Clinical trials: Xenotransplantation
Alveolar Ridge Deficiency
Horizontal Ridge Augmentation With Demineralized Bone Allograft Layered With Xenograft - a Prospective Clinical Study
The aim of this case series is to evaluate the outcomes of horizontal ridge augmentation performed using a combination of demineralized freeze-dried bone allograft layered with xenograft bone with a resorbable native collagen…
- Trial name
- NCT06342973
- Testing
- Xenograft and allograft
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Hopeless Teeth
Xenograft with or Without Erythropoietin in Immediate Dental Implant
The aim of this study is to evaluate changes in buccal bone thickness after immediate implant placement with xenograft mixed with erythropoietin in the anterior maxilla with a thin buccal bone
- Trial name
- NCT06601400
- Testing
- Erythropoietin (EPO) with xenograft, Xenograft alone
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
AML - Acute Myeloid Leukemia
Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX
The goal of this observational study is to develop new ways to test new drug combinations to kill tumour cells, in patients with acute myeloid leukemia (AML).
- Trial name
- COSMOS-Avatar (NCT06782971)
- Where
- 4 sites in Australia
- Volunteers
- 25 people
- Sponsor
- Clinical Hub for Interventional Research (CHOIR)
Tooth Extraction
The Effect of Alveolar Ridge Preservation After Tooth Extraction in the Posterior Maxilla
This study is designed to assess the effects of Alveolar Ridge Preservation (ARP) after tooth extraction compared to extraction alone in the posterior maxilla.
- Trial name
- NCT02952209
- Testing
- Xenograft
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
End Stage Renal Disease
Study of ChoironeX GalKO Porcine Thymokidney Xenotransplantation in End-Stage Renal Disease
The goal of this clinical trial is to learn if a GalKO Porcine Thymokidney can maintain renal function, without the need for dialysis, after transplantation into adult subjects with End Stage Renal Disease.
- Trial name
- NCT07696962
- Testing
- ChoironeX GalKO Porcine Thymokidney
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Xeno Holdings (US), LLC dba ChoironeX
Bone Loss in Jaw
Demineralized Bone Allograft Fibers Versus Particulate In Sinus Augmentation
The purpose of this clinical trial is to assess if the addition of DFDBA fibers to DBBM results in greater vital bone formation than the addition of DFDBA particles to DBBM.
- Trial name
- NCT06173791
- Testing
- DFDBA fibers, DFDBA particles, DBBM
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Upper Urinary Tract Urothelial Carcinoma, Nephroureterectomy
New Models for the Evaluation of Preclinical Treatment for Urothelial Carcinomas of the Upper Excretory Tract.
Upper Urinary Tract Urothelial Carcinomas are rare, aggressive tumors, accounting for 5 to 10% of all urothelial tumors. These include tumors which develop in the renal cavities (renal pelvis, calices) and ureteral tumors.
- Conditions
- Upper Urinary Tract Urothelial Carcinoma, Nephroureterectomy, Tumor, Xenograft Model
- Trial name
- CICLOP (NCT04944550)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Prostheses, Endosseous Dental Implant Failure
Pink Esthetic Score Around Immediate Implants Using PDDM as Jumping Gap Filling Material.
Will there be a difference in Pink Esthetic score and soft tissue changes around immediate implants in maxillary esthetic zone following grafting the jumping gap with partially demineralized dentin matrix compared with xenograft?
- Trial name
- NCT05952765
- Testing
- Immediate implant
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Malignant Melanoma, Head and Neck Cancer
Tissue and Hematopoietic/Mesenchymal Stem Cell for Humanized Xenograft Studies in Melanoma and Squamous Head and Neck Cancer
The overall goal of this study is to develop a pre-clinical platform of melanoma and head and neck squamous cell cancer that will allow the investigators to learn more about these diseases and discover better and more…
- Trial name
- NCT02331134
- Testing
- Filgrastim
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Colorado, Denver
Bone Resorption, Alveolar Bone Loss
Autogenous Bone Mixed With Xenograft Versus Xenograft Alone Versus Absorbent Gelatin Sponge
Alveolar bone atrophy post-extraction has been well documented in the past years. normal healing event results in a minimal loss of vertical height (around 1 mm), but a substantial loss of width in the buccal-lingual plane (4-6…
- Conditions
- Bone Resorption, Alveolar Bone Loss, Alveolar Bone Resorption, Bone Graft Failure
- Trial name
- NCT03584984
- Testing
- Mixture of Autogenous bone & Anorganic Bovine Bone (ABB), Anorganic Bovine Bone (ABB), Absorbable gelatin sponge
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sticky Bone
Guided Bone Regeneration Using a Mixture of Autogenous and Xenograft Particulate Versus Patient-Specific Sticky Bone for Horizontal Anterior Maxillary Defect
This study aims to enhance healing while minimizing invasiveness and restoring tissues to their proper structure and function by using patient specific sticky bone that will enhance the soft tissue reaction and maintain the graft…
- Trial name
- NCT07113886
- Testing
- Mixture of Autogenous and Xenograft Particulates, Patient-Specific Sticky Bone
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Sinus; Dental
Hyaluronic Matrix Efficacy for Maxillary Sinus Augmentation
Sinus augmentation is a predictable method when alveolar bone height is not sufficient for dental implant placement in posterior maxillary alveolar region..The aim of this prospective, randomized, controlled clinical study is…
- Trial name
- NCT02692261
- Testing
- Maxillary Sinus Augmentation
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Corneal Transplantation
Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea
The performance of keratoplasty is hampered by the limited availability of donor cornea in many countries, especially in Asia. For this reason, attempts have been made to fabricate artificial substitutes for natural human cornea.
- Trial name
- NCT03105466
- Testing
- Deep anterior lamellar keratoplasty, Acellular Porcine Cornea, Tacrolimus eye drops
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Badly Broken Maxillary Premolars Indicated for Extraction
Immediate Implants in Maxillary Premolar Region Using Xenograft vs Allograft
Immediate implant placement has the disadvantage of difficulty in obtaining primary stability, lack of adequate soft tissue coverage and also the control of the implant position is difficult in addition to the cost of the graft.
- Trial name
- NCT03716323
- Testing
- immediate premolar implant with xenograft and allograft
- Volunteers
- 42 people
- Sponsor
- Cairo University
Pharmacokinetics Study in de Novo Kidney Transplantation
Comparison of a Tacrolimus Hexal® Based Regimen Versus a Prograf® Based Regimen in de Novo Renal Transplant Recipients
The purpose of this study was to investigate if Tacrolimus Hexal® has similar pharmacokinetic properties compared to Prograf® in de novo renal transplant patients and whether the comparable exposure resulted in similar renal…
- Trial name
- Spartacus (NCT01649427)
- Testing
- Prograf, Tacrolimus Hexal
- Where
- 5 sites in Germany
- Volunteers
- 73 people
- Sponsor
- Novartis Pharmaceuticals
Periodontal Intrabony Defects
DFDBA and Xenograft (Cerabone)TM With Decortication in Intrabony Defects
DFDBA is an allograft that possesses osteoconductive and osteoinductive properties. It has the potential for osteoinduction due to increased expression of bone morphogenetic protein (BMP).Cerabone™ has shown maximum resemblance…
- Trial name
- NCT02949557
- Testing
- Decortication + bone grafts
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Socket Preservation
Radiographic and Histomorphometric Evaluation of Xenograft as a Socket Preservation Material in Maxillary Posterior Teeth.
Radiographic and Histomorphometric Evaluation of Xenograft as a Socket Preservation Material in Maxillary Posterior Teeth: A Randomized-Controlled Clinical Study
- Trial name
- NCT07250256
- Testing
- S1-XB, Control (Standard treatment)
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Peri-implant Bone and Soft Tissues
Dimensional Changes of Peri-implant Tissues Following Jumping Gap Grafting Using Erythropoietin Gel Mixed With Xenograft.
This study will be conducted to compare the effect of Erythropoietin gel mixed with xenograft versus xenograft alone in grafting the jumping gap around immediate implant.
- Trial name
- NCT07523412
- Testing
- Erythropoetin gel mixed with xenogenic bone graft, Xenogenic bone with gelling aget CMC ( carboxymethyl cellulose)
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Ain Shams University
Deep Full-thickness Burn Injury (Disorder)
Evaluation of Safety and Efficacy of realSKIN® (Skin Xenotransplant) for Complete Closure of Severe Burn Wounds
This is a Phase 1/2, Open-label, Multi-center, Clinical Trial to evaluate the safety, tolerability, and efficacy of realSKIN® to provide complete wound closure of severe and extensive deep-partial and full-thickness burn wounds.
- Trial name
- NCT03695939
- Testing
- realSKIN (skin xenotransplant), Human Cadaver Allograft
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- XenoTherapeutics, Inc.
Posterior Maxillary Atrophy, Maxillary Sinus Augmentation
Comparison of Allograft, Xenograft and Combined Grafting in Maxillary Sinus Augmentation
This prospective randomized clinical study evaluates and compares three different grafting approaches (allograft, xenograft, and combined grafting) used in lateral maxillary sinus augmentation prior to dental implant placement.
- Trial name
- SINUS-GRAFT (NCT07407361)
- Testing
- Lateral Maxillary Sinus Augmentation with Allograft, Lateral Maxillary Sinus Augmentation with Xenograft, Lateral Maxillary Sinus Augmentation with Combined Graft
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Tokat Gaziosmanpasa University