Clinical trials: asthma
Pediatric Asthma, Maternal Depression
Intervention for Depressed Latina Mothers of Children With Asthma
This study is to develop and pilot test a new group-based intervention for depressed Latina mothers of children with asthma. The investigators ongoing work has identified that close to 50% of Latina mothers of children with…
- Trial name
- MAADRE (NCT01326182)
- Testing
- MAADRE, MAAS
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 114 people
- Sponsor
- Rhode Island Hospital
Asthma
Randomised Study Comparing the Effects of Inhaled Fluticasone Furoate (FF)/Vilanterol (VI; GW642444M) Combination and FF on an Allergen Induced Asthmatic Response
We propose to use an inhaled allergen challenge model to explore the individual contributions of the components of a novel long-acting beta agonist (LABA)/ inhaled corticosteroid (ICS) combination product on protection from…
- Trial name
- NCT01128569
- Testing
- Fluticasone Furoate, FF/Vilanterol (VI; GW642444M)
- Where
- 4 sites in Germany, New Zealand and 1 more
- Volunteers
- 52 people
- Sponsor
- GlaxoSmithKline
Asthma
Breathing Exercises for Asthma
Despite the advances in pharmacological therapy for asthma, there has been an increasing worldwide interest in alternative therapies for asthma.
- Trial name
- NCT02151422
- Testing
- Breathing exercise
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Asthma
A Phase 4, Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Effect of Dupilumab on Sleep Disturbance in Patients With Uncontrolled Persistent Asthma
Primary Objective: To assess the effect of dupilumab on sleep Secondary Objectives: To evaluate the effect of dupilumab on additional participant reported sleep outcomes To evaluate the effect of dupilumab on objective sleep…
- Trial name
- MORPHEO (NCT04502862)
- Testing
- SAR231893
- Where
- 55 sites in United States, Argentina and 9 more
- Volunteers
- 202 people
- Sponsor
- Sanofi
Asthma
Sorting and Expression Profiling of Airway Cells From Humans (The SEARCH Study)
This will be a single site, mechanistic study of asthmatic subjects and healthy, non-asthmatic controls involving a baseline characterization visit and a research bronchoscopy visit.
- Trial name
- SEARCH (NCT02791542)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Asthma
Efficacy of Symbicort Versus Its Monocomponents - SPRUCE 160/4.5
The purpose of this study is to compare Symbicort with budesonide alone and with formoterol alone in the treatment of asthma in adolescents and adults
- Trial name
- NCT00652002
- Testing
- budesonide/formoterol, budesonide, formoterol
- Volunteers
- 450 people
- Sponsor
- AstraZeneca
Asthma
Comparison of Flutter and PEP Mask on Chest Clearance, Dyspnea in Elderly Asthmatic Patients
This study will be a Randomized controlled and will be conducted in Allied Hospital, Faisalabad. The study will be completed within the duration of 10 months. Convenience sampling study technique will be used to collect the data.
- Trial name
- NCT05618873
- Testing
- Flutter device, positive expiratory pressure mask
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Asthma
Fluticasone/Salmeterol (FP/SM) Versus Double the Dose Fluticasone (FP) in Patients With Mild to Moderate Asthma
The purpose of this study is to compare the effects of Fluticasone/ salmeterol combination and double the dose of fluticasone on airway hyper-responsiveness to methacholine in a randomised, double blind, double dummy, cross-over…
- Trial name
- CLE001 (NCT00830505)
- Testing
- fluticasone/salmeterol, fluticasone
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University of Dundee
Pulmonary Disease, Chronic Obstructive
Genomic/ Proteomic/ Metabonomic Profiling in Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by progressive airflow obstruction, chronic cough and dyspnoea in advanced stages. We hope to develop a better understanding of lung disease.
- Trial name
- NCT00655694
- Testing
- sputum, blood, urine, exhaled breath, lung function
- Where
- United Kingdom
- Sponsor
- Imperial College London
Asthma in Children
Clinical Study on Chinese Children's Asthma Action Plan
This study is a multi-center randomized controlled trial of children with asthma. The objective of the study is to assess the efficacy of China Children Asthma Action Plan (CCAAP), which is the first asthma action plan for…
- Trial name
- NCT03435822
- Testing
- asthma action plan management group, conventional management group
- Volunteers
- 400 people
- Sponsor
- Beijing Children's Hospital
Allergic Bronchopulmonary Aspergillosis, Severe Asthma
Real-World Effectiveness of Benralizumab in Allergic Bronchopulmonary Aspergillosis
An open-label study will evaluate effects of Benralizumab in the treatment of severe asthma in patients with allergic bronchopulmonary aspergillosis
- Conditions
- Allergic Bronchopulmonary Aspergillosis, Severe Asthma, ABPA
- Trial name
- NCT07530770
- Testing
- Fasenra
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Qianfoshan Hospital
Asthma
Risk Factors for Early Remodelling in Severe Asthma in Children
Background: Asthma is a frequent disease characterized by bronchial hyperresponsiveness, inflammation and remodeling. Consistent epidemiological data indicate that outcome of asthma in adults may be determined in early childhood.
- Trial name
- P'tit-ASTHME (NCT02806466)
- Testing
- Fiberoptic bronchoscopy
- Where
- 2 sites in France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Bordeaux
Asthma
A Study Comparing the Efficacy and Safety of CHF 1535 (BDP +FF) Inhalation Powder, Administered Via the NEXT Inhaler, Versus CHF 1535 (BDP +FF), Administered Via a pMDI, in Moderate to Severe Asthma
To demonstrate that CHF 1535 via NEXT DPI (beclomethasone dipropionate + formoterol fumarate 100 + 6 μg), 1 inhalation or 2 inhalations twice daily, for 12 weeks is non-inferior to the corresponding dose of CHF 1535 via HFA-134a…
- Trial name
- NCT00862394
- Testing
- BDP/Formoterol Next DPI, Foster
- Where
- Germany
- Volunteers
- 783 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma, Copd
Monitoring Metered Dose Inhalation (MDI) Volume and Timing With a Respimetrix Device in Obstructive Lung Disease.
To Determine whether use of the Respimetrix flow test device a) can determine "good" versus "poor" inhaler techniques, and b) the effects of the inhaler training on technique.
- Trial name
- NCT05495256
- Testing
- Respimetrix
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Pulmonary Critical Care Associates of Baltimore
Asthma
Study to Evaluate the Pharmacokinetic Profile of Salbutamol Delivered by Unit Dose Dry Powder Inhaler (UD-DPI) Compared to the Diskus and Metered Dose Inhaler (MDI) in Healthy Volunteers.
This is an open-label, two part, six period- cross over, randomised, single dose, single centre study in healthy subjects. This is the first clinical study for the UD-DPI. This study is divided into two parts.
- Trial name
- NCT01984086
- Testing
- Salbutamol Sulphate 150mcg UD-DPI Blister(1.6% blend), Salbutamol Sulphate 200mcg UD-DPI Blister(1.6% blend), Salbutamol Sulphate 250mcg UD-DPI Blister(1.6% blend)
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Asthma
The Effect of Prasugrel on Bronchial Hyperreactivity and on Markers of Inflammation in Patients With Chronic Asthma
Cysteinyl leukotrienes (cys-LTs) are lipid inflammatory mediators that abound in mucosal inflammation and play a validated role in the pathogenesis of human asthma.
- Trial name
- PRINA (NCT01305369)
- Testing
- Prasugrel
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- University of Milan
Asthma, Asthma in Children
Prospective Multicentre Study on Symptoms in First-onset Bronchial Asthma in Children and Adolescents
Bronchial asthma may present with symptoms other than the commonly reported complaints (cough, chest tightness, shortness of breath and wheezing).
- Conditions
- Asthma, Asthma in Children, Dyspnea, Cough
- Trial name
- NCT06201494
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Charles University, Czech Republic
Asthma, Allergy
Efficacy of Air Cleaners in Asthmatics Allergic to Cat in ALYATEC Environmental Exposure Chamber
The aim of this study is to determine the efficacy of Rowenta® "Intense Pure Air XL" air cleaner on the early and late bronchial response, in cat-allergic asthmatic patients during an allergen exposure in ALYATEC environmental…
- Trial name
- NCT03928561
- Testing
- Active intense Pure Air XL air cleaner
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Alyatec
Chronic Obstructive Pulmonary Disease, Asthma
Video vs. TTG Respiratory Inhaler Technique Assessment and InstructioN (V-TRaIN)
The purpose of this study is to evaluate the effectiveness of two different ways to teach subjects while hospitalized how to use respiratory inhalers and to follow-up after discharge home from the hospital to determine durability…
- Trial name
- NCT02611531
- Testing
- Video Module Education (VME), Teach-To-Goal (TTG)
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Chicago
Child Development, Child Obesity
Southampton Women's Survey
The Southampton Women's Survey was established to assess the influence of factors operating before conception and during pregnancy on the health and development of the offspring.
- Conditions
- Child Development, Child Obesity, Child Behavior, Nutritional and Metabolic Diseases
- Trial name
- SWS (NCT04715945)
- Volunteers
- 12,583 people, healthy volunteers welcome
- Sponsor
- University of Southampton
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