Clinical trials: asthma
Severe Asthma
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)
The objective of this study is to assess the potential for GB-0895 to improve the health of adolescents and adults with severe asthma that is uncontrolled by inhaled corticosteroids (ICS) and conventional asthma controllers.
- Trial name
- NCT07276724
- Testing
- GB-0895
- Where
- 134 sites in United States, Brazil and 15 more
- Volunteers
- 786 people
- Sponsor
- Generate Biomedicines
Asthma
A 12-week Study to Compare the Efficacy and Safety of Albuterol Spiromax® Versus a Placebo in People 12 Years and Older With Persistent Asthma
The study will measure the change in lung function in subjects with asthma after inhaling from either of two inhalers: Albuterol Spiromax® or placebo.
- Trial name
- NCT01424813
- Testing
- Albuterol MDPI
- Where
- 38 sites in United States
- Volunteers
- 158 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma
Efficacy of Oral AB1010 in Adult Patients With Severe Persistent Corticosteroid Dependent Asthma
The aim of the study is to evaluate, comparatively to a placebo, the activity of oral AB1010, administered at three dose levels during 4 months to patients with severe persistent corticosteroid dependent asthma, assessed on : the…
- Trial name
- NCT00842270
- Testing
- AB1010
- Volunteers
- 44 people
- Sponsor
- AB Science
Asthma
TELICAST : Telithromycin in Acute Exacerbations of Asthma
Primary Objective: The primary objective is to evaluate the clinical efficacy of telithromycin versus placebo as a supplement to the usual standard of care during an acute exacerbation of asthma.
- Trial name
- NCT00273520
- Testing
- Telithromycin
- Sponsor
- Sanofi
Allergic Asthma, Allergy to House Dust
Validation of Strasbourg Environmental Exposure Chamber ALYATEC in Mite Allergic Subjects With Asthma
This is a randomized, double blind, cross-over study designed to determine the concentration of airborne house dust mite allergen inducing bronchial response in asthmatic subjects allergic to mite, during allergen exposures in…
- Conditions
- Allergic Asthma, Allergy to House Dust, Allergy
- Trial name
- NCT04663880
- Testing
- Exposure to three concentrations of HDM allergen in EEC, Exposure to a single concentration of HDM allergen in EEC
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Alyatec
Asthma
Indirect Cost of Illness Study of Moderate and Severe Asthma in Quebec
Rationale Asthma is a chronic inflammatory disorder of the airways affecting persons of all ages and is recognized as one of the most common chronic diseases.
- Trial name
- NCT02153346
- Testing
- Valuation of lost productivity questionnaire, Work productivity and activity impairment questionnaire
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- GlaxoSmithKline
Asthma
Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma
This is a phase 2, open-label extension study to evaluate the long-term safety and efficacy of lunsekimig in adult participants with asthma who have previously completed the parent studies.
- Trial name
- AIRPHRODITE (NCT06609239)
- Testing
- Lunsekimig
- Where
- 150 sites in United States, Argentina and 18 more
- Volunteers
- 900 people
- Sponsor
- Sanofi
Asthma
Efficacy and Safety Study of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.
This study aimed to determine the efficacy and safety of QAW039 150 mg and QAW039 450 mg, compared with placebo, when added to GINA (Global Initiative for Asthma) steps 4 and 5 standard-of- care (SoC) asthma therapy (GINA 2016)…
- Trial name
- NCT02555683
- Testing
- QAW039
- Where
- 234 sites in United States, Argentina and 25 more
- Volunteers
- 894 people
- Sponsor
- Novartis Pharmaceuticals
Asthma, Exercise-Induced
Montelukast Compared With Placebo and Salmeterol in Exercise-Induced Bronchoconstriction (0476-316)
To determine the effect of an approved medication being studied in support of a new approach in the prevention of exercise-induced asthma (a worsening of asthma caused by exercise, also known as exercise-induced bronchospasm), in…
- Trial name
- NCT00245570
- Testing
- Comparator: Montelukast, Comparator: Salmeterol
- Volunteers
- 47 people
- Sponsor
- Organon and Co
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Asthma
Chronic Asthma Study in 2- to 5-Year-Old Patients (MK0476-072 )
A study in 2-5 year old children to evaluate the safety and tolerability of montelukast and placebo administered once daily at bed time.
