Clinical trials: Zonulin
Postoperative Delirium
The Relationship Between Zonulin and Interleukin-8 Levels and Postoperative Delirium Development
The relationship between zonulin and interleukin-8 levels and postoperative delirium development in patients who had femur fracture surgery under regional anesthesia
- Trial name
- ZolDel (NCT04875182)
- Testing
- Evaluation of Delirium development
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Dr. Gokhan Vural
Heart Failure and ST Elevation Myocardial Infarction
Predictors of Heart Failure After ST-segment Elevation Myocardial Infarction (HF-EXPRESS)
Objective: The purpose of this project is to study the post miyocardial infaction (MI) damage and subsequently developed post-infarct cardiac repair process on the basis of cellular, molecular and imaging techniques.
- Trial name
- HF-EXPRESS (NCT02650934)
- Testing
- Percutanous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 312 people
- Sponsor
- Dr. Nafiz Korez Sincan State Hospital
Surgical Site Infection, Zonulin
Zonulin Biomarker for Diagnosis of Hip and Knee Infections
Prior studies investigating the etiopathogenesis of surgical site infection (SSI) traditionally suggested three main ways for the infection to occur: local contamination occurring during the surgery, hematogenous translocation of…
- Trial name
- NCT04666519
- Testing
- Zonulin Biomarker
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Infertility Female, Zonulin
Effect Of The Mediterranean Diet On Zonulin And Infertility
The goal of this clinical trial is to learn if mediterranean diet works to treat infertility in women. It will also learn about the initial and end of study zonulin levels of mediterranean diet and control group.
- Conditions
- Infertility Female, Zonulin, Intestinal Permeability, Mediterranean Diet
- Trial name
- NCT07072936
- Testing
- mediterranean diet
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- SINEM BAYRAM
Crohn's Disease
Effect of VSL#3 on Intestinal Permeability in Pediatric Crohn's Disease
The purpose of this study is to determine the effect of a probiotic formulation, VSL#3, on intestinal permeability in pediatric patients with Crohn's disease.
- Trial name
- NCT00944736
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's Mercy Hospital Kansas City
Preeclampsia
Haptoglobin and Preeclampsia
The purpose of this study is to show that a certain protein called haptoglobin protects against preeclampsia which is a common pregnancy complication.
- Trial name
- NCT01027130
- Where
- Israel
- Sponsor
- Bnai Zion Medical Center
Celiac Disease, Nutritional Deficiency
Intestinal Permeability, Nutritional Status and Quality of Life in Celiac Disease
Celiac disease is defined as an autoimmune enteropathy with malabsorption of gluten protein. In recent studies, it has been stated that in individuals diagnosed with celiac disease, intestinal epithelial barrier integrity is…
- Conditions
- Celiac Disease, Nutritional Deficiency, Quality of Life
- Trial name
- NCT04351828
- Testing
- Blood draw once a time
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Marmara University
HIV Infection
Analysis of Genetic Factors Which May Influence the Course of HIV Infection
Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease.
- Trial name
- NCT00159068
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Deborah Rund
Varicocele, Male Infertility
Zonulin Levels in Varicocele Patients
This prospective cross-sectional observational study was designed to evaluate serum and seminal plasma zonulin levels in infertile men with clinically diagnosed varicocele and compare them with those in infertile men without…
- Conditions
- Varicocele, Male Infertility, Zonulin
- Trial name
- VARIZON (NCT07748104)
- Where
- Turkey (Türkiye)
- Volunteers
- 119 people
- Sponsor
- Süleyman Tümer Çalışkan
Inflammatory Bowel Diseases
A Diagnostic Accuracy Study Testing Fecal Biomarkers In Comparison To Endoscopic Examination
In this study it will be explored whether the levels of fecal biomarkers are associated with histologic inflammation of the intestinal mucosa and concomitant alteration of the mucosal permeability.
- Trial name
- NCT04849936
- Testing
- Testing Fecal Biomarkers In Comparison To Endoscopic Examination With Confocal Laser Endomicroscopy
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Universität Duisburg-Essen
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm
Magnesium Treating Subarachnoid Hemorrhage Vasospasm
A randomized clinical trial investigating magnesium sulphate ability to reduce risk of cerebral vasospasm after acute subarachnoid hemorrhage hence improving outcome particularly in haptoglobin 2-2 patients who are highly…
- Trial name
- MATSH-SHapE (NCT04613960)
- Testing
- Magnesium sulfate, normal saline
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Intestinal Permeability, Leaky Gut Syndrome
Dietary Supplements for Reduction of Intestinal Permeability Levels
A randomised and controlled trial, in which the effect of a dietary supplement is evaluated for reduction of intestinal permeability levels of subjects with high levels of zonulin in feces
- Conditions
- Intestinal Permeability, Leaky Gut Syndrome, Zonulin
- Trial name
- permeability (NCT06760377)
- Testing
- Dietary supplement Group
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Diabetes, Myocardial Infarction
Prevention of Cardiovascular Complications in Diabetic Patients With Vitamin E Treatment
The purpose of this study is to determine whether Vitamin E treatment to Diabetic patients, who carry the Haptoglobin 2-2 Phenotype, prevents cardiovascular complications such as acute MI and Stroke.
- Conditions
- Diabetes, Myocardial Infarction, Cardiovascular Disease
- Trial name
- NCT00220831
- Testing
- Natural source Vitamin E 400IU/day
- Where
- Israel
- Volunteers
- 2,000 people
- Sponsor
- Technion, Israel Institute of Technology
Diabete Type 1
Effect of a Probiotic Supplement on Gut Microbiota and Glycemic Control in Patients With Type 1 Diabetes (PRODIAB)
This randomized, double-blind clinical trial aims to evaluate the effect of a probiotic supplement on gut microbiota composition and glycemic control in adults with type 1 diabetes mellitus.
- Trial name
- PRODIAB (NCT07062224)
- Testing
- Probiotic/Prebiotic Supplement
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Postoperative Delirium
Association of Haptoglobin 2-2 With Postoperative Delirium
Patients with major orthopedic surgery will be recruited. Participants will be monitored for delirium after surgery. Participants' blood will be harvested for the determination of haptoglobin types, levels of oxidative stress and…
- Trial name
- NCT03392480
- Where
- 8 sites in China
- Sponsor
- Sun Yat-sen University
Diabetes, Cardiovascular Disease
Associations Between Diabetes Care and Haptoglobin Genotype On outComes
The ADHOC Cohort comprised 3044 DM individuals, treated in 47 CHS primary care clinics, that underwent haptoglobin genotyping between 2 march, 2005 and 26 September 2006.
- Conditions
- Diabetes, Cardiovascular Disease, Myocardial Infarction, Stroke
- Trial name
- ADHOC (NCT00872456)
- Volunteers
- 3,054 people
- Sponsor
- Clalit Health Services
Gastric Cancer
Glycans Bound to Serum Haptoglobin: a Novel Gastric Cancer Tumor Biomarker
The purpose of this study is to evaluate sensitivity and specificity of newly defined tumor biomarker with gastric cancer pts and cancer-free healthy volunteers.
- Trial name
- NCT02848066
- Testing
- Blood sample(10cc) collection
- Where
- South Korea
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Gestational Diabetes
Trimester Sequential Estimation of Serum Zonulin as a Predictor of Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is the development of glucose intolerance (GI) during pregnancy in a previously normoglycemic (NG) woman and associated with insulin resistance (IR).
- Trial name
- NCT06336512
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Benha University
Anemia
Effects of Carnitine on Oxidative Stress to IVIR Administration to CKD Patients:Impact of Haptoglobin Genotype
Anemia is a common disorder in CKD patients. It is largely attributed to decreased erythropoietin (EPO) production and iron deficiency. Therefore, besides EPO, therapy includes iron replenishment.
- Trial name
- NCT02312414
- Testing
- L-Canitine
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- The Nazareth Hospital, Israel
Parkinson's Disease
Haptoglobin and Iron in Parkinson's Disease
This is a case/control epidemiology study to identify what are the iron-metabolism abnormalities in Parkinson's disease (PD) patients, and risk factors relevant to PD predisposition.
- Trial name
- HPPD (NCT02422992)
- Where
- 3 sites in United States
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Bastyr University