Clinical trials: Wound Infection, Surgical
Orthopaedic Surgery (30 Minutes or Longer)
The Effect of Plasma-air-filtration on the Incidence of Surgical Site Infections in Orthopaedic Surgery
The study is a multicenter, double-blind, randomized, controlled trial conducted at six major university and teaching hospitals with a catchment population of approximately 2 million.
- Trial name
- EPOS (NCT02695368)
- Testing
- Novaerus NV800 on, Novaerus NV800 off, Novaerus NV800 on or off
- Where
- Sweden
- Volunteers
- 45,000 people
- Sponsor
- Karolinska Institutet
Surgical Site Infection
Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections
In a rural hospital in Tanzania the rate of surgical site infections (SSI) was 21.6%. Inappropriate choice of antibiotics and of administration time were determined as sole risk factors in this setting.
- Trial name
- SSI2 (NCT00801099)
- Testing
- Amoxicillin/Clavulanic Acid
- Where
- Switzerland
- Volunteers
- 276 people
- Sponsor
- Swiss Tropical & Public Health Institute
Antibiotic Reaction, Wound Infection Superficial
Antibiotic Prophylaxis in Metabolic Bariatric Surgery
SUMMARY Rationale: Prophylactic antibiotics in laparoscopic surgeries, including Metabolic Bariatric Surgery (MBS), are routinely provided to reduce postoperative infections, especially at wound incision sites.
- Conditions
- Antibiotic Reaction, Wound Infection Superficial, Wound Infection Deep, Bariatric Surgery Candidate
- Trial name
- NCT06510452
- Testing
- 2000 mg of Cefazolin, 500 mg of Metronidazole IV, NACL 0.9% 100 ml
- Where
- 2 sites in Egypt, Netherlands
- Volunteers
- 3,352 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Surgical Site Infection
Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients
Intervention: This study will involve three different study arms with different interventions prior to surgery: (1) shower only, (2) shower plus Theraworx wipes, (3) shower plus chlorhexidine wipes Study Design: Single center RCT…
- Trial name
- NCT03401749
- Testing
- Chlorhexidine Gluconate 2% Wipe, Theraworx Bath Wipes
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- University of Alabama at Birmingham
Radius Fracture Distal, Surgery
Volar Locking Plate Versus External Fixation for Distal Radius Fracture - a Longterm Follow up
A 10-year follow up of a fusion of two earlier published randomized controlled trials. 203 patients with displaced distal radius fractures were randomized to surgery with a volar locking plate or external fixation.
- Conditions
- Radius Fracture Distal, Surgery, Surgery--Complications, Treatment Complication
- Trial name
- EXTEND (NCT05371938)
- Testing
- Volar locking plate, external fixation
- Where
- Sweden
- Volunteers
- 203 people
- Sponsor
- Olof Skoldenberg
Hydrocephalus, Ventriculoperitoneal Shunt Infection
Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies
Objectives Primary: To measure the reduction in VP shunt infection rates using topical vancomycin powder. Secondary: To compare efficacy across different Etiological Strata (Congenital, Post-hemorrhagic, post-inflammatory).
- Conditions
- Hydrocephalus, Ventriculoperitoneal Shunt Infection, Surgical Site Infection (SSI), Cerebrospinal Fluid Shunt Infection
- Trial name
- NCT07547826
- Testing
- Topical Vancomycin Powder, Standard Perioperative Care
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Assiut University
Surgical Site Infection
Gaps Between Evidence and Practice in Prevention of Surgical Site Infection in Spain
Web-based survey to members of 10 Spanish Associations of surgical nurses and surgeons of different specialities to know the application of preventative measures for surgical site infection.
- Trial name
- SurveyOIC (NCT04310878)
- Testing
- Survey among perioperative nurses and surgeons
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital de Granollers
Surgical Site Infection
The Impact of Using Triclosan-antibacterial Sutures on the Incidence of Surgical Site Infection
To compare conventional polyglactin 910 sutures with triclosan-coated polyglactin 910 antimicrobial sutures for the reduction of surgical site infections and any associated health and economic benefits.
- Trial name
- NCT01019447
- Testing
- Vicryl Plus, Vicryl
- Where
- 2 sites in Egypt
- Volunteers
- 701 people
- Sponsor
- Cairo University
Surgical Site Infection, Coronary Artery Bypass Grafting (CABG)
Effect of Nurse-Led Education and Tele-Interventions on Reducing Surgical Site Infections in Patients After Coronary Artery Bypass Surgery: a Clinical Trial
The goal of this clinical trial is to determine if nurse-led education and tele-interventions can reduce the incidence of surgical wound infections in patients after coronary artery bypass surgery.
- Trial name
- NCT06586749
- Testing
- Group B: nurse-led education, Group C: nurse-led education and implementation of teleinterventions
- Where
- Greece
- Volunteers
- 220 people
- Sponsor
- Hellenic Mediterranean University
Surgical Site Infection
The Inselspital Surgical Cohort Study
Personalizing surgical care is of enormous clinical relevance, when considering the number of patients undergoing surgery in Switzerland every year.
- Trial name
- InSurg (NCT04096885)
- Testing
- Blood and urine samples, skin and stool swabs
- Where
- Switzerland
- Volunteers
- 1,226 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Surgical Site Infection, Surgical Complication
A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™
Goal of the Clinical Trial: The purpose of this clinical trial is to learn whether Xperience™ surgical irrigation solution is more effective than a standard dilute povidone-iodine solution in reducing surgical site infections…
- Conditions
- Surgical Site Infection, Surgical Complication, Implant Infection, Implant Complication
- Trial name
- NCT06649890
- Testing
- Xperience™ Advanced Surgical Irrigation, Dilute Povidone-Iodine
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Surgical Wound Infection
A Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO™) or Standard Care Dressings (AQUACEL® Ag SURGICAL Dressing)
The aim of this study is to assess the prevention of incision healing complications in patients undergoing revision TKA and THA treated with either Single-Use NPWT (PICO) compared to standard of care dressings (AQUACEL Ag…
- Trial name
- NCT02664168
- Testing
- Aquacel Ag Surgical Dressing, Single-Use Negative Pressure Wound Therapy (PICO)
- Where
- United States
- Sponsor
- Rothman Institute Orthopaedics
Surgical Wound Infection
Skin Perfusion After Abdominal Surgery
The purpose of this study is to evaluate the consequences of 3 selected surgical procedures on abdominal wall perfusion in order to help to reduce postoperative complication related to inadequate tissue perfusion.
- Trial name
- DIRTSURGERY (NCT03057249)
- Testing
- Dynamic infrared thermography (DIRT)
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Surgical Incision, Surgery--Complications
Zinc Oxide Versus Petrolatum Following Skin Surgery
Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this…
- Conditions
- Surgical Incision, Surgery--Complications, Surgical Wound, Surgical Site Infection
- Trial name
- NCT03561376
- Testing
- Topical zinc oxide vs. petrolatum post-surgical scars
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Melissa Pugliano-Mauro
Total Knee Replacement
Comparison of Surgical Site Infection After Skin Closure by Prolene or Staples in Bilateral Knee Arthroplasty Patients
Knee arthroplasty also known as the total knee replacement is an orthopedic surgical procedure done to resurface the knee that has been severely damaged by arthritis.
- Trial name
- NCT04492852
- Testing
- Polypropylene (PROLENE) sutures, Staple Sutures
- Volunteers
- 82 people
- Sponsor
- Indus Hospital and Health Network
30% Oxygen Concentration During Colorectal Surgery, 80% Oxygen Concentration During Colorectal Surgery
Supplemental Oxygen in Colorectal Surgery: A Quality Improvement Project
Our primary objective is to develop a clinical pathway for care of patients having colorectal surgery at the Clinic. In particular, the investigators would like to determine what intraoperative concentration of oxygen is optimal…
- Trial name
- NCT01777568
- Testing
- 30% oxygen, 80% oxygen
- Where
- United States
- Volunteers
- 5,749 people
- Sponsor
- The Cleveland Clinic
Colorectal Surgery
A Single Dose of a Marketed Drug Being Studied for a New Indication to Treat Surgical Site Infection Following Colorectal Surgery as Compared to a Marketed Drug Approved for This Indication (0826-039)
The objective of this study is to evaluate the safety and efficacy of a one time dose of an intravenous marketed drug being evaluated for a new indication as compared to a marketed drug already approved for the prevention of…
- Trial name
- NCT00090272
- Testing
- MK0826, ertapenem sodium, Comparator: cefotetan
- Volunteers
- 952 people
- Sponsor
- Merck Sharp & Dohme LLC
INFECTION
Topical Use of Vancomycin in Reducing Sternal Wound Infection in Cardiac Surgery (SWI Trial)
The purpose of this research is to determine if using the antibiotic vancomycin as a preventative topical (on the surface of the skin) treatment during open-heart surgery will reduce the risk of developing a sternal wound…
- Trial name
- SWI (NCT02374853)
- Testing
- Vancomycin, No Vancomycin
- Volunteers
- 1,037 people
- Sponsor
- University of Alberta
Surgical Site Infection
Comparative Effectiveness and Cost-Benefit Analysis of Vancomycin Powder in High Risk Spine Surgery Patients
Despite the use of prophylactic systemic antibiotics and improved surgical technique, surgical site infections remain a serious concern.
- Trial name
- NCT01566422
- Testing
- Vancomycin powder
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Dehiscence of Laparotomy Wound, Surgical Wound Infection
Short Stitch Monomax®
A number of studies identifies abdominal hernia as the most frequent postoperative complication following laparotomy with percentages of 9-20% - depending on duration of follow-up.
- Trial name
- Short-Stitch (NCT01938222)
- Testing
- Short Stitch
- Where
- Germany
- Volunteers
- 351 people
- Sponsor
- Diakonie-Klinikum Schwäbisch Hall gGmbH
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