Clinical trials: Wrinkles and Rhytides
Skin Texture Disorder, Photoaging
Safety and Efficacy Evaluation of the Mosaic Ultra Device
Evaluate the Safety and Efficacy of the Mosaic Ultra 1550nm system for the treatment of skin tone and texture, facial rejuvenation, photoaging, wrinkles, scars, stretch marks, acne vulgaris and hair loss.
- Conditions
- Skin Texture Disorder, Photoaging, Wrinkle, Scar
- Trial name
- NCT06117293
- Testing
- Mosaic
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CynosureLutronic
Skin Laxity
Radio Frequency Microneedling for Suprapatellar Skin
The human skin aging process is characterized by thinning dermis, atrophy of the extracellular matrix, and reduced collagen synthesis.
- Trial name
- NCT03507036
- Testing
- Profound system
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Facial Rhytides, Skin Folds, Loss of Volume and Skin Quality
A Study to Evaluate Participant Satisfaction With Facial Appearance Overall and the Aesthetic and Psychosocial Impact of Combined Facial Treatment
The objective of this study is to quantify the psychological and emotional impact of comprehensive aesthetic treatment with a portfolio of Allergan products by measuring the change in participant's satisfaction with facial…
- Trial name
- NCT03712449
- Testing
- JUVÉDERM®, BOTOX Cosmetic®, BELKYRA®
- Where
- 7 sites in Canada
- Volunteers
- 59 people
- Sponsor
- Allergan
Facial Aging, Skin Aging
Hyaluronic Acid Crosslinking Clinical Study
This prospective observational case series aims to evaluate the clinical efficacy, safety, and patient satisfaction associated with hyaluronic acid dermal fillers with different degrees of divinyl sulfone (DVS) crosslinking.
- Conditions
- Facial Aging, Skin Aging, Facial Volume Loss, Facial Rhytides
- Trial name
- HACS (NCT07744464)
- Testing
- Hyaluronic Acid Dermal Fillers
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Antony de Paula Barbosa
Wrinkles, Fine Lines
Feasibility Study To Collect Safety And Preliminary Efficacy Data For A Radiofrequency Microneedling Device
The intended use of the Potenza™ device is to collect clinical data for brow lifting and/or treatment of dermatologic conditions in which electrocoagulation and hemostasis is a viable mechanism for means of improvement.
- Conditions
- Wrinkles, Fine Lines, Crepey Skin, Acne Scars
- Trial name
- NCT05254210
- Testing
- RF Device (Potenza™)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cynosure, Inc.
Atopic Dermatitis
Effect of Holly Mangrove Shower Gel in Atopic Dermatitis Patients
Atopic dermatitis is a chronic intermittent inflammatory skin disease. Currently, there are many cosmeceutical skin products in which their major action affects skin hydration and skin barrier function.
- Trial name
- NCT02178215
- Testing
- Holly Mangrove Shower Gel
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Rhytides
Comparison of AmnioFix Laser and Standard of Care Treatment
This is a comparison trial with novel application of AmnioFix and a control arm. Patients electively being treated with facial lasers will be assigned to receive AmnioFix in addition to the normal standard of care placed on half…
- Trial name
- NCT02659124
- Testing
- AmnioFix plus Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Skin Ageing, Facial Wrinkles - Rough Texture - Hyperpigmentation
Clinical Effects of Two Oral Bioactive Collagen Peptides On Skin Properties and Aging Hallmarks
This randomized, controlled clinical trial evaluated whether daily oral intake of a collagen peptides supplement improved age-associated skin beauty parameters in healthy women with visible facial wrinkles.
- Conditions
- Skin Ageing, Facial Wrinkles - Rough Texture - Hyperpigmentation, Skin Hydration in Healthy Volunteers
- Trial name
- NCT07302789
- Testing
- Dietary Supplement: Collagen Peptides Supplement, Dietary Supplement: Competitor's Collagen Supplement
- Where
- Spain
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Bionos Biotech S.L.
Wrinkle
Clinical Study for the Evaluation of the Safety and Effectiveness of Use of a Poly-L Lactic Acid Injectable Filler for the Aesthetic Treatment of Nasolabial Folds
The purpose of this study is to assess the effectiveness and safety of Gana V, a Poly L-lactic acid filler for the aesthetic treatment of nasolabial folds, in comparison with Sculptra.
