Clinical trials: Wounds, Nonpenetrating
Acute Blunt Soft Tissue Injuries/Contusions
Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Blunt Trauma Injuries
The purpose of this study is to evaluate the efficacy of DSG 1% compared with placebo applied four times a day in subjects with acute blunt soft tissue injuries/contusions of the limbs
- Trial name
- NCT01272947
- Testing
- Diclofenac sodium
- Where
- 6 sites in Germany
- Volunteers
- 204 people
- Sponsor
- Novartis
Mild Traumatic Brain Injury
Combining Attention and Metacognitive Training to Improve Goal Directed Behavior in Veterans With TBI
Veterans with mild traumatic brain injury continue to deal with symptoms that interfere with their ability to engage in productive activities.
- Trial name
- NCT04044456
- Testing
- Goal Management Training, Attention Training, Brain Health Workshop
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Blunt Injury of Thorax, Multiple Rib Fractures, Involving Three Ribs
Low Dose Ketamine for Blunt Thoracic Trauma
The goal of this Randomized controlled double-blinded trial is to compare the addition of a ketamine infusion to placebo, when added to standard care in adult blunt trauma patients with multiple rib fractures.
- Trial name
- NCT06236113
- Testing
- Ketamine 1 Mg/mL-NaCl 0.9% Intravenous Solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Memorial Health Care
Traumatic Brain Injury
TBI MR Study 3 Houston Methodist
This hypothesis-generating feasibility study to determine potential associations between a broad range of clinical neurological symptoms and Magnetic Resonance Image (MRI), data, and clinical findings involved in mild traumatic…
- Trial name
- NCT02218216
- Testing
- MRI Diagnostic
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- GE Healthcare
Concussion, Traumatic Brain Injury
Concussion Device Audiological Measures
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02262507
- Testing
- Device Wearing
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Headache, Post-Concussion Syndrome
The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome
Pilot study looking at the Osteopathic Manipulative Treatment (OMT) for various headache types in patients with post-concussion syndrome (PCS).
- Trial name
- NCT04732338
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hackensack Meridian Health
Concussion Injury of Cerebrum, Cranial Osteopathic Medicine
Cranial Osteopathic Manipulative Medicine as an Adjunct Treatment for Concussion
Patients who have concussions exhibit an array of symptoms, also known as post-concussive symptoms, including headaches, feeling slowed down or foggy and difficulty with concentration.
- Trial name
- NCT03225599
- Testing
- Cranial Osteopathic Manipulative Medicine
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Concussion Post Syndrome, Headaches Posttraumatic
Pediatric Concussion Outcomes
This is a randomized, placebo-controlled, double-blinded trial in which subjects with a post concussive headache meeting inclusion criterion will be assigned to one of two treatment groups: placebo or nortriptyline.
- Conditions
- Concussion Post Syndrome, Headaches Posttraumatic, Mild Traumatic Brain Injury
- Trial name
- PeCon (NCT04226365)
- Testing
- Nortriptyline
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Mild Traumatic Brain Injury, Balance; Distorted
Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life
- Trial name
- NCT03479541
- Testing
- Timing of Rehabilitation, Biofeedback
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Brain Concussion, Brain Injuries
Screening Brain MRI in High School Football: Does the Guardian Cap Reduce the Risk of Traumatic Brain Injury
Screening Brain magnetic resonance imaging (MRI) with Fluid-attenuated Inversion Recovery (FLAIR) and Susceptibility Weighted Imaging (SWI) sequences will be performed pre and post season on high school football players.
- Conditions
- Brain Concussion, Brain Injuries, Diffuse Axonal Injury, Athletic Injuries
- Trial name
- NCT02757053
- Testing
- Guardian Cap
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Mosaic Life Care
Insomnia, Traumatic Brain Injury
Cognitive-Behavioral Therapy for Veterans With TBI
Many Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn era Veterans have suffered a mild traumatic brain injury (mTBI), and now cope with multiple post-injury symptoms, including sleep disturbances (especially…
- Trial name
- NCT02658669
- Testing
- Cognitive-Behavioral Therapy for Insomnia, Sleep Education
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Chronic Post-traumatic Headache, Mild Traumatic Brain Injury
Acupuncture in Traumatic Brain Injury
The purpose of the study is to determine the effect of a low vs. high dose of acupuncture treatment in individuals with chronic post-traumatic headache (CPTH).
- Trial name
- AccuTBI (NCT04369911)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- HealthPartners Institute
Brain Concussion, Blast Injuries
Metacognitive Training to Enhance Strategy Use in Blast-Related TBI
Enhanced Goal Management Training (GMT) is a 10-week group or individual therapy that teaches strategies to improve an individual's ability to complete everyday tasks.
- Trial name
- NCT00857207
- Testing
- Goal Management Training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Acute Blunt Soft Tissue Injuries/Contusions
Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Compared to Placebo in Subjects With Acute Blunt Trauma Injuries
This study will assess the analgesic efficacy of DSG 1% compared to placebo in the reduction of the pain associated with acute blunt trauma injuries.
- Trial name
- NCT02290821
- Where
- 10 sites in United States
- Volunteers
- 215 people
- Sponsor
- Novartis
Mild Traumatic Brain Injury
High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for Sensory Deficits in Complex Traumatic Brain Injury
Aim 1: To use magnetoencephalography (MEG) and magnetic resonance imaging (MRI) in Veterans and civilians with mild traumatic brain injury (mTBI) and sensory postconcussive symptoms (PCS) to demonstrate the mechanism of…
- Trial name
- NAVIGATE-TBI (NCT03799458)
- Testing
- Active High-definition transcranial direct current stimulation (HD-tDCS)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Concussion, Brain, Traumatic Brain Injury
Ghrelin (OXE--103) for Acute Concussion Management
Concussions are the leading form of mild traumatic brain injury. Management of concussions and mild traumatic brain injury is a high priority medical focus, social concern, and research topic.
- Trial name
- NCT04558346
- Testing
- Ghrelin (OXE-103)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Michael Rippee
Head Trauma, Crushing Skull Injury
Detecting Traumatic Intracranial Hemorrhage With the InfraScanner 2500™ in Uganda
The goal of this study is to determine the sensitivity, specificity, and positive and negative predictive values of the portable near-infrared-based device (portable NIR-based device), the InfraScanner 2500™, to detect…
- Conditions
- Head Trauma, Crushing Skull Injury, Head Injury, Head Injuries, Multiple
- Trial name
- NCT06491173
- Testing
- InfraScanner 2500™
- Where
- 2 sites in Uganda
- Volunteers
- 180 people
- Sponsor
- Duke University
Traumatic Brain Injury
Effects of LEDs on Memory in TBI Patients
The purpose of the study is to investigate whether transcranial, high-intensity LED placed on the scalp can improve working memory in people who have sustained a concussion with lingering effects or a mild brain injury.
- Trial name
- LED (NCT01598532)
- Testing
- MedX Health Phototherapy (light therapy)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Spaulding Rehabilitation Hospital
Concussion, Mild
Delivery of Digital Cognitive Behavioural Therapy Following Concussion
Concussion is common and patients can go on to suffer with a constellation of symptoms which impacts their functional outcome and quality of life.
- Trial name
- HEADON (NCT05069948)
- Testing
- HeadOn
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Post-Concussion Syndrome
The Effectiveness of Biofeedback for Individuals With Long-term Post-concussive Symptoms
Most concussions resolve within 7-10 days, but approximately 40% of individuals do not fully recover and suffer from persistent post-concussive symptoms.
- Trial name
- NCT03338036
- Testing
- Heart Rate Variability Biofeedback, Neurofeedback
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Western University, Canada