Clinical trials: XEROSTOMIA
Experimental, Dementia
Salivary Gland Massage and Olfactory Stimulation for Relieving Feeding Difficulty and Triggering Oral Intake Among People With Dementia
Feeding difficulties are a common issue among individuals with dementia during moderate to advanced stages, particularly those in long-term care (LTC) facilities.
- Conditions
- Experimental, Dementia, RCT, Dry Mouth
- Trial name
- NCT07678515
- Testing
- SMART program (Salivary gland massage combined with aromatherapy
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Cheng Kung University
Xerostomia, Radiation-induced Parotid Damage,Predictivevalue,Head and Neck Cancer
Prospective Study on Monitoring Parotid Gland Injury After Radiotherapy for Head and Neck Tumors Using Multimodal Radiomics
Exploring a non-invasive and objective method for ultra early quantitative assessment of radiation-induced parotid gland injury.
- Trial name
- NCT06792526
- Testing
- IVIM Imaging MRF Imaging
- Volunteers
- 20 people
- Sponsor
- Hainan People's Hospital
SCAD, Addison Disease
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
- Conditions
- SCAD, Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome
- Trial name
- NCT03941184
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic
Sjögren´s Disease
Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden
The purpose of this study is to demonstrate the efficacy and safety of ianalumab (VAY736) 300 mg administered subcutaneously (s.c.) monthly for 52 weeks in adult participants with Sjögren's disease who have high symptom burden.
- Trial name
- THALASSA (NCT07621809)
- Testing
- VAY736
- Where
- 33 sites in United States, Australia and 6 more
- Volunteers
- 570 people
- Sponsor
- Novartis Pharmaceuticals
Xerostomia, Dry Mouth
Efficacy of Transcutaneous Electrical Nerve Stimulation in Patients With Xerostomia (ETENX)
Saliva is a complex fluid with essential functions in the oral cavity, such as lubricating tissues, protecting against microorganisms, and facilitating processes like chewing, swallowing, and speaking.
- Trial name
- ETENX (NCT06708195)
- Testing
- Group experimental
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Murcia
Dry Mouth, Xerostomia
"Hyaluronan" Formulation for Dry Mouth in Sleep Apnea Patients
During routine clinical practice, it is observed that patients with suspected obstructive sleep apnea (OSA) often reported waking up with a dry mouth during the night or in the morning.
- Conditions
- Dry Mouth, Xerostomia, OSA, Sleep Apnea
- Trial name
- NCT03295019
- Testing
- Test Oral Spray
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- You First Services
Thirst in Intensive Care Unit (ICU) Practice, Thirst; Due to Deprivation of Water
The Effect of Cold Water Spray Application on Dry Mouth and Thirst Symptoms and Comfort of Patients After Endonasal Endoscopic Surgery After Admission to Intensive Care Unit
The aim of this observational study was to evaluate the effect of cold water spray application on dry mouth and thirst symptoms and comfort of patients who underwent endonasal endoscopic pituitary surgery in neurosurgery in the…
- Conditions
- Thirst in Intensive Care Unit (ICU) Practice, Thirst; Due to Deprivation of Water, Thirst, Dry Mouth
- Trial name
- NCT06763133
- Testing
- Cold Water Spray Application, Clinical routine practice
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Head and Neck Cancer, Radiation Therapy Complication
The Use of Chewing Gum for Xerostomia and Hyposalivation After Radiotherapy for Oral and Oropharyngeal Tumors
This study evaluates the possible benefits of a tasteless and sugar free chewing gum as a salivary stimulant for head and neck cancer patients treated with curative intended radiotherapy.
- Conditions
- Head and Neck Cancer, Radiation Therapy Complication, Xerostomia, Hyposalivation
- Trial name
- NCT03302676
- Testing
- Chewing gum
- Where
- Denmark
- Volunteers
- 109 people
- Sponsor
- Odense University Hospital
Dry Mouth, Salivary Gland Diseases
Efficacy of Manuka Honey Oral Rinse in Treatment of Xerostomia
Xerostomia causes many clinical problems, including oral infections, speech difficulties, and impaired chewing and swallowing of food thus may affect the individual's quality of life, therefore this study aimed to evaluate the…
- Trial name
- NCT06240806
- Testing
- Manuka Honey, Saline mouthwash
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- British University In Egypt
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT07170358)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Primary Sjögren's Syndrome
Safety, Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Primary Sjögren's Syndrome
This study did evaluate the safety,tolerability and preliminary therapeutic efficacy of multiple doses of intravenous infusion of CFZ533 monoclonal antibody in patients with primary Sjögren's syndrome(pSS)
- Trial name
- NCT02291029
- Testing
- CFZ533 active - Cohort 1, CFZ533 active - Cohort 2, CFZ533 active -Cohort 3
- Where
- 9 sites in United States, Germany and 3 more
- Volunteers
- 69 people
- Sponsor
- Novartis Pharmaceuticals
Sjögren's Syndrome
A Clinical Trial to Evaluate the Safety and Efficacy of Traditional Chinese Medicine in Sjögren's Syndrome.
To investigate the efficacy and safety of traditional Chinese medicine in patients with Sjogren's syndrome.
- Trial name
- NCT04111341
- Testing
- TCM (Gan-Lu-Yin)GLY
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chung Shan Medical University
Psychiatric Disorders, Xerostomia Due to Hyposecretion of Salivary Gland
This Present Study Can be Used by Clinicians Who Treat Psychiatric Patients: Dentists Might Expect Xerogenic Side Effects of Specific Psychiatric Drugs Which Can Affect Dental Treatment, and the Results Can Help Psychiatrist to Choose the Less Xerogenic Psychiatric Medication
The goal of this observational study is to learn about the effects of psychiatric drug therapies on intra- and extra-oral sicca symptoms and salivation.
- Trial name
- NCT06920472
- Volunteers
- 361 people
- Sponsor
- Semmelweis University
Xerostomia
Development of a Milk Product Substitution for Patients Suffering From Xerostomia Caused by Medication
Dry mouth is in most cases due to iatrogenic causes, particularly drugs. The existing products such as saliva substitutes are often disappointing (bad taste, poor efficiency).
- Trial name
- LactoXeros (NCT01960101)
- Testing
- LactoXeros, Aequasyal
- Where
- 2 sites in France
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Thirst, Mouth Dryness
Package of Mentholated Measures for the Relief of Thirst in the Anesthesia Recovery Room
Package of mentholated measures for the relief of thirst in the anesthesia recovery room: Randomized clinical trial
- Conditions
- Thirst, Mouth Dryness, Irritation Lips
- Trial name
- NCT02869139
- Testing
- Mentholated lip moisturizer and ice popsicle, Non-mentholated lip moisturizer and ice popsicle
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade Estadual de Londrina
Otorhinolaryngologic Disease, Otorhinolaryngologic Neoplasm
Ultrasound Evaluation of Tongue Movements in Speech and Swallowing
This study will assess the use of ultrasound-a test that uses sound waves to produce images-as a diagnostic tool for evaluating speech and swallowing.
- Conditions
- Otorhinolaryngologic Disease, Otorhinolaryngologic Neoplasm, Pharyngeal Neoplasm, Polymyositis
- Trial name
- NCT00001167
- Where
- United States
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Systemic Lupus Erythematosus, Systemic Sclerosis (SSc)
A Study of ATG-201 in Adult Participants With Autoimmune Diseases
This is a phase I, open-label study of ATG-201 in participants with autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Systemic Sclerosis (SSc), Sjogren's Disease, Autoimmune Diseases
- Trial name
- ATTRACT (NCT07732309)
- Testing
- ATG-201
- Where
- 22 sites in China
- Volunteers
- 149 people
- Sponsor
- Antengene Biologics Limited
Oral Dryness and Saliva Altered, Oral Manifestations
The Effects of Using Augmented Reality (AR) System to Train Foreign Care Workers.
The aim of this study was to evaluate the effect of augmented reality (AR) system training intervention of foreign care workers on the salivary biomarker and oral function of older people.
- Conditions
- Oral Dryness and Saliva Altered, Oral Manifestations, Swallowing Disorder
- Trial name
- NCT05938166
- Testing
- oral care augmented reality (AR), video-based oral hygiene education course
- Where
- Taiwan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Xerostomia
Effect of Low-level Laser Therapy on Salivary Flow, pH and Quality of Life in Irradiated Oropharyngeal Cancer Patients
There are multiple treatment modalities for head and neck cancer. They include radiation therapy, chemotherapy and surgery. Radiation therapy aims to control the tumor with minimum damage to adjacent tissues.
- Trial name
- NCT04738227
- Testing
- Low-Level Laser Therapy
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Ziauddin University
Sjögren's Syndrome
HRR as a Novel Biomarker in Sjögren's Syndrome
Sjögren's syndrome (SS) is an autoimmune disorder characterized by chronic salivary and lacrimal gland dysfunction leading to dry mouth (xerostomia) and dry eye (xerophthalmia) sensation (1).
- Trial name
- NCT05633524
- Testing
- blood sample analysis
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital