Clinical trials: Young Adults
Constitutional Thinness
Energy Expenditure and Neuromuscular Function in Young Adult Women With a Naturally Thin Build (LeanErgy)
People with a low BMI (<17.5) are most often considered to have anorexia nervosa (AN). However, recent literature suggests that there is a category of individuals with the same low BMI who do not meet the diagnostic criteria for…
- Trial name
- LeanErgy (NCT07233109)
- Testing
- Evaluation of the maximum oxidation point of lipids, Evaluation of the energy cost of walking, Neuro-muscular assessments
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Emile Roux
Protein Metabolism
Effects of Protein Type and Mineral Form on Amino Acid Availability
To compare postprandial plasma amino acid availability, expressed as incremental area under the curve (iAUC), over a 6 hour period following ingestion of 25 g of different protein isolates in healthy, young adults.
- Trial name
- ProMin (NCT07677098)
- Testing
- Protein beverage
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sickle Cell Disease
Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease
Adolescents and young adults with sickle cell disease (SCD) face challenges managing their illness and maintaining their well-being.
- Trial name
- NCT06555939
- Testing
- Collaborative Care Model, Promoting Resilience in Stress Management
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Boston Children's Hospital
Cancer
A Biobehavioral Intervention for Latino/Hispanic Young Adults with Cancer
Building upon the results of a single-arm trial designed to investigate the feasibility and acceptability of a novel intervention, Goal-focused Emotion-Regulation Therapy (GET), this trial is a randomized-controlled biobehavioral…
- Trial name
- NCT06338475
- Testing
- Goal-Focused Emotion-Regulation Therapy (GET), Individual Supportive Listening (ISL)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Irvine
Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants, Adolescents and Adults With Hearing Loss Due to Otoferlin Mutations
Regeneron is conducting a study of an investigational new drug called DB-OTO. DB-OTO is a gene therapy that is being developed to treat pediatric and adult participants who have severe-to profound and profound hearing loss due to…
- Trial name
- CHORD (NCT05788536)
- Testing
- DB-OTO
- Where
- 17 sites in United States, Germany and 3 more
- Volunteers
- 36 people
- Sponsor
- Regeneron Pharmaceuticals
Acute Lymphoblastic Leukemia, B-precursor, Non-Hodgkin Lymphoma, B-cell
T-cells Expressing Anti-CD19 CAR in Pediatric and Young Adults With B-cell Malignancies
This phase 1 / 2 study will evaluate the response of B-cell malignancies expressing CD19 to autologous T cells transduced with a second generation anti-CD19 chimeric antigen receptor in children and young adults.
- Trial name
- NCT02772198
- Testing
- CD19 CAR T cells
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Neoplasms
Evaluation of a Video Game for Adolescents and Young Adults With Cancer
The purpose of this study is to determine the effects of playing the interactive video game, Re-Mission, on patient outcomes, including adherence to medical treatment regimes, self-care behaviors, quality of life, stress…
- Trial name
- NCT00425139
- Testing
- Re-Mission
- Where
- 34 sites in United States, Australia and 1 more
- Volunteers
- 375 people
- Sponsor
- HopeLab Foundation
Healthy
Feasibility and Acceptability of Mindful Self-Compassion Among Transgender and Nonbinary Young Adults
The goal of this single-arm feasibility study is to evaluate the feasibility and acceptability of an 8-week mindful self-compassion intervention and associated data-collection plan among transgender and nonbinary young adults.
- Trial name
- NCT06409975
- Testing
- Mindful Self-Compassion (MSC)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Osteogenesis Imperfecta (OI)
Open-label Extension of Study 20130173 of Denosumab in Children and Young Adults With Osteogenesis Imperfecta
To evaluate long-term safety of denosumab in children/young adults with pediatric osteogenesis imperfecta (OI) who completed the prior study 20130173 (NCT02352753).
- Trial name
- NCT03638128
- Testing
- Denosumab, Alternative osteoporosis medications
- Where
- 22 sites in United States, Australia and 10 more
- Volunteers
- 75 people
- Sponsor
- Amgen
Pain, Postoperative
Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia
The purpose of this study is to determine whether, for surgery of the tibia, one dose of methadone provides better control of pain afterward as compared to morphine, which is the usual drug given to control pain after surgery.
