy for Retried Professional Football Players
This is a randomized, double-blind, placebo-controlled, parallel-group trial with an open-label extension to evaluate the efficacy of growth hormone (GH) on cognitive functions of retired professional football players with growth…
- Conditions
- TBI (Traumatic Brain Injury), Concussion, Brain, Sport Injury, Anterior Pituitary Hyposecretion Syndrome
- Trial name
- NCT04121780
- Testing
- Growth Hormone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Center for Neurological Studies
Inflammatory Disorder, Autoimmune
Taper Or Abrupt Steroid Stop: TOASSTtrial
This study is an Investigator-initiated, placebo-controlled, multicenter noninferiority trial, comparing rapid termination of systemic glucocorticoid treatment with a tapering regime over 4 weeks.
- Trial name
- TOASST (NCT03153527)
- Testing
- Prednisone
- Where
- 16 sites in Germany, Switzerland
- Volunteers
- 530 people
- Sponsor
- University Hospital, Basel, Switzerland
Disorder Related to Renal Transplantation
Steroid Withdrawal Immunosuppression After Renal Transplantation
The investigators analyze the clinical outcome of steroid withdrawal protocol starting at 3 months after kidney transplantation using tacrolimus, Mycophenolate Mofetil (MMF), and basiliximab.
- Trial name
- NCT01550445
- Testing
- Prednisolone
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Ajou University School of Medicine
Opioid-Related Disorders
Evaluation of Lofexidine for Treatment of Opiate Withdrawal - 10
The purpose of this study is to assess the safety of lofexidine in the treatment of opiate-dependent individuals.
- Trial name
- NCT00000345
- Testing
- Lofexidine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Addiction
Opiate Detoxification Using the Combined Hemoperfusion-hemodialysis
The purpose of this study is to determine whether combined hemoperfusion-hemodialysis treatment is an alternative drug-free, effective, and safe treatment for opiate detoxification.
- Trial name
- HPDMT (NCT01021566)
- Testing
- Combined hemoperfusion-hemodialysis, Methadone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First People's Hospital of Foshan
Stress Disorders, Post-Traumatic
Post Traumatic Stress Among Relatives of Brain-dead, Withdrawal of Life Support, and Sudden Death Patients
This study concerns the nearest relatives of patients who have passed away within 3 days of admission to an ICU due to: (1) brain death with multiple organ donation +/- tissues or (2) death via limitation and / or cessation of…
- Trial name
- NCT01412502
- Testing
- IES-R and HDAS scores
- Where
- 6 sites in France
- Volunteers
- 119 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Plaque Psoriasis
A Study of JNJ-77242113 in Adolescent and Adult Participants With Moderate to Severe Plaque Psoriasis
The purpose of this study is see how effective is JNJ-77242113 in participants with moderate to severe plaque psoriasis.
- Trial name
- ICONIC-LEAD (NCT06095115)
- Testing
- JNJ-77242113
- Where
- 170 sites in United States, Argentina and 14 more
- Volunteers
- 684 people
- Sponsor
- Janssen Research & Development, LLC
Polyps
Adenoma Detection Rate With Position Change at Colonoscopy
The hypothesis to be tested is that position changes during the withdrawal phase of colonoscopy leads to a higher adenoma (polyp) detection rate because of better distension of the colon.
- Trial name
- NCT00234650
- Testing
- Colonoscopy
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- London North West Healthcare NHS Trust
Sexual Dysfunction, Ejaculation
A Study of Withdrawal Effects With Dapoxetine in the Treatment of Premature Ejaculation
The primary purpose of the study is to assess the possible withdrawal effects after abruptly stopping daily therapy with dapoxetine compared with continuing daily therapy in men with premature ejaculation (PE).
- Trial name
- NCT00210613
- Testing
- Dapoxetine
- Volunteers
- 199 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Opioid Dependence
Improving Buprenorphine Detoxification Outcomes With Isradipine
This application seeks to address the problem of opioid withdrawal by examining the utility of the L-type calcium channel blocker (CCB) isradipine as an adjunct to BUP detoxification.
- Trial name
- NCT01895270
- Testing
- Isradipine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Arkansas
Urinary Tract Infection, Bacteriuria
Prophylactic Antibiotics on Urethral Catheter Withdrawal
Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The purpose of this study is to determine whether antibiotic prophylaxis for urinary catheter removal is useful at preventing…
- Trial name
- NCT00126698
- Testing
- trimethoprim-sulfamethoxazole, ciprofloxacin
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- St. Antonius Hospital
Vitiligo
Assess the Long Term Efficacy and Safety of Ruxolitinib Cream in Participants With Vitiligo
The purpose of this study is to evaluate the duration of response following withdrawal of ruxolitinib cream (Cohort A vehicle group), safety and maintenance of response with continued use of ruxolitinib cream in participants who…
- Trial name
- NCT04530344
- Testing
- ruxolitinib, Vehicle
- Where
- 84 sites in United States, Bulgaria and 6 more
- Volunteers
- 458 people
- Sponsor
- Incyte Corporation
Rocuronium Adverse Reaction, Lidocaine Adverse Reaction
Effects of Pretreatment With Different Doses of Lidocaine on Injection Pain
One of the medications administered to patients in general anesthesia practice is rocuronium, which causes pain during intravenous administration.
- Trial name
- NCT06865300
- Testing
- Lidocain 40 mg, lidocain 1 mg/kg, serum physiologic
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Giresun University
Cannabis Dependence
Gabapentin Treatment of Cannabis Dependence
This is a study to evaluate the efficacy of the medication gabapentin in treating persons with cannabis dependence.
- Trial name
- NCT00395044
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Scripps Research Institute
Alcohol-Induced Disorders
Magnesium After Alcohol Withdrawal Treatment
The primary purpose is to see if magnesium tablet supplementation will decrease elevated GGT enzyme activity in alcoholic patients immediately after they had been treated for alcohol withdrawal.
- Trial name
- NCT00325299
- Testing
- Magnesium
- Where
- Finland
- Volunteers
- 178 people
- Sponsor
- Finnish Foundation for Alcohol Studies
Alcohol Withdrawal
Evaluation of Bilateral HF-rTMS on Abstinence in Alcohol Use Disorder Patients With Executive Dysfunction
High frequency repetitive transcranial magnetic stimulation (HF-rTMS) over dorsolateral prefrontal cortex (DLPFC) could correct defective executive functions over the hyperactive reward circuit through the meso-fronto-limbic…
- Trial name
- STIM-ALC (NCT04997330)
- Testing
- Active rTMS
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Smoking
Effects of Auricular Acupressure and Group Counseling on Smoking Cessation Tobacco Withdrawal Symptoms
Objective The purpose of this study is to examine the effects of auricular acupressure and group counseling with positive psychology and motivational interviewing on smoking cessation and tobacco withdrawal symptoms.
- Trial name
- NCT02916628
- Testing
- group counseling, Auricular acupressure
- Where
- South Korea
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Inha University Hospital
Alcohol Withdrawal Delirium
Treating Alcohol Withdrawal With Oral Baclofen
The purpose of this study is determine if subjects with alcohol withdrawal who receive oral baclofen, plus standard benzodiazepine therapy, will experience less severe withdrawal symptoms than those who receive placebo plus…
- Trial name
- NCT00597701
- Testing
- Baclofen, Lorazepam
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Essentia Health
Schizophrenia
Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia
The purpose of the study is to evaluate the relapse prevention of KarXT in the treatment of participants with Schizophrenia
- Trial name
- NCT07686263
- Testing
- Xanomeline/Trospium Chloride
- Where
- 54 sites in United States, Argentina and 5 more
- Volunteers
- 472 people
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
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