Clinical trials: Wound of Skin
Penis/Surgery, Penis/Injuries
Autologous Fat Grafting Beneath Penile Split Thickness Skin Graft Placement During Penile Reconstruction
The goal of this randomized interventional clinical trial is to learn if placement of a thin layer of fatty tissue (fat graft) beneath a split-thickness skin graft on the surface of the penis improved outcomes of surgery in men…
- Conditions
- Penis/Surgery, Penis/Injuries, Penile Skin, Adult-Acquired Buried Penis
- Trial name
- NCT07316491
- Testing
- Autologous fat grafting, Genitourinary Reconstruction with Split-Thickness Skin Grafting
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pittsburgh
Skin Graft Donor Site, Wound Healing
Autologous Skin Cell Suspension (RECELL®) for Accelerated Healing of Split-Thickness Skin Graft Donor Sites: A Randomized, Intra-Patient (Split-Site) Controlled Trial
This study evaluates whether applying RECELL® autologous skin cell suspension (ASCS) to one half of a split-thickness skin graft (STSG) donor site accelerates re-epithelialization and improves long-term scar quality compared with…
- Conditions
- Skin Graft Donor Site, Wound Healing, Split-Thickness Skin Graft
- Trial name
- RECELL®-STSG (NCT07888166)
- Testing
- RECELL® Autologous Cell Harvesting Device, Standard Transparent Film Dressing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Surgical Site Infection, Skin Cancer
Cyanoacrylate Skin Adhesive After Mohs Surgery or Wide Local Excision
This study will compare surgical site infection after linear repair with or without cyanoacrylate skin adhesive following Mohs micrographic surgery or wide local excision.
- Conditions
- Surgical Site Infection, Skin Cancer, Wound Healing
- Trial name
- NCT07844681
- Testing
- Cyanoacrylate Skin Adhesive, Fast Gut Running Epidermal Suture Closure, Vicryl Rapide Running Epidermal Suture Closure
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Minnesota
Pressure Ulcer
CMAP Refinement for Pressure Injury Prevention
For Veterans with spinal cord injury who use a wheelchair, pressure injuries related to sitting are a significant daily threat to well-being.
- Trial name
- NCT04309864
- Testing
- Use of CMAP app for education (in-hospital), Use of CMAP app (in-home)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pyoderma Gangrenosum, Skin Diseases
Guselkumab in the Treatment of Adults With Pyoderma Gangrenosum (PG)
A single-arm open-label study assessing short-term (week 6, 16) and long-term (week 32) efficacy of guselkumab in adult participants with pyoderma gangrenosum (PG)
- Conditions
- Pyoderma Gangrenosum, Skin Diseases, Wound Heal, Pyoderma
- Trial name
- GEORGE (NCT06563323)
- Testing
- Guselkumab
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Oregon Health and Science University
Skin Pruritus, Itch
Efficacy and Safety of HA35 Gel for Ultra-Rapid Skin Pruritus Relief
This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of topical 10% high-concentration 35 kDa hyaluronan (HA35) gel for ultra-rapid relief of moderate-to-severe skin pruritus…
- Conditions
- Skin Pruritus, Itch, Eczema Itch, Neurodermatitis
- Trial name
- HA35-ITCH (NCT07580911)
- Testing
- 10% High-Concentration 35 kDa Hyaluronan (HA35) Topical Anti-Pruritic Gel
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nakhia Impex LLC
Burn Injury, Burn Scar
Tissue Quality of Integra vs. BTM Treated Burns
An observational analysis of Integra-treated burns and Novosorb Biodegradable Temporizing Matrix (BTM)-treated burns will be undertaken 12-36 months post final skin graft application by retrospectively analyzing the patient's…
- Conditions
- Burn Injury, Burn Scar, Burn Wounds - Partial Thickness (2nd Degree), Skin Grafting
- Trial name
- NCT06760611
- Sponsor
- Integra LifeSciences Corporation
Wound of Skin, Ulcers
TrueLok Elevate PMCF Study
The TrueLok Elevate Transverse Bone Transport System is a modular external fixation device designed for transverse bone transport.
- Conditions
- Wound of Skin, Ulcers, Soft Tissue Defect
- Trial name
- NCT07079774
- Testing
- Transverse Bone Transport System
- Where
- 14 sites in Germany, Italy and 4 more
- Volunteers
- 153 people
- Sponsor
- Orthofix s.r.l.
Skin Wound, Scar, Hypertrophic
Umbilical Cord Stem Cells for Skin Grafts in Donor Site Wounds
The goal of this clinical trial is to evaluate the safety and effectiveness of human umbilical cord mesenchymal stem cell (hUCMSC) therapy in patients undergoing medium-thickness skin grafts for donor site wounds.
- Trial name
- NCT05984628
- Testing
- human umbilical cord mesenchymal stem cells, blank solvent
- Where
- China
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Skin Transplantation, Skin Grafting
Lower Extremity Graft Study (LEGS): A Multicentre Randomised Controlled Trial of Negative Pressure Wound Therapy Versus Conventional Dressings for Split-thickness Skin Grafts After Lower Leg Skin Tumour Excision
The goal of this clinical trial is to compare the effect of negative pressure wound therapy (NPWT) versus traditional dressings on the incidence of transplant infection in adult patients undergoing split-thickness skin grafting…
- Conditions
- Skin Transplantation, Skin Grafting, Split Thickness Skin Graft, Negative-Pressure Wound Therapy
- Trial name
- LEGS (NCT07040683)
- Testing
- Negative Pressure Wound Therapy (NPWT), Traditional Dressing
- Where
- Sweden
- Volunteers
- 232 people
- Sponsor
- Region Skane
Skin Wound
Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Full-Thickness Skin Defects in Adults and Children
This phase II trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in adults and children with full-thickness Skin defects.
- Trial name
- NCT03394612
- Testing
- EHSG-KF, STSG
- Where
- 7 sites in Italy, Netherlands and 1 more
- Volunteers
- 21 people
- Sponsor
- CUTISS AG
Surgical Wound, Wound Heal
Influence of Sun Protection and Linear Repair of Cutaneous Surgical Defects
The purpose of this study is to determine the potential influence of sun protection on the aesthetic outcome of post-surgical scars following the reconstruction of Mohs micrographic surgery defects via linear repair.
- Conditions
- Surgical Wound, Wound Heal, Wound of Skin, Scar
- Trial name
- NCT05074238
- Testing
- Zinc containing suncreen
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Wound of Skin, Burns
Manual Implantation of Full-Thickness Skin Microcolumns
The objective of this study is to validate the proof of concept regarding the approach of manual implantation of full-thickness skin microcolumns (FTSMs) as coverage for open wounds without creating an additional donor scar and…
- Trial name
- NCT05223998
- Testing
- Full-thickness skin microcolumns implantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Metis Foundation
Wound of Skin, Burns
Suprathel® Use During Prolonged Field Care to Promote Healing and Reduce the Need for Grafting of Burn Wounds
The purpose of this study is to determine the effect to which Suprathel® (Polymedics Innovations GmbH, Denkendorf, Germany) can reduce the need for grafting compared to Standard of Care (SoC).
- Trial name
- NCT05462860
- Testing
- Suprathel®
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The Metis Foundation
Skin Stiffness, Skin Thickness
Evaluation Skin Stiffness Gradient on Skin After LLLT
This study evaluates the effects of Low-Level Laser Therapy (LLLT) on skin elasticity by measuring a 3x3 stiffness gradient across 9 points spaced 1 cm apart.
- Conditions
- Skin Stiffness, Skin Thickness, DFU, Wound and Injuries
- Trial name
- NCT07680309
- Testing
- LLLT intervention on skin biomechanical properties in different duration and wavelength, LLLT intervention on skin biomechanical properties in different duty cycle and applied frequency
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Asia University
Wound, Wound of Skin
Point-spectroscopy Trial
Evaluation and characterization of autofluorescence signals of tissue in and around wounds as identified by MolecuLight fluorescence image.
- Trial name
- NCT05183698
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- MolecuLight Inc.
Wounds, Wound of Skin
MolecuLightDX Measurement Feature Clinical Validation
This is a prospective, single-arm, paired clinical evaluation of the MolecuLightDX device in the measurement of surface wounds in patients.
- Trial name
- NCT06682923
- Testing
- MolecuLight DX Imaging Device
- Where
- 2 sites in Canada
- Volunteers
- 34 people
- Sponsor
- MolecuLight Inc.
Skin Ulcer, Pressure Ulcer (PU)
Study Title: A Multicenter, Prospective, Modified Platform Trial Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Matched Standard of Care Controls in the Management of Nonhealing Pressure Ulcers.
A multicenter prospective modified platform trial evaluating several cellular, acellular, and matrix like products and standard of care versus matched standard of care controls in the management of nonhealing pressure ulcers.
- Conditions
- Skin Ulcer, Pressure Ulcer (PU), Pressure Ulcer of Skin, Pressure Sore
- Trial name
- RESTORE (NCT07665268)
- Testing
- Activate™ Matrix + SOC, AmnioDefend™ FT Matrix + SOC, Palisade™ DM Matrix + SOC
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Sequence LifeScience, Inc.
Wound Healing, Surgical Wound Infection
The Application of Infrared Thermography in the Prediction of Skin Healing in Surgery
This study investigates whether infrared thermography, a harmless and non-invasive thermal camera technique, can help monitor how surgical wounds heal after skin surgery.
- Conditions
- Wound Healing, Surgical Wound Infection, Postoperative Complications, Skin Neoplasms
- Trial name
- THERMS (NCT07524062)
- Testing
- Infrared thermography
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Skin Wounds, Abrasion
A Study to Evaluate the Safety and Clinical Performance of a Dexpanthenol Medicated Hydrogel Patch in the Treatment of Standardized Superficial Abrasions
Clinical evaluation of a Dexpanthenol-medicated wound plaster on standardized superficial skin abrasions
- Trial name
- Dexpanthenol (NCT07642973)
- Testing
- hydrogel plaster with dexpanthenol, Standard plaster
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wooshin Labottach Co., Ltd.