Clinical trials: Wrinkles and Rhytides
Fine Lines, Wrinkle
Assess Injectable Hyaluronic Acid Gel for the Treatment of Volume Loss, Skin Laxity and Fine Lines
Clinical trial to assess the real-world effectiveness of Obagi® Saypha® MagIQ™ Injectable Hyaluronic Acid (HA) gel for the treatment of mild-to-moderate facial aging, including volume loss, fine lines, and skin laxity, following…
- Conditions
- Fine Lines, Wrinkle, Facial Laxity, Volume Loss
- Trial name
- NCT07421544
- Testing
- Obagi® Saypha® MagIQ™ Injectable Hyaluronic Acid
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Aging, Wrinkle
Restylane Refyne for Correction of Horizontal Neck Rhytides
Subjects with grades ranging from 1---3 on the Transverse Neck Line Scale, will be randomized to receive up to 1cc of Restylane Refyne on one side of their neck utilizing a cannula and up to 1cc of Restylane Refyne on the other…
- Conditions
- Aging, Wrinkle, Rhytides
- Trial name
- NCT04162496
- Testing
- Restylane Refyne
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Siperstein Dermatology
Skin Aging
Comparison of Outcome Parameters in Laser Rhytide Treatment
We previously published a comparative split-face study which has shown a significant, albeit moderate, effect of ablative fractional laser treatment.
- Trial name
- NCT00994474
- Testing
- Fractional carbon dioxide laser treatment, Fractional Er:YAG laser treatment
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Laserklinik Karlsruhe
Wrinkle
Impact of Near-Infrared Vein Mapping on Outcomes and Satisfaction After Botox/Filler Treatment
Researchers are studying how vein mapping impacts patient outcomes and satisfaction after facial injection procedures.
- Trial name
- NCT04240080
- Testing
- Accuvein® Veinfinder
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Wrinkle
Safety and Efficacy of the BTL-754 Device for Laser Skin Resurfacing Treatment of the Face
This study will evaluate the clinical safety and the performance of the BTL-754 device (equipped with the 754-4 applicator) for reduction of facial wrinkles by the means of laser skin resurfacing treatment.
- Trial name
- NCT06158438
- Testing
- BTL-754-4 Treatment
- Where
- Bulgaria
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Nasolabial Fold Wrinkles
BC-101 in Treatment of Nasolabial Fold Wrinkles
This is an open-label, single-arm, dose-escalating study to evaluate the safety and tolerability of BC-101 administered via subcutaneous/intradermal injection in the treatment of moderate to severe nasolabial folds.
- Trial name
- NCT05162326
- Testing
- BC-101
- Volunteers
- 9 people
- Sponsor
- Bright Cell, Inc.
Rhytids, Wrinkles
Outcomes and Patient Experience After Soft Tissue Dermal Filler Injections
Purpose of the study: The overall goal of this study is to better understand patient experience with injectable facial fillers so that the investigators may provide the best results for their patients.
- Trial name
- NCT01034956
- Testing
- hyaluronic acid or calcium hydroxylapatite filler
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The New York Eye & Ear Infirmary
Lateral Canthal Lines
Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to determine the safety and efficacy of 2 sequential doses of RT001 compared to vehicle control following applications at Baseline (Day 0) and Week 2.
- Trial name
- NCT00884234
- Testing
- Vehicle Control, RT001 (Botulinum Toxin Type A Topical Gel)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Wrinkle Appearance, Skin Pigment
Cosmetic Effects of Topical Acetyl Zingerone
Cosmeceuticals are an emerging market within dermatology and the growth of natural products and derivatives of natural products has accelerated in use within the field.
- Conditions
- Wrinkle Appearance, Skin Pigment, Erythema, Side Effect
- Trial name
- NCT03530787
- Testing
- Acetyl Zingerone Topical Cream, Topical cream
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Neck Lines
A Study to Assess Adverse Events and Effectiveness of Injected JUVÉDERM® VOLITE™ Gel Filler for Change in Neck Lines in Adult Chinese Participants
The cumulative effect of aging and environmental exposures (ie, ultraviolet, infrared, and visible light radiation and pollution) leads to wrinkles, discoloration, laxity, and roughness of sun exposed skin.
- Trial name
- NCT05741034
- Testing
- JUVÉDERM® VOLITE™, Control
- Where
- 9 sites in China
- Volunteers
- 159 people
- Sponsor
- AbbVie
Wrinkle
Clinical Study for the Evaluation of the Safety and Effectiveness of Use of a Poly-L Lactic Acid Injectable Filler for the Aesthetic Treatment of Nasolabial Folds
The purpose of this study is to assess the effectiveness and safety of Gana V, a Poly L-lactic acid filler for the aesthetic treatment of nasolabial folds, in comparison with Sculptra.
- Trial name
- PLLA (NCT05215054)
- Testing
- Gana V®, Sculptra®
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- GCS Co., Ltd
Wrinkles and Folds in Lower Face
Perception of Facial Expressions Following Correction of Wrinkles and Folds
The purpose of this study is to evaluate the perception of facial expressions following correction of wrinkles and folds in the lower face using Emervel Classic Lidocaine and Emervel Deep Lidocaine.
- Trial name
- NCT02573337
- Testing
- Emervel Classic Lidocaine, Emervel Deep Lidocaine
- Where
- 3 sites in Germany
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Laxity; Skin, Volume Deficiency in the Mid-Face
Prospective Clinical Evaluation of the Safety and Performance of the Aesthetic Medical Device MEC REGENERATE® (Injectable Recombinant Collagen-based Product)
Prospective, spontaneous, open-label pre-market clinical trial with a single injection session; monitoring visits at baseline and 60 days post-treatment.
- Conditions
- Laxity; Skin, Volume Deficiency in the Mid-Face, Wrinkles
- Trial name
- NCT07413445
- Testing
- Treatment with experimental device
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- 303 Pharma s.r.l.
Facial Wrinkles
Multicenter Study of the Safety and Efficacy of Dermal Filler, Belotero® Soft
This study is to determine the safety and effectiveness of Belotero® Soft compared to active comparator in the correction of mild facial wrinkles, such as nasolabial folds.
- Trial name
- NCT00877279
- Testing
- CosmoDerm1, Belotero Soft
- Where
- 5 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Intentional Correction of Forehead Wrinkles (crow's Feet)
A Prospective, Multicenter, Blind, Randomized Controlled, Optimal Clinical Trial to Evaluate the Safety and Efficacy of Medical Collagen Fillers for Facial Dermal Tissue Filling to Correct Frontal Wrinkles (crow's Feet)
With the development of medical technology and the improvement of life treatment, people's concept of aging is also changing, people of all ages are constantly pursuing a young and healthy life, the use of lasers and fillers to…
- Trial name
- NCT06703294
- Testing
- Crow's feet injection filling, Humanized collagen filling crow's feet
- Volunteers
- 260 people
- Sponsor
- Fiman (Changchun) Pharmaceutical Biotechnology Company Limited
Wrinkle
Study to Identify if Saie Beauty's Under Eye Concealer Works to Improve Under-Eye Skin Appearance and Reduce Imperfections
Saie Beauty has developed 'Hydrabeam Sheer Brightening Under Eye Concealer' that is specifically designed for improving under-eye skin health.
- Trial name
- NCT05231681
- Testing
- Saie Beauty's Hydrabeam Sheer Brightening Under Eye Concealer
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Saie Beauty
Dry Eye, Dry Eye Syndromes
Assessing the Impact of Tixel Treatment of Periorbital Wrinkles on Dry Eye Symptoms and Signs
Pilot study where effect of standard Tixel treatment as used for periorbital wrinkles would be assessed on Dry Eye Disease symptoms and signs
- Trial name
- NCT04730336
- Testing
- Tixel
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- Aston University
Skin Aging
Proof of Concept Anti-ageing Clinical Study in Healthy Subjects
The objective of this POC clinical study is to evaluate the moisturising effects on fine lines and wrinkles, texture, barrier function, hydration and elasticity delivered by 4 weeks of twice daily application of the test product…
- Trial name
- NCT03180645
- Testing
- Test product (Moisturising cream), Positive control (Commercial market place moisturising cream), No treatment
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Moderate to Severe Glabellar Lines
A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows
The purpose of this study is to assess the effectiveness and safety of a single dose of Corabotase (also known as IPN10200) compared to placebo (double-blind phase) and how well and safely repeat doses of Corabotase work over…
- Trial name
- LAURITE 2 (NCT07435428)
- Testing
- Corabotase
- Where
- 60 sites in United States, France and 2 more
- Volunteers
- 1,300 people
- Sponsor
- Ipsen
Wrinkles Such as Nasolabial Folds
Restylane + Lidocaine and Restylane Lyft for the Treatment of Nasolabial Folds
This study is designed to assess and compare the efficacy of two hyaluronic acid (HA) fillers on moderate, severe and extreme nasolabial folds (NLF).
- Trial name
- NCT04174131
- Testing
- Restylane + Lidocaine, Restylane® Lyft
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.