Clinical trials: asthma
Asthma
Japanese Phase 1 Study of Mepolizumab
SB-240563 is a fully humanized monoclonal antibody which is specific for human interleukin-5 (IL-5) and has been under development for severe refractory asthma. This study is the first study in Japanese subjects.
- Trial name
- NCT01471327
- Testing
- SB-240563
- Where
- Australia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Asthma, Bronchial, Lung Diseases, Obstructive
A Study To Examine The Safety And Efficacy Of PF-00610355 In Moderately Asthmatic Subjects
This study (A7881006) is the first multiple dose study in moderate asthmatic subjects and aims to determine the safety and efficacy of PF-00610355 when subjects take PF-00610355 on a daily basis for 4 weeks in subjects maintained…
- Conditions
- Asthma, Bronchial, Lung Diseases, Obstructive, Respiratory Tract Diseases, Bronchial Diseases
- Trial name
- A7881006 (NCT00830427)
- Testing
- PF-00610355, PF - 00610355
- Sponsor
- Pfizer
Asthma
Safety and Immunogenicity of Sequential Pneumococcal Immunization in Preschool Asthmatics
Asthma is a major health problem in preschool children. Infections by pneumococci a the most frequent cause of airway infections, which tend to cause worsening of asthma.
- Trial name
- PAPSI (NCT00836641)
- Testing
- prevenar, pneumovax
- Volunteers
- 70 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Asthma, Lung Diseases
Genetics of Asthma and Bronchial Hyperresponsiveness
To investigate the genetics of asthma by reexamining a carefully characterized population of patients with asthma, and by studying their families.
- Trial name
- NCT00005359
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obstructive Lung Disease, Chronic Obstructive Pulmonary Disease
Treatment With AKL1 in Obstructive Airways Disease (The TAKL Study)
Obstructive airways disease is a very common condition. This condition includes patients with asthma, chronic obstructive pulmonary disease (COPD), emphysema or chronic bronchitis.
- Conditions
- Obstructive Lung Disease, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- TAKL (NCT00920127)
- Testing
- AKL1
- Where
- United Kingdom
- Volunteers
- 164 people
- Sponsor
- University of East Anglia
Asthma (Diagnosis)
ADO-5030 in Bronchoconstriction Challenge, Phase 1b
This is a Phase 1 study to learn about the safety and pharmacokinetics of the study drug in patients with asthma and whether the study drug has effect during a respiratory challenge.
- Trial name
- NCT07281274
- Testing
- ADO-5030
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Adovate
Asthma
The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma
Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat.
- Trial name
- NCT05496582
- Testing
- No intervention
- Where
- 2 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Asthma
Pediatric Study to Evaluate Treatment of Persistent Moderate or Severe Asthma With the Association Fluticasone 250 mcg/Dose and Salmeterol 50 mcg/Dose - ADERE PROJECT
Prospective, parallel-group, randomized study to evaluate the compliance to the treatment of children aged between 6 and 14 years old with persistent moderate or severe asthma, receiving the association Fluticasone 250 mcg/dose…
- Trial name
- ADERE (Ped) (NCT01476059)
- Testing
- Telephone follow-up, No telephone follow-up
- Volunteers
- 472 people
- Sponsor
- GlaxoSmithKline
Asthma
Implementing a Healthcare Provider Education Intervention in Rural Communities to Reduce Asthma Morbidity
The aim of the study is to pilot test the implementation of healthcare provider education interventions to improve asthma outcomes in rural youth residing in Bradford County, Florida.
- Trial name
- NCT04060823
- Testing
- Easy Breathing program
- Where
- 4 sites in United States
- Volunteers
- 512 people
- Sponsor
- University of Florida
Asthma
A Randomized Study To Evaluate The Efficacy And Safety Of An Investigational Drug In Adolescent And Adult Subjects With Asthma Uncontrolled on Non-steroidal Therapy.
This study is designed to determine if the investigational drug is effective and safe in individuals with asthma.
- Trial name
- NCT00603382
- Testing
- GW685698X
- Where
- 149 sites in United States, Bulgaria and 12 more
- Volunteers
- 599 people
- Sponsor
- GlaxoSmithKline
Asthma
A Study Evaluating Disease Characteristics and Outcomes in Participants With Asthma in Routine Clinical Practice
The main aim of the study to describe the characteristics of participants with asthma across the spectrum of disease severity, including sociodemographic and clinical characteristics, treatment and disease burden, biomarkers, and…
- Trial name
- AIRITY (NCT07556159)
- Testing
- Procedure: Investigational Procedures
- Where
- 83 sites in United States, Canada and 4 more
- Volunteers
- 2,500 people
- Sponsor
- Sanofi
Chronic Obstructive Pulmonary Disease (COPD), Asthma
A Study to Evaluate the Disposition of Drug in Body and Safety After Administration of Single Inhaled Doses of Drugs Abediterol and AZD7594 Administered Alone, in Fixed Dose Combination and in Free Combination Using the Dry Powder Inhaler in Healthy Male Participants
AZD7594 is a non steroidal, potent and selective modulator of the glucocorticoid receptor (GR) under development for once daily inhaled treatment of chronic obstructive pulmonary disease (COPD) and asthma.
- Trial name
- NCT02967159
- Testing
- Abediterol, AZD7594, AZD7594/abediterol
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma (Diagnosis)
Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma
Acute asthma exacerbation is caused by dysregulated pulmonary inflammatory pathways such that standard treatment includes prompt administration of exogenous systemic corticosteroids (SCs), but there remains an ongoing dialogue…
- Trial name
- PATCH (NCT07455396)
- Testing
- Dexamethasone (0.6mg/kg; Max 16mg) Once Daily, Dexamethasone (0.25 mg/kg/dose, Max dose 16mg) every 6-hours, Methylprednisolone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Johns Hopkins All Children's Hospital
Asthma in Children, Allergy
Advanced Multimodal Wireless Vital Signs Monitoring for Patients With Asthma and Anaphylaxis
The primary objective of this study is to assess the function and reliability of a non-invasive, skin-like electronic sensor. We hypothesize that this skin sensor will address an unmet need to wirelessly, noninvasively, and…
- Trial name
- NCT04360213
- Testing
- Advanced multimodal wireless vital signs monitor
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Northwestern University
Asthma in Children
Ex Vivo Pilot Study of the Impact of Nasal Breathing During the Administration of Inhaled Corticosteroids by Inhalation Chamber in Asthmatic Children Ages Between 1 and 4-year-old
The main purpose of this open randomized, ex-vivo comparative study, is to assess and to compare the inhalable dose of inhaled corticosteroid collected through a nasal filter and a mouth filter located in a partitioned face mask…
- Trial name
- MASQUE (NCT03364959)
- Testing
- Corticosteroids inhalation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Asthma
Retrospective Cohort Study on Asthma With Frequent Acute Attacks Phenotype
1. Identify the risk factors for frequent acute exacerbations of asthma: establish a retrospective study, classify patients into frequent acute exacerbation group and non-frequent acute exacerbation group based on the number of…
- Trial name
- NCT06026462
- Testing
- Observation of clinical indicators related to asthma
- Volunteers
- 540 people
- Sponsor
- Qianfoshan Hospital
Asthma
Characterization of Aerosol Generation and Transport in the Human Lung
This study is aiming at evaluating whether the number