Clinical trials: Xerostomia
Xerostomia Following Radiotherapy
MSC in Patients With Xerostomia Post XRT in Head and Neck Cancer
This is a single center pilot study designed to determine the safety and tolerability of autologous bone marrow-derived Mesenchymal Stromal Cells (MSCs) in patients with xerostomia (dry mouth) after undergoing radiation therapy…
- Trial name
- NCT04489732
- Testing
- Autologous bone-marrow derived, interferon gamma stimulated mesenchymal stromal cells
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Wisconsin, Madison
Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery
Does Craniosacraltherapy Combined With Exercises That Focuses om Respiration and Posture in the Upper Body Have an Effect on Xerostomia and Other Late Sequelae on People Who Has Been Suffering From Cancer in Mouth and Throat?
The current study aims to assess the efficacy of manual treatment with craniosacral therapy of fascial tissue in throat, neck, cranial and mouth region, on radiation and/or surgery-induced salivary gland hypofunction and…
- Conditions
- Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery, Other Late Sequelae Following Radiotherapy and Cancer Surgery in Neck or Head
- Trial name
- NCT05882890
- Testing
- Craniosacral Therapy, Exercices Targeting Upper Posture and Respiration
- Where
- 2 sites in Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cathrine Rahbek
Radiation-Induced Xerostomia, Head and Neck Cancer
Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer
This study is being done to find out what effects, good and/or bad, acupuncture has on participants and their xerostomia caused by radiation therapy for the treatment of the cancer.
- Conditions
- Radiation-Induced Xerostomia, Head and Neck Cancer, Radiation Toxicity, Oral Complications of Chemotherapy and Head/Neck Radiation
- Trial name
- ACUPUNCTURE (NCT02589938)
- Testing
- Standard Oral Hygiene, Standard Oral Hygiene + True Acupuncture
- Where
- 36 sites in United States
- Volunteers
- 258 people
- Sponsor
- Wake Forest University Health Sciences
Sjogren's Syndrome
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren's Syndrome
Background: An autoimmune disease is one in which the immune system attacks a person's own body. Sjogren's syndrome (SS) is an autoimmune disease. It often involves multiple systems and organs of the body.
- Trial name
- NCT04496960
- Testing
- tofacitinib
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Squamous Cell Carcinoma of the Head and Neck
Margin-Based Vs. Robust Photon Radiotherapy Planning in IMRT of HN-SQCC
This is a research study to evaluate the quality of life and amount of dry mouth experienced as a result of radiotherapy in subjects who have squamous cell carcinoma of the head and neck (HN-SQCC).
- Trial name
- NCT03552965
- Testing
- Robust Radiotherapy planning, Margin-Based Radiotherapy planning
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Arkansas
Dry Mouth, Xerostomia
Clinical Evaluation of MucoPEG™ for Xerostomia
The purpose of this study is to evaluate the effectiveness of the oral rinse comparing to MucoPEG™ and Biotene®. This is a randomized open-label crossover study with 42 patients receiving treatment.
- Trial name
- CEMPEG (NCT04986501)
- Testing
- MucoPEG, Biotene
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- SunBio, Inc.
Xerostomia
Trial of Parotid Sparing Whole Brain Radiation
The purpose of this study is to evaluate the efficacy of parotid sparing in reducing measurable xerostomia (dry mouth) in patients undergoing whole brain radiotherapy.
- Trial name
- NCT03595878
- Testing
- Parotid sparing WBRT, Standard WBRT
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Xerostomia
Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray
The purpose of the clinical trial is to evaluate and validate the performance of the experimental mouth spray when used by persons with mild to severe dry mouth symptoms.
- Trial name
- NCT04186806
- Testing
- 3M Dry Mouth Moisturizing Spray to Biotene Moisturizing Mouth Spray, Biotene Moisturizing Mouth Spray to 3M Dry Mouth Moisturizing Spray
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Solventum US LLC
Xerostomia
Exploratory Study on Effect of Whitening Agent With Emulsion Gel in Xerostomic Population
Xerostomia, is a subjective sensation of dryness of the mouth. There are more than 700 medications that can lead to the salivary hypofunction that results in dry mouth.
- Trial name
- NCT04996069
- Testing
- Crest Whitening Emulsions
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Tufts University
Primary Sjögren's Syndrome
Efficacy and Safety of S95011 in Primary Sjögren's Syndrome Patients
The purpose of this study is to assess the effect of multiple intravenous infusions of S95011 compared to placebo in reducing disease activity in patients with primary Sjögren's syndrome.
- Trial name
- NCT04605978
- Testing
- S95011 concentrate for solution for infusion
- Where
- 19 sites in United States, Australia and 5 more
- Volunteers
- 48 people
- Sponsor
- Institut de Recherches Internationales Servier
Xerostomia, Head and Neck Cancer
Blinded Dry Mouth Spray Crossover Study
To identify the effectiveness of two mouth sprays at relieving symptoms of xerostomia in patients who have received radiation for carcinoma of the head and neck.
- Conditions
- Xerostomia, Head and Neck Cancer, Xerostomia Following Radiotherapy
- Trial name
- NCT04608773
- Testing
- Remineralizing Extreme Dry Mouth Spray with Xylitol, Alcohol-Free Moisturizing Dry Mouth Spray
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- Jonas Johnson
Xerostomia
SaliPen Human Factors Study for OTC Labeling
This Human Factors Validation Testing will assess user interactions to verify the capability of potential users to assess if the study product fits their needs and if they can use it correctly based on the provided Information…
- Trial name
- SaliPen (NCT05058430)
- Testing
- Electrical salivary stimulator system assigned to subjects with xerostomia, No Electrical salivary stimulator system assigned to subjects without xerostomia
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Saliwell Ltd.
Xerostomia
Effects of an External Oral Irrigation Device on Patients With Dry Mouth
The purpose of this research study is to test the effectiveness of treating dry mouth through water rehydration using this extra oral water pump/irrigation device.
- Trial name
- NCT04901507
- Testing
- The Voutia System
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Commonwealth University
Head and Neck Cancer
A Trial of Concurrent Radiation Therapy, Cisplatin, and BMX-001 in Locally Advanced Head and Neck Cancer
This is a Phase 1 / Phase 2 study of newly diagnosed patients with biopsy-proven head and neck cancer (squamous cell carcinoma) who are undergoing standard radiation therapy and treatment with cisplatin.
- Trial name
- BMX-HN (NCT02990468)
- Testing
- BMX-001, Radiation Therapy, Cisplatin
- Where
- 4 sites in United States
- Volunteers
- 29 people
- Sponsor
- BioMimetix JV, LLC
Hyposalivation
Fluoride Retention in the Mouth of Older Adults
Individuals with dry mouth (a reduction in the production of saliva) suffer from high rates of oral diseases. Dry mouth is a common problem among older individuals, because many medications to control chronic conditions (such as…
- Trial name
- NCT04239872
- Testing
- Fluoride mouthwash, Calcium and fluoride mouthwash
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sjögren Syndrome
A Phase 2 Study to Evaluate the Safety and Efficacy of LOU064 in Patients With Moderate to Severe Sjögren's Syndrome
This was an adaptive design phase 2 study to establish safety and efficacy; and to characterize the dose-response of LOU064 in subjects with moderate to severe Sjögren's syndrome.
- Trial name
- LOUiSSe (NCT04035668)
- Testing
- Remibrutinib
- Where
- 26 sites in United States, Australia and 10 more
- Volunteers
- 73 people
- Sponsor
- Novartis Pharmaceuticals
Xerostomia
Mesenchymal Stemcells for Radiation Induced Xerostomia
The current study aims to assess the safety and feasibility of the injection of autologous adipost tissue derived MSCs on radiation-induced salivary gland hypofunction and xerostomia in head and neck cancer participants.
- Trial name
- MESRIX (NCT02513238)
- Testing
- Mesenchymal stem cell, Isotonic NaCl
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Xerostomia
Clinical Evaluation of Oral Rinse for Xerostomia
Xerostomia causes a difficulty in eating, have irritated oral tissues, and a poor quality of life. The new oral rinse was designed to reduce the symptoms and improve the patient's quality of life.
- Trial name
- NCT04289051
- Testing
- HYDRAL Oral Rinse, BIOTENE® Oral Rinse
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Sunstar Americas
Xerostomia, Sjogren's Syndrome
Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome
The purpose of this study is to exploratively investigate the clinical efficacy of rebamipide on dry mouth in patients with Sjögren's syndrome in comparison with placebo.
- Trial name
- NCT00233363
- Testing
- Rebamipide
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Dry Mouth
Improvement of Dry Mouth Sufferers After Using an Experimental Dry Mouth Rinse Compared to a Water Control
The objective of this study is to evaluate dry mouth relief in subjects with self-reported feeling of dry mouth after using an experimental mouth rinse or a positive control compared to a water control.
- Trial name
- NCT04189081
- Testing
- dry mouth rinse, Water Control
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble