Clinical trials: Wrinkle
Nasolabial Fold Correction, Facial Aging
Bridging Technique Validation for Nasolabial Folds JN-BRIDGE-1
The goal of this clinical study is to learn whether the Bridging Technique can safely and effectively treat nasolabial folds (NLF, also known as smile lines) in adults.
- Conditions
- Nasolabial Fold Correction, Facial Aging, Skin Rejuvenation, Wrinkles Such as Nasolabial Folds
- Trial name
- BRIDGING (NCT07178119)
- Testing
- (Bridging) Horizontal Cannula Technique for Treatment of Nasolabial Folds using AILEENE Vol. 2
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. Joseph M Novoa Libermann
Unwanted Wrinkles
Evaluate the Performance of the PicoWayTM Picosecond Fractional Laser for Wrinkles Reduction
Prospective clinical study, Up to 100 healthy adult volunteers seeking Treatment of Wrinkles Reduction in the facial area, males or females of 18 to 75 years of age, from up to 5 investigational sites.
- Trial name
- NCT02600104
- Testing
- PicoWayTM
- Where
- 4 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Wrinkles Such as Nasolabial Folds
Post Market Study of Safety and Performance of RefillHA Volume+ for Facial Soft Tissue Augmentation and Correction of Wrinkles and Folds
This post market study was designed to collect clinical data regarding the safety and performance of RefillHA Volume+ upon its launch, from patients treated with the product in a routine clinical setting of treatments.
- Trial name
- NCT07109635
- Where
- Israel
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Glyance
Fine Lines, Wrinkle
A Clinical Study to Evaluate the Efficacy of an Anti-Aging Serum
This double-blind, randomized, controlled, single-center clinical trial was conducted to assess the efficacy and tolerance of an anti-aging serum to improve moderate overall photodamage and skin fatigue of aging skin after 7 days…
- Conditions
- Fine Lines, Wrinkle, Photoaging
- Trial name
- NCT05271136
- Testing
- Anti-aging Serum, Facial Moisturizer, Cleansing Lotion
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Wrinkles
Argireline in Treatment of Periorbital Wrinkles
The purpose of this study is to determine whether La Jolie gel is effective in the treatment of periorbital wrinkles.
- Trial name
- NCT01381484
- Testing
- 10% Argireline
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Facial and Neck Rhytides
Prospective Pellevé™ Neck Wrinkle Study
Use of RF device to treat wrinkles of the neck
- Trial name
- NCT01299090
- Testing
- Pelleve Wrinkle Treatment System - includes the Pelleve Handpiece and S5 generator
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ellman International
Perioral Wrinkles, Crow's Feet
Prospective, Non-interventional Study Assessing Perioral Rejuvenation Procedure
The goal of this observational study is to learn how a perioral rejuvenation procedure affects perioral line severity and lip volume over time in adults undergoing routine aesthetic treatment in a single clinical center.
- Conditions
- Perioral Wrinkles, Crow's Feet, Lip Volume Enhancement, Lip Aging
- Trial name
- NCT07398768
- Testing
- Saypha® Rich, Saypha® Filler Lidocaine
- Where
- Austria
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yuvell
Skin Wrinkling
Study to Determine If the Volume Used to Dilute BOTOX Cosmetic™ for Injection Affects Its Overall Effect and Duration.
It is thought that the amount of fluid used to dilute Botox for injection has an effect on the quality of the result and the duration of effect on the treatment of upper face rhytides, even though the dose remains the same.
- Trial name
- NCT00250952
- Testing
- Botox Cosmetic™
- Where
- 2 sites in United States, Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Carruthers Dermatology Centre
Nasolabial Folds, Marionette Lines
Emervel for the Correction of Lower Face Wrinkles & Folds
This study is designed to 1. evaluate the naturalness of facial expressions in motion (2D video images), by treating investigator assessment 2.
- Conditions
- Nasolabial Folds, Marionette Lines, Wrinkles
- Trial name
- NCT02718040
- Testing
- Emervel Classic and/or Deep Treatment Group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Improvement of Wrinkles/Elastosis as Well as General Skin Tone
Impact of Synergistic Sequential Treatment (SST)
At least thirty (30) subjects, Fitzpatrick-Goldman Skin Type II-V will be enrolled in 2 clinical sites; each clinic will enroll at least 15 subjects. Subjects should present visible wrinkles and/or elastosis requiring treatment.
- Trial name
- NCT01940445
- Testing
- M22 ResurFX, M22 ResurFX and QS
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lumenis Be Ltd.
Lateral Canthal Lines, Crow's Feet
Efficacy and Safety Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to evaluate the safety and efficacy of 2 sequential doses of RT001 compared to placebo gel to treat moderate to severe lateral canthal lines in adults.
- Conditions
- Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
- Trial name
- NCT00968942
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Sebum Production, Stool Microbiome
Pilot Study of Triphala and Rubia Cordifolia on Gut Microbiome and Skin
Few studies have assessed the effects of Triphala and Rubia Cordifolia from a skin biophysical perspective. Here, we aim to understand how these herbs can modulate the skin's barrier properties and the gut microbiome.
- Conditions
- Sebum Production, Stool Microbiome, Transepidermal Water Loss, Facial Brrightness
- Trial name
- NCT03477825
- Testing
- Rubia Cordifolia, Triphala
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Wrinkle
BTL-785F Device for Improving the Structure of Facial Muscles
This study will evaluate the clinical safety and the performance of the BTL-785F system equipped with the BTL-785-7 applicator for non-invasive facial remodeling and investigate its effect on muscles and wrinkles.
- Trial name
- NCT05524740
- Testing
- BTL-785-7
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Wrinkle
Safety and Efficacy of the BTL-FR2000 Device for the Treatment of Facial Wrinkles
The study will evaluate safety and effectivity of the BTL-FR2000 device for the treatment of facial wrinkles.
- Trial name
- NCT03548025
- Testing
- BTL-703 (Treatment group)
- Where
- Bulgaria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Wrinkles in Frontal Area
Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A
The objective of this study is to compare the field of effects of the botulinum toxins (Dysport® and Botox®) using two equivalence-ratios and to gather supportive information, such as more detailed data on the effectiveness in…
- Trial name
- NCT00989768
- Testing
- Botulinum Toxin Type A (Dysport®), Botulinum Toxin Type A/Botox®, Botulinum Toxin Type A/Dysport®
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Photoaging
Photoaging Treatment With Imiquimod
Recently it was demonstrated that imiquimod in addition to exerting a repairing effect in pre malignant and malignant lesions caused by UV radiation it reverses histopathological changes associated with the photoaging skin.
- Trial name
- NCT01935310
- Testing
- Imiquimod
- Where
- Colombia
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- CES University
Skin Aging
Proof of Concept Anti-ageing Clinical Study in Healthy Subjects
The objective of this POC clinical study is to evaluate the moisturising effects on fine lines and wrinkles, texture, barrier function, hydration and elasticity delivered by 4 weeks of twice daily application of the test product…
- Trial name
- NCT03180645
- Testing
- Test product (Moisturising cream), Positive control (Commercial market place moisturising cream), No treatment
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Wrinkle
Safety and Efficacy of the BTL-785F Device for Non-invasive Reduction of Wrinkles
This study will evaluate the clinical safety and the performance of the BTL-785F system for non-invasive treatment of facial wrinkles. The study is a multicenter single-arm, open-label, interventional study.
- Trial name
- NCT05476211
- Testing
- BTL-785F
- Where
- Bulgaria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Wrinkle, Acne Scars - Mixed Atrophic and Hypertrophic
AV-23-001 AVAVA MIRIA Pilot Study
This non-significant risk study is intended to demonstrate the use of the MIRIA Skin Treatment System can show improvement in dermatologic conditions currently indicated for treatment with a laser (such as, but not limited to…
- Conditions
- Wrinkle, Acne Scars - Mixed Atrophic and Hypertrophic, Pigmented Lesions, Skin Laxity
- Trial name
- NCT06557434
- Testing
- MIRIA
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- AVAVA, Inc.
Rhytidosis Facialis
A Study Evaluating Blended Belotero for the Treatment of Etched-in Fine Facial Lines
This is a single center study for adult females or males ages 25 to 75 years who are seeking treatment for etched-in fine lines of the cutaneous lip, and/or radial cheek area, and/or nasolabial folds, and/or melolabial folds…
- Trial name
- NCT02626598
- Testing
- Blended Belotero
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skin Care and Laser Physicians of Beverly Hills