Clinical trials: Young Adults
High Grade Glioma, Diffuse Intrinsic Pontine Glioma
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
The goal of this study is to determine the efficacy of the 1) ribociclib and everolimus to treat pediatric and young adult patients newly diagnosed with a high-grade glioma (HGG), including DIPG, that have genetic changes in…
- Conditions
- High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Anaplastic Astrocytoma, Glioblastoma
- Trial name
- NCT05843253
- Testing
- Ribociclib, Everolimus, Temozolomide (TMZ)
- Where
- 20 sites in United States, Australia and 4 more
- Volunteers
- 120 people
- Sponsor
- Nationwide Children's Hospital
Out-Of-Hospital Cardiac Arrest
Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac Arrest
The goal of this observational study is to establish the protocol of systemic analysis of the causes of non-traumatic cardiac arrest in young patients.
- Trial name
- NCT06122337
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
HIV-related Stigma
Empathy in Frames: Animated Cartoons To Reduce HIV Stigma Among South African Young Adults
This study looks at whether using cartoons that reflect the culture of South Africa can help change how young adults there think about HIV/AIDS.
- Trial name
- NCT06724445
- Testing
- Thabo cartoon, Steve cartoon
- Where
- South Africa
- Volunteers
- 1,496 people
- Sponsor
- Columbia University
Smartphone Addiction, Neck Pain
Smartphone Addiction and Cervical Muscular Health
This cross-sectional observational study investigates how smartphone addiction affects neck pain severity, pressure pain threshold, and mechanical properties of cervical muscles in healthy young adults.
- Trial name
- NCT07038980
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Saglik Bilimleri Universitesi
Lymphoma
Mind-Body Medicine for the Improvement of Quality of Life in Adolescents and Young Adults Coping With Lymphoma
This trial studies how well a mind-body intervention works in improving overall quality of life in adolescents and young adults with lymphoma.
- Trial name
- NCT04270266
- Testing
- Educational Intervention, Meditation Therapy, Questionnaire Administration
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- M.D. Anderson Cancer Center
Imagery, Psychotherapy, Exercise
Comparative Effects of Kinesthetic Motor Imagery and Dual-Task Training on Balance and Cognitive Function in Young Adults: Randomized Controlled Trial
The goal of this clinical trial is to investigate the effects of kinesthetic motor imagery training and dual-task training on cognitive and motor functions in healthy young people.
- Conditions
- Imagery, Psychotherapy, Exercise, Stroop Test, Healthy Participants
- Trial name
- NCT05870072
- Testing
- Dual task training, Kinesthetic motor imagery training, Balance exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Rare Bone Disorders
Ready to Sail 2: A Pilot Study of Sail-Assisted Telerehabilitation in Rare Skeletal Diseases
"Ready to Sail 2 - EXTEND" is a pilot randomized interventional trial designed to assess the feasibility, safety, and preliminary impact of an innovative rehabilitation model combining sailing therapy (velatherapy) with a remote…
- Trial name
- PaS2-EXTEND (NCT07102875)
- Testing
- Sailing Intervention Plus Home-Based Telerehabilitation, Home-Based Telerehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Istituto Ortopedico Rizzoli
Diffuse Intrinsic Pontine Glioma (DIPG), Brain Stem Glioma
Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
The standard of care for children with DIPG includes focal radiotherapy (RT) but outcomes have remained dismal despite this treatment.
- Trial name
- BRAVO (NCT03396575)
- Testing
- TTRNA-DC vaccines with GM-CSF, TTRNA-xALT, Cyclophosphamide + Fludarabine Lymphodepletive Conditioning
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Florida
Metabolic Syndrome
Exercise and Carotid Artery Function in Metabolic Syndrome
The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely…
- Trial name
- NCT07430839
- Testing
- exercise, Diagnostics, Inhaled CO2-mixed air
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Influenza
Immunogenicity and Safety Study to Assess Influenza Vaccine Formulated With Haemagglutinin (HA) Antigen From Two Different Suppliers
The purpose of this study is to assess the humoral immune response and safety of the parenteral formulation of the 2010/2011-season virosomal subunit influenza vaccine Inflexal V using two different HA antigen suppliers (AdImmune…
- Trial name
- NCT01412281
- Testing
- Virosomal influenza vaccine (AdImmune HA Antigen), Virosomal influenza vaccine (CSL HA Antigen)
- Where
- Switzerland
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
STD
Study of Oral Papillomavirus In Teens and Twenties
Recently human papillomavirus (HPV) has been recognized to cause some oropharyngeal (tonsil) cancer. But very little is known about oral HPV infection and risk factors.
- Trial name
- SPITT (NCT00994019)
- Where
- 2 sites in United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Ewing Sarcoma, Rhabdomyosarcoma
Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies
Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back…
- Conditions
- Ewing Sarcoma, Rhabdomyosarcoma, Wilms Tumor, Neuroblastoma
- Trial name
- NYMC195 (NCT04308330)
- Testing
- Vorinostat
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York Medical College
Lymphoma, Non-Hodgkin
A Safety and Efficacy Study of Ibrutinib in Pediatric and Young Adult Participants With Relapsed or Refractory Mature B-cell Non-Hodgkin Lymphoma
The purpose of this study is to confirm that the pharmacokinetics of ibrutinib in pediatric participants is consistent with that in adults (part 1) and to assess efficacy (event-free survival [EFS]) of ibrutinib in combination…
- Trial name
- NCT02703272
- Testing
- Ibrutinib, Rituximab, Ifosfamide
- Where
- 76 sites in United States, Belgium and 18 more
- Volunteers
- 72 people
- Sponsor
- Janssen Research & Development, LLC
Anxiety, Stress and Anxiety
A Psychomotor Group Intervention for Young Adults With Anxiety Symptoms
The goal of this clinical trial is to learn if a psychomotor (a body-oriented therapy) group intervention can be feasibly delivered to a group of young adults (age 18-35) with anxiety symptoms within a higher educational setting.
- Conditions
- Anxiety, Stress and Anxiety, Interoceptive Awareness, Interoception
- Trial name
- NCT07681765
- Testing
- Ten weekly psychomotor therapy group sessions
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- VIA University College
NF1, Low-grade Glioma
A Phase II Trial of Poly-ICLC for Low-Grade Gliomas
This is a phase II, prospective, longitudinal, multi-center trial of poly-ICLC (Hiltonol ®) treatment for progressive low-grade gliomas in pediatric patients with NF1.
- Trial name
- NF111 (NCT04544007)
- Testing
- Poly ICLC
- Where
- 12 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Alabama at Birmingham
Hypertension
A Pilot Randomized Controlled Trial to Reduce Salt Intake Among Hypertensive Young Adults in Hong Kong
A pilot randomized controlled trial will be conducted to investigate the feasibility and effectiveness of a salt intake reduction intervention to young hypertension patients in Hong Kong who had high salt intake.
- Trial name
- NCT02920437
- Testing
- Four-week weekly intervention to reduce salt intake, Usual government pamphlets
- Where
- China
- Volunteers
- 19 people
- Sponsor
- The University of Hong Kong
Depression, Anxiety Disorders
Rumination-focused CBT Training for the Prevention of Depression and Anxiety
Depression and anxiety disorders are highly prevalent and associated with reduced quality of life for patients and enormous economic costs for society.
- Trial name
- NCT01223677
- Testing
- Rumination Focused CBT
- Where
- Netherlands
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
Lymphoid Leukemia
Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy
To use a consistent and standardized platform to retrospectively and prospectively study children and young adults with B cell malignancies receiving Immunotherapy, blinatumomab and/or inotuzumab ozogamicin.
- Trial name
- NCT05865301
- Testing
- Questionnaire for patients receiving therapy
- Where
- 22 sites in United States
- Volunteers
- 500 people
- Sponsor
- Stanford University
Tobacco Use, Cigar Smoking
The Effect of Sweet Flavoring on the Rewarding and Reinforcing Value of Cigarillo Use Among Young Adults
This within-subjects study aims to evaluate the subjective rewarding value, the relative reinforcing value, and the absolute reinforcing value of sweet flavored cigarillos across three separate laboratory visits among 86 young…
- Trial name
- FLAV (NCT05092919)
- Testing
- Flavor
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Acute Lymphoblastic Leukaemia - Category
UNDERSTANDING THE T-CELL AND B-CELL RECEPTOR REPERTOIRE IN CHILDREN AND YOUNG ADULTS WITH ANTI-DRUG ANTIBODIES AGAINST PEG ASPARAGINASE
The aim of this sub study is to identify biomarkers in children and young adults with Acute Lymphoblastic Leukemia with hypersensitivity to PEG-asparaginase.
- Trial name
- NCT07499336
- Testing
- Hypersensitivity reaction to asparaginase
- Volunteers
- 45 people
- Sponsor
- Aarhus University Hospital
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