- Trial name
- NCT00968201
- Testing
- montelukast sodium
- Volunteers
- 689 people
- Sponsor
- Organon and Co
Severe Asthma
Characterization and Clinical Outcomes of Severe Asthma Patients in Israel Treated With Benralizumab (SAIL-B)
A retrospective, observational, one arm, single country study, using the computerized database of Maccabi Health Services (MHS).
- Trial name
- SAIL-B (NCT07218172)
- Where
- Israel
- Volunteers
- 197 people
- Sponsor
- AstraZeneca
Severe IgE-mediated Asthma
Study to Assess the Efficacy and Safety of Omalizumab Treatment on ICS Reduction for Severe IgE-mediated Asthma
Assess efficacy and safety of omalizumab treatment during 12 months in order to reduce the use of inhaled corticosteroid (ICS) in pediatric and adult participants with severe Immunoglobulin E (IgE)-mediated asthma inadequately…
- Trial name
- MEXIC (NCT01912872)
- Testing
- Omalizumab, Budesonide, Formoterol
- Where
- 21 sites in Mexico
- Volunteers
- 112 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
Influence Of Different Airflow Resistances On Drug Effect Of 50μg Salmeterol And 6 μg Formoterol
Effect of inhaled drugs administered as dry powder is not only dependent on drug efficacy but also on technical properties of the inhalers.
- Trial name
- NCT00327353
- Testing
- formoterol (TURBOHALER), Salmeterol (DISKUS)
- Where
- 2 sites in Germany
- Volunteers
- 77 people
- Sponsor
- GlaxoSmithKline
Asthma
Cost-effectiveness Study of Beclomethasone Versus Ciclesonide as Controller Medications in Pediatric Asthma
The Objective was to Develop a Cost-Effectiveness study that compares Ciclesonide and Beclomethasone in pediatric asthma control.
- Trial name
- NCT01333800
- Testing
- Beclomethasone, Ciclesonide
- Where
- Colombia
- Volunteers
- 94 people
- Sponsor
- Grünenthal Colombiana S.A.
Asthma
An Evaluation of VR942 in Healthy Volunteers and Patients With Mild Asthma
The purpose of the study is to Evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of single inhaled doses of VR942 in healthy subjects (part 1) and repeated doses in mild asthmatics (part 2).
- Trial name
- NCT02473939
- Testing
- VR942 delivered via a Vectura Dry Powder Inhaler
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Vectura Limited
Asthma
Clinical Trial of MG-K10 in Stage III of Moderate to Severe Asthma
A randomized, double-blind, placebo-controlled Phase III clinical trial on the efficacy and safety of MG-K10 humanized monoclonal antibody injection in adolescent and adult patients with moderate to severe asthma.
- Trial name
- NCT06837922
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Shanghai Mabgeek Biotech.Co.Ltd
Asthma
Single Ascending Dose Study of CM326 in Healthy Volunteers
Single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of CM326 in healthy volunteers.
- Trial name
- NCT04842201
- Testing
- CM326
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Keymed Biosciences Co.Ltd
Asthma
A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
The primary objective of this study is to describe the efficacy of rocatinlimab in reducing asthma exacerbations.
- Trial name
- NCT06376045
- Testing
- Rocatinlimab
- Where
- 154 sites in United States, Argentina and 17 more
- Volunteers
- 317 people
- Sponsor
- Amgen
Asthma
Efficacy and Safety of Roflumilast in Patients With Asthma (BY217/M2-012)
The aim of the study is to compare the effects of oral roflumilast with placebo on lung function in patients with asthma.
- Trial name
- NCT00073177
- Testing
- Roflumilast
- Where
- 41 sites in United States, Argentina and 3 more
- Volunteers
- 819 people
- Sponsor
- AstraZeneca
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