Clinical trials: XEROSTOMIA
Dry Eye Disease
Efficacy and Safety of 20% and 100% Autologous Serum Eye Drops in Patients With Severe Dry Eye Disease (AST)
A prospective, single-blinded, randomized, controlled crossover trial was conducted in patients with severe dry eye syndrome. Topical treatment with autologous serum eye drops (ASED) diluted at 20%, undiluted ASED and…
- Trial name
- AST (NCT07469865)
- Testing
- Preservative-free artificial tears, Autologous serum eyedrops 20%, Autologous serum eyedrops 100%
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- University Hospital, Ghent
Rheumatoid Arthritis, Palindromic Arthritis
Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity
Social determinants of health (SDoH), defined by the World Health Organization as "the conditions in which people are born, grow, work, live and age and the wider set of forces and systems shaping the conditions of daily life"…
- Conditions
- Rheumatoid Arthritis, Palindromic Arthritis, Juvenile Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- RAISE (NCT05715463)
- Testing
- Resource sheets, Community Resource Specialist, Nurse Navigator
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Brigham and Women's Hospital
Oral Mucositis, Chemotherapy-induced Oral Mucositis
Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis
Oral mucositis is a frequent and often debilitating complication of radiotherapy and chemotherapy, particularly in patients treated for head and neck cancers.
- Conditions
- Oral Mucositis, Chemotherapy-induced Oral Mucositis, Head and Neck Neoplasms
- Trial name
- OZOMUC (NCT07491536)
- Testing
- Gas Ozone Therapy, Biomimetic Oral Care Regimen
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Pavia
Sjogren's Syndrome
Fecal Microbial Transplant (FMT) for Sjogrens Syndrome
This is an open label study to evaluate the effect of Fecal Microbiota Transplantation (FMT) on the gut microbiome and Systemic parameters.
- Trial name
- NCT03926286
- Testing
- FMP-30
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
Dry Eye Syndromes, ATD
Viveye Ocular Magnetic Neurostimulation System (OMNS) for the Management of Severe Dry Eye Disease
The objective of this study is to evaluate the safety and effectiveness of Viveye OMNS non-invasive treatment for management of the signs and symptoms of severe dry eye disease.
- Conditions
- Dry Eye Syndromes, ATD, Sjogren's Syndrome
- Trial name
- OMNS (NCT04143841)
- Testing
- Viveye OMNS treatment
- Where
- 3 sites in Israel
- Volunteers
- 50 people
- Sponsor
- Epitech Mag Ltd.
Dry Mouth
Efficacy of Cevimeline Versus Pilocarpine in the Secretion of Saliva
The main objectives were: 1) To determine the efficacy of both cevimeline and pilocarpine in the secretion of saliva in patients with xerostomia, and 2) To compare the side-effects between the treatment for xerostomia with…
- Trial name
- NCT01690052
- Testing
- Cevimeline, Pilocarpine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Kentucky
Dry Eye Disease, Xerostomia
Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness
Dry Eye Disease (DED) is a multifactorial pathology characterized by inflammation of the lacrimal functional unit that develops in ocular surface pathology, severely affecting patients quality of life.
- Trial name
- NCT05187533
- Testing
- Osteopathic protocol of Sphenopalatine Ganglion Stimulation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Rheumatoid Arthritis, Sjogren's Syndrome
Ultrasound Characteristics of the Salivary Glands in Patients With Rheumatoid Arthritis
The prevalence of Sjogren's syndrome (SS) in rheumatoid arthritis (RA) patients varies from 3.5 to 31%. Between 30% and 90% of patients with (RA) have dry eye and/or mouth syndrome.
- Conditions
- Rheumatoid Arthritis, Sjogren's Syndrome, Sicca, Asthenia, Polyalgia Syndrome (SAPS)
- Trial name
- EchoPR (NCT05782049)
- Testing
- Ultrasound of the salivary glands, Measurement of salivary flow, A Schirmer test
- Where
- France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sjogren's Syndrome
Reliability, Validity, and Responsiveness of the Turkish Version of Eating Assessment Tool-10 for Patients With Primer Sjögren's Syndrome
Evaluations will be made by researchers following the guidance of individuals with primary Sjögren's Syndrome who receive diagnosis, routine medical care, and treatment management.
