Clinical trials: Wound; Knee
Complications; Arthroplasty, Knee Injuries
Ultrasound-guided Adductor Canal Block for Total Knee Replacement
Total knee arthroplasty is associated with intense early postoperative pain. Fast track recovery programs including early therapy protocols and early hospital discharge are being implemented at various hospitals.
- Trial name
- NCT02100579
- Testing
- Bupivacaine, Preservative free normal saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Skin Tumor
Negative-pressure Wound Therapy on Full-thickness Skin Grafts of the Lower Leg
This randomized controlled non-sponsored trial on 60 patients evaluates if a portable negative-pressure device improves graft-take and decrease the risk of surgical complications for skin-cancer surgeries below the knee.
- Trial name
- NCT05451680
- Testing
- Negative pressure device, Conventional care
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Helsinki University Central Hospital
Wound Healing, Scarring
The Effects of Topical Calcium Glycerophosphate on Surgical Wound Healing and Residual Scarring
The purpose of this study is to determine whether topical application of calcium glycerophosphate will result in superior wound appearance and scar minimization.
- Trial name
- TOPCGP-2008 (NCT01264588)
- Testing
- Topical calcium glycerophosphate lotion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- AkPharma Inc.
Patellar Dislocation
Non-operative Treatment in First-time Patellar Dislocation
Study to evaluate the conservative treatment of patients after their first episode of primary lateral patellar dislocation. Randomized controlled trial with 2 groups: standard treatment (2-weeks with brace) followed by physical…
- Trial name
- NCT06086080
- Testing
- Standard care, Taping
- Where
- Colombia
- Volunteers
- 50 people
- Sponsor
- Fundacion Clinica Valle del Lili
Anterior Cruciate Ligament Injuries
Individualized Anterior Cruciate Ligament Versus Conventional Reconstruction
A randomised prospective control trial comparing the efficiency of a more individualized approach in ACL reconstruction with the help of neuromuscular computer models with traditional ACL reconstruction practices.
- Trial name
- IACLR (NCT04366362)
- Testing
- Individualised ACL reconstruction, Conventional ACL reconstruction
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Larissa University Hospital
Knee Injuries
Non- vs Partial Controlled Weightbearing After Multiple Knee Ligament Reconstruction
This is a prospective randomized controlled trial with the purpose to determine if patients undergoing isolated posterior cruciate ligament (PCL) reconstruction, or isolated medial collateral ligament (MCL) reconstruction, or…
- Trial name
- NCT05073276
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Twin Cities Orthopedics
Acute Injury of Anterior Cruciate Ligament
Feasibility Trial Using Imaging and Biochemical Technologies to Measure Knee Cartilage Composition in Acute ACL Injury
This study will evaluate the bio-mechanical and biochemical abnormalities in acute ACL-injured knees over time. Data will be collected through advanced quantitative MR imaging, functional testing, and bio-specimen collection.
- Trial name
- NCT02010125
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anterior Cruciate Ligament Rupture, Rehabilitation After ACL Reconstruction
Effect of the Hockey Slideboard Training Combined With Blood Flow Restriction (BFR) in the Rehabilitation Following Anterior Cruciate Ligament Surgical Reconstruction (ACL-R)
ACL injuries represent a major health and economic burden. The overall incidence of ACL injuries has increased and is likely to continue to increase, in part due to increased sports participation.
- Trial name
- NCT06955026
- Testing
- Hockey slideboard combined with BFR training, Hockey slideboard
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Spitalul Municipal Odorheiu Secuiesc
Hip Fractures, Knee Fracture
Evaluation of Multidisciplinary Recovery After Surgery Program in Orthopedics and Traumatology
The aim of the recovery protocol is to reduce surgical trauma, postoperative pain, and complications, shorten hospital treatment and improve postoperative recovery.
- Conditions
- Hip Fractures, Knee Fracture, Hip Arthritis, Knee Arthritis
- Trial name
- NCT03822247
- Testing
- Multidisciplinary Recovery Program
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Anterior Cruciate Ligament, Injury
Comparison of Doubled Quadrupled Versus Quadrupled Allograft Tissue Constructs for Anterior Cruciate Ligament (ACL) Reconstruction
The purpose of this study is to compare two different soft tissue allografts, double bundle tibialis anterior allograft or quadruple bundle hamstring allograft, used in repairing a torn anterior cruciate ligament (ACL) of the…
- Trial name
- NCT01148784
- Testing
- ACL reconstruction
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Oregon Health and Science University
Knee Injuries, ACL Tear
ACL Reconstruction With Simple and Double Bundle Technique Using Two Different Implants for Graft Fixation
In this study our objective is to compare two tibial ACL graft fixation systems in patients undergoing two different reconstructions technique (with simple and double bundle) in terms of tendon graft osteointegration…
- Conditions
- Knee Injuries, ACL Tear, ACL Injury, Sports Injury
- Trial name
- NCT04550299
- Testing
- Surgical technique combined with a specific choice of the material for the ligament reconstruction
- Where
- Brazil
- Volunteers
- 112 people
- Sponsor
- Vita Care
Anterior Cruciate Ligament Injuries
Evaluation of the Results of Two Different Methods in Management of Antero-lateral Instability of the Knee
This randomized clinical study will be conducted to compare the results of anterior cruciate ligament reconstruction (ACLR) combined with either anterolateral ligament reconstruction using peroneus longus autograft or…
- Trial name
- NCT06222814
- Testing
- ACL reconstruction combined with anterolateral ligament reconstruction using peroneus longus autograft, ACL reconstruction combined with extra-articular tenodesis (Modified Lemaire)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Patellar (or Kneecap) Instability and Mal-alignment, Patellar Dislocation
MPFL Reconstruction Versus Rehabilitation
This study involves patients between the ages of 16 and 25 and have been diagnosed with a first-time traumatic patellar dislocation within the past 3 months.
- Trial name
- ANTI-GLIDE (NCT06926699)
- Testing
- Medial Patellofemoral Ligament Reconstruction, Rehabilitation
- Sponsor
- McMaster University
Anterior Cruciate Ligament Injuries
Patient Specific Instrumentation in ACL Reconstruction
Rationale: In anterior cruciate ligament (ACL) reconstruction, anatomical femoral tunnel positioning has proven to be difficult with current techniques.
- Trial name
- SONAR (NCT05574452)
- Testing
- ACL reconstruction using the SONAR Femoral Aimer PSI
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Knee Injuries, Shoulder Injuries
Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery
The primary objective of this study is to prospectively determine, at 10 days after orthopedic shoulder or knee surgery, if pulsed electromagnetic field (PEMF) therapy is beneficial in reducing patient-reported post-operative…
- Conditions
- Knee Injuries, Shoulder Injuries, Pain, Postoperative
- Trial name
- NCT04109638
- Testing
- Endonovo SofPulse
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Stanford University
Anterior Cruciate Ligament Injury
Effects of a Targeted Prevention Program on Change-of-Direction Biomechanics and Performance in Elite Female Soccer Players
Anterior cruciate ligament (ACL) injuries are common in female soccer and frequently occur during change-of-direction (COD) movements without contact.
- Trial name
- PREV-COD-FF (NCT07523178)
- Testing
- Targeted Injury Prevention Program
- Where
- Belgium
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Liege
Knee Injuries
Large-scale ex Vivo Expansion and Characterization of Two Kinds of MSC From Knee for Clinical Application
According to many researches, mesenchymal stem cells (MSC) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis.
- Trial name
- NCT02386163
- Testing
- MSC from synovial membrane and infrapatellar Fat Pad
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- EMO Biomedicine Corporation
Anterior Cruciate Ligament Injury
Clinical Comparison of Femoral Nerve Versus Adductor Canal Block Following Anterior Ligament Reconstruction
This study will examine the potential differences between femoral nerve blockade (FNB) and adductor canal blockade (ACB) for pain control and quadriceps muscle activation for patients following anterior cruciate ligament (ACL)…
- Trial name
- FNB vs ACB (NCT03704376)
- Testing
- 30 ml of 0.2% ropivacaine, 15 ml of 0.2% ropivacaine, 100 mcg clonidine
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Reliability and Validity of Inline Dynamometry Study for Measuring Knee Extensor Torque
This study will investigate the reliability and validity of an inline 'pull-type' dynamometer for measuring peak knee extensor torque.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05109871
- Testing
- KForce Link
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
ACL Injury Prevention
Effect of Specific ACL Injury Prevention Training in Female Handball Players
The anterior Cruciate Ligament (ACL) injuries rates in female handball are high, particularly among adolescents. Therefore, the primary purpose of this randomized control trial is to explore the effects of an 8-week ACL injury…
- Trial name
- NCT05955599
- Testing
- ACL Injury Prevention Training, Control - Shoulder Injury Prevention Training
- Where
- 3 sites in Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
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