Clinical trials: Xenotransplantation
Missing Maxillary Anterior Teeth
Poly Tetra Fluro Ethylene vs Native Collagen Membrane for Gbr in Anterior Maxilla
evaluation of amount of bone gained in the anterior maxilla using collagen membranes vs ptfe membrane while using a 1:1 mix of xenograft and autogenous bone
- Trial name
- NCT03839615
- Testing
- guided bone regenerations
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Urothelial Carcinoma
EGCG Modulate the Cytotoxic Effects of Chemotherapeutic Agents in Human Urothelial Carcinoma Cells
Urothelial carcinoma (UC) is the most common cancer of urinary tract. Patients with metastatic UC are usually treated with systemic chemotherapy.
- Trial name
- NCT01993966
- Where
- 2 sites in Taiwan
- Volunteers
- 25 people
- Sponsor
- National Taiwan University Hospital
Gingival Recession, Xenograft Model
Two Different Surgical Techniques for the Treatment of Multiple Gingival Recessions With Porcine Collagen Matrix
The gold standard for gingival recession treatment is the coronal repositioning of the flap associated with the subepithelial connective tissue graft.
- Conditions
- Gingival Recession, Xenograft Model, Gingival Recession, Generalized
- Trial name
- NCT03619096
- Testing
- tunnel technique for Root coverage with Porcine collagen Matrix, extended fla technique for Root coverage with Porcine collagen Matrix
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Genito Urinary Cancer, Bladder Cancer
Reconstitution of a Human Immune System in a Patient Derived Xenograft (PDX) Model of Genitourinary (GU) Cancers
The objective of this study is to obtain human blood CD34+ hematopoietic stem/progenitor cells (HSPCs) to reconstitute a match human immune system in our PDX model.
- Conditions
- Genito Urinary Cancer, Bladder Cancer, Kidney Cancer, Prostate Cancer
- Trial name
- Immune PDX (NCT03134027)
- Testing
- Bone marrow biopsy, Tumor biopsy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Duke University
Sticky Bone
Guided Bone Regeneration Using a Mixture of Autogenous and Xenograft Particulate Versus Patient-Specific Sticky Bone for Horizontal Anterior Maxillary Defect
This study aims to enhance healing while minimizing invasiveness and restoring tissues to their proper structure and function by using patient specific sticky bone that will enhance the soft tissue reaction and maintain the graft…
- Trial name
- NCT07113886
- Testing
- Mixture of Autogenous and Xenograft Particulates, Patient-Specific Sticky Bone
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Alveolar Bone Loss, Tooth Extraction Status Nos
Assessment of Labial Plate Thickness After Immediate Implant Placement Using Two Different Xenografts in the Esthetic Zone
This randomized clinical trial aims to evaluate labial bone plate changes following immediate implant placement in Type II extraction sockets using two different xenograft materials and de-epithelialized free gingival graft in…
- Conditions
- Alveolar Bone Loss, Tooth Extraction Status Nos, Immediate Implant Placement
- Trial name
- NCT07449806
- Testing
- Immediate Implant Placement with Medpark S1 xenograft, Immediate Implant Placement with bio-Oss xenograft
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Basma Gamal Mohamed Ahmed
Bone Resorption Disorder
Guided Bone Regeneration in Atrophic Anterior Maxillary Ridges
This study is aiming to evaluate clinically, radiographically ,and histologically GBR using collagen membrane in combination with a mixture of ABBM and autogenous particulated bone compared to collagen membrane with ABBM in…
- Trial name
- NCT03731416
- Testing
- GBR by xenograft and autogenous bone
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Badly Broken Down Vital Teeth
Immediate Implant Placement With Deproteinized Bovine Bone vs Deproteinized Bovine Bone With HAM Gel
Statement of the problem: Immediate implant placement is faced with several problems. One of the most important is the jumping gap present after implant placement and whether it needs to be augmented or not.
- Trial name
- NCT06916026
- Testing
- Xenograft, Xenograft mixed with HAM gel.
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Knee Injuries
Clinical Evaluation of dCELL® ACL Scaffold for Reconstruction of the Anterior Cruciate Ligament
The safety and performance of dCELL® ACL Scaffold will be evaluated in 40 patients who have been implanted with the investigational product following a ruptured anterior cruciate ligament (ACL) of the knee.
- Trial name
- NCT02540811
- Testing
- dCELL® ACL Scaffold
- Where
- 8 sites in Poland, Spain and 1 more
- Volunteers
- 40 people
- Sponsor
- Tissue Regenix Ltd
Alveolar Bone Resorption, Edentulous Alveolar Ridge
Ridge Preservation Using Xenogenic Bone Graft and Pre-hydrated Collagen Membrane
This pilot multicentric randomized controlled clinical trial is aimed at evaluating the composition of the new-formed tissue into the dental socket after 6 months from tooth extraction and the application of a combination of…
- Trial name
- NCT04955873
- Testing
- Treatment of the dental extraction socket using newly-released biomaterials, Treatment of the dental extraction socket using well-known biomaterials
- Where
- 5 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Fondazione Bruno Kessler
Dental Implant
Mucograft Seal in ARP Follow-up
Rationale: Early implant placement with alveolar ridge preservation (ARP) using either a collagen matrix or a palatal graft rendered similar esthetic, clinical and PROMs to early implant placement without ARP, up to 1 year after…
- Trial name
- NCT05663385
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Erasmus Medical Center
Furcation Defects
Surgical Treatment of Mandibular Furcations Using a Xenograft With/Without a Collagen Membrane
The aim of the study was to perform a randomized controlled clinical study in order to compare the effects of a bovine derived xenograft (with 10% collagen) + a bioabsorbable membrane (control group, CG) vs a bovine derived…
- Trial name
- NCT03354182
- Testing
- Open flap surgery, Bio-oss collagen, Bio-gide
- Volunteers
- 19 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Autogenous Demineralized Dentin, Xenograft Bone Graft
Clinical and Radiographic Assessment of Socket Preservation Using Autogenous Demineralized Dentin Matrix Versus Xenograft
Total of 40 participants were planned for enrollment for socket preservation, 20 in the Autogenous Demineralized Dentin group and 20 in the Xenograft group these materials used for socket preservation after extraction.
- Trial name
- NCT07777588
- Testing
- Autogenous Demineralized Dentin, application of xenograft
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Maxillary Sinus
Comparison Between PEEK With Autogenous Bone Graft and PEEK With Xenograft in Maxillary Sinus Augmentation
Comparison Between PEEK With Autogenous Bone Graft and PEEK With Xenograft in Maxillary Sinus Augmentation
- Trial name
- NCT06521853
- Testing
- PEEK With Autogenous Bone Graft, PEEK With Xenograft
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Localized Aggressive Periodontitis
Nigella Sativa Oil Extract and Xenograft Bone Graft in Treatment of Infra-bony Defects
The aim of this study will be to evaluate, clinically, and radiographically the effect of Nigella Sativa oil extract Mixed with xenograft versus xenograft alone in the treatment of intra-bony defects in patients with aggressive…
- Trial name
- NCT04722380
- Testing
- periodontal regenerative surgery
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tanta University
Multiligament Knee Injuries
OrthoPureXT Multiligament PMCF Study
To monitor residual risks in the post-market phase and to ensure continued clinical evaluation of the device safety and performance to ensure that no new or unexpected risks arise when used during multi-ligament knee…
- Trial name
- NCT05655156
- Testing
- OrthoPure XT
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Tissue Regenix Ltd
Burns
Use of Nile Tilapia Fish Skin as a Xenograft for Burn Treatment: Phase III Study
The present study is a Phase III Randomized Clinical Trial aiming to evaluate the efficacy of Nile tilapia (Oreochromis niloticus) skin as an occlusive biological dressing in the treatment of superficial partial-thickness burns…
- Trial name
- NCT04202289
- Testing
- Nile Tilapia Fish Skin, Silver Sulfadiazine Cream 1%
- Where
- 2 sites in Brazil
- Volunteers
- 115 people
- Sponsor
- Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara
Tooth Loss
Comparison of Dimensional Changes After Tooth Extractions Between Xenograft and Allograft
To compare dimensional changes in extraction socket of single rooted teeth, 6 months post extraction, when grafted with xenograft versus allograft.
- Trial name
- PilotXenAllo (NCT04550689)
- Testing
- Bone graft
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- UConn Health
Closed Sinus Lift, Apigenin Loaded Scaffold
Closed Sinus Lifting Using Xenograft With or Without Liposomal Apigenin-Loaded Scaffold
aims to evaluate the effectiveness of closed sinus lifting using xenograft with or without a liposomal Apigenin-loaded scaffold in the posterior maxilla.
- Trial name
- NCT07678749
- Testing
- sinus lifting
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University