- Trial name
- PLLA (NCT05215054)
- Testing
- Gana V®, Sculptra®
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- GCS Co., Ltd
Wrinkle
Efficacy and Safety of 675-nm Laser for Dorsal Hand Rejuvenation
This study aimed to evaluate efficacy and safety of 675-nm laser for dorsal hand rejuvenation in Thai patients. Twenty-six subjects aged 50 to 65 years diagnosed with wrinkle and solar lentigines on both dorsums of hands were…
- Trial name
- NCT06486727
- Testing
- Redtouch
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Rhytides, Wrinkle
Safety and Efficacy of SofWave Treatment to Lift the Upper Lip and Improve the Peri-Oral Rhytids
Open-label, non-randomized, prospective, multi-center, self-controlled
- Trial name
- NCT06104514
- Testing
- Sofwave
- Where
- 6 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sofwave Medical LTD
Health Behavior
Oral Sialic Acid Product Beauty Efficacy Test
Evaluate and compare the effects on female facial skin of oral placebo (Product A), N-acetylneuraminic acid (Product B), and ACAI-PLUS (Product C) after 28, 56, and 84 days under normal usage conditions.
- Trial name
- NCT07640321
- Testing
- Oral N-acetylneuraminic acid, OralACAI-PLUS
- Where
- China
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Wuhan CASOV Green Biotech Co., Ltd
Glabellar Frown Lines
Xeomin Treatment of Glabellar Lines Using OLD Versus COLD
This is a blinded, randomized study in the US to compare the duration response of two different concentrations of Xeomin in healthy female subjects with moderate to severe dynamic glabellar lines on maximum frown.
- Trial name
- NCT05305768
- Testing
- IncobotulinumtoxinA
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Clinical Testing of Beverly Hills
Healthy Volunteers
Evaluation of the Effects of DracoBelle Nu in Skin Health After Oral Intake
The goal of this clinical trial is to study the effects of DracoBelleTM Nu in different skin parameters associated with age. Volunteers will be asked to take either placebo of DracoBelleTM Nu capsules once a day by oral intake…
- Trial name
- NCT06059534
- Testing
- Dietary supplementation with DracoBelleTM Nu.
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bionos Biotech S.L.
Photoaged Facial Skin, Photoaging
Study of RRS® HA Long Lasting for Improving Facial Wrinkles and Skin Quality
The objective of this clinical study is to confirm the clinical performance and long-term safety of the CE-marked RRS® HA Long Lasting in the treatment of skin photoaging and its consequences, with a primary focus on improving…
- Conditions
- Photoaged Facial Skin, Photoaging, Wrinkle Reduction, Skin Quality Improvement
- Trial name
- ORACLE LL (NCT07551609)
- Testing
- RRS® HA Long Lasting
- Where
- 6 sites in Spain
- Volunteers
- 207 people
- Sponsor
- Skin Tech Pharma Group S.L.U.
Facial Wrinkles (Nasolabial Folds)
A Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate (HPL) in Facial Wrinkles(Nasolabial Folds)
This is a multicentre, open label, pilot study to evaluate safety and efficacy of Autologous Human Platelet Lysate (HPL) in subjects with Facial Wrinkles (Nasolabial Folds). The study is being conducted at 2 centers in India.
- Trial name
- NCT01644461
- Testing
- Autologous Human Platelet Lysate
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Kasiak Research Pvt. Ltd.
Skin Wrinklings
Regenarative Treatment of Periocular Wrinkles With PDRN
This randomized clinical trial aims to compare two application techniques-needling (intradermal needling) and microneedling-for the delivery of an active-ingredient formulation containing 0.2% polynucleotides (PDRN), 2%…
- Trial name
- NCT07280637
- Testing
- Intradermal injection, Micro needling
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Taubate
Décolleté Wrinkles
Investigation of the Effectiveness and Safety of MRZF111 in the Treatment of Décolleté Wrinkles
To evaluate the effectiveness and safety of MRZF111 treatment for improvement of décolleté wrinkles as assessed on the Merz Aesthetics Scales (MAS) Décolleté Wrinkles-At Rest.
- Trial name
- NCT04177212
- Testing
- MRZF111
- Where
- 9 sites in Germany
- Volunteers
- 117 people
- Sponsor
- Merz Aesthetics GmbH
Acne, Acne Scars - Mixed Atrophic and Hypertrophic
AVAVA MIRIA General Use
A general protocol to treat a variety of dermatologic conditions and collect patient feedback. Primary outcome is the collection and analysis of patient questionnaires related to the overall experience of the device treatment.
- Conditions
- Acne, Acne Scars - Mixed Atrophic and Hypertrophic, Scars, Wrinkle
- Trial name
- NCT06868615
- Testing
- AVAVA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- AVAVA, Inc.
Rhytides
The Effect of Almonds on Skin Lipids and Wrinkles
Investigators hypothesize that regular consumption of almonds will augment the long chain fatty acid profile and the alpha-tocopherol levels, improve the skin barrier function, and improve the appearance of facial wrinkles in…
- Trial name
- NCT02954315
- Testing
- Almonds
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of California, Davis