Clinical trials: Wrinkle
Periorbital Hyperpigmentation, Periorbital Edema
A 12 Week Study to Evaluate the Efficacy of an Eye Cream
This single center, open-label clinical study was conducted to assess the efficacy and tolerance of a topical eye cream when used over the course of 12 weeks by healthy women with moderate to severe under-eye dark circles…
- Conditions
- Periorbital Hyperpigmentation, Periorbital Edema, Fine Lines, Wrinkle
- Trial name
- NCT05807620
- Testing
- Gentle Cleansing Lotion, Facial Moisturizer, Sunscreen SPF 30
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Wrinkles
Injectable Filler for Facial Soft Tissue Augmentation
The purpose of this study is to assess the safety and performance of Hydroxytite in all subjects who have received sub dermal or deep dermal injections.
- Trial name
- NCT02218788
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Panaxia Ltd
Skin Manifestations, Skin Abnormalities
Efficacy of Vinh Wellness Collagen on Skin Health
The most visible signs of aging are on the skin. As skin gets older it shows a decrease in epidermal thickness, with a flattening of the dermal-epidermal junction. At the same time, loss of elasticity and wrinkle formation begin.
- Trial name
- NCT04449159
- Testing
- Vinh Wellness Collagen
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vinh Hoan Corporation
Facial Aging, Facial Wrinkles and Rhytides Reduction
Intradermal Microbotulinum Toxin for Sebum Reduction and Facial Pore Improvement
This study aims to evaluate the efficacy and safety of microdoses of botulinum toxin type A (microtoxin) for improving periocular skin quality and reducing fine wrinkles.
- Trial name
- MICROTOX-PORE (NCT07526870)
- Testing
- Botulinum Toxin Type A (Dysport®)
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Nasolabial Folds
Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds
Safety \& tolerability study that compares Restylane to Restylane with Lidocaine (Restylane-L) while correcting wrinkles in the area around your nose.
- Trial name
- NCT00797459
- Testing
- Restylane and Restylane-L
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medicis Global Service Corporation
Lax Skin
Treatment to Lift Facial Lax Skin and Improve Facial Wrinkles Using Precise and Lift Applicators
Open-label, non-randomized single-arm prospective, multi-center, self-controlled clinical study with masked evaluation.
- Trial name
- NCT06333067
- Testing
- Sofwave
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sofwave Medical LTD
Rhytidosis Facialis
A Study Evaluating Blended Belotero for the Treatment of Etched-in Fine Facial Lines
This is a single center study for adult females or males ages 25 to 75 years who are seeking treatment for etched-in fine lines of the cutaneous lip, and/or radial cheek area, and/or nasolabial folds, and/or melolabial folds…
- Trial name
- NCT02626598
- Testing
- Blended Belotero
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Skin Care and Laser Physicians of Beverly Hills
Facial Wrinkles - Rough Texture - Hyperpigmentation
Evaluation of Microinjected Amnion-derived Collagen by Dermapen in the Smoothing of Skin Wrinkles
The aim of this work was to assess the efficacy of irradiated amniotic collagen matrix in comparison with platelet rich plasma in facial rejuvenation.The present study included 20 patients with facial wrinkles divided into 2…
- Trial name
- NCT06054646
- Testing
- Amnion collagen, Platelet-rich plasma
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Egyptian Atomic Energy Authority
Rhytides
Comparison of AmnioFix Laser and Standard of Care Treatment
This is a comparison trial with novel application of AmnioFix and a control arm. Patients electively being treated with facial lasers will be assigned to receive AmnioFix in addition to the normal standard of care placed on half…
- Trial name
- NCT02659124
- Testing
- AmnioFix plus Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
Efficacy and Tolerance Evaluation of a Topical "Revitalizing" Face Day Cream
Aim of the study was to evaluate clinically and by non-invasive instrumental evaluations the "revitalizing" activity of a face cream applied twice a day, morning and evening, for an uninterrupted period of 8 weeks, by healthy…
- Trial name
- NCT02230397
- Testing
- plantaricin a (active product)
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Derming SRL
Wrinkles in Frontal Area
Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A
The objective of this study is to compare the field of effects of the botulinum toxins (Dysport® and Botox®) using two equivalence-ratios and to gather supportive information, such as more detailed data on the effectiveness in…
- Trial name
- NCT00989768
- Testing
- Botulinum Toxin Type A (Dysport®), Botulinum Toxin Type A/Botox®, Botulinum Toxin Type A/Dysport®
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Skin Aging
Efficacy of a Dietary Supplement on Parameters of Skin Aging in Men and Women
As the body ages, the skin experiences natural changes in structure and composition. These changes may manifest visibly as increased skin dryness, wrinkling, and a loss of firmness/elasticity.
