Clinical trials: Wound Closure
Diabetic Foot
Trial of Vacuum Assisted Closure® Therapy in Amputation Wounds of the Diabetic Foot
The purpose of this study is to compare the effectiveness of Vacuum Assisted Closure® (V.A.C.®) Therapy to moist wound therapy of amputation wounds of the diabetic foot.
- Trial name
- NCT00224796
- Testing
- V.A.C. ® System
- Volunteers
- 146 people
- Sponsor
- KCI USA, Inc
Abdominal Wall Defect, Abdominal Wall Hernia
The Efficacy and Security of the Small Stitch Technique in Emergency Surgery
This study evaluates the abdominal closure technique in emergency surgery. Half of participants will be perform the classic Large Stitch technique, while the other half will undergo the Small Stitch technique.
- Conditions
- Abdominal Wall Defect, Abdominal Wall Hernia, Eventration, Evisceration; Operation Wound
- Trial name
- STCU (NCT03765060)
- Testing
- Monomax® 2/0 HR26, Monomax® 1 HR48
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Injury Caused by Animal Bites, Wound Infection
Incisional Negative Pressure Therapy to Prevent Animal Induced Wound Infection
Animal injuries are a significant public health issue, with the most common being bites or scratches from cats and dogs. Every year, over 40 million people in China are bitten or scratched by cats and dogs, which can lead to…
- Trial name
- NCT06558942
- Testing
- incisional negative pressure wound technology
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Wound Closure
Comparison of Cyanoacrylate Adhesives to Sutures in the Palate After Connective Tissue Graft
Cyanoacrylate tissue adhesives have been successfully used for wound closure. The purpose of this clinical trial is to compare cyanoacrylate tissue adhesives to polytetrafluoroethylene (PTFE) sutures in the donor site of…
- Trial name
- NCT02935426
- Testing
- n-butyl cyanoacrylate and 2-octyl cyanoacrylate, 5-0 Polytetrafluoroethylene (PTFE) suture
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Wound Closure
Symmetric on Total Knee Arthroplasty (TKA)
A post-marketing prospective, multicenter, randomized controlled study to evaluate the wound closure efficiency of STRATAFIX™ Symmetric PDS™ Plus Knotless Tissue Control Device (STRATAFIX Symmetric PDS Plus) compared to…
- Trial name
- SFX (NCT03305887)
- Testing
- "STRATAFIX™ Symmetric" Knotless Tissue, VICRYL® PLUS, "STRATAFIX Spiral" sutures
- Where
- 7 sites in China
- Volunteers
- 184 people
- Sponsor
- Johnson & Johnson Medical, China
Appendicitis
Appendicectomy Skin Closure Technique: Changing Paradigms (ASC)
To compare the results associated with two different skin closure techniques in open appendectomy. 200 patients were included after acute appendicitis diagnosis in emergency department.
- Trial name
- ASC (NCT02625987)
- Testing
- Continuous intradermic stitch, Separated stitches
- Volunteers
- 200 people
- Sponsor
- María Valeria Jiménez Baez
Impaired Wound Healing
A Prospective, Randomized, Controlled, Multi-Center, Study Evaluating AutoloGel Therapy for Complete Closure of Wagner Grade 1-4 Diabetic Foot Ulcers, Venous Leg Ulcers and Stage II-IV Pressure Ulcers
This study is designed to demonstrate the outcome of complete ulcer closure of patients with Wagner Grade 1-4 DFUs, VLUs or Stage II-IV PUs using AutoloGel versus Usual and Customary Care (UCC).
- Trial name
- NCT02248077
- Testing
- AutoloGel, Usual and Customary Care (UCC)
- Sponsor
- Cytomedix
Intra Abdominal Hypertension, Abdominal Compartment Syndrome
The Effect of Different Types of Temporary Abdominal Closure on Intra Abdominal Hypertension.
This is a prospective comparison trial. Patients that will be included in the trial are those that will have operations in which their abdominal closure is temporary, i.e. patients sustaining trauma or septic abdomen.
- Trial name
- TACACS (NCT02229695)
- Volunteers
- 42 people
- Sponsor
- Soroka University Medical Center
Burns
Oleogel-S10 Versus Standard of Care in Healing of Grade 2a Burn Wounds
The main goal of this phase III clinical trial is to show safety and efficacy of Oleogel-S10 in the acceleration of wound healing of grade 2a burn wounds.
- Trial name
- NCT01657292
- Testing
- Oleogel-S10 ointment, Octenilin® wound gel
- Where
- 9 sites in Germany, Sweden and 2 more
- Volunteers
- 61 people
- Sponsor
- Birken AG
Chronic Wounds, Venous Leg Ulcer (VLU)
Evaluation of Cold Plasma in Chronic Wound Healing
The goal of this clinical trial is to evaluate the effectiveness of cold atmospheric plasma treatment in promoting the healing of chronic wounds in adult participants suffering from chronic wounds.
- Conditions
- Chronic Wounds, Venous Leg Ulcer (VLU), Diabetic Foot Ulcer (DFU), Pressure Ulcer (PU)
- Trial name
- PLASANAGENESIS (NCT06964048)
- Testing
- Cold Atmospheric Plasma treatment
- Volunteers
- 66 people
- Sponsor
- Plasana Medical
Osteoarthritis
Bandgrip vs Traditional Sutures TJA
Total Joint Arthroplasty (TJA) has become one of the most performed elective procedures. While the results of this procedure are often consistent with high patient satisfaction and return-to-function, wound-related complications…
- Trial name
- NCT05166642
- Testing
- Bandgrip Micro-Anchor Wound Closure, Suture closure
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Center for Innovation and Research Organization
Wound Heal
Comparing the Effectiveness of Cyanoacrylate Tissue Adhesives and Conventional Sutures
This study compares the effectiveness of two materials used for intraoral wound closure after removal of impacted mandibular third molar tooth.
- Trial name
- NCT04898816
- Testing
- closure of wound using n- butyl 2-octyl cyanoacrylate tissue adhesive, closure of wound using braided silk suture
- Where
- Malaysia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Appendicitis, Surgical Wound Infection
Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial)
The goal of this clinical trial is to compare primary wound closure (PC) versus delayed primary closure (DPC) after standardized wound decontamination using the High-Efficiency Incision and Drainage with Irrigation (HIEDI)…
- Conditions
- Appendicitis, Surgical Wound Infection, Postoperative Complications, Wound Healing
- Trial name
- HIEDI-Yemen (NCT07688109)
- Testing
- Primary Closure with HIEDI, Delayed Primary Closure with HIEDI
- Where
- 3 sites in Yemen
- Volunteers
- 200 people
- Sponsor
- Sana'a University
Cesarean Section; Complications, Wound, Hematoma
Suture Material for Closure of Hysterotomy
Retrospective chart review evaluating different suture types on surgical outcomes for cesarean delivery and vaginal birth after cesarean delivery outcomes when different sutures are used.
- Trial name
- NCT03026647
- Testing
- Suture
- Where
- United States
- Sponsor
- St. Louis University
Open Surgical Wounds
Effectiveness of Wound Closure Using V-Loc™ 90 Sutures in Lipoabdominoplasty Patients
VLock suture studied in abdominal wound closure. Time and cosmesis was studied
- Trial name
- NCT01574378
- Testing
- conventional closure, V-Loc 90
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vladimir Grigoryants MD
Epidermolysis Bullosa (EB)
Efficacy and Safety Study to Evaluate SD-101 in Epidermolysis Bullosa
The upcoming trial is for EB patients is a topically applied whole-body treatment of patients with either Simplex, RDEB or Junctional (nH) ages 1 month to 12 years old at study entry.
- Trial name
- NCT07482787
- Testing
- SD-101 Dermal Cream (6%), Vehicle (SD-101 0%)
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Paradigm Therapeutics
Surgical Wound Infection, Wound; Abdomen, Abdominal Wall
Surgical Site Infection Rate After Intra-Abdominal Surgery Using Negative Pressure Wound Therapy at Initial Closure
The goal of this study is to present a large single-institution experience reporting surgical site infection rates in patients who have undergone intra-abdominal surgery followed by wound closure with Negative Pressure Wound…
- Conditions
- Surgical Wound Infection, Wound; Abdomen, Abdominal Wall, Surgery
- Trial name
- NCT01924884
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Johns Hopkins University
Cesarean Section, Complication
A Skin Glue Versus Subcuticular Suture for Cesarean Closure Study
The aim of this study is to compare cesarean incision outcomes between patients with incision closed with the Dermabond Prineo system compared to standard subcuticular suture.
- Conditions
- Cesarean Section, Complication, Wound
- Trial name
- NCT05903547
- Testing
- Dermabond Prineo, Suture
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Columbia University
Incisional Hernia, Wound Dehiscence
Hernia After Colorectal Cancer Surgery
Defects in the abdominal wall (incisional hernia) is a frequent negative outcome after surgery. Reinforcing the incision with mesh seem to lower the incidence but in surgery that includes bowel resection a simple alternative…
- Conditions
- Incisional Hernia, Wound Dehiscence, Wound Complication, Quality of Life
- Trial name
- Rein4CeTo1 (NCT03390764)
- Testing
- 4:1 closure group, RTL plus 4:1 closure group
- Where
- Sweden
- Volunteers
- 152 people
- Sponsor
- Skane University Hospital
Surgical Wound
The Closer Trial: A Safety and Efficacy Study of the Rex Medical Vascular Sealing System
The objective of this trial is to demonstrate the safety and effectiveness of the Rex Medical Closer Vascular Sealing System in sealing femoral arterial access sites.
- Trial name
- Closer (NCT02136004)
- Testing
- Closer VSS
- Where
- 12 sites in United States
- Volunteers
- 220 people
- Sponsor
- Rex Medical