- Trial name
- NCT06401811
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Sjogren's Syndrome
Effects of Acupuncture on Sjögren's Syndrome
Sjögren's syndrome (SS) is a multisystemic chronic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, resulting in salivary and lacrimal glands hypofunction, with symptoms of dry eyes and mouth.
- Trial name
- NCT04056221
- Testing
- Acupuncture
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Ana Carolina Fragoso Motta, DDS, PhD
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT06700863)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Primary Sjögren's Syndrome, Xerostomia
Effect of B-cell Depletion in Patients With Primary Sjögren's Syndrome
The primary purpose of the study is to determine whether B-cell depletion with Rituximab has an effect on the oral, ocular and general disease manifestations in patients with primary Sjögren´s syndrome, that is, an effect on the…
- Conditions
- Primary Sjögren's Syndrome, Xerostomia, Hyposalivation, Keratoconjunctivitis Sicca
- Trial name
- NCT00426543
- Testing
- MabThera (rituximab), Rituximab, Mabthera
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cancer of Head and Neck, Cancer
Efficacy of Novel Edible Gel-based Artificial Saliva in Cancer Patients
The purpose of this study is to determine whether continuous use of edible, gel-based artificial saliva in cancer patients with dry mouth problems will reduce signs and symptoms of dry mouth and improve quality of patients'…
- Conditions
- Cancer of Head and Neck, Cancer, Radiation-induced Xerostomia, Dry Mouth
- Trial name
- NCT01885065
- Testing
- Gel-based artificial saliva
- Where
- Thailand
- Volunteers
- 25 people
- Sponsor
- Dental Innovation Foundation Under Royal Patronage
Oral Mucositis, Osteoradionecrosis
Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention
Introduction: There are several manifestations in the oral mucosa resulting from antineoplastic treatments by chemo (QT) or radiotherapy (RT).
- Conditions
- Oral Mucositis, Osteoradionecrosis, Osteonecroses, Bisphosphonate, Osteonecrosis Due to Drugs, Jaw
- Trial name
- NCT04717765
- Testing
- Preventive, LLL Phototherapy and topical Vit E, Curative, LLL Phototherapy and topical Vit E, Preventive, LLL Phototherapy and LPRF
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
ANCA Associated Vasculitis, Sjogren's Syndrome
Patients With Co-occurrence of ANCA Vasculitis and Sjögren Syndrome
ANCA vasculitis and Sjögren syndrome are two rare diseases, and even more rarely associated. These two conditions have specific organ involvements, and specific follow-up.
- Trial name
- NCT04895878
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier
Xerostomia
Coconut Oil: Managing Radiation-Induced Xerostomia
This study will seek to assess the experience of using of coconut oil as an approach to managing radiation-induced xerostomia in patients previously treated for cancer in the head and neck.
- Trial name
- NCT03176368
- Testing
- Coconut Oil
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Sjogren's Syndrome
Rituximab Treatment in Sjogren's Syndrome
This study is an evaluation of the effect of rituximab compared to placebo in combination with steroids on salivary flow and serological and clinical parameters in patients with primary SS.
- Trial name
- NCT00363350
- Testing
- rituximab (anti-CD20)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Primary Gougerot-Sjögren Syndrome, Systemic Sclerosis, Diffuse
Quantification and Characterization of Circulating Epithelial and Endothelial Cells in Gougerot-Sjögren Syndrome, Compared to Systemic Sclerosis
Primary Gougerot-Sjögren's syndrome is a systemic autoimmune disease belonging to the group of connectivities, whose physiopathology remains largely unknown.
- Trial name
- CIRCEE (NCT05528809)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Sjogren's Syndrome
Acupuncture for Primary Sjögren Syndrome
The purpose of this study is to determine whether acupuncture is effective and safe in the treatment of Primary Sjögren Syndrome.
- Trial name
- NCT02691377
- Testing
- acupuncture group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Systemic Autoimmune Disease, Chronic Inflammatory Rheumatism
Study of Leukocyte Populations in Patients With Chronic Inflammatory
Exploration of pathophysiological mechanisms in chronic inflammatory rheumatism and rare systemic autoimmune diseases with the objective of identifying therapeutic targets.
- Conditions
- Systemic Autoimmune Disease, Chronic Inflammatory Rheumatism, Sjogren's Syndrome, Spondyloarthritis
- Trial name
- LIMA (NCT04749875)
- Testing
- blood sample
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris