Clinical trials: Wound Infection, Surgical
Seroma, Surgical Site Infection
Prevention of Seroma Following Inguinal Lymph Node Dissection With Prophylactic Incisional Negative Pressure Wound Therapy
Inguinal lymph node dissection (ILND) is indicated following metastatic malignant melanoma, and is associated with a high-complication rate, of which many begin with the formation of seroma and ends in complicated wound healing…
- Conditions
- Seroma, Surgical Site Infection, Lymphedema, Quality of Life
- Trial name
- NCT03433937
- Testing
- Negative pressure wound therapy, Micropore tape
- Where
- 4 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Surgical Site Infection, Surgery--Complications
Prophylaxis of Surgical Wound Infection With Topical Antibiotics
Surgical site infection (SSI) is the main complication of surgery. The prevention of superficial SSI by topical prophylaxis is controversial.
- Conditions
- Surgical Site Infection, Surgery--Complications, Colorectal Surgery, Cesarean Section; Infection
- Trial name
- NCT04476212
- Testing
- Topical antibiotic prophylaxis
- Where
- Spain
- Volunteers
- 560 people
- Sponsor
- Hospital de Granollers
SARS-CoV2 Infection, Hip Fractures
Hip Fracture and COVID-19
Hip fracture in the elderly is a worldwide public health issue and a medical challenge for early postoperative rehabilitation. More than 2 million people are treated annually with an annual incidence between 100 and 300/100,000…
- Conditions
- SARS-CoV2 Infection, Hip Fractures, Surgery
- Trial name
- COLCOVID (NCT04944329)
- Testing
- Hip fracture surgery
- Where
- France
- Volunteers
- 73,661 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Hydrocephalus
UVC in Prevention of Surgical Wound Infection
The LF-PODD study investigates the use of UVC (270nm) light in the prevention of surgical wound infections. Three devices are used in the study, two of which are actively producing UVC light (265 and 275 nm) and one device does…
- Trial name
- UVCJAS (NCT07600463)
- Testing
- UVC Irradiation
- Where
- Finland
- Volunteers
- 75 people
- Sponsor
- Ville Leinonen
Wound Infection, Breast Neoplasms
Wound Infections in Breast Cancer Surgery After Preoperative Skin Preparation With Chlorhexidine vs. Povidone-iodine
The development of surgical site infections (SSI) in clean-contaminated surgery is regarded as being preventable. Known to be effective in the prevention of surgical site infection are the adequate sterilization of the surgical…
- Trial name
- NCT02479347
- Testing
- Chlorhexidine, Povidone-Iodine
- Where
- Italy
- Volunteers
- 2,158 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Stoma Site Infection
Negative Pressure Wound Therapy for Wound Healing After Stoma Reversal
Stoma reversal is associated with high incidence of post-surgical complications, including Surgical Site Infections (SSI). Negative Pressure Wound Therapy (NPWT) has been successfully applied to surgical wound management…
- Trial name
- NESTOR (NCT03781206)
- Testing
- PICO™ 7
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Clinico Humanitas
Surgical Site Infections
The Skin Prep Study
The investigators propose a randomized controlled clinical trial to determine the comparative effectiveness of chlorhexidine-alcohol and iodine-alcohol preoperative skin preparation for preventing surgical site infections at…
- Trial name
- NCT01472549
- Testing
- Iodine-alcohol, Chlorhexidine-alcohol
- Where
- United States
- Volunteers
- 1,147 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Infection, Surgical Site
IO vs IV Vancomycin in Tourniquetless TKA
Purpose of this study is to compare the efficacy of intravenous and intraosseous antibiotic administration techniques during tourniquetless total knee arthroplasty.
- Trial name
- NCT05705843
- Testing
- Intraosseous Vancomycin Injection, Intravenous Vancomycin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Surgical Site Infection, Cesarean Section; Infection
Abdominal Closure Bundle to Reduce Surgical Site Infection in Patients Undergoing C-sections. Cesarean Section Lead to Reduction in Surgical Site Infection? - A Randomized Controlled Trial
This study is a single center, randomized controlled trial investigating the use of an abdominal closure bundle to reduce surgical site infection in patients undergoing cesarean section.
- Trial name
- NCT03500055
- Testing
- Abdominal Closure Bundle
- Where
- United States
- Volunteers
- 850 people
- Sponsor
- Abington Memorial Hospital
Mitochondrial Oxygenation Measurement, Surgical Site Infection
Anaesthetic Management Guided by COMET Measurements
Surgical site infection (SSI) is a significant cause of morbidity and mortality, prolonged hospital stays and healthcare costs. Perioperative low tissue oxygen tension is associated with a high risk of SSI.
- Trial name
- AIMED COMET (NCT05841576)
- Testing
- COMET monitoring device
- Where
- Netherlands
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Rick Hulskes
Surgical Site Infection
Understanding the Drivers of Surgical Site Infection: Investigating and Modeling the Swissnoso Surveillance Data
Surgical site infection (SSI) is the most common healthcare-associated infection, multifactorial in nature, and a typical preventable harm.
- Trial name
- WATUSSI (NCT03883009)
- Where
- Switzerland
- Volunteers
- 318,000 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Surgical Site Infection
Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients
Intervention: This study will involve three different study arms with different interventions prior to surgery: (1) shower only, (2) shower plus Theraworx wipes, (3) shower plus chlorhexidine wipes Study Design: Single center RCT…
- Trial name
- NCT03401749
- Testing
- Chlorhexidine Gluconate 2% Wipe, Theraworx Bath Wipes
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- University of Alabama at Birmingham
Cruciate Ligament Reconstruction Infection, Septic Arthritis
A Metagenomic Next-generation Sequencing (mNGS)-Guided Sequential Culture Strategy for Postoperative Cruciate Ligament Reconstruction Infection (CLRI): a Retrospective Cohort Study
This retrospective cohort study evaluates a sequential diagnostic strategy for patients with postoperative cruciate ligament reconstruction infection (CLRI).
- Conditions
- Cruciate Ligament Reconstruction Infection, Septic Arthritis, Surgical Wound Infection, Joint Infection
- Trial name
- NCT07852598
- Testing
- Metagenomic next-generation sequencing (mNGS), mNGS-guided modified culture, Conventional microbiological culture
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Surgical Site Infection
Study for Antibiotic Impregnated Calcium Sulfate Beads as Prophylaxis for Surgical Site Infection
The CDC quotes a rate of wound infection of 2-5% for inpatient surgery. Patients undergoing a vascular operation, however, are generally at an increased risk of wound infection with rates often close to 5-10%.
- Trial name
- NCT03308253
- Testing
- Stimulan Rapid Cure, Vancomycin, Tobramycin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Gastrointestinal Surgery, Mirabilite
External Application of Mirabilite to Promote Recovery in Patients After Gastrointestinal Surgery
This study evaluates the efficacy and safety of topical Mirabilite (sodium sulfate) application for managing postoperative outcomes in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Surgery, Mirabilite, Surgical Site Infection, Postoperative Gastrointestinal Dysfunction
- Trial name
- NCT06696729
- Testing
- Topical Mirabilite Application for Postoperative Gastrointestinal Patients, Standard Postoperative Care for Gastrointestinal Patients
- Where
- China
- Volunteers
- 301 people
- Sponsor
- Nanchang University
Limb Edema, Surgical Site Infections
Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages
The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients.
- Conditions
- Limb Edema, Surgical Site Infections, Leg Swelling, Compression Bandages
- Trial name
- PEACCE (NCT06603961)
- Testing
- CPG-EB group
- Where
- 2 sites in Thailand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Surgical Site Infection
Novosyn® CHD vs Polyglactin 910 Suture to Close Wounds After Emergency or Elective Laparotomy or Laparoscopic Surgery
The aim of the study is to elucidate, if the colonization of bacteria is lower on the Novosyn® CHD suture compared to uncoated Polyglactin 910 suture, which will be assessed by the incidence of surgical site infections (SSI: A1…
- Trial name
- POLYNOVO-CHD (NCT05966961)
- Testing
- Novosyn® in emergency or elective laparotomy or laparoscopic surgery, Polyglactin 910 in emergency or elective laparotomy or laparoscopic surgery
- Where
- 4 sites in Italy, Spain
- Volunteers
- 2,998 people
- Sponsor
- Aesculap AG
Wound Infection
A Comparison of Surgical Preparations and Wound Infection Rates for Elective Cesarean Sections
The purpose of this study is to find out if chlorhexidine gluconate solution is better at reducing the rate of wound infection after cesarean section compared to povidone-iodine.
- Trial name
- NCT00528008
- Testing
- povidone-iodine solution, chlorhexidine gluconate
- Where
- Canada
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Surgical Site Infection After Major Surgery, Surgical Site Infections
Assessing the Effect of the Silver Dressing on Surgical Site Infections in Adult Patients Post Cardiac Surgery: a Single Center Randomized Control Trial
RCT on post-cardiac surgery patients using silver dressings vs. standard care. Conducted in ICU, CCU, telemetry units. Outcomes assessed via checklist \& modified Parsonnet Score.
- Trial name
- NCT07008040
- Testing
- Silver dressing
- Where
- Saudi Arabia
- Volunteers
- 145 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Surgical Site Infection
Suprafascial Vancomycin Powder for Prevention of Surgical Site Infections After Instrumented Posterior Spinal Fusion
Surgical site infections (SSI) after spine surgery may occur in up to 12% of cases and can lead to increased morbidity, and healthcare costs In this randomized controlled trial the investigators aim to prospectively investigate…
- Trial name
- VANCO (NCT04017468)
- Testing
- Vancomycin
- Where
- 7 sites in Switzerland
- Volunteers
- 450 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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