Clinical trials: Zonulin
Attention-deficit/Hyperactivity Disorder
Occludin and Zonulin in Attention-deficit/Hyperactivity Disorder
The association between levels of zonulin and occludin and behavioral/emotional problems in children with ADHD are investigated.
- Trial name
- NCT05502471
- Testing
- Zonulin, Occludin
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Lactose Intolerance, Adult Type, Intestinal Permability
Lactose Intolerance and Intestinal Permability
"This study evaluates the interplay between lactose intolerance, intestinal barrier function (zonulin), and intestinal inflammation (fecal calprotectin) in adults, aiming to clarify their independent contributions to symptom…
- Conditions
- Lactose Intolerance, Adult Type, Intestinal Permability, IBS (Irritable Bowel Syndrome)
- Trial name
- LI (NCT07424898)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bezmialem Vakif University
Ankylosing Spondylitis
The Impacts of Gluten-free Diet in Patients With Ankylosing Spondylitis
Subclinical intestinal inflammation and intestinal permeability have been reported in patients with ankylosing spondylitis. Gluten is one of the main triggers of zonulin releaseand gluten intake may contribute to the development…
- Trial name
- NCT07166874
- Testing
- Gluten Free Diet
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi
Diabetes Mellitus Type 2
Type 2 Diabetes Haptoglobin Phenotype and Vitamin E
This is a biomarker exploratory study which is designed to investigate the function and oxidation of the high density lipoprotein (HDL) (the good cholesterol) in patients with type 2 diabetes mellitus treated with Vitamin E…
- Trial name
- IDEAL2 (NCT01113671)
- Testing
- Vitamin E (d-alpha-tocopheryl acetate)
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Technion, Israel Institute of Technology
Autism Spectrum Disorder (ASD), Nutrition
Effect of Gluten-free Casein-free Diet on Serum Zonulin and Claudin-5 Levels and Some Clinical Symptoms in Children With Autism Spectrum Disorder
This study will investigate the effects of a gluten-free casein-free diet (GFCF) on serum zonulin and claudin-5 levels in children diagnosed with ASD, in relation to intestinal permeability and blood-brain barrier permeability…
- Trial name
- NCT07274930
- Testing
- Gluten Free Casein Free Diet, Normal Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Karadeniz Technical University
Pulmonary Disease, Chronic Obstructive
Prevalence of Different Haptoglobin Phenotypes in Patients With COPD- Frequent Exacerbators Versus Non Exacerbators
Chronic obstructive pulmonary disease (COPD) is a common disease in smokers. COPD has a slowly deteriorating course, punctuated by exacerbations- acute events characterized by increasing shortness of breath and putrid sputum.
- Trial name
- NCT01745419
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Carmel Medical Center
Irritable Bowel Syndrome
Is There Any Correlation Between Plasmatic Zonulin and Expression of Intestinal Tight Junction Proteins in IBS Patients?
Increased intestinal permeability is one of the main pathophysiological mechanisms involved in irritable bowel syndrome. The expression of some intestinal tight junction proteins is decreased mostly in IBS-diarrhoea patients.
- Trial name
- BISII (NCT02877654)
- Testing
- colonoscopy with biopsies in the left colon to assess intestinal permeability
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Rouen
Subarachnoid Hemorrhage
Haemoglobin And Vancomycin Pharmacokinetics in the Cerebrospinal Fluid Following Subarachnoid Haemorrhage
The HAPTO study will recruit adult patients with aSAH due to a burst aneurysm. These patients must be scheduled to have their aneurysm treated surgically to prevent further bleeds, and need an external ventricular drain for…
- Trial name
- HAPTO (NCT06373640)
- Testing
- Insertion of drains, Vancomycin
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Impaired Wound Healing, Diabetes Mellitus
Wound Healing In Diabetes (WHy) Study
This observational study aims to identify risk factors and molecular mechanisms of impaired wound healing, to guide better foot care in the diabetic population.
- Trial name
- WHy (NCT01002521)
- Where
- Barbados
- Volunteers
- 605 people
- Sponsor
- The University of The West Indies
Irritable Bowel Syndrome
Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome
This study aimed to evaluate the effects of a Low-FODMAP diet on intestinal permeability, symptom severity, and quality of life in patients with Irritable Bowel Syndrome (IBS).
- Trial name
- NCT07467278
- Testing
- low fodmap diet, dietary intervention
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Critical Illness, Gastro Intestinal Surgery
Undiluted and Diluted Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Gastro Intestinal Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT07352150
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 2 sites in Poland
- Volunteers
- 80 people
- Sponsor
- John Paul II Catholic University of Lublin
Parkinson Disease
Effect of Aerobic Training on Oxidative Stress Markers in Patients With Parkinson's Disease
Parkinson's disease is a chronic, neurodegenerative disorder characterized with the loss of dopamine-producing neurons. This loss is likely to be related with several environmental and genetic factors.
- Trial name
- NCT05511402
- Testing
- Exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Saglik Bilimleri Universitesi
Functional Dyspepsia
Intestinal Permeability in Children/Adolescents With Functional Dyspepsia
The main purpose of this study is to evaluate whether intestinal permeability and/or serum zonulin concentration is increased in children/adolescents with functional dyspepsia (FD).
- Trial name
- NCT00363597
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Schizophrenia, Celiac Disease
Intracellular Tight Junction Permeability in Schizophrenia: Focus on Zonulin
The purpose of this protocol is to collect serum zonulin levels in people with schizophrenia. This one time visit will collect zonulin levels, antibodies to gliadin (tissue transglutaminase and antigliadin antibodies) and other…
- Trial name
- NCT01558570
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Diabetes, Coronary Artery Disease
Evaluation of ALT-2074 in Subjects With Type-2 Diabetes, Haptoglobin Type 2-2 Genotype and Coronary Artery Disease
ALT-2074 (BXT-51072) belongs to a class of drugs called "glutathione peroxidase mimics." ALT-2074 works by imitating a substance produced in various tissues in the body, which prevents damage of the heart and blood vessels.
- Trial name
- NCT00491543
- Testing
- ALT-2074
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- Synvista Therapeutics, Inc
Obesity, Morbid, Bariatric Surgery
Evaluation of Metabolic Parameters, Intestinal Permeability and Gastrointestinal Symptoms After Bariatric Surgery in Body Weight Management
This study aims to evaluate the changes in metabolic parameters, intestinal permeability, and gastrointestinal symptoms in individuals who have undergone bariatric surgery (Laparoscopic Sleeve Gastrectomy - LSG) for obesity…
- Conditions
- Obesity, Morbid, Bariatric Surgery, Intestinal Permeability, Gastrointestinal Symptoms
- Trial name
- METABAR (NCT07643376)
- Testing
- Clinical and Biochemical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Toros University
Intracerebral Hemorrhage
Association Between Haptoglobin Genotype and Brain Swelling
Intracerebral hemorrhage is bleeding into the brain and is a major cause of stroke and other complications. Brain injury from intracerebral hemorrhage occurs in two phases.
- Trial name
- NCT02054117
- Testing
- Intracerebral Hemorrhage
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Florida