Clinical trials: asthma
Asthma
Phase 2 Study to Evaluate RPT193 in Adults With Moderate to Severe T2-high Asthma
Randomized, multi-center, double-blind, placebo-controlled, parallel group, proof of-concept study with RPT193 in subjects with T2-high, moderate-to-severe asthma who are partially controlled on medium or high doses of inhaled…
- Trial name
- NCT05935332
- Testing
- RPT193
- Where
- 29 sites in United States, Bulgaria and 2 more
- Volunteers
- 38 people
- Sponsor
- RAPT Therapeutics, Inc., a member of the GSK plc group of companies
Asthma
BI 671800 in Asthmatic Patients on Inhaled Corticosteroids
This is a 6 week study to assess the effect of BI 671800 in patients with asthma. It is a double blind, parallel arm trial testing the safety and efficacy of BI 671800. The main objective is to assess the effect on lung function.
- Trial name
- NCT01103349
- Testing
- BI 671800, Montelukast
- Where
- 53 sites in United States, Austria and 7 more
- Volunteers
- 243 people
- Sponsor
- Boehringer Ingelheim
Asthma
A Study to Explore the Utility of Fractional Exhaled Nitric Oxide (FeNO) Compared With Methacholine Challenge (MCC) Testing in the Assessment of Patients With Suspected But Undiagnosed Asthma
Objective: To explore the utility of Fractional Exhaled Nitric Oxide (FeNO) compared with Methacholine Challenge (MCC) testing in assessing patients with suspected but undiagnosed asthma Number of participants: Approximately 50…
- Trial name
- NCT01648920
- Testing
- NIOX MINO® Instrument (09-1100)
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- Aerocrine AB
Asthma
Using Computers to Assist in the Treatment of Asthma in a Pediatric Setting
This study seeks to improve physician adherence to four recommendations of the NHLBI asthma treatment guidelines: 1. Improve case detection of asthma among patients with pulmonary symptoms, 2.
- Trial name
- NCT01312805
- Testing
- CHICA Asthma Module, CHICA Control
- Where
- United States
- Volunteers
- 2,098 people, healthy volunteers welcome
- Sponsor
- Indiana University
Asthma
Dose-Response of Salmeterol in Children
To examine whether a breathing test (methacholine challenge using impulse oscillometry) can be used to tell the difference between two different doses of an inhaled drug, salmeterol, delivered by Advair in children with asthma
- Trial name
- NCT01907334
- Testing
- Advair Diskus100/50 µg, Flovent Diskus 100 µg, Methacholine Chloride
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Asthma
Telemedicine Enhanced Asthma Management Through the Emergency Department
In the US, children from minority ethnic and racial backgrounds suffer disproportionately from asthma and account for substantially more emergency department (ED) visits and hospitalizations than non-minority children.
- Trial name
- TEAM-ED (NCT02752165)
- Testing
- TEAM-ED, Enhanced Usual Care
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- University of Rochester
Asthma
A Randomized Trial Comparing Metered Dose Inhalers and Breath Actuated Nebulizers
This study is determines if metered dose inhalers are as effective as breath actuated nebulizers for the treatment of mild to moderate asthma exacerbations in pediatric patients presenting to the emergency department.
- Trial name
- NCT02777125
- Testing
- Metered Dose Inhaler, Breath Actuated Nebulizer
- Volunteers
- 980 people
- Sponsor
- Le Bonheur Children's Hospital
Severe Asthma
Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor Initiation
Eosinophilic inflammation in the small airways of patients with severe asthma is considered to be an important marker of disease severity.
- Trial name
- IMPOSE (NCT05147155)
- Testing
- Mepolizumab
- Where
- Greece
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Asthma
Dose-response of Inhaled Formoterol Using Methacholine Challenge as a Bioassay
The purpose of this study is to find out whether a difference between two doses of formoterol can be detected by methacholine challenge.
- Trial name
- NCT00643578
- Testing
- formoterol, Dry Powder Inhaler (Twisthaler)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Florida
Congenital Diaphragmatic Hernia
Airway Inflammation in Congenital Diaphragmatic Hernia Patients
We propose to examine Congenital Diaphragmatic Hernia (CDH) patients for evidence of airway inflammation as a first step to characterize the reported bronchodilator responsiveness.
- Trial name
- NCT02453750
- Testing
- Hypersaline, Bronchodilator Response
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- The Hospital for Sick Children
Bronchial Asthma
Clinical Pharmacodynamic Bioequivalence Study of Beclomethasone Dipropionate 40 mcg INH
To compare the therapeutic equivalence of Beclomethasone Dipropionate MDI (Inhalation Aerosol) 0.04 mg/ INH with the marketed QVAR® 40 mcg (Beclomethasone dipropionate hydrofluoroalkane (HFA)) and to demonstrate superiority of…
- Trial name
- QVR (NCT04051710)
- Testing
- Test Product, Reference Product
- Where
- India
- Volunteers
- 1,550 people
- Sponsor
- Aurobindo Pharma Ltd
Asthma
A Study to Evaluate the Efficacy of MEDI-528 on Late Asthmatic Response With Atopic Asthma
This is a Phase 2a, randomized multicenter study to evaluate the efficacy of MEDI-528 on LAR in adult patients with atopic asthma.
- Trial name
- NCT00394654
- Testing
- MEDI-528 9 mg/kg
- Where
- 3 sites in Canada
- Volunteers
- 30 people
- Sponsor
- MedImmune LLC
Chronic Cough, Eosinophilic Bronchitis
Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases
Cough is the most common presenting symptom to family physician. Chronic Cough affects approximately 10-12% of the general population and is one of the commonest reasons for referral to secondary care.
- Conditions
- Chronic Cough, Eosinophilic Bronchitis, Asthma
- Trial name
- MUCOSA (NCT04765722)
- Testing
- Mepolizumab, Normal Saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- McMaster University
Asthma, Exercise-Induced
Montelukast in Exercise-Induced Bronchospasm - 2003 (0476-270)
The purpose of this study is to determine the effect of an approved medication being studied in support of a new approach in the prevention of exercise-induced asthma (a worsening of asthma caused by exercise, also known as…
- Trial name
- NCT00092131
- Testing
- Comparator: Montelukast
- Volunteers
- 51 people
- Sponsor
- Organon and Co
Asthma
Albuterol Versus Xopenex in Treatment of Acute Asthma in the Emergency Department (ED)
The purpose of this study is to determine in a large, double-blind, randomized, prospective pediatric clinical trial whether the use of continuous levalbuterol (Xopenex) in addition to standard emergency department treatment for…
- Trial name
- Xopenex (NCT00585039)
- Testing
- xopenex
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Phoenix Children's Hospital
Asthma
Asthma Symptom Management Through Mindfulness Training
Asthma is one of the four most common adult chronic disorders. Supporting asthma patients in improving their asthma control and symptoms as well as their quality of life are important goals in clinical management.
- Trial name
- NCT02275559
- Testing
- Mindfulness Based Stress Reduction (MBSR), Healthy Living Course (HLC)
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Asthma
Efficacy of Inhaled Albuterol Spiromax® in Subjects With Persistent Asthma With Steady State Pharmacokinetics
The primary objective of this study is to evaluate the efficacy of Albuterol Spiromax® versus placebo in subjects with persistent asthma.
- Trial name
- NCT01747629
- Testing
- Albuterol MDPI
- Where
- 35 sites in United States
- Volunteers
- 160 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma
Asthma Intervention Research (AIR) Trial
The purpose of this study is to demonstrate the effectiveness and safety of the Alair System for the treatment of asthma. This will be a multicenter, randomized controlled study comparing the effects of treatment with the Alair…
- Trial name
- NCT00214526
- Testing
- Bronchial thermoplasty with the Alair System, Conventional therapy with ICS+LABA
- Volunteers
- 112 people
- Sponsor
- Asthmatx, Inc.
Asthma
Study of Safety of QAW039 in Patients With Asthma Inadequately Controlled on Standard-of-care Asthma Treatment
This study was a 2-treatment period, randomized, multicenter parallel-group study. The overall purpose of this study was to provide long- term safety data for fevipiprant (QAW039) (Dose 1 and Dose 2), compared with placebo, when…
- Trial name
- NCT03052517
- Testing
- QAW039 150 mg, QAW039 450 mg
- Where
- 347 sites in United States, Argentina and 40 more
- Volunteers
- 2,538 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease
Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Subjects
AZD8871 is a new chemical entity possessing long-acting effect in a single molecule which presents a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an…
- Trial name
- NCT02814656
- Testing
- AZD8871
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
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