Clinical trials: Wrinkles and Rhytides
Glabellar Rhytides
Safety and Efficacy Study of PurTox® Botulinum Toxin Type A to Treat Frown Lines Between the Eyebrows
The overall purpose of this study is to evaluate the safety and effectiveness of an intramuscular dose of Mentor Purified Toxin for the reduction of frown lines, compared with placebo.
- Trial name
- PT-03a (NCT00752297)
- Testing
- Preservative-free Saline, Mentor Purified Toxin
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- Mentor Worldwide, LLC
Skin Aging, Skin Wrinkling
Evaluation of Safety and Efficacy of Using EndyMed Pro Skin Treatment System for Skin Wrinkle Treatment on Body Areas
Skin aging is a multifactorial process involving the 3 layers of the skin: Epidermis, dermis and hypodermis. Skin aging process involves among others: skin roughness (epidermis), skin dyschromia (epidermis, dermis), wrinkles and…
- Trial name
- NCT01029301
- Testing
- Device: EndyMed Pro System for Skin Tightening
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Endymion Medical Ltd
Wrinkle, Fine Lines
Study To Assess A Radiofrequency Microneedling Device For Dermatologic Conditions
Subjects are to be enrolled in this clinical study if they are 18 - 55 years old. Up to 120 subjects will be enrolled at multiple study centers.
- Conditions
- Wrinkle, Fine Lines, Crepey Skin, Acne Scars
- Trial name
- NCT05097157
- Testing
- Potenza
- Where
- 4 sites in United States
- Volunteers
- 79 people
- Sponsor
- Cynosure, Inc.
Wrinkles in Decolletage
An Open-label Study of Poly-l-lactic Acid for Correction of Wrinkles in the décolletage Area
This is a prospective open-label study to evaluate safety and effectiveness of two different reconstitution volumes of poly-l-lactic acid (PLLA) for correction of wrinkles in the décolletage area.
- Trial name
- NCT05538728
- Testing
- poly-l-lactic acid (Sculptra)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Collagen Degeneration, Wrinkle
The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles
Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal…
- Conditions
- Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin
- Trial name
- NCT06571721
- Testing
- Topical Product: Almond Oil, Topical Product: Almond oil augmented with 0.5% Vitamin E, Topical Product: 0.025% Tretinoin oil augmented with castor oil
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Facial Wrinkles
Global Management of Facial Rejuvenation With a New Range of Hyaluronic Acid Dermal Fillers
The aim of this study is to assess performance and tolerance as well as investigator and subject satisfaction linked to the global management of facial rejuvenation with a new range of hyaluronic acid dermal fillers.
- Trial name
- FRESH (NCT01151436)
- Testing
- hyaluronic acid dermal fillers
- Where
- 5 sites in France, Germany
- Volunteers
- 77 people
- Sponsor
- Galderma R&D
Wrinkle Reduction
Assessment of the Safety and Effectiveness of a Micro-RF Skin Treatment Device (nebulyft）
The objective of the study is to evaluate the safety, efficacy and usage compliance of the home-use device nebulyft for self-treatment of wrinkles appearance. The participants do treatment 5 time /week and last 4 weeks.
- Trial name
- ASEMRSTD (NCT06623214)
- Testing
- nebulyft
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Hangzhou Rebecca Medical Science and Technology Ltd.
Hair Reduction, Tattoo Removal
Clinical Study to Evaluate the Safety and Efficacy of Candela Technology
This is a non-randomized, multi-center, open-label, prospective clinical study evaluating the clinical treatment with Candela Medical Technology.
- Conditions
- Hair Reduction, Tattoo Removal, Wrinkle, Acne
- Trial name
- NCT06202274
- Testing
- Nordlys, Gentle, Picoway, Vbeam, Profound, Profound Matrix, eTwo, Exceed, CO2RE
- Where
- 3 sites in United States, Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Glabellar Rhytides, Frown Lines Between the Eyebrows
Safety and Efficacy Study of Repeat Treatment With PurTox® Botulinum Toxin Type A for Frown Lines Between the Eyebrows
The overall purpose of this study is to evaluate the safety and effectiveness of repeat treatment of an intramuscular dose of Mentor Purified Toxin for the reduction of frown lines, compared with placebo.
- Trial name
- PT-03b (NCT00752050)
- Testing
- Mentor Purified Toxin Botulinum Toxin Type A, Preservative-free Saline
- Where
- United States
- Volunteers
- 699 people
- Sponsor
- Mentor Worldwide, LLC
Nasolabial Folds, Wrinkles
Study of JTM104 Injection vs. Juvederm in Treating Moderate to Severe Nasolabial Folds
Study of JTM104 Injection vs. Juvederm in Treating Moderate to Severe Nasolabial Folds
- Trial name
- NCT07265791
- Testing
- JTM104, Juvederm® ULTRA PLUS XC
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Jetema Co., Ltd.
