Clinical trials: Wrinkles and Rhytides
Wrinkles, Folds
A Clinical Investigation Comparing the Safety and Performance of RefillHA Solid With Hydryalix Ultra Deep Lidocaine for the Correction of Moderate-to-severe Nasolabial Folds
Prospective, controlled, randomized, monocentric, double-blind, split-face non-inferiority clinical study to evaluate the safety and performance of injectable implant based on hyaluronic acid hydrogel with lidocaine for…
- Trial name
- NCT07736703
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Glyance
Photodamaged Skin, Rhytids
2910 nm Erbium-Doped Fluoride Fiber Glass Laser for the Treatment of Advanced Perioral Lines and Wrinkles
The primary objective is to assess the efficacy, safety and satisfaction associated with the resurfacing treatment of perioral lines and wrinkles with the 2,910 nm mid-infrared Fiber Laser (UltraClear, Acclaro Medical) using both…
- Conditions
- Photodamaged Skin, Rhytids, Lines Skin, Wrinkles and Rhytides
- Trial name
- NCT07222397
- Testing
- Laser Resurfacing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- FA Corporation
Wrinkles
A Clinical Study to Evaluate the Efficacy and Safety of YVOIRE Classic Plus Versus YVOIRE Classic in Nasolabial Fold Injection
The objective of this study was to evaluate the efficacy and safety of HA IDF plus (with lidocaine) injected in the nasolabial fold compared to HA IDF (without lidocaine).
- Trial name
- NCT02340091
- Testing
- HA IDF plus, HA IDF
- Volunteers
- 62 people
- Sponsor
- LG Life Sciences
Intrinsic Aging of Skin, Skin Wrinkling
Study of Intradermal Injections of RCS-01 in Male and Female Subjects
The primary purpose of this study is to assess the safety profile of RCS-01 injections as compared to placebo injections. This study will also measure the impact these injections will have on skin markers related to aging through…
- Conditions
- Intrinsic Aging of Skin, Skin Wrinkling, Solar Degeneration of Skin
- Trial name
- NCT02391935
- Testing
- RCS-01
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- RepliCel Life Sciences, Inc.
Wrinkled Structure, Circumference Reduction
Evaluation of Safety and Efficacy of Using Venus Freeze™ (MP)2 V2 System for Wrinkles Rhytides and Cellulite Treatment
Skin aging is a multifactorial process involving the 3 layers of the skin: Epidermis, dermis and hypodermis. Radio-frequency (RF) devices have been used for many years for a variety of surgical applications.
- Trial name
- NCT01234259
- Testing
- Venus Freeze (MP2 V2 System
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Venus Concept
Acne Scars - Mixed Atrophic and Hypertrophic, Wrinkle
Fractional Radiofrequency for the Treatment and Reduction of Acne Scars and Wrinkles
The objective of this clinical study is to evaluate the efficacy of fractional RF for the treatment and reduction of acne scarring or facial wrinkles.
- Trial name
- NCT04057768
- Testing
- Venus Viva
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Venus Concept
Nasolabial Fold Wrinkles
BC-101 in Treatment of Nasolabial Fold Wrinkles
This is an open-label, single-arm, dose-escalating study to evaluate the safety and tolerability of BC-101 administered via subcutaneous/intradermal injection in the treatment of moderate to severe nasolabial folds.
- Trial name
- NCT05162326
- Testing
- BC-101
- Volunteers
- 9 people
- Sponsor
- Bright Cell, Inc.
Wrinkle
Study to Evaluate the Safety and Efficacy of the Cytrellis Micro-Coring Device for the Treatment of Moderate to Severe Facial Wrinkles
Study evaluating the efficacy of a micro coring device for the treatment of moderate to severe check wrinkles
- Trial name
- NCT03793348
- Testing
- MCD
- Where
- 6 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cytrellis Biosystems, Inc.
Skin Aging, Skin Wrinkling
Evaluation of the Safety and Performance Characteristics of Mesofiller Mesotox for the Correction of Wrinkles and Rehydration of the Face.
The investigation is a single-centre, interventional, prospective, non-randomized, open-label, uncontrolled, single-arm, un-blinded investigation for the evaluation of the safety and performance of the product mesofiller® mesotox…
- Trial name
- NCT06477432
- Testing
- mesofiller® mesotox
- Where
- Bulgaria
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mesoestetic Pharma Group S.L.
Décolleté Wrinkles
A Study of Octave System for Improving Lines and Wrinkles of the Décolleté
To demonstrate the safety and effectiveness of the Octave System for improving lines and wrinkles of the décolleté.
- Trial name
- NCT04681352
- Testing
- Octave-Ultherapy treatment
- Where
- 10 sites in United States
- Volunteers
- 99 people
- Sponsor
- Merz North America, Inc.
