Clinical trials: XEROSTOMIA
Radiation-induced Xerostomia
The Efficacy of Hibiscus Sabdariffa in Xerostomia
The goal of this [ type of study: Clinical trial] is to test effectiveness of Hibiscus Sabdariffa L. mouth rinse using the subjective dry mouth score as a primary objective and to assess the effect of that mix on the salivary…
- Trial name
- NCT06413550
- Testing
- Hibiscus Sabdariffa
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Pregnancy, Systemic Lupus Erythematosus
Duke Autoimmunity in Pregnancy Registry
It is difficult to predict how a women with an autoimmune disease will do during pregnancy. Some women will improve, others will worsen. Some pregnancies progress normally and others become very complicated.
- Conditions
- Pregnancy, Systemic Lupus Erythematosus, Cutaneous Lupus, Rheumatoid Arthritis
- Trial name
- DAP Registry (NCT00513591)
- Where
- United States
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- Duke University
Mortality, Oral Health
De-adoption of Oral Chlorhexidine Prophylaxis and Implementation of an Oral Care Bundle (CHORAL)
The objective of the CHORAL study is to evaluate the de-adoption of oral chlorhexidine and the introduction of a bundle of oral care practices on selected outcomes in critically ill mechanically ventilated adults.
- Conditions
- Mortality, Oral Health, Dryness, Mouth, Pain, Orofacial
- Trial name
- CHORAL (NCT03382730)
- Testing
- Chlorhexidine Mouth Rinse, Chlorhexidine Mouth Rinse De-Adoption
- Where
- 5 sites in Canada
- Volunteers
- 3,260 people
- Sponsor
- University of Toronto
Xerostomia
Clinical Evaluation of Oral Rinse for Xerostomia
Xerostomia causes a difficulty in eating, have irritated oral tissues, and a poor quality of life. The new oral rinse was designed to reduce the symptoms and improve the patient's quality of life.
- Trial name
- NCT04289051
- Testing
- HYDRAL Oral Rinse, BIOTENE® Oral Rinse
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Sunstar Americas
Lupus Erythematosus, Systemic, Sjogren's Syndrome
Dehydroepiandrosterone Administration in Women With Systemic Lupus Erythematosus or Primary Sjögren's Syndrome
The purpose of the study is to examine whether dehydroepiandrosterone (DHEA) administration improves fatigue and general well-being in patients with systemic lupus erythematosus or primary Sjögren's syndrome
- Trial name
- NCT00391924
- Testing
- Dehydroepiandrosterone
- Where
- 2 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Xerostomia Due to Hyposecretion of Salivary Gland
Salivary Markers in Patients With Xerostomia
The purpose of this study was to investigate the salivary levels of inflammatory and their association with oral health in xerostomía patient
- Trial name
- NCT03156569
- Testing
- Analysis of the saliva
- Where
- 2 sites in Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Xerostomia, Halitosis
Effect of Whitening Agent With Emulsion Gel in Saliva and Halitosis
The objective of this study is to evaluate how well the study product, Crest Daily Whitening Serum, alleviates Xerostomia and perceived halitosis over 1 week of use.
- Trial name
- NCT06194123
- Testing
- Crest Daily Whitening Serum
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Tufts University
Sjogren Syndrome
Intra-Nasal Mechanical Stimulation (INMEST) as a Potential Treatment Method for Sjogren's Syndrome (SS)
The purpose of the study is to investigate the effect and safety of the Walther System delivering INMEST (intranasal mechanical stimulation) on people with Sjogren\'s syndrome.
- Trial name
- A-SS-001 (NCT06626477)
- Testing
- Intra nasal mechanical stimulation treatment (INMEST)
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Abilion Medical Systems AB
Burning Mouth Syndrome, Quality of Life
Effect to the Photobiomodulation in the Burning Mouth Syndrome
Introduction: Burning mouth syndrome (BMS) is a pathology with a low prevalence, affecting between 0.1% and 3.7% of the general population, the ratio between women and men is between 3 and 7:1.
- Conditions
- Burning Mouth Syndrome, Quality of Life, Anxiety Depression, Dry Mouth
- Trial name
- PBM-BMS (NCT05871580)
- Testing
- Low frequency laser activated photobiomodulation, Low frequency laser photobiomodulation inactive
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Sjogren's Syndrome
The Functioning of Immune and Hormonal Systems in Patients With Sjogren's Syndrome and in Healthy Volunteers
This study aims to learn more about how the immune and hormonal systems function in patients with Sjogren's syndrome, a disease in which the immune system does not function properly.
- Trial name
- NCT00001953
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dry Eye Disease, Sjögren Syndrome
Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome
This study will examine the efficacy and safety of tivanisiran sodium eye drops versus vehicle after a 2-week run-in phase when dosed once daily for 3 months in subjects with signs and symptoms of dry eye disease (DED) due to…
- Trial name
- NCT04819269
- Testing
- Tivanisiran sodium ophthalmic solution, Vehicle ophthalmic solution
- Where
- 46 sites in United States, Spain
- Volunteers
- 203 people
- Sponsor
- Sylentis, S.A.
Xerostomia, COVID-19
The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19.A Randomized Controlled Trial.
Coronavirus (COVID-19) is a newly emerging zoonotic agent that emerged in December 2019 in China (2019-nCoV) as a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV -2).
- Conditions
- Xerostomia, COVID-19, Long COVID, Persistent COVID-19
- Trial name
- NCT05760092
- Testing
- Institutional standard treatment for xerostomia and Long Covid, Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Nove de Julho
Sjogren's Syndrome, Oral Health
Oral Health Needs Assessment of Sjogren s Syndrome and Salivary Gland Dysfunction Cohorts and Healthy Volunteers Evaluating Oral Health Disparities as Determinants of Oral Health in a High-Risk Population
Background: A person s dental health depends on many factors. Some are social, economic, or behavioral. Some are environmental. People with Sj(SqrRoot)(Delta)gren s Syndrome have a change in the amount and quality of saliva.
- Trial name
- NCT03327870
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Healthy, Sicca Syndrome
A Longitudinal, Observational Biomarker Study in Participants With Primary Sjogren's Syndrome
The main objective of the study is to characterize the gene expression in immune and epithelial cells in salivary gland biopsy samples and blood of pSS (primary Sjögren's syndrome) and non-pSS participants including healthy…
- Conditions
- Healthy, Sicca Syndrome, Sjögren's Syndrome
- Trial name
- NCT02422407
- Testing
- Biopsy
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Biogen
Keratoconus, Ocular Surface Disease
Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting
EYEdeal Scanning Technology enables rapid measurement of corneal and scleral topography. By accurately measuring the ocular surface with this imaging technology, the current iterative fitting method required to fit PROSE…
- Conditions
- Keratoconus, Ocular Surface Disease, Pellucid Marginal Corneal Degeneration, Ectasia
- Trial name
- NCT04649177
- Testing
- Ocular surface optical coherence tomography
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston Sight
Xerostomia, Sjogren Syndrome
Green Tea Lozenges for the Management of Dry Mouth
The goal of this proposal is to investigate the effectiveness of a Medical College of Georgia patent pending formulation of natural plant extracts on patients with xerostomia.
- Conditions
- Xerostomia, Sjogren Syndrome, Dry Mouth
- Trial name
- NCT01647737
- Testing
- MighTeaFlow, Xylitol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Sjogren's Syndrome, Xerostomia
the Effect of Mixture of Natural Products As Salivary Substitutes in Treatment Of Xerostomia
evaluate the efficacy of natural herbal mixture of aloe vera gel, coconut oil and peppermint in comparison to the carboxy methyl cellulose on xerostomia in a sample of patients with Sjogren's syndrome.
- Trial name
- RCT (NCT04252209)
- Testing
- natural herbs of coconut, aloe vera, and pepperint, carboxy methyl cellulose
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Sjogren's Syndrome, Autoimmune Diseases
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren's Syndrome
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren's Syndrome
- Trial name
- NCT05085431
- Testing
- Assigned Interventions CD19/BCMA CAR T-cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Zhejiang University
Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome (SS)
A Clinical Study of TI-0032-III Injection in Patients With Relapsed and Refractory Autoimmune Diseases
This is an open-label, dose escalation study in patients with relapsed and refractory autoimmune diseases. Study drug, TI-0032-III injection, is composed of lipid nanoparticles (LNPs) targeting T cells that encapsulate circular…
- Conditions
- Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome (SS), Systemic Sclerosis (SSc), Inflammatory Myopathy
- Trial name
- in vivo CAR-T (NCT07413341)
- Testing
- TI-0032-III injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Therorna
Sjogren's Syndrome
A Prospective Pilot Study to Explore Efficacy and Safety of Baricitinib in Active Primary Sjogren's Syndrome Patients
Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease characterized by dysfunction of the exocrine glands, which results in sicca symptoms in affected patients.
- Trial name
- NCT04916756
- Testing
- Baricitinib 2 MG
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Peking Union Medical College Hospital