Clinical trials: acne
Acne Vulgaris
Efficacy and Safety of Adapalene Gel and Hyaluronic Acid Versus Adapalene Gel Alone in Mild to Moderate Acne Vulgaris
Acne vulgaris affects around 85% of adolescents and young adults. Adapalene, a topical retinoid, is a common treatment but often causes irritation, leading to poor adherence.
- Trial name
- NCT07102186
- Testing
- use of adapalene gel 0.1% and hyaluronic acid at bedtime, use of adapalene gel 0.1% once daily at bedtime
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Badr University
Acne
Addition of a Topical Steroid to a Topical Retinoid in Acne Patients
A randomized, split-face, placebo-controlled, double-blind, single-center clinical trial comparing topical retinoid on half the face and retinoid plus topical steroid on the other half.
- Trial name
- NCT02704507
- Testing
- Triamcinolone, Tretinoin, Emollient
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Acne Vulgaris, Isotretinoin
Investigation of the Effect of Oral Isotretinoin on Skin Thickness and Elasticity in Patients With Atrophic Acne Scar
Acne scar is a common complication of acne vulgaris (AV). Early and effective treatment of AV has a crucial role in managing both acne and acne scarring.
- Conditions
- Acne Vulgaris, Isotretinoin, Atrophic Acne Scar
- Trial name
- NCT05413200
- Testing
- Isotretinoin
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Training and Research Hospital
Skin Fold, Skin Laxity
A Safety and Effectiveness Study of CELLBOOSTER® Lift (Stabilized Booster Complex Using CHAC Technology)
The current post-market clinical investigation has been designed to evaluate the efficacy and safety of CELLBOOSTER® Lift, a HA-based product marketed by SUISSELLE SA.
- Conditions
- Skin Fold, Skin Laxity, Skin Texture Disorder, Skin Depression
- Trial name
- NCT06000839
- Testing
- (D0) Intradermal injection - micropapula technique, (D14) Intradermal injection - micropapula technique, (D28) Intradermal injection - micropapula technique
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Suisselle
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06253468
- Testing
- tested product
- Where
- Singapore
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Acne Vulgaris
P2 Multi-center Study of SB204 Gel in the Treatment of Acne Vulgaris
This is a randomized, multi-center, double-blinded study in subjects with moderate to severe acne vulgaris. Subjects eligible to enroll will be treated once or twice daily with 2 concentrations of a topical drug in development or…
- Trial name
- NCT02242760
- Testing
- SB204 2%, SB204 4%, Vehicle Gel
- Where
- 20 sites in United States
- Volunteers
- 213 people
- Sponsor
- Novan, Inc.
Acne Vulgaris
Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne Vulgaris
This is a randomized, comparator-controlled, single-blind, parallel-group study. The current study proposes to compare a fixed-dose combination product containing 3% benzoyl peroxide (BPO) and 1% clindamycin against a cream…
- Trial name
- NCT02058628
- Testing
- Clindamycin + BPO, Azelaic acid
- Where
- 11 sites in Germany
- Volunteers
- 222 people
- Sponsor
- GlaxoSmithKline
Atrophic Acne Scars
Efficacy of Human UC-MSC-derived Exosomes and BM-MSC-derived Exosomes for Atrophic Acne Scar
The goal of this clinical trial is to learn if exosomes from human umbilical cord and bone marrow can improve atrophic acne scars when used after fractional CO₂ laser treatment in adults.
- Trial name
- NCT07510295
- Testing
- Exosomes derived from human umbilical cord and bone marrow mesenchymal stem cells, Hyaluronic Acid (HA)
- Where
- Vietnam
- Volunteers
- 22 people
- Sponsor
- Ngô Anh Tuấn
Acne
Phase 1/2 Sequentially Staged Safety Study in Healthy Subjects and Subjects With Mild Acne
The purpose of this study is to determine the safety of photodynamic therapy (PDT) with lemuteporfin topical solution (LTS) in healthy subjects and subjects with mild acne.
- Trial name
- NCT01490736
- Testing
- Lemuteporfin
- Where
- Canada
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Dermira, Inc.
Acne
The Use of Oracea and Epiduo Forte in Severe Acne Patients
This is a single-center, open label pilot study. The study is comprised of 5 study visits; Screening, Baseline, and weeks 4, 8, and 12. All subjects will receive Oracea once daily (QD) and Epiduo Forte at Baseline.
- Trial name
- NCT03457636
- Testing
- Doxycycline Anhydrous 40 MG, Adapalene/Benzoyl Peroxide Gel 0.3-2.5%
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Derm Research, PLLC
Hidradenitis Suppurativa (HS)
Efficacy and Safety Study of Adalimumab in the Treatment of Hidradenitis Suppurativa
A study to evaluate the safety and efficacy of treatment with adalimumab in adults with moderate to severe hidradenitis suppurativa (HS).
- Trial name
- PIONEER II (NCT01468233)
- Testing
- adalimumab
- Volunteers
- 326 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Acne
RCT of an Oral Acne Supplement for Adult Women
This study is to assess the efficacy and tolerability of an oral supplement in mild to moderate acne in adult females.
- Trial name
- NCT06097871
- Testing
- Skin Nutraceutical Supplement
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Nutraceutical Wellness Inc.
Hidradenitis Suppurativa (Acne Inversa)
Efficacy, Safety, and Pharmacokinetics Study of CJM112 in Hidradenitis Suppurativa Patients
This is a randomized, double blind, multicenter study in patients with moderate to severe chronic hidradenitis suppurativa in parallel groups, to determine the efficacy and safety of multiple doses of CJM112 in comparison to…
- Trial name
- NCT02421172
- Testing
- CJM112
- Where
- 16 sites in United States, Denmark and 3 more
- Volunteers
- 66 people
- Sponsor
- Novartis Pharmaceuticals
Acne Vulgaris
Correlation Between Depression Scores and Serum NF-ĸB/NLRP3 Axis, Biotinidase, and HMGB After Treatment With Isotretinoin in Patients With Acne Vulgaris
Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinization, inflammation, and bacterial colonization of hair follicles on the face, neck…
- Trial name
- NCT06242288
- Testing
- ISOtretinoin 20 MG
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mostafa Bahaa
Acne Vulgaris, Female
Correlation Between Dehydroepiandrosterone Sulfate and Sebum Level in Adult Female Acne Vulgaris
The aim of this study is to determine the correlation between Dehydroepiandrosterone sulfate (DHEAS) and sebum level in adult female acne. A cross sectional study was conducted with 50 samples, in June to October 2017.
- Trial name
- NCT04555018
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Oily Skin, Acne Prone Skin
Dermal and Ophthalmological Acceptability and Comedogenicity Assessment of a Cosmetic Product
The goal of this clinical trial is to evaluate the dermatological and ophthalmological safety of a cosmetic product and to assess its comedogenic and acnegenic potential in participants with oily or acne-prone skin.
- Trial name
- NCT07848555
- Testing
- moisturizing cream
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Acne Vulgaris
Efficacy of Lappa Arctium (Homoeopathic Medicine) in Treatment of Acne Vulgaris
Acne is one of the most common skin problems in teenagers and adolescents. There are many lesser known homoeopathic medicines which have been mentioned in the literature for treatment of acne but their potential has not been…
- Trial name
- NCT01040390
- Testing
- Lappa Arctium
- Where
- India
- Volunteers
- 34 people
- Sponsor
- Miglani, Anjali
Acne Vulgaris
Photodynamic Therapy (PDT) With Methyl Aminolevulinate (MAL) Cream in Patients With Skin Type V or IV With Acne Vulgaris
In this multicenter study, patients with dark skin and acne vulgaris will be included. The patients will receive treatment with MAL PDT and placebo PDT.
- Trial name
- NCT00673933
- Testing
- Methyl aminolevulinate (MAL) PDT
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Photocure
Hidradenitis Suppurativa, Acne Inversa
Intense Pulsed Light Therapy for Hidrosadenitis Suppurativa
6 monthly treatments with IPL laser in patients with Hidradenitis Suppurativa. The effect in measured on several severity scores.
- Trial name
- NCT03203122
- Testing
- IPL laser
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Zealand University Hospital
Anterior Cutaneous Nerve Entrapment Syndrome, Nerve Entrapment Syndrome
A Pilot Study to Explore the Use of Skin Biopsy as Diagnostic Tool in Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)
ACNES is a neuropathic pain condition of the abdominal wall. It is a clinical diagnosis based on patient's history and physical examination. No diagnostic test is available to confirm the diagnosis.
- Conditions
- Anterior Cutaneous Nerve Entrapment Syndrome, Nerve Entrapment Syndrome, Chronic Pain Syndrome, Diagnosis
- Trial name
- Biopsy-ACNES (NCT05678127)
- Testing
- Skin biopsy
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Maxima Medical Center
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