Clinical trials: XEROSTOMIA
Rheumatoid Arthritis, Spondylitis, Ankylosing
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases
Introduction: Patients with autoimmune rheumatic diseases (ARDs), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PAs), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary…
- Conditions
- Rheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- RZVRheum (NCT05879419)
- Testing
- Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation
- Where
- Brazil
- Volunteers
- 2,005 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies
Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases
To evaluate the safety of UTAA09 injection in the treatment of relapsed/refractory (R/R) autoimmune disease (AID). To evaluate the pharmacokinetic (PK) profile of UTAA09 injection in patients with R/R AID.
- Conditions
- Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathies, Systemic Sclerosis, Sjogren's Syndrome
- Trial name
- NCT06417398
- Testing
- T cell injection targeting CD19 chimeric antigen receptor
- Volunteers
- 10 people
- Sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Primary Sjögren's Syndrome (pSS)
Clinical Study to Investigate the Efficacy of Orally Administered SA001 in Patients With Primary Sjögren's Syndrome
This is a phase2a, multicenter, double-blind, placebo control, randomized study to investigate the efficacy and safety of SA001 in subjects with pSS.
- Trial name
- NCT05269810
- Testing
- SA001 Low dose, SA001 Mid dose, SA001 High dose
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Samjin Pharmaceutical Co., Ltd.
Primary Sjogren's Syndrome, Secondary Sjogren's Syndrome
Abatacept for Patients With Inflammatory Arthritis Associated With Sjögren's Syndrome: an Open-Label Phase II Study
The primary purpose of this pilot study is to evaluate the efficacy and safety of Abatacept in subjects with Sjogren's Syndrome (SS).
- Conditions
- Primary Sjogren's Syndrome, Secondary Sjogren's Syndrome, Inflammatory Arthritis, Rheumatoid Arthritis
- Trial name
- NCT02027298
- Testing
- Abatacept
- Where
- United States
- Sponsor
- The Cleveland Clinic
Dry Mouth
Bioequivalency Study of 5 mg Piolocarpine Tablets Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Pilocarpine Tablets, 5 mg, to SALAGEN® Tablets, 5 mg (MGI Pharma) under fed conditions using a single-dose, 2-treatment, 2-period, crossover design.
- Trial name
- NCT00601211
- Testing
- Pilocarpine
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Sjogren's Syndrome
Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome
The purpose of this large multicenter, randomized, double-blinded, controlled clinical study is to investigate the efficacy and safety of Cyclosporin A for primary Sjogren's syndrome associated pneumonitis(pSS-IP), which has…
- Trial name
- CTRIPS (NCT02370550)
- Testing
- Cyclosporin A, Prednisone, Calcium carbonate D
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University People's Hospital
Sjogren's Syndrome
Hydroxychloroquine Blood Levels in Primary Sjögren Syndrome Patients
Introduction. Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by chronic inflammatory infiltration of the salivary and lacrimal glands causing dry eye and mouth.
- Trial name
- 1ASSJHCQ (NCT04546542)
- Testing
- Parallel Assignment
- Where
- 2 sites in Brazil
- Volunteers
- 74 people
- Sponsor
- University of Sao Paulo General Hospital
Sarcopenia, Sjogren's Syndrome
Prevalence and Factors of Sarcopenia and in Patients With Primary Sjogren's Syndrome
Sarcopenia is a progressive condition characterized by decline in muscle strength and muscle mass. Although the mechanism of sarcopenia has not been fully elucidated, it may be caused by protein-poor diet, vitamin D deficiency…
- Conditions
- Sarcopenia, Sjogren's Syndrome, Rheumatologic Disease
- Trial name
- NCT05015114
- Testing
- Sarcopenia Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Acibadem University
Xerostomia Following Radiotherapy
MSC in Patients With Xerostomia Post XRT in Head and Neck Cancer
This is a single center pilot study designed to determine the safety and tolerability of autologous bone marrow-derived Mesenchymal Stromal Cells (MSCs) in patients with xerostomia (dry mouth) after undergoing radiation therapy…
- Trial name
- NCT04489732
- Testing
- Autologous bone-marrow derived, interferon gamma stimulated mesenchymal stromal cells
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Wisconsin, Madison
Diabetes Mellitus, Sarcoidosis
Salivary Proteins in Disease and Health
This study will examine saliva samples from healthy volunteers and patients with various diseases to learn more about how disease affects the mouth and salivary glands.
- Conditions
- Diabetes Mellitus, Sarcoidosis, Dental Caries, Sjorgren's Syndrome
- Trial name
- NCT00100204
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Xerostomia
Interest of Auriculotherapy in the Treatment of Xerostomia
The aim of the study is to show that auriculotherapy is effective in the treatment of xerostomia
- Trial name
- AURICULOXERO (NCT04222478)
- Testing
- Specific auriculotherapy, Non-specific auriculotherapy
- Where
- 4 sites in France
- Volunteers
- 65 people
- Sponsor
- Hopital Foch
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Xerostomia, Hyposalivation
The Effect of Biotene® on the Symptoms of Xerostomia and Mastication and Swallowing
This study will compare the effects of Biotene® Oral Balance Moisturizing Gel (Biotene), an over-the-counter artificial saliva, that the effects of a sham condition on oral health-related quality of life, mastication, and…
- Trial name
- NCT04323384
- Testing
- Biotene® Oralbalance Moisturizing Gel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Sjogren's Syndrome
Ultra-High Frequency Ultrasonography in Sjögren's Syndrome
Patients diagnosed with a diagnosis of Sjogren's syndrome performed according to the ACR/EULAR criteria will be included in the study.
- Trial name
- UltraSjögren (NCT06338735)
- Testing
- Ultra-High Frequency Ultrasound scan of minor salivary glands
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- University of Pisa
ESRD
Smell, Taste, Salivary Flow, and Oral Health in Patient Receiving Dialysis: A Before and After Study.
Studies show that the change of smell and taste, also dry mouth are the most common symptoms in end stage renal disease patients, the accumulation of uremic toxins would damage the intrinsinc antioxidant systems of the olfactory…
- Trial name
- NCT04401358
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- National Taiwan University Hospital
Sjogren's Syndrome
Evaluation of Hand Functions in Newly Diagnosed Primary Sjögren's Syndrome
Hand functions are decreased in rheumatic diseases such as systemic sclerosis and rheumatoid arthritis. Sjögren's syndrome (SS) is a chronic systemic rheumatic disease characterized by lymphoplasmacytic infiltration of exocrine…
- Trial name
- NCT05115487
- Testing
- digital dynamometer
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Sjogren's Syndrome
Safety and Efficacy Study of Subcutaneous Belimumab and Intravenous Rituximab Co-administration in Subjects With Primary Sjogren's Syndrome
This study is a multi-national, multi-center, double-blind (sponsor open), randomized, placebo-controlled trial in subjects with active primary Sjögren's syndrome designed to understand the safety and tolerability profile of…
- Trial name
- NCT02631538
- Testing
- Belimumab, Rituximab
- Where
- 36 sites in Argentina, Canada and 8 more
- Volunteers
- 86 people
- Sponsor
- GlaxoSmithKline
Sjogren's Syndrome, Salivary Gland
The Pathogenesis and Natural History of Sjogren's Disease
Background: -Sjogren s Disease (formerly: Sjogrens Syndrome, Sj(SqrRoot)(Delta)gren s syndrome) is a disease that affects about 1-4 million Americans. It is more common in women.
- Conditions
- Sjogren's Syndrome, Salivary Gland, Pathogenesis
- Trial name
- NCT01425892
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Systemic Lupus Erthematosus, Systemic Sclerosis (SSc)
Safety and Efficacy of Universal CD19-targeting CAR-γδT Cells in Refractory Autoimmune Diseases
Autoimmune diseases refer to a common category of diseases caused by the immune system reacting to self-antigens, leading to tissue damage.
- Conditions
- Systemic Lupus Erthematosus, Systemic Sclerosis (SSc), Sjogren Syndrome, ANCA Associated Vasculitis (AAV)
- Trial name
- NCT06828042
- Testing
- anti-CD19 CAR T cell therapy
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
KERATOCONJUNCTIVITIS SICCA, XEROSTOMIA
Laser Therapy to Treat the Dry Mouth of Sjogren's Syndrome
This study was designed to test the efficacy and safety of low laser therapy to treat the xerostomia of patients with primary Sjogren's Syndrome.
- Conditions
- KERATOCONJUNCTIVITIS SICCA, XEROSTOMIA, SICCA SYNDROME, PRIMARY SJOGREN SYNDROME
- Trial name
- NCT02066896
- Testing
- Lasertherapy
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Federal University of São Paulo