Clinical trials: Young Adults
Sarcoma, Osteosarcoma
A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors
Background GD2 is a well-characterized tumor antigen in neuroblastoma, which is also expressed on osteosarcomas and some other sarcomas.
- Conditions
- Sarcoma, Osteosarcoma, Neuroblastoma, Melanoma
- Trial name
- NCT02107963
- Testing
- Anti-GD2-CAR engineered T cells, AP1903, Cyclophosphamide
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Influenza
The Human Mucosal Immune Responses to Influenza Virus (SLVP026)
This study will examine the immune responses to the seasonal influenza vaccine in single cells of the nasal passages when compared with cells in circulating blood.
- Trial name
- NCT03023553
- Testing
- Fluzone®, FluMist®
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Stanford University
Attention Deficit Hyperactivity Disorder
A Study of SPD465 in Young Adult Drivers With Attention-Deficit Hyperactivity Disorder (ADHD) Using Driving Simulators
The purpose of this study is to determine whether SPD465 is safe and effective in the treatment of ADHD in young adult drivers after a duration of 16 hours.
- Trial name
- NCT00458445
- Testing
- SPD465
- Where
- United States
- Sponsor
- Shire
Analogue Generalized Anxiety Disorder
The Resistance Exercise Training for Worry Trial: Replication and Expansion
This protocol details the full methods of a ten-week moderate-to-high intensity, guidelines-based resistance exercise training intervention compared to a low intensity sham attention control among young adult women with analogue…
- Trial name
- RETRAIN REP-EX (NCT06804629)
- Testing
- Moderate-to-High Intensity Resistance Exercise Training
- Where
- Ireland
- Volunteers
- 68 people
- Sponsor
- University of Limerick
Sickle Cell Disease
Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease
Adolescents and young adults with sickle cell disease (SCD) face challenges managing their illness and maintaining their well-being.
- Trial name
- NCT06555939
- Testing
- Collaborative Care Model, Promoting Resilience in Stress Management
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Boston Children's Hospital
Leukemia, Acute Myeloid
Epigenetic Reprogramming in Relapse AML
Successful treatment for children and young adults with relapsed acute myeloid leukemia (AML) continues to be a significant challenge.
- Trial name
- NCT02412475
- Testing
- Decitabine, Vorinostat, Fludarabine
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Michael Burke
Antisocial Behavior
Multisystemic Therapy-Emerging Adults (MST-EA) for Substance Abuse
This study's purpose is to examine the effectiveness of a promising intervention for emerging adults (EAs) with alcohol and other drug (AOD) abuse and justice involvement in achieving the ultimate outcome of reduced criminal…
- Trial name
- NCT03035877
- Testing
- Multisystemic Therapy-Emerging Adults, Enhanced Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 183 people
- Sponsor
- Chestnut Health Systems
Postprandial Glucose, Glucose Levels
Ultra-processed Food-reducing Intervention and Continuous Glucose Monitoring
The goal of this trial is to investigate whether reduction in ultra-processed food intake through dietary counseling and education can improve postprandial glucose responses and glycemic variability compared with a usual diet in…
- Conditions
- Postprandial Glucose, Glucose Levels, Hyperglycemias
- Trial name
- ULTRA-CGM (NCT07175701)
- Testing
- 40-minute one-on-one dietary counseling and nutrition education aimed at reducing ultra-processed food consumption, Standard dietary counseling and nutrition education based on national guidelines
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Korea University
Heavy Metal Exposure From Vaping
Examining Heavy Metal Exposure and Respiratory Health in Young Adult Electronic Cigarette Users
This study investigates heavy metal exposure in young adults who use electronic cigarettes.
- Trial name
- NCT07215065
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Lymphatic Malformations
Selenium in the Treatment of Complicated Lymphatic Malformations
The investigators propose a pilot trial to obtain preliminary information regarding the safety and response rate of patients with symptomatic lymphatic malformations treated with oral Selenium.
- Trial name
- NCT01212965
- Testing
- Selenium
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical College of Wisconsin
Sickle Cell Disease
A Study of Intravenous L-Citrulline in Patients Aged 6-21 Years Old With Sickle Cell Disease Presenting to Emergency Departments in Acute Vaso-Occlusive Crisis
This study is being done to learn more about a possible new treatment for pain episodes (called vaso-occlusive crises or VOCs) in children, teens, and young adults with sickle cell disease (SCD).
