Clinical trials: XEROSTOMIA, open to volunteers
Meibomian Gland Dysfunction, Dry Eye Syndromes
Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients
This observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy…
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07810569
- Volunteers
- 150 people
- Sponsor
- Assiut University
Systemic Lupus Erythematosus (SLE), Diffuse Systemic Sclerosis
YTS109 in Pediatric Relapsed/Refractory Autoimmune Diseases
This exploratory, single-arm, open-label study will evaluate the safety and preliminary efficacy of YTS109 cell therapy in pediatric patients with relapsed/refractory autoimmune diseases, including systemic lupus erythematosus…
- Conditions
- Systemic Lupus Erythematosus (SLE), Diffuse Systemic Sclerosis, Idiopathic Inflammatory Myopathies (IIMs), ANCA Associated Vasculitis (AAV)
- Trial name
- NCT07439029
- Testing
- YTS109 cell
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Fudan University
Xerostomia
d-Limonene +Radiation +PlatinumBasedChemo for Xerostomia Prevention in LocallyAdvanced HNSCC
This study explores the safety of d-limonene, a commercially-available dietary supplement (food) as a potential therapeutic for the severe dry mouth (xerostomia) experienced by patients with head and neck cancer as a side effect…
- Trial name
- NCT04392622
- Testing
- D-Limonene Gelcaps, Intensity modulated radiotherapy (IMRT), Cisplatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Rheumatoid Arthritis, Systemic Lupus Erythematosus
A Trial in Healthy Adult Participants and Adults With Autoimmune Diseases to Test How HBM7020 is Tolerated and How it Behaves in the Body
This first-in-human study evaluates the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of HBM7020.
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis, Sjögren's Disease
- Trial name
- NCT07649265
- Testing
- HBM7020
- Where
- Australia
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Refractory Rheumatoid Arthritis (RA), Idiopathic Inflammatory Myopathies (IIMs)
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
A Basket Trial of Refractory Rheumatoid Arthritis (RA), Sjögren's Disease (SjD), Idiopathic Inflammatory Myopathies (IIMs) and Systemic Sclerosis (SSc) subjects to evaluate the safety and efficacy of AlloNK, a non-genetically…
- Conditions
- Refractory Rheumatoid Arthritis (RA), Idiopathic Inflammatory Myopathies (IIMs), Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA
- Trial name
- NCT06991114
- Testing
- Allogeneic NK Cells
- Where
- 52 sites in United States, Brazil and 9 more
- Volunteers
- 90 people
- Sponsor
- Artiva Biotherapeutics, Inc.
Systemic Lupus Erythematosus, Inflammatory Myopathy
BCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases
The objective of this study is to evaluate the efficacy and safety of BCMA/CD19 chimeric antigen receptor (CAR)-modified T cells in the treatment of autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Inflammatory Myopathy, Systemic Sclerosis (SSc), ANCA-associated Vasculitis
- Trial name
- NCT06794008
- Testing
- BCMA-CD19 CAR-T therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Nasopharyngeal Carcinoma ,Xerostomia,Radiotherapy
Xerostomia-optimised IMRT Versus Standard IMRT in NPC
This is a multi-center, non-inferiority, open-label, randomized controlled phase III clinical trial in primary diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis.
- Trial name
- NCT06282497
- Testing
- Optimised neck CTV, standard neck CTV
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome
Universal CAR-T Cells (BRL-301) in Relapse or Refractory Autoimmune Diseases
This is an investigator initiated trial to assess the efficacy and safety of BRL-301 in the relapse or refractory autoimmune diseases of China.
- Conditions
- Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome, Systemic Sclerosis, Inflammatory Myopathy
- Trial name
- NCT05859997
- Testing
- BRL-301
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Bioray Laboratories
Radiation-Induced Xerostomia and Hyposalivation
Study of Circular RNA Treatment in Patients With Radiation Induced Xerostomia-1
This is a first-in-human clinical study to evaluate the safety, tolerability and efficacy of RXRG001 administered in the ducts of the parotid glands in adult patients with radiation-induced xerostomia (dry mouth) and…
- Trial name
- SPRINX-1 (NCT06714253)
- Testing
- RXRG001
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- RiboX Therapeutics Ltd.
Sjögren's Syndrome
Exosomes in Patients With Ocular Involvement of Sjögren's Syndrome
This study is a single-center, multiple-dosing, prospective, nonrandom, single-arm trial.
- Trial name
- NCT07192666
- Testing
- Exosome Preparation
- Volunteers
- 12 people
- Sponsor
- Guangdong ProCapZoom Biosciences Co., Ltd.
