Clinical trials: XEROSTOMIA
Oral Complications, Quality of Life
Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids
RATIONALE: Pilocarpine may help to relieve dry mouth in patients receiving opioids for cancer therapy. It is not yet known whether pilocarpine is more effective than no further treatment for this condition.
- Trial name
- NCT00003686
- Testing
- pilocarpine hydrochloride
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- NCIC Clinical Trials Group
Xerostomia, Polypharmacy
Treatment of Salivary Gland Hypofunction With Neuro- Electrostimulation
The objective of the study is to evaluate with clinical parameters the performance of Saliwell Crown as a neuro-electrostimulator of the submandibular and sublingual salivary glands in hypofunction status due to polypharmacy or…
- Conditions
- Xerostomia, Polypharmacy, Sjögren's Syndrome
- Trial name
- SALELECTROSTIM (NCT01174329)
- Testing
- Automatic neuro-electrostimulation by "Saliwell Crown", Patient-regulated neuro-electrostimulation by "Saliwell Crown"
- Where
- Mexico
- Volunteers
- 14 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Autoimmune Disease, Crohn Disease
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
This phase Ib trial studies the side effects of nivolumab and to see how well it works alone and in combination with other treatments, such as ipilimumab, cabozantinib, platinum containing therapy, and fluoropyrimidine, in…
- Conditions
- Autoimmune Disease, Crohn Disease, Dermatomyositis, Hematopoietic and Lymphoid Cell Neoplasm
- Trial name
- NCT03816345
- Testing
- Biospecimen Collection, Cabozantinib, Fluoropyrimidine
- Where
- 52 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- National Cancer Institute (NCI)
Meibomian Gland Dysfunction, Dry Eye Syndromes
Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients
This observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy…
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07810569
- Volunteers
- 150 people
- Sponsor
- Assiut University
Xerostomia
Interest of the Sialendoscopy Associated With a Local Injection of Corticosteroids in the Treatment of Radio-induced Xerostomia in Comparison With the Hygiene Rules
Xerostomia is defined as the subjective sensation of dry mouth, and may be associated with a reduction in saliva secretion and composition.
- Trial name
- SIALORAD (NCT04584164)
- Testing
- sialendoscopy
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Primary Sjögren's Syndrome
The Efficacy and Safety of Iguratimod (IGU) in the Treatment of Primary Sjögren's Syndrome
A multi-center, prospective, open-label, randomized controlled study of efficacy and safety of Iguratimod in patients with Primary Sjögren's syndrome
- Trial name
- NCT04981145
- Testing
- Iguratimod Tablets, Hydroxychloroquine Sulfate Tablets
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sjogren's Syndrome
Anifrolumab Treatment for 24 Weeks in Patients With Primary Sjögren's Syndrome
The ANISE-II study is a randomized, double-blind, placebo-controlled phase IIa proof-of-concept trial. Thirty patients with primary Sjögren's syndrome (pSS) are randomized in a 2:1 ratio to either anifrolumab or placebo treatment…
- Trial name
- ANISE-II (NCT05383677)
- Testing
- Anifrolumab
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Quality of Life, Oral Mucositis
Efficacy of a Probiotic and Microbiological Analysis on Oral Complications in Patients With HNC
The study is a Clinical Trial and the main objective is to Evaluate the effects of probiotics on oral complications induced by antineoplastic therapies in patients with head and neck cancer, attended at the radiotherapy service…
- Conditions
- Quality of Life, Oral Mucositis, Dental Plaque, Periodontal Diseases
- Trial name
- HNC (NCT06122636)
- Testing
- The probiotic to be used in the intervention corresponds to PRODEFEN Plus manufactured by ITALFARMACO S.A. laboratory
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Barcelona
Head and Neck Cancer, Radiation Toxicity
Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer
RATIONALE: Moving a salivary gland out of the area that will undergo radiation therapy may protect the gland from side effects of radiation therapy and may prevent xerostomia (dry mouth).
- Conditions
- Head and Neck Cancer, Radiation Toxicity, Xerostomia
- Trial name
- NCT00068237
- Testing
- salivary gland transfer, Post-operative radiation therapy
- Where
- 12 sites in United States, Canada
- Volunteers
- 49 people
- Sponsor
- Radiation Therapy Oncology Group
Dry Mouth Associated With Sjogren's Syndrome, Xerostomia
A Safety and Efficacy Study of 552-02 in Subjects With Dry Mouth Associated With Sjogren's Syndrome
This clinical study is to determine whether daily administration of a formulation of 552-02 improves the dry mouth condition in subjects with primary Sjögren's syndrome.
- Trial name
- NCT00852839
- Testing
- 552-02
- Where
- 15 sites in United States
- Volunteers
- 140 people
- Sponsor
- Parion Sciences
Rhinoplasty
The Effect of Ice Cold Mentholated Water Spray After Rhinoplasty
This clinical trial aims to evaluate the effects of a menthol-infused cold water spray on thirst perception, dry mouth, nausea, and physiological parameters in patients after rhinoplasty.
- Trial name
- NCT07233057
- Testing
- Menthol Cool Water Spray, Ice water spray
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Firat University
Xerostomia, Hyposalivation, Saliva Substitute, Radiation-induced Toxicity, Nasopharyngeal Cancer
Saliva Substitute Mouthwash in NPC Survivors With Xerostomia: A Randomized Controlled Trial
Nasopharyngeal carcinoma (NPC) is the highest reported otorhinolaryngological malignancy reported in Malaysia affecting predominantly male adults between 40-60 years old [1, 2].
- Trial name
- NCT04491435
- Testing
- Summated Xerostomia Inventory, Sialometry
- Where
- Malaysia
- Volunteers
- 94 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Bullous Keratopathy, Corneal Erosion
AONDA Therapeutic Indication Study I
This study will be used to support assessment of AIR OPTIX® NIGHT \& DAY® AQUA (AONDA) Soft Contact Lenses' safety and performance in accordance with updated European Union Medical Device Regulation (EU MDR) requirements.
- Conditions
- Bullous Keratopathy, Corneal Erosion, Entropion, Corneal Edema
- Trial name
- NCT05891106
- Testing
- Lotrafilcon A contact lenses
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Alcon Research
Keratopathy, Sjogren's Syndrome
Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy
Topical preparations (eye drops) derived from the blood have become a relatively common treatment for more advanced forms of keratopathy.
- Conditions
- Keratopathy, Sjogren's Syndrome, GVHD - Graft-Versus-Host Disease
- Trial name
- NCT03064984
- Testing
- CBS eyedrops, PBS eyedrops
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Xerostomia, Chronic Renal Failure
Effects of Photobiomodulation in Salivary Analysis of Chronic Renal Failure Patients
End-stage renal disease patients undergoing hemodialysis can present alteration in flow, concentrations and composition of saliva affecting oral health.
- Trial name
- NCT03647813
- Testing
- Photobiomodulation
- Volunteers
- 44 people
- Sponsor
- University of Nove de Julho
Xerostomia in Advanced Cancer Patients
Proof-of-concept (PoC) Study of APD515
A study to look at the effectiveness of a drug called APD515, designed to be applied to the lining inside the mouth, at relieving dryness of the mouth.
- Trial name
- NCT01331746
- Testing
- APD515
- Where
- 11 sites in Denmark, United Kingdom
- Volunteers
- 32 people
- Sponsor
- Acacia Pharma Ltd
Dysphagia, Pain
Dexamethasone in Reducing Oral Pain and Dry Mouth After Surgery in Patients With Oropharyngeal Cancer
This randomized pilot clinical trial studies dexamethasone in reducing oral pain and dry mouth after surgery in patients with oropharyngeal cancer. Dexamethasone may help lower pain and dry mouth caused by surgery.
- Conditions
- Dysphagia, Pain, Stage I Oropharyngeal Squamous Cell Carcinoma, Stage II Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT01748942
- Testing
- Dexamethasone, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- OHSU Knight Cancer Institute
Xerostomia Due to Hyposecretion of Salivary Gland, Xerostomia Due to Radiotherapy
Repeated Mesenchymal Stem Cell Therapy for Radiation-Induced Hyposalivation and Xerostomia in Head and Neck Cancer Survivors
Dry mouth leads to debilitating symptoms 24/7. The two primary causes for dry mouth are Sjögrens disease and after radiotherapy of a head and neck cancer.
- Conditions
- Xerostomia Due to Hyposecretion of Salivary Gland, Xerostomia Due to Radiotherapy, Sjögren´s Syndrome
- Trial name
- MESRIX-more (NCT07290946)
- Testing
- ALLOGENEIC AND EXPANDED ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS
- Volunteers
- 100 people
- Sponsor
- Christian von Buchwald
Lacrimal Apparatus Disease, Salivary Gland Disease
DHEA Treatment for Sjogren's Syndrome
This study will evaluate the effectiveness of the male hormone dehydroepiandrosterone (DHEA) in treating Sjogren's syndrome. This autoimmune disorder, in which the immune system attacks the salivary glands and tear glands…
- Conditions
- Lacrimal Apparatus Disease, Salivary Gland Disease, Sjogren's Syndrome, Xerostomia
- Trial name
- NCT00001598
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Head and Neck Cancer
Topical/Oral Melatonin for Preventing Concurrent Radiochemotherapy Induced Oral Mucositis/Xerostomia Cancer Patients
The study evaluates the effect of melatonin for preventing concurrent radiochemotherapy induced oral mucositis and xerostomia and improving quality of life in head and neck cancer patients.
- Trial name
- NCT02430298
- Testing
- Melatonin
- Where
- Thailand
- Volunteers
- 39 people
- Sponsor
- Khon Kaen University