Clinical trials: Wounds
Chronic Pain, Post Stroke Pain
Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief.
- Conditions
- Chronic Pain, Post Stroke Pain, Phantom Limb Pain, Spinal Cord Injuries
- Trial name
- NCT03029884
- Testing
- Open-Loop DBS, Closed-Loop DBS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Prasad Shirvalkar, MD, PhD
Osteoporosis, Bone Fracture
Longitudinal Effects of Denosumab on Trabecular Bone Score and Femur Strength Index
The purpose of this study is to validate the long-term benefit of denosumab for osteoporosis treatment in a real-world clinical practice setting.
- Trial name
- NCT02435147
- Testing
- denosumab
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- HealthEast Care System
Spinal Cord Injuries, Polytrauma
Reduction of Opioid Dose Using Conditioning & Open-Label Placebo (COLP) in Intensive Rehabilitation
The use of conditioning open-label placebo (COLP) will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury.
- Conditions
- Spinal Cord Injuries, Polytrauma, Burn Injury, Pain Management
- Trial name
- COLP (NCT03906721)
- Testing
- Oxycodone, Essential Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Wound Open, Chronic Venous Hypertension (Idiopathic) With Ulcer
Efficacy of Laser Debridement on Pain and Bacterial Load in Chronic Wounds
Bacterial load is frequently associated with impaired healing of chronic wounds. As well, sharp debridement is often associated with pain, causing patient distress, and thereby occasionally contributing to inadequacy of…
- Conditions
- Wound Open, Chronic Venous Hypertension (Idiopathic) With Ulcer, Diabetic Foot Ulcer
- Trial name
- NCT03182582
- Testing
- Erbium:Yttrium-Aluminum-Garnet (Er:YAG) Laser Debridement, Scalpel/Curette Debridement
- Volunteers
- 22 people
- Sponsor
- Stanford University
Fractured Tooth, Decayed Tooth
Celtra Duo Computer Assisted Design/Computer Assisted Machining (CAD/CAM) Dental Crown Study
This investigation will be a clinical trial to study the performance of a newly developed high strength ceramic material for crowns. The ceramic has been approved by the FDA for patient treatment.
- Conditions
- Fractured Tooth, Decayed Tooth, Unsatisfactory Restoration of Tooth
- Trial name
- NCT03036579
- Testing
- Celtra Duo
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Michigan
Head Trauma
Effect of Cervical Collar on the Optic Nerve Sheath Diameter in Minor Head Trauma
This is randomized, controlled and blinded study was performed in minor head trauma patients. Two sonographers measured optic nerve sheath diameters (ONSD) of each subjects' eyes separately for different time points.
- Trial name
- NCT03742427
- Testing
- ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Marmara University
Brain Concussion
Enhanced Problem-Solving Training
Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom.
- Trial name
- E-PST (NCT03759223)
- Testing
- Enhanced Problem-Solving Training (E-PST), Healthy Living Messages (HLM), Enhanced Problem-Solving Training (E-PST) (non-randomized)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Surgical Site Infection, Unplanned Fracture-Related Reoperation
Pre-operative Alcohol Skin Solutions in Fractured Extremities
The prevention of infection is an important goal influencing peri-operative care of extremity fracture patients. Standard practice in the operative management of extremity fractures includes sterile technique and pre-operative…
- Conditions
- Surgical Site Infection, Unplanned Fracture-Related Reoperation, Open Appendicular Fracture, Closed Lower Extremity Fracture
- Trial name
- PREPARE (NCT03523962)
- Testing
- DuraPrep, ChloraPrep
- Where
- 27 sites in United States, Canada
- Volunteers
- 8,485 people
- Sponsor
- University of Maryland, Baltimore
Soft Tissue Injuries
Study of PK and Safety of the LicartTM Topical System in Pediatric and Adult Participants With Minor Soft Tissue Injury
A multi-center, prospective, open-label, controlled study of the pharmacokinetics and safety of the LicartTM topical system in pediatric and adult participants with minor soft tissue injuries.
- Trial name
- NCT05171673
- Testing
- Licart™ (diclofenac epolamine) topical system
- Where
- 11 sites in United States
- Volunteers
- 151 people
- Sponsor
- IBSA Institut Biochimique SA
Hip Fracture, Femoral Neck Fracture
Validity and Reliability of Thai Version of Barthel Index for Hip Fracture Patients
Since an increasing in population age, there was an increasing in geriatric patients. Most of elderly patients needed rehabilitation programs to regain their quality of life during their medical treatments.
- Conditions
- Hip Fracture, Femoral Neck Fracture, Intertrochanteric Fracture
- Trial name
- NCT02512094
- Where
- Thailand
- Volunteers
- 53 people
- Sponsor
- Mahidol University
Head Trauma
Pain in Traumatic Brain Injury - Basile, MD
The observation through a chart review of persistent pain on neuro psychological functioning and how it applies to the community integration with patients that had suffered traumatic brain injury.
- Trial name
- NCT01136486
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Northwell Health
Hip Surgery Corrective, Knee Injuries
Prospective, Randomized Clinical Investigation of Two Different Postoperative Wound Dressings
The primary objective of this investigation is to evaluate if complications related to surgical wound are more common in the treatment group compared to the control group starting from operation day until last visit.
- Trial name
- MxBPo02 (NCT02653183)
- Testing
- Active Comparator: Aquacel Surgical, Experimental: Mepilex Border Post-Op
- Where
- 3 sites in Belgium, Sweden
- Volunteers
- 118 people
- Sponsor
- Molnlycke Health Care AB
Amputation, Traumatic, Traumatic Amputation of Lower Extremity
What is the Optimal Stiffness and Height of a Running-specific Prosthesis?
The proposed study aims to characterize the effects of running-specific leg prosthetic stiffness and height during on performance during running and sprinting to optimize running-specific prosthesis prescription.
- Conditions
- Amputation, Traumatic, Traumatic Amputation of Lower Extremity, Wounds and Injuries
- Trial name
- NCT02318979
- Testing
- Otto Bock prosthesis, Ossur prosthesis, Freedom Innovations prosthesis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Osteoporosis
Comparison of the Effect of an Ongoing Treatment With Alendronate or a Drug Holiday on the Fracture Risk in Osteoporotic Patients With Bisphosphonate Long Term Therapy
The purpose of this study is to evaluate the efficacy and safety of bisphosphonates in long term treatment of osteoporosis.
- Trial name
- BILANZ (NCT01512446)
- Testing
- Alendronate
- Where
- Germany
- Volunteers
- 436 people
- Sponsor
- Evangelisches Krankenhaus Lutherhaus gGmbH
Fracture
Platelet Rich Plasma Injection in Pilon Fractures
Patients who sustain broken ankles have a very high risk of developing arthritis soon after injury (within 2 years). This arthritis can cause increased pain and a decrease level of function, especially if the injury occurs at an…
- Trial name
- NCT02481869
- Testing
- Arthrocentesis/PRP, Arthrocentesis/Saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Missouri-Columbia
Trauma-related Wound, Burns
StrataGraft® Skin Tissue as an Alternative to Autografting Full-thickness Complex Skin Defects
About 20 participants will be enrolled in this trial if they have had an accident that damages both the dermal (outside) and epidermal (inside) layers of skin on up to 49% of their body.
- Conditions
- Trauma-related Wound, Burns, Skin Wound
- Trial name
- NCT03005054
- Testing
- StrataGraft Skin Tissue, Autograft
- Where
- 4 sites in United States
- Volunteers
- 3 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Hip Fractures, Femoral Neck Fractures
Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures
Each year, hip fracture, an injury that can impair independence and quality of life, occurs in about 280,000 Americans and 36,000 Canadians.
- Trial name
- HEALTH (NCT00556842)
- Testing
- Total hip arthroplasty, Hemi-arthroplasty
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,495 people
- Sponsor
- McMaster University
Traumatic Brain Injury
Acute Neurobehavioral Program for Improving Functional Status After TBI
The specific aims of the proposed study are to 1) evaluate the efficacy of FANCI for improving functional status following treatment using the FIM, 2) examine the impact of FANCI on broader outcome measures of general emotional…
- Trial name
- NCT01166386
- Testing
- FANCI
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Wake Forest University Health Sciences
Tetraplegia, Spinal Cord Injury
Microelectrode Brain-Machine Interface for Individuals With Tetraplegia
The purpose of this research study is to demonstrate the safety and efficacy of using two NeuroPort Arrays (electrodes) for long-term recording of brain activity.
- Trial name
- NCT01364480
- Testing
- Implantation of NeuroPort Arrays in the motor cortex
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Michael Boninger
Melanoma (Skin)
Wearable Device Intervention to Improve Sun Behaviors in Melanoma Survivors
Over 5 million new cases of skin cancer are diagnosed in the United States each year, more than all other cancers combined. Most of these cases are caused by excess exposure to ultraviolet radiation from the sun and artificial…
- Trial name
- NCT03927742
- Testing
- Shade + app with messaging, Shape + app without messaging
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- University of Minnesota
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.