Xerostomia, Graft-versus-host-disease
Dose-Escalation Trial of Mesenchymal Stromal Cells in Patients With Medical Xerostomia
The goal of this clinical trial is to evaluate the safety and tolerability of injecting certain cells produced in bone marrow called mesenchymal stromal cells (MSCs) into salivary glands.
- Conditions
- Xerostomia, Graft-versus-host-disease, Sjogren's Disease
- Trial name
- NCT06392711
- Testing
- Mesenchymal Stromal Cells (MSC) Dose Level 0, Mesenchymal Stromal Cells (MSC) Dose Level 1
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Wisconsin, Madison
Xerostomia Following Radiotherapy
The Effect of Ozone on Salivary Flow in Patients With Xerostomia and Hyposalivation After Radiotherapy (OZONEXEROSTOMI)
Patients who underwent head and neck radiotherapy and developed xerostomia and/or hyposalivation will be selected. The patients will be randomly assigned into two groups, defined as control and treatment.
- Trial name
- ozonexerostomi (NCT07571356)
- Testing
- Ozone therapy
- Volunteers
- 100 people
- Sponsor
- University of Brasilia
Xerostomia Due to Radiotherapy (Disorder)
Screening of Biomarkers and Related Mechanisms for RIX
A large number of patients undergoing radiotherapy and chemotherapy are suffering from dry mouth. Due to reduced saliva secretion, patients may experience symptoms such as difficulty chewing and swallowing.
- Trial name
- RIX (NCT07170358)
- Testing
- Radiation Therapy
- Where
- 4 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Systemic Lupus Erythematosus, Rheumatoid Arthritis (RA)
A Phase 1 Study of QLS2416 Injection in Participants With Autoimmune Diseases
The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity, and efficacy of QLS2416 injection in participants with autoimmune diseases (AID).
- Conditions
- Systemic Lupus Erythematosus, Rheumatoid Arthritis (RA), Primary Sjögren's Syndrome (pSS), Systemic Sclerosis (SSc)
- Trial name
- NCT07906145
- Testing
- QLS2416 Injection
- Volunteers
- 76 people
- Sponsor
- Shanghai Qilu Pharmaceutical Research and Development Center LTD
Head and Neck Neoplasms, Xerostomia
Foot Reflexology and Ta-VNS for Symptom Management in Head and Neck Cancer During CCRT
Head and neck cancer (HNC) patients undergoing concurrent chemoradiotherapy (CCRT) frequently experience pain, xerostomia, fatigue, sleep disturbance, and other treatment-related toxicities that impair quality of life and…
- Conditions
- Head and Neck Neoplasms, Xerostomia, Cancer-related Fatigue, Pain
- Trial name
- NCT07711626
- Testing
- True Foot Reflexology, True ta-VNS, True Auricular Acupressure
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Tzu Chi University
Oral Malodor (Halitosis), Oral Dryness
Effects of a 50+ Toothpaste on Halitosis and Oral Comfort in Healthy Adults
The goal of this clinical trial is to compare a toothpaste designed for adults aged 50 years and older with a standard toothpaste in orally healthy adults.
- Trial name
- HALI-50PLUS (NCT07780474)
- Testing
- 50+ Toothpaste, Standard Fluoride Toothpaste
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Sjogren Syndrome, Healthy Volunteers
"Core Stabilization Strenght and Pelvic Floor Functions in Primary Sjogren's"
This study aims to explain the comparison of core stabilization strength and pelvic floor functions between individuals diagnosed with Sjogren syndrome and a healthy control group. (Sjogren syndrome group n=27; control group n=27)
- Trial name
- NCT06879444
- Testing
- Core Muscle testing and patient reported outcome measures
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Xerostomia Due to Hyposecretion of Salivary Gland
Hyaluronic Acid in the Treatment of Hyposalivation
The goal of this clinical trial is to learn if drug containing non-crosslinked hyaluronic acid and amino acids solution (Sunecos-200) works to treat hyposalivation in adults.
- Trial name
- NCT07309588
- Testing
- Sunecos-200 Injectable Hyaluronic acid and amino acids solution
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Type 2 Diabetes, Obesity & Overweight
Effects of GLP-1 Receptor Agonists on Saliva and Oral Health
This study aims to evaluate the effects of GLP-1 receptor agonists (GLP-1RA) on salivary parameters and oral health in individuals who will use this medication for the first time due to a diagnosis of Type 2 diabetes and/or…
- Conditions
- Type 2 Diabetes, Obesity & Overweight, Xerostomia, Dental Caries
- Trial name
- NCT07818226
- Testing
- GLP-1 Receptor Agonists
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kırıkkale University