Clinical trials: asthma
Asthma
A Study in Asthmatic Children (6 to <12 Yrs) Comparing Single Doses of Formoterol and Foradil® Evaluating Efficacy
This purpose of the study is to investigate the bronchodilating effects of 3 different dosages of formoterol given in combination with budesonide as Symbicort pMDI.
- Trial name
- CHASE 2 (NCT01136655)
- Testing
- 80/2.25 μg Symbicort pMDI, 80/4.5 μg Symbicort pMDI, Foradil Aerolizer 12 μg
- Where
- 34 sites in United States, Bulgaria and 4 more
- Volunteers
- 54 people
- Sponsor
- AstraZeneca
Chronic Asthma, COPD
Intervention to Improve Inhalative Adherence
Despite progress in pharmacological and non-pharmacological treatment in recent years, the burden of disease among asthma and COPD patients is high and patients may be frequently hospitalized due to exacerbations.
- Trial name
- NCT02386722
- Testing
- Electronic Monitoring with audio reminders and additional support
- Where
- 2 sites in Switzerland
- Volunteers
- 169 people
- Sponsor
- Cantonal Hospital, Baselland
Bronchial Asthma
Symbicort Rapihaler Therapeutic Equivalence Study
The purpose of the this study is to evaluate the efficacy and safety of 2 actuations Symbicort®pMDI® 40/2.25 μg twice daily compared with1 inhalation Symbicort Turbuhaler® 80/4.5 μg twice daily and 1 inhalation…
- Trial name
- ESTHER (NCT00536731)
- Testing
- Symbicort Turbuhaler, Symbicort pMDI, Pulmicort Turbuhaler
- Where
- 48 sites in Bulgaria, Czechia and 2 more
- Volunteers
- 742 people
- Sponsor
- AstraZeneca
Asthma Chronic
Azithromycin Treatment for the Airway Microbiome in Asthma
The purpose of this study to determine whether the bacteria inside the lungs of people with asthma can be modified (changed) if they are given an antibiotic and if this change is associated with an improvement in asthma symptoms.
- Trial name
- NCT03736629
- Testing
- Azithromycin
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Asthma
RVA Breathes: A Richmond City Collaboration to Reduce Pediatric Asthma Disparities
The goal of this study is to evaluate a sustainable, community-engaged program to reduce asthma disparities among 5 to 11-year-old children in Richmond, Virginia.
- Trial name
- NCT03297645
- Testing
- School, Asthma education, Home environmental remediation
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Virginia Commonwealth University
Asthma
Dietary Supplementation With Soy Isoflavones in Asthma
An epidemiologic study of patients with asthma has shown that increased intake of soy isoflavones correlates with less severe asthma.
- Trial name
- NCT00277446
- Testing
- Soy isoflavones
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Northwestern University
Allergic Asthma
Predicting the Clinical Response to Omalizumab With Anti-Immunoglobulin E (IgE) Ab Response or Syk Expression in Basophils
This research is being done to test whether differences in blood cells at baseline (start of the study) can be used to predict how well omalizumab will work in a patient. Omalizumab (Xolair) is a drug approved by the U.S.
- Trial name
- NCT02023151
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Johns Hopkins University
Pediatric Asthma
Developing a Childhood Asthma Risk Passive Digital Marker
Underdiagnosis and undertreatment is a major problem in childhood asthma management, especially in preschool-aged children. Current prognostic approaches using risk-score based tools have poor-to-modest accuracy, are impractical…
- Trial name
- NCT05826561
- Testing
- Childhood Asthma Passive Digital Marker
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Indiana University
Asthma
Step-up Yellow Zone Inhaled Corticosteroids to Prevent Exacerbations
The objective of this study is to determine whether, in children receiving low-dose inhaled corticosteroids (ICS), quintupling the dose of inhaled corticosteroids at the onset of symptoms previously associated with upper…
- Trial name
- STICS (NCT02066129)
- Testing
- Fluticasone 44 mcg, Fluticasone 220 mcg
- Where
- 18 sites in United States
- Volunteers
- 254 people
- Sponsor
- Milton S. Hershey Medical Center
Asthma
A Study of Mometasone Furoate Metered Dose Inhaler in Children With Persistent Asthma (P04223)
The primary objective of this study is to demonstrate the dose-related efficacy, by evaluating morning (AM) lung function at the end of the dosing interval (AM pre-dose percent predicted forced expiratory volume in one second…
- Trial name
- NCT01502371
- Testing
- Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 25 mcg, Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 50 mcg, Mometasone Furoate (MF) Metered Dose Inhaler (MDI), 100 mcg
- Volunteers
- 583 people
- Sponsor
- Organon and Co
Asthma
Single Dose Study to Assess Efficacy, Safety and Tolerability of LAS100977 in Asthmatic Patients.
The purpose of this study is to evaluate the pharmacodynamics of single doses of inhaled LAS100977 QD in patients with persistent asthma.
- Trial name
- NCT01425801
- Testing
- LAS100977 0.313 μg, LAS100977 0.625 μg, LAS100977 1.25 μg
- Where
- 9 sites in Germany, United Kingdom
- Volunteers
- 62 people
- Sponsor
- AstraZeneca
Asthma
A Study to Evaluate the Safety and Tolerability of the Administration of MEDI-528 When Administered in Multiple Doses to Adults With Mild Persistent Asthma
The primary objective of this study is to evaluate the safety and tolerability of escalating multiple SC doses of MEDI-528 in adult patients with mild persistent asthma.
- Trial name
- NCT00507130
- Testing
- MEDI528 0.3 mg/kg, MEDI528 1 mg/kg, MEDI528 3 mg/kg
- Where
- 9 sites in United States, Canada
- Volunteers
- 36 people
- Sponsor
- MedImmune LLC
Asthma
Asthma Express: Bridging the Emergency to Primary Care in Underserved Children
Asthma is the number one cause of pediatric emergency department (ED) visits in young minority children and is responsible for high healthcare costs.
- Trial name
- NCT01981564
- Testing
- Asthma Express Intervention, Standard Asthma Education Control Group
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Johns Hopkins University
Asthma
Efficacy And Safety Of GW642444M Comparing Placebo In Adolescent And Adult Subjects With Persistent Asthma.
This study is designed to determine if the investigational drug is effective and safe in individuals with asthma
- Trial name
- NCT00600171
- Testing
- GW642444M
- Where
- 89 sites in United States, Argentina and 14 more
- Volunteers
- 614 people
- Sponsor
- GlaxoSmithKline
Allergic Bronchopulmonary Aspergillosis
Phase 1 Three Part SAD, MAD & Cross-Over Study of ZP-059 in Healthy and Asthmatic Subjects
The primary safety objectives were: Part 1: To determine the safety and tolerability of single doses of ZP-059 in healthy subjects Part 2: To determine the safety and tolerability of multiple doses of ZP-059 in subjects with mild…
- Trial name
- NCT04229303
- Testing
- Voriconazole inhaled, oral voriconazole
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Zambon SpA
Eosinophilic Asthma
A Study to Evaluate the Efficacy and Safety of Reslizumab (3.0 mg/kg) in the Reduction of Clinical Asthma Exacerbations in Patients (12-75 Years of Age) With Eosinophilic Asthma
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy, safety, and immunogenicity of treatment with reslizumab in patients with eosinophilic asthma.
- Trial name
- NCT01287039
- Testing
- Reslizumab
- Where
- 128 sites in United States, Australia and 15 more
- Volunteers
- 489 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma
Comparing the Efficacy of Bricanyl M2 and Bricanyl M3 at 0.5 and 1.5 mg Dose Levels, to Allow for a Switch From Bricanyl Turbuhaler M2 to Bricanyl Turbuhaler M3
A randomised, double-blind, double-dummy, multi-site, phase III, single dose, 4-way cross-over pharmacodynamic study evaluating the efficacy of Bricanyl Turbuhaler M3 compared to Bricanyl Turbuhaler M2 by studying the protective…
- Trial name
- NCT02322788
- Testing
- Terbutaline sulphate
- Where
- 4 sites in Canada, Netherlands and 1 more
- Volunteers
- 95 people
- Sponsor
- AstraZeneca
Asthma
An Evaluation of Dupilumab in Patients With Moderate to Severe Uncontrolled Asthma
Primary Objective: To evaluate the efficacy of different doses and regimens of dupilumab in participants with moderate to severe uncontrolled asthma.
- Trial name
- NCT01854047
- Testing
- Dupilumab, ICS/LABA therapy, Salbutamol/albuterol
- Where
- 201 sites in United States, Argentina and 14 more
- Volunteers
- 776 people
- Sponsor
- Sanofi
Asthma
A 6 Month Safety Study Comparing Symbicort With Inhaled Corticosteroid Only in Asthmatic Adults and Adolescents
The purpose of the study is to evaluate the safety of Symbicort compared to inhaled corticosteroid alone during 6 months in adult and adolescent patients with asthma
- Trial name
- NCT01444430
- Testing
- Symbicort pMDI, budesonide pMDI
- Where
- 340 sites in United States, Argentina and 24 more
- Volunteers
- 12,460 people
- Sponsor
- AstraZeneca
Asthma, Allergic Rhinitis
Sunovion Growth Study Pediatric Subjects With Mild Asthma & Allergic Rhinitis
This study will provide the clinicians guidance on the safest combination of inhaled and nasal corticosteroids for children with mild asthma and allergic rhinitis respectively; however, one safety concern is that these products…
- Trial name
- NCT01550471
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- West Penn Allegheny Health System
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