- Trial name
- NCT06989567
- Testing
- L-citrulline
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Acute Leukemia, Myelodysplastic Syndrome
Study of QUAIL-100 in Pediatric and Young Adult Participants With High-Risk Hematologic Malignancies Who Have Received a Hematopoietic Stem Cell Transplantation
Study of QUAIL-100 in Patients With High Risk Acute Leukemia and Myelodysplastic Syndrome Who Have Received Hematopoietic Stem Cell Transplant
- Trial name
- NCT07573111
- Testing
- QUAIL-100
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Laguna Biotherapeutics, Inc.
Hematopoietic and Lymphoid Cell Neoplasm
Psycho-Educational Cognition Intervention in Patients With Blood and Lymph Cancer
This pilot trial studies how well a psycho-educational program called Emerging from the Haze works in helping patients with blood and lymph cancer.
- Trial name
- NCT03804164
- Testing
- Educational Intervention, Quality-of-Life Assessment, Survey Administration
- Where
- United States
- Sponsor
- City of Hope Medical Center
Healthy Young Adults
High vs Low Volume Intensity Training With IMT On Pulmonary Function And Breathing Efficiency On Recreational Swimmers.
This study aims to evaluate the impact of inspiratory muscle training (IMT) on respiratory function and swimming performance in competitive swimmers.
- Trial name
- NCT06604741
- Testing
- Assigned Interventions for LVIMT, Assigned interventions for HVIMT
- Where
- Pakistan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Gastroparesis, Gastroparesis-like Syndrome
GpCRC Pediatric Gastroparesis Registry 2
The objective of the Pediatric Gastroparesis Registry 2 is to create a national prospective registry of children, adolescents, and young adults with gastroparesis and gastroparesis-like syndrome (symptoms of gastroparesis but…
- Trial name
- PGpR2 (NCT05981300)
- Where
- 6 sites in United States
- Volunteers
- 216 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL, Infants With Very High Risk KMT2A B-ALL
Orphan Indications for CD19 Redirected Autologous T Cells
This is an open-label, four-cohort, phase 2 study to determine the efficacy of CART19 in pediatric and young adult patientswith hypodiploid (Cohort A) or t(17;19) B-ALL (Cohort B), infants with very high risk KMT2A B-ALL (Cohort…
- Conditions
- Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALL, Infants With Very High Risk KMT2A B-ALL, Patients With Central Nervous System Relapse Who Did Not Receive Cranial Radiation or Bone Marrow Transplantation
- Trial name
- NCT04276870
- Testing
- Murine CART19
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- Stephan Grupp MD PhD
Recurrent Childhood Neuroblastoma, Recurrent Childhood Osteosarcoma
Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, GD2-CAR PERSIST Trial
This phase I trial investigates the side effects and determines the best dose of an immune cell therapy called GD2CART, as well as how well it works in treating patients with osteosarcoma or neuroblastoma that has come back…
- Conditions
- Recurrent Childhood Neuroblastoma, Recurrent Childhood Osteosarcoma, Recurrent Neuroblastoma, Recurrent Osteosarcoma
- Trial name
- NCT04539366
- Testing
- Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration
- Where
- 6 sites in United States
- Volunteers
- 73 people
- Sponsor
- National Cancer Institute (NCI)
Alcohol Use, Marijuana Use
Development and Testing of a Smartphone Application to Reduce Substance Use and Sexual Risk Among Homeless Young Adults
A pilot trial (N=60) will be conducted to test the feasibility and preliminary effectiveness of OnTrack (a smartphone application to self-monitor substance use and sexual behaviors among homeless young adults) plus a brief…
- Conditions
- Alcohol Use, Marijuana Use, Sexual Behavior
- Trial name
- NCT02530645
- Testing
- OnTrack, Treatment as Usual, Brief Motivational Interviewing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Family Relations, Nutrition Disorders
Family Relationships and Nutrition in TGGD Youth and Young Adults
The purpose of this study is to assess how family relationships are related to health and nutrition behaviors among transgender and gender diverse youth and young adults.
- Conditions
- Family Relations, Nutrition Disorders, Health Behavior, Transgenderism
- Trial name
- NCT05163860
- Testing
- Survey
- Where
- United States
- Volunteers
- 714 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Clinical High-Risk, Psychological
Skills Group for Youth at Clinical High-Risk for Psychosis
This study is intended to test the feasibility of an integrated cognitive behavioral therapy (CBT) and dialectical behavioral therapy (DBT) skills group for adolescents and young adults at clinical high-risk (CHR) for psychosis.
- Trial name
- NCT05398120
- Testing
- Skills Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
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