Skin Wrinkling
Emervel Classic Lidocaine Versus Juvederm® Ultra in Treatment of Moderate to Severe Facial Wrinkles and Folds
The purpose of this study is to compare the effectiveness and safety of Emervel Classic Lidocaine versus Juvederm® Ultra in the treatment of moderate to severe facial wrinkles and folds.
- Trial name
- NCT01205048
- Testing
- Emervel Classic Lidocaine, Juvederm® Ultra
- Where
- 12 sites in United States
- Volunteers
- 171 people
- Sponsor
- Galderma R&D
Glabellar Lines, Wrinkles
Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines
This study is designed to evaluate the safety, efficacy, and subject and investigator satisfaction of 2 different injection volumes of Dysport in the glabellar lines. 1.
- Trial name
- NCT02718118
- Testing
- Dysport reconstituted at 1.5 mL (0.05 mL/injection), Dysport reconstituted at 2.5 mL (0.08 mL/injection)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Glabellar Rhytides, Frown Lines Between the Eyebrows
Safety and Efficacy Study of Repeat Treatment With PurTox® Botulinum Toxin Type A for Frown Lines Between the Eyebrows
The overall purpose of this study is to evaluate the safety and effectiveness of repeat treatment of an intramuscular dose of Mentor Purified Toxin for the reduction of frown lines, compared with placebo.
- Trial name
- PT-03b (NCT00752050)
- Testing
- Mentor Purified Toxin Botulinum Toxin Type A, Preservative-free Saline
- Where
- United States
- Volunteers
- 699 people
- Sponsor
- Mentor Worldwide, LLC
Wrinkle
Study To Assess The Safety And Efficacy Of The Tempsure Flexsure Applicators For Abdominal Wrinkles
Subjects will be enrolled at 1 study center. Subjects may receive 5 treatments with the TempSure® device on the abdomen for wrinkles.
- Trial name
- NCT04930705
- Testing
- Treatment with TempSure Applicator
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cynosure, Inc.
Skin Aging
Pilot Study to Evaluate the Safety and the Efficacy of the Matrix and Cells Obtained by the AmeaCell® Device and Intended for the Filling of Wrinkles on the Face.
The purpose of this study is to evaluate the filling using the Matrix and Cells, obtained by the Ameacell® device from autologous adipose tissue and intended for the filling of wrinkles on the face.
- Trial name
- SKINMAT (NCT03529292)
- Testing
- AmeaCell
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Symbioken
Skin Aging
Efficacy of Extract of Trigonella Foenum-graceum as Topical Phytoestrogen in Skin Aging Treatment of Post Menopausal Women
Skin is subjected to intrinsic aging and extrinsic aging. Intrinsic aging is influenced by genetic and hormonal factors. Estrogen has significant role in modulating skin physiology.
- Trial name
- NCT04123743
- Testing
- Trigonella foenum-graceum extract topical cream, Facial Wash, Sunscreen Cream
- Where
- Indonesia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Facial Wrinkles
Safety and Effectiveness of Belotero® in Subjects With Fitzpatrick Phototypes IV Through VI
This is a study to assess how safe and effective an investigational product, Belotero® is in people with all skin types with facial wrinkles, such as nasolabial folds.
- Trial name
- NCT00922623
- Testing
- Belotero®
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Merz North America, Inc.
Skin, Skin Manifestations
Placebo Controlled Efficacy Evaluation of the Hydrolyzed Collagen Peptide In Adult Females
The aim of this study is to evaluate the contribution of hydrolized collagen products to elasticity, hydration and roughness of the skin of female volunteers.
- Conditions
- Skin, Skin Manifestations, Wrinkle
- Trial name
- NCT05235997
- Testing
- Hydrolized Collagen Peptide
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sel Sanayi Urunleri Ticaret ve Pazarlama A.S.
Periorbital Wrinkles, Periorbital Area
Non-invasive Rejuvenation of the Periorbital Area and Lower Eyelid
The goal of this clinical trial is to determine the BTL-785-7-11 applicator effectiveness for an under-eye appearance improvement by evaluation of the periorbital area in healthy adult volunteers.
- Conditions
- Periorbital Wrinkles, Periorbital Area, Under-eyes Dark Circles, Crows Feet
- Trial name
- NCT07028203
- Testing
- Treatment with BTL-785 with the applicator BTL-785-7-11
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Skin Laxity, Skin Aging
Cucurbita Pepo Flowers Extract to Promote Skin Health
The aim of this cosmetic clinical trial is to learn if an extract of Cucurbita pepo flower (CpLfe) works to enhance skin health and resilience in adult women with photo-damage.
- Conditions
- Skin Laxity, Skin Aging, Skin Wrinkling
- Trial name
- EACpLfe22S01 (NCT06674005)
- Testing
- Cucurbita pepo L. Flowers Extract
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ritamaria Di Lorenzo