Skin Aging
Evaluation of the PlasmaJet Neutral Argon Plasma System to Treat Skin Ageing
The purpose of this study is to determine the comparative effects of the PlasmaJet neutral argon plasma system and the Rhytec Portrait PRS nitrogen plasma system in the treatment of aging facial skin
- Trial name
- NCT00761878
- Testing
- Exposure to plasma energy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Plasma Surgical Inc
Wrinkles
A Clinical Study to Evaluate the Efficacy and Safety of YVOIRE Volume Plus Versus YVOIRE Volume in Nasolabial Fold Injection
The objective of this study was to evaluate the efficacy and safety of HA IDF II plus (with lidocaine) injected in the nasolabial fold compared to HA IDF II (without lidocaine).
- Trial name
- NCT02340078
- Testing
- HA IDF II plus, HA IDF II
- Volunteers
- 62 people
- Sponsor
- LG Life Sciences
Facelift
Evaluation of Safety and Efficacy of the Apollo™ System for Treatment of Wrinkles and Rhytides
Non-invasive, energy-based, aesthetic treatments are becoming increasingly popular among female and male patients of all ages. Different technologies are presently available to rejuvenate skin, including therapeutic ultrasound…
- Trial name
- NCT01283711
- Testing
- apollo device
- Where
- 2 sites in United States, Israel
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Pollogen
Skin Laxity, Wrinkle
Clinical Feasibility Study to Evaluate the Safety and Performance of the Profound Matrix System
This is a non-randomized, multi-center, open-label clinical trial evaluating clinical feasibility treatments with the Profound Matrix system.
- Conditions
- Skin Laxity, Wrinkle, Skin Condition
- Trial name
- NCT06157567
- Testing
- Profound Matrix
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Facial Wrinkles
A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique.
To assess the likelihood of keloid and scar formation, pigmentation disorders and hypersensitivity reactions in patients with skin of color undergoing correction of facial soft tissue contour deficiencies with Hylaform, Hylaform…
- Trial name
- NCT00293163
- Testing
- Hylaform, Hylaform Plus (hylan B gel)
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Genzyme, a Sanofi Company
Wrinkle Reduction
A Prospective Pilot Study to Evaluate Safety and Effectiveness of GP0122 and GP0124 for Correction of Lines and Wrinkles in the Cheek Area
The primary objective of the study is to evaluate the safety of GP0122 and GP0124 for the correction of lines and wrinkles in the cheek area.
- Trial name
- NCT07344584
- Testing
- GP0122, GP0124
- Where
- 5 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Glabellar Lines, Wrinkles
Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines
This study is designed to evaluate the safety, efficacy, and subject and investigator satisfaction of 2 different injection volumes of Dysport in the glabellar lines. 1.
- Trial name
- NCT02718118
- Testing
- Dysport reconstituted at 1.5 mL (0.05 mL/injection), Dysport reconstituted at 2.5 mL (0.08 mL/injection)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Skin Wrinkling
Emervel® Deep Lidocaine vs. Juvederm® Ultra Plus in Treatment of Moderate to Severe Facial Wrinkles and Folds
The purpose of the study was to compare the effectiveness and safety of Emervel Deep Lidocaine versus Juvederm Ultra Plus in the treatment of moderate to severe facial wrinkles and folds.
- Trial name
- NCT01205061
- Testing
- Emervel Deep Lidocaine, Juvederm Ultra Plus
- Where
- 11 sites in United States
- Volunteers
- 162 people
- Sponsor
- Galderma R&D
Skin Texture Irregularities, Facial Skin Wrinkles
Safety & Efficacy Evaluation of a Radiofrequency & Laser/Light System for Improvement of Skin Texture
Evaluate the clinical performance, safety and efficacy, of a Radiofrequency and Laser/Light based device for the treatment of facial wrinkles.
- Trial name
- NCT01597323
- Where
- 3 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Skin Wrinkling
Emervel Classic Lidocaine Versus Juvederm® Ultra in Treatment of Moderate to Severe Facial Wrinkles and Folds
The purpose of this study is to compare the effectiveness and safety of Emervel Classic Lidocaine versus Juvederm® Ultra in the treatment of moderate to severe facial wrinkles and folds.
- Trial name
- NCT01205048
- Testing
- Emervel Classic Lidocaine, Juvederm® Ultra
- Where
- 12 sites in United States
- Volunteers
- 171 people
- Sponsor
- Galderma R&D