- Trial name
- NCT01430182
- Testing
- Methadone, Morphine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Cervical Proprioceptive Error in Healthy Young Individuals
Proprioceptive Puzzle: Effects on Quantitative Sensory Tests and Body Awareness
Background: Cervical proprioception, referring to the awareness of the head's position in space, plays a crucial role in maintaining postural control and preventing musculoskeletal injuries.
- Trial name
- NCT06559397
- Testing
- Assessment of cervical proprioception
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nagihan Acet
Young Adults, Lymphoma, Non-Hodgkin
Fitness Assessment in Young Adults Recovered From Lymphoma
Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density.
- Conditions
- Young Adults, Lymphoma, Non-Hodgkin, Hodgkin Disease
- Trial name
- CUPCAKE (NCT05188755)
- Testing
- Indirect calorimetric test during submaximal exercise
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Myopia Progression
Effectiveness of Orthokeratology in Decreasing Myopic Progression in a Young Adult Population Enrolled in a Professional Optometric Curriculum
The high prevalence of myopia - especially in Asian countries - is well documented, as are the sight-threatening complications of high or degenerative myopia.
- Trial name
- NCT02623543
- Testing
- OrthoK
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Illinois College of Optometry
Obesity and Overweight, Dysbiosis
Effect of Watermelon on Gut and Cardiometabolic Health
The goal of this clinical trial is to evaluate the effect of daily fresh watermelon consumption for 6-weeks on gut health, including microbiome diversity, gut barrier and immune function in young adults with overweight and…
- Trial name
- NCT06588218
- Testing
- Watermelon, Belvita Breakfast Sandwich + 12 oz Water
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Florida State University
Malignant Rhabdoid Tumor, Rhabdoid Tumor of the Kidney
Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers
This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.
- Conditions
- Malignant Rhabdoid Tumor, Rhabdoid Tumor of the Kidney, Epithelioid Sarcoma, Chordoma (Poorly Differentiated or De-differentiated)
- Trial name
- NCT04416568
- Testing
- Nivolumab, Ipilimumab
- Where
- 8 sites in United States
- Volunteers
- 30 people
- Sponsor
- Dana-Farber Cancer Institute
Risk Reduction
Utilizing Text Messaging to Improve Vehicle Safety Among At-Risk Young Adults
The "Safe Vehicle Engagement (SaVE)" trials are 3 parallel randomized clinical trials that aim to determine the impact of text messaging (SMS) vehicle safety interventions vs.
- Trial name
- SaVE (NCT03833713)
- Testing
- SMS Dialogue, SMS Assessments
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- University of Pittsburgh
Rhabdomyosarcoma
Mocetinostat With Vinorelbine in Children, Adolescents & Young Adults With Refractory and/or Recurrent Rhabdomyosarcoma
This phase I trial studies the side effects and best dose of mocetinostat when given together with vinorelbine to see how well it works in treating children, adolescents, and young adults with rhabdomyosarcoma that has spread to…
- Trial name
- NCT04299113
- Testing
- Vinorelbine, Mocetinostat
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Leukemia, Lymphoblastic, Acute, ALL, Childhood
Optimal Methods of Disease Detection in Children and Young Adults With Acute Lymphoblastic Leukemia in the Pediatric Oncology Branch
Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. It occurs when a bone marrow cell develops errors in its DNA. Certain tests are used to help detect the disease.
- Trial name
- NCT03627208
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Cancer Institute (NCI)
Cerebral Palsy
Home-Based Training With Feedback to Improve Outcomes in Adolescents and Young Adults With Cerebral Palsy..
This clinical trial aims to determine whether extrinsic feedback through music enhances the effects of home-based motor training for adolescents and young adults with cerebral palsy (CP) and whether feedback improves adherence to…
- Trial name
- THRIVE-CP (NCT06962618)
- Testing
- Music Motion Group, Control
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Copenhagen
Congenital Adrenal Hyperplasia
A Study of a Virtual Education-Based Transition Intervention to Improve Transition Readiness in Adolescent and Young Adults With Congenital Adrenal Hyperplasia
Background: Children with congenital adrenal hyperplasia (CAH) can survive well into adulthood with proper treatment. But the change from pediatric to adult care can be challenging.
- Trial name
- NCT05663320
- Testing
- virtual educational based transition intervention self-paced
- Where
- United States
- Sponsor
- National Institutes of Health Clinical Center (CC)