- Trial name
- NCT06083402
- Testing
- HyaCera™
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Natals, Inc. dba Ritual
Wrinkle
Clinical and Histological Evaluation of BTL-785F Non-invasive Treatment for Facial Rejuvenation
This study will evaluate the clinical efficacy, safety and the performance of the BTL-785-2 applicator of the BTL-785F system for non-invasive treatment of facial wrinkles and correcting facial skin laxity.
- Trial name
- NCT05987917
- Testing
- BTL-785-2, No Treatment
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Photoaging
Efficacy in Daily Use of a Novel Skin Care Product for the Treatment of Photoaged Skin
Photoaged or chronically sun-exposed skin is characterised by a number of clinical features including fine and coarse wrinkles. The pathogenesis of wrinkle formation has yet to be determined fully but recent work suggests that…
- Trial name
- NCT03144193
- Testing
- Topical anti-aging cosmetic cream
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Wrinkle
Evaluation of Safety and Efficacy of the BTL-785F Device for Non-invasive Reduction of Wrinkles
This study will evaluate the clinical safety and the performance of the BTL-785F system equipped with BTL-785-2 applicator for non-invasive treatment of facial wrinkles.
- Trial name
- NCT04447963
- Testing
- Non-invasive treatment of facial wrinkles
- Where
- Bulgaria
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Hair Reduction, Tattoo Removal
Clinical Study to Evaluate the Safety and Efficacy of Candela Technology
This is a non-randomized, multi-center, open-label, prospective clinical study evaluating the clinical treatment with Candela Medical Technology.
- Conditions
- Hair Reduction, Tattoo Removal, Wrinkle, Acne
- Trial name
- NCT06202274
- Testing
- Nordlys, Gentle, Picoway, Vbeam, Profound, Profound Matrix, eTwo, Exceed, CO2RE
- Where
- 3 sites in United States, Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Wrinkles
Prospective Study Evaluating the Treatment of Hyperdynamic Forehead Wrinkles
To evaluate the safety and effectiveness of the iovera° device with the blunt tip cannula for the treatment of forehead wrinkles.
- Trial name
- NCT01984619
- Testing
- Cryotherapy for the utilization of wrinkle reduction (iovera)
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Wrinkles in Decolletage
An Open-label Study of Poly-l-lactic Acid for Correction of Wrinkles in the décolletage Area
This is a prospective open-label study to evaluate safety and effectiveness of two different reconstitution volumes of poly-l-lactic acid (PLLA) for correction of wrinkles in the décolletage area.
- Trial name
- NCT05538728
- Testing
- poly-l-lactic acid (Sculptra)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Wrinkles
Quantified Evaluation of Whole Face 8-points Supra-periosteum High Molecular Weight Hyaluronic Acid Injection in Asian
Facial aging is a complex process characterized by skin atrophy, subcutaneous fat loss, and alterations in bone structure. The loss of volume, primarily due to bone resorption and loss of adjacent fat volume from different facial…
- Trial name
- NCT06871592
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chang Chang Cheng
Wrinkle
Micro-injections of Transparent Hyaluronic Acid Gel (Restylane® Silk) for Rejuvenation of the Aging Cheek
The objective of this study is to determine the efficacy and safety of Restylane® Silk microinjections when used in a grid-like injection pattern for the correction of fine lines to the cheeks.
- Trial name
- NCT03461198
- Testing
- Restylane® Silk
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff