Clinical trials: Wounds
Brain Injury
Traumatic Brain Injury (TBI) Screening Instruments
Goal: The ultimate goal of this research program is to improve the health and quality of life for wounded warriors from Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) through screening, risk assessment, and outcome…
- Trial name
- NCT00875329
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Thoracic Surgery, Cardiopulmonary Bypass
Cerebral Autoregulation Monitoring During Cardiac Surgery
Neurological complications from cardiac surgery are an important source of operative mortality, prolonged hospitalization, health care expenditure, and impaired quality of life.
- Trial name
- NCT00981474
- Testing
- blood pressure maintenance based on cerebral blood flow autoregulation measurement, Control group
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Northwestern University
Head Trauma
Pain in Traumatic Brain Injury - Basile, MD
The observation through a chart review of persistent pain on neuro psychological functioning and how it applies to the community integration with patients that had suffered traumatic brain injury.
- Trial name
- NCT01136486
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Northwell Health
Trauma/Injury Problem
Early Whole Blood in Patients Requiring Transfusion After Major Trauma
The proposal will assess if patients who require massive transfusion can be accurately predicted early after emergency department arrival and assess if the use of stored whole blood during initial resuscitation will reduce…
- Trial name
- NCT01227005
- Testing
- Transfusion of blood products
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- The University of Texas Health Science Center, Houston
Carpal Tunnel Syndrome
Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome
Between 2008 and 2012 the investigators performed a single-center randomized double-blind placebo-controlled trial to assess the efficacy of local injection of two different doses of methylprednisolone (80 mg and 40 mg) in…
- Trial name
- NCT02652390
- Testing
- Methylprednisolone 80 mg, Methylprednisolone 40 mg, Saline
- Volunteers
- 111 people
- Sponsor
- Region Skane
Insomnia, Spinal Cord Injury
Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia
The purpose of this study is to determine if replacing melatonin function with a melatonin agonist (ramelteon) in individuals that lack endogenous melatonin production (tetraplegia) helps to alleviate self-reported sleep…
- Conditions
- Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
- Trial name
- NCT00507546
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Trauma, Vascular System Injury
Humacyte Acellular Tissue Engineered Vessel (ATEV) in Patients With Vascular Trauma
This study evaluates the use of the Acellular Tissue Engineered Vessel (ATEV) in adults with vascular trauma below the neck who are undergoing vascular reconstructive surgery.
- Trial name
- NCT03005418
- Testing
- Acellular Tissue Engineered Vessel (ATEV)
- Where
- 29 sites in United States, Israel
- Volunteers
- 72 people
- Sponsor
- Humacyte, Inc.
Traumatic Injury, Venous Thromboembolism
Evaluation of Venous Thromboembolism Prevention in High-Risk Trauma Patients
This is a pilot study to determine if anti-thrombin III (AT-III) serum concentrations differ between patients with normal versus subtherapeutic anti-Xa trough concentrations when placed on enoxaparin 30 mg twice daily for VTE…
- Trial name
- NCT02412982
- Testing
- Enoxaparin 40 mg q12h, Enoxaparin 30 mg q8h
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Cincinnati
Spondylolisthesis, Neurologic Deficits
A Postmarket Surveillance Study of the Paradigm Spine Dynamic Stabilization System (DSS)
The purpose of the Post-Market Surveillance study is to evaluate safety.
- Conditions
- Spondylolisthesis, Neurologic Deficits, Kyphosis, Pseudarthrosis
- Trial name
- DSS (NCT01461005)
- Testing
- Dynamic Stabilization System (DSS)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Paradigm Spine
Anterior Cruciate Ligament Tear
Personalized Blood Flow Restriction for Anterior Cruciate Ligament Rehabilitation
This is a cross-sectional study on the use of personalized blood flow restriction during rehabilitation exercises and its effects on biomechanics on people who have had an anterior cruciate ligament reconstruction and healthy…
- Trial name
- NCT04635579
- Testing
- Blood flow restriction
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Washington
Rotator Cuff Tear
Early Mobilization Following Arthroscopic Rotator Cuff Repair
Shoulder rotator cuff (RC) tears are a significant cause of pain and disability. Surgery is done to reconnect the torn RC tendon(s) to the bone.
- Trial name
- NCT01333527
- Testing
- No Sling, Sling
- Where
- Canada
- Volunteers
- 211 people
- Sponsor
- University of Alberta
Neonatal Brachial Plexus Palsy
NMES Efficacy on Patients With NBPP
Neonatal Brachial Plexus Palsy (NBPP), characterized by weakness and sensory loss in the affected arm, results from damage in the prenatal period to the nerves extending from the spine to the arm.
- Trial name
- NCT01999465
- Testing
- Standard NMES device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
ACL Injury, Postoperative Pain
Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery
1. The investigators aim to examine the use of IV and oral ketorolac as an adjunctive agent to the standard of care pain protocol for postoperative pain control following ACL reconstruction surgery. 2.
- Trial name
- NCT04246554
- Testing
- Ketorolac, Oxycodone-Acetaminophen
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Spinal Cord Injury, Autonomic Dysreflexia
The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
Dysregulation of blood pressure (BP), secondary to decentralized autonomic nervous system (ANS) control of the cardiovascular system, often results in chronic hypotension and orthostatic hypotension (OH) in persons with spinal…
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Baroreceptor Integrity, Sympathetic Integrity
- Trial name
- NCT02893553
- Testing
- Midodrine Hydrochloride, Pyridostigmine Bromide, Mirabegron
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Bone Fractures, Radius Fractures
Management of Distal Radius Fractures in Children Younger Than 11 Years Old.
This fractures have been managed with anatomical reduction performed under anesthesia or using sedatives. In our institution this means prolonged hospital stay, involvement of an anesthesiologist and the use of an special room in…
- Conditions
- Bone Fractures, Radius Fractures, Closed Fractures
- Trial name
- NCT02670629
- Testing
- Partial reduction with overriding position, Closed anatomic reduction
- Volunteers
- 58 people
- Sponsor
- Carlos A Acosta-Olivo
Bronchopulmonary Dysplasia
Pragmatic Research on Diuretic Management in Early BPD Pilot
Babies who are born prematurely often develop a chronic lung disease called bronchopulmonary dysplasia (BPD). BPD puts babies at higher risk for problems with growth and development.
- Trial name
- PRIMED (NCT05898022)
- Testing
- Furosemide (plus potassium chloride)
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
This is an open-label, non-randomized, prospective, multi-site, parallel group (segment), hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between…
- Trial name
- mTBI-phase2 (NCT02556177)
- Testing
- MRI
- Where
- 7 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Spinal Cord Injury, Acute, Neurogenic Bladder
Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury
The purpose of this study is to see what effects sacral neuromodulation has on bladder function and quality of life in patients with acute spinal cord injury.
- Conditions
- Spinal Cord Injury, Acute, Neurogenic Bladder, Incontinence, Urinary Tract Infections
- Trial name
- NCT03083366
- Testing
- PrimeAdvanced Surescan 97702 Neurostimulator - Medtronic (Minneapolis, MN)
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Traumatic Brain Injury, Cognitive Impairment
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
Difficulties with intellectual functioning, particularly memory functions, are common and source of long-term disability after Traumatic Brain Injury (TBI).
- Trial name
- RIVET (NCT01670526)
- Testing
- Rivastigmine Transdermal Patch
- Where
- 8 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Concussion, Mild
Novel Protection Against Potential Brain, Hearing and Vision Injury During Blast Wave Exposure
The purpose of the study is to monitor changes in brain structure and function between the pre-training and post-training, in a population of tactical team members wearing the Device and compared to a similar population not…
- Trial name
- BLAST (NCT03017924)
- Testing
- Q collar
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
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