Clinical trials: Xenotransplantation
Gingival Recession
Clinical and Histomorphometric Analysis of Collagen Matrix Versus Connective Tissue Graft in Mucogingival Surgery in Orthodontic Patients
There are some orthodontics treatments that perform risk movements ,and a bone dehiscence may be expected. In that cases mucogingival surgery , such as connective tissue grafts, is necessary prior to tooth movement.
- Trial name
- NCT03533933
- Testing
- Collagen matrix, autologous connective tissue graft
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Elena Ruiz de Gopegui Palacios
Socket Shield
Comparison of Peri-implant Tissues Using Socket Shield Technique Versus Xenograft
The aim of this study is to clinically and radiographically evaluate the dimensional changes of soft and hard peri-implant tissues around single immediate post-extraction implants in the esthetic zone.
- Trial name
- NCT03684356
- Testing
- socket shield technique, xenograft
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Symphysis Onlay Bone Graft, Platelet Rich Fibrin
Effect of Symphysis Onlay Bone Graft, Injectable Platelet Rich Fibrin (I-PRF) and Xenograft on Horizontal Alveolar Ridge Augmentation in Esthetic Zone
The aim of the study: was to evaluate whether mandibular symphysis Onlay autogenous bone graft mixed with Injectable PRF could offer any advantages for patients undergoing horizontal alveolar ridge widening regarding increase…
- Conditions
- Symphysis Onlay Bone Graft, Platelet Rich Fibrin, Xenograft, Horizontal Alveolar Ridge Augmentation
- Trial name
- NCT06388837
- Testing
- Injectable Platelet Rich Fibrin, Xenograft
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- October 6 University
Socket Preservation
Sticky Bone vs Xenograft With Cross-linked Hyaluronic Acid in Socket Preservation
The present study aimed to evaluate clinical and radiographic outcomes of sticky bone in comparison to crosslinked hyaluronic acid mixed with xenograft in alveolar ridge preservation.
- Trial name
- NCT06983015
- Testing
- sticky bone, xenograft mixed with cross-linked hyaluronic acid
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Atrophic Anterior Maxillary Ridges
Horizontal Ridge Reconstruction of Atrophic Anterior Maxillary Ridges Using Customized Xenograft Bone Shell With 1 :1 Mixture of Autogenous and Xenograft Bone Particulate
Using customized Xenograft bone shell with mixture of autogenous and xenograft particulate in modified cortical shell technique. by 3D printed model from The CT scans segmentation by special software
- Trial name
- NCT04075942
- Testing
- Atrophic Anterior Maxillary Ridges
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Manal Ahmed Hassan Ahmed
Tooth Extraction, Socket Preservation
Injectable Platelet-rich Fibrin and Advanced Platelet-rich Fibrin With Xenograft on the Socket Preservation of Mandibular Extracted Molars
Different materials and techniques are employed for socket preservation to reduce the alveolar bone resorption in both the horizontal and vertical dimensions as well as the soft tissue collapse after tooth extraction.
- Trial name
- NCT06936358
- Testing
- Control, A-PRF, I-PRF
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Hams Hamed Abdelrahman
Pancreatic Cancer, Liver Metastases
A Study of Pancreatic Cancer in Xenografts From Liver Metastases
This is a feasibility study to perform image-guided liver biopsies in 25 patients who have pancreatic cancer with liver metastasis (cancer in the pancreas that has spread to the liver).
- Conditions
- Pancreatic Cancer, Liver Metastases, Tumor Tissue Biopsy, Blood Samples
- Trial name
- NCT01774643
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University Health Network, Toronto
Socket Preservation, Alveolar Ridge Preservation
Evaluation of the Effectiveness of the Socket Preservation Technique Using Allogeneic and Xenogeneic Materials
Tooth extraction is among the most common dental treatments. The procedure results in the formation of a bone defect. During the healing phase, the vertical and horizontal diameters of the alveolar ridge decrease, which has a…
- Conditions
- Socket Preservation, Alveolar Ridge Preservation, Xenograft, Allograft
- Trial name
- NCT07565558
- Testing
- Socket preservation with xenograft, Socket preservation with allograft
- Where
- 2 sites in Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Silesia
Knee Injuries
Clinical Evaluation of dCELL® Meniscus for Partial Replacement of the Meniscus
The safety and performance of dCELL® Meniscus will be evaluated in 60 patients after partial replacement of the native medial or lateral meniscus with the investigational product.
- Trial name
- NCT02270905
- Testing
- dCELL® Meniscus
- Where
- 4 sites in Poland, United Kingdom
- Volunteers
- 32 people
- Sponsor
- Tissue Regenix Ltd
Class II Furcation Defect
Enamel Matrix Derivative and Xenograft for Mandibular Molar Furcation Defects
This randomized controlled clinical trial aims to compare two regenerative surgical approaches for the treatment of mandibular molar Class II furcation defects in patients with periodontitis.
- Trial name
- NCT07776756
- Testing
- Periodontal Regenerative Surgery With Xenograft and Enamel Matrix Derivative, Periodontal Regenerative Surgery With Xenograft and Collagen Membrane
- Where
- Vietnam
- Volunteers
- 24 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Type 1 Diabetes
Open-label Investigation of the Safety and Effectiveness of DIABECELL(R) in Patients With Type I Diabetes Mellitus
The purpose of this study is to establish the safety of xenotransplantation of DIABECELL(R)[immunoprotected (alginate-encapsulated) porcine islets] in patients with established type 1 diabetes mellitus, and to establish…
- Trial name
- NCT00940173
- Testing
- DIABECELL(R)
- Where
- New Zealand
- Volunteers
- 16 people
- Sponsor
- Diatranz Otsuka Limited
Connective Tissue Graft, Volume Collagen Matrix Xenograft
Volumetric Dimensional Changes After Surgical Pontic Site Development Procedures With Connective Tissue Graft or Collagen Matrix
The aim of this research project is to compare two surgical procedures to improve soft tissue volume. Both procedures have already been validated, but despite their great clinical relevance, little data exists in the literature.
- Trial name
- NCT06335628
- Testing
- Geistlich Fibro-Gide®
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Bern
Metastatic Non-Small Cell Lung Carcinoma
Pembrolizumab for Metastatic NSCLC Patients Expressing PD-L1 Who Have Their Own PDX
This is a single center, open-label, single arm study in patients with metastatic non-small cell lung cancer (NSCLC) expressing PD-L1 after failure of platinum-based combination chemotherapy.
- Trial name
- NCT03134456
- Testing
- Pembrolizumab Injection
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center
Periodontal Diseases, Periodontal Bone Loss
Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth.
This study was performed to investigate the adjunctive clinical benefit of the application of enamel matric derivatives and xenograft with the modified minimally invasive surgical technique in the treatment of isolated intrabony…
- Trial name
- NCT07310732
- Testing
- modified minimally invasive surgical technique, modified minimally invasive surgical technique plus emdogain, modified minimally invasive surgical technique plus emdogain and xenograft
- Where
- India
- Volunteers
- 45 people
- Sponsor
- Rungta College of Dental Sciences and Research
Alveolar Ridge Deficiency
Ridge Preservation Comparing 2 Membranes
The purpose of this study is to compare the clinical and histologic outcomes for acellular dermal matrix and a nonresorbable membrane to determine if either provides a significant therapeutic advantage.
- Trial name
- NCT01905280
- Testing
- Non-resorbable membrane, Acellular dermal matrix
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Impacted Mandibular Third Molar Extraction, Dentin Graft
Autologous Dentine Graft Compared to Xenograft in Managing Periodontally Compromised Second Molar After Third Molar Removal
The goal of this study is to evaluate the efficacy of autologous dentin graft (ADG) in treating periodontal defects on the distal aspect of mandibular 2nd molar (M2) after surgical removal of impacted mandibular 3rd molar (M3) by…
- Conditions
- Impacted Mandibular Third Molar Extraction, Dentin Graft, Xenograft, Bone Defects
- Trial name
- NCT07362394
- Testing
- Autologous dentin graft, Xenograft
- Where
- Malaysia
- Volunteers
- 34 people
- Sponsor
- National University of Malaysia
Triple Negative Breast Cancer
Patient-derived Xenograft (PDX) Modeling of Treatment Response for Triple Negative Breast Cancer
This study will determine if patient-derived tumor xenograft (PDX) mouse models can serve as a reliable model for treatment response for individual patients with triple negative breast cancer.
- Trial name
- NCT02247037
- Testing
- Chemotherapy
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Squamous Cell Carcinoma of the Head and Neck
Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer
The investigators want to have a collection of fresh primary or recurrent tumor tissue for establishment of patients-derived xenografts in order to: generate a biobank of in vivo patient xenografts representing the different…
- Trial name
- UCL-Xenog (NCT02572778)
- Testing
- Local biopsy in the tumor
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Alveolar Ridge Preservation
Polynucleotide-Hyaluronic Acid Gel With Xenograft for Alveolar Ridge Preservation
This randomized controlled clinical trial will evaluate the efficacy of polynucleotide-hyaluronic acid gel combined with xenograft and collagen membrane for alveolar ridge preservation following tooth extraction.
- Trial name
- NCT07771257
- Testing
- Polynucleotide-Hyaluronic Acid Gel With Xenograft, Xenograft With Collagen Membrane
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Alveolar Bone Loss, Tooth Extraction Status Nos
Assessment of Labial Plate Thickness After Immediate Implant Placement Using Two Different Xenografts in the Esthetic Zone
This randomized clinical trial aims to evaluate labial bone plate changes following immediate implant placement in Type II extraction sockets using two different xenograft materials and de-epithelialized free gingival graft in…
- Conditions
- Alveolar Bone Loss, Tooth Extraction Status Nos, Immediate Implant Placement
- Trial name
- NCT07449806
- Testing
- Immediate Implant Placement with Medpark S1 xenograft, Immediate Implant Placement with bio-Oss xenograft
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Basma Gamal Mohamed Ahmed