Clinical trials: Working Memory Deficits
Attention-Deficit/Hyperactivity Disorder (Combined-subtype)
Effect of Working Memory Training on ADHD Brain Function
There is evidence both that computer-administered cognitive training can improve ADHD working memory deficits and that this type of training in non-ADHD enhances normal working memory ability by altering brain activity in…
- Trial name
- NCT02151396
- Testing
- Working memory training, Functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Hartford Hospital
Attention Deficit Disorder With Hyperactivity, Learning Disorders
Effects Of A Computerized Working Memory Training Program On Attention, Working Memory, And Academics, In Adolescents With Severe ADHD/LD
Our primary aim is to determine whether a computerized working memory (WM) training program will help students with severe learning and attention problems, in terms of improving their WM.
- Trial name
- NCT00930449
- Testing
- Cogmed Working Memory Training Program., Academy of Math, Special Education/Individualized Tutoring
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- The Hospital for Sick Children
ADHD, Weight Loss
Obesity Treatment Enhanced With Working Memory Training
This study will examine the effects of providing subjects who have attention deficits, with or without a formal diagnosis of attention deficit hyperactivity disorder (ADHD), with Working Memory computerized training and explore…
- Trial name
- Focus (NCT02529397)
- Testing
- Adaptive Working Memory Training, Non-adaptive cognitive training
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Attention Deficit Disorder
Neurofeedback and Working Memory Training for Children and Adolescents With ADHD
The purpose of this study is to investigate if neurofeedback and working memory training improves core symptoms of ADHD in children and adolescents.
- Trial name
- KITE (NCT01841151)
- Testing
- SCP training, Live Z-score training, WM training
- Where
- Sweden
- Volunteers
- 202 people
- Sponsor
- Karolinska Institutet
Schizophrenia
Adjuvant Therapy With Pergolide in Treating Cognitive Deficits in Schizophrenia
The objective of this study is to compare the modulation of pergolide, a D1/D2 receptor agonist, to placebo in non-acute schizophrenic subjects under concomitant therapy with atypical antipsychotics on specific PFC functions.
- Trial name
- NCT01066403
- Testing
- Pergolide
- Where
- 4 sites in Germany
- Volunteers
- 28 people
- Sponsor
- Heidelberg University
Attention Deficit Hyperactivity Disorders
Low-dose vs. Normal-dose Psychostimulants on Executive Functions in Individuals With ADHD
This double-blind crossover study aims to compare cognitive performance (e.g., working memory, selective attention and cognitive flexibility) of children ages 6-18 years diagnosed with ADHD of the combined type (ADHD-C) or…
- Trial name
- NCT02167048
- Testing
- Psychostimulants
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Working Memory Deficits
Transcranial Direct Current Stimulation (tDCS) on Working Memory in College Going Students
Working memory deficiencies, might make it difficult for students to recall instructions, complete complex activities, and grasp and follow directions solving a math problem or writing a sentence.
- Trial name
- NCT05737498
- Testing
- Transcranial direct current stimulation (tDCS)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
ADHD
Accelerated iTBS Targeting of Working Memory Versus Inhibitory Control in Adolescent ADHD
The objective of this project is to examine the differential therapeutic effect of intermittent theta burst stimulation (iTBS; a type of repetitive transcranial magnetic stimulation) to the left DLPFC versus right PreSMA in…
- Trial name
- WINK (NCT07219810)
- Testing
- intermittent theta burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Bradley Hospital
Attention Deficit Hyperactivity Disorder
The Effects of Methylphenidate and Non-invasive Brain Stimulation on Inhibitory Control in Children With ADHD
The aim of this study is comparing the effects of non-pharmacological intervention (transcranial Direct Current Stimulation, tDCS) with those of drug (methylphenidate, MPH) administration in children and adolescents with ADHD.
- Trial name
- NCT04964427
- Testing
- Methylphenidate, anodal tDCS
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Schizophrenia
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory
Deficits in working memory (WM) performance are the most significant cognitive impairments in schizophrenia (SCZ). It has also been shown that WM performance is contingent on the cortex synchronization, a process that relies on…
- Trial name
- NCT01494623
- Testing
- repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Relapsing Remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis
Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis
Noninvasive brain stimulations (NIBS) will be used in MS patients with cognitive impairments to enhance their cognitive aptitudes.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Secondary-progressive Multiple Sclerosis, Cognitive Deficits, Motor Deficits
- Trial name
- MScog-tDCS (NCT02266121)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Attention Deficit Disorder
Working Memory Training in College Students With Attention-Deficit Hyperactivity Disorder/Learning Disabilities
The overall objective of the current study is to determine whether computerized Working Memory (WM) training will enhance WM capacity in college students with Attention Deficit Hyperactivity Disorder (ADHD)/Learning Disabilities…
- Trial name
- NCT01154686
- Testing
- Cogmed
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Toronto
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Attention-Deficit Hyperactivity Disorder
Working Memory Training in ADHD (The Engage Study)
The overall objective of the current study is to determine whether computerized Working Memory (WM) training will enhance WM capacity in college students with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT01657721
- Testing
- Cogmed Working Memory Training Program
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Mild Cognitive Impairment, Memory Impairment
Enhancing Frontal Lobes Plasticity in Mild Cognitive Impairment
More than 5 million people live with Alzheimer's dementia (AD) in North America. No effective treatment exists yet probably because by the time AD has developed it is too late to intervene.
- Trial name
- PAS-MCI (NCT04583215)
- Testing
- Paired Associative Stimulation (PAS)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Memory, Short-Term
Ginkgo Biloba to Improve Short-Term Memory Losses Associated With Electroconvulsive Therapy (ECT)
Electroconvulsive therapy (ECT) is an effective treatment for severe or medication-resistant depression and other psychiatric disorders. A common side effect of ECT is problems with short-term memory during treatment.
- Trial name
- NCT00070954
- Testing
- ginkgo biloba
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Attention Deficit Hyperactivity Disorder, Stimulant Use
Acute Effects of Stimulant Medication in College Students With ADHD
The investigators will examine the acute effects of stimulant medication on executive functioning. The rationale for the proposed study is to examine the efficacy of stimulants for college students with ADHD and help prevent…
- Conditions
- Attention Deficit Hyperactivity Disorder, Stimulant Use, Working Memory, Change in Sustained Attention
- Trial name
- NCT03935646
- Testing
- Adderall IR 10mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Wyoming
Schizophrenia, Attention Deficit Disorder With Hyperactivity (ADHD)
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior.
- Trial name
- NCT07217652
- Testing
- High-resolution fMRI during working memory, cognitive control, and decision-making tasks
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kai Hwang
ADHD
A Novel fNIRS Neurofeedback Intervention for Enhancement of Working Memory in Attention Deficit Hyperactivity Disorder (ADHD)
The proposed study is to test and validate a novel intervention that integrates computerized cognitive training with real-time neuromonitoring and neurofeedback to enhance working memory by probing the individualized neural…
- Trial name
- NCT04002167
- Testing
- Neurofeedback, Cognitive training
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Stanford University
ADHD With Working Memory Deficits
Brain Stimulation for Working Memory Deficits in Adolescents With ADHD
Working memory (WM) is the foundational cognitive control process of holding information 'in mind' to execute goal-directed behaviors. WM deficits are an established component of ADHD.
- Trial name
- NCT03480737
- Testing
- Magstim Super Rapid2 stimulator, 10 Hz condition, Magstim Super Rapid2 stimulator, iTBS condition
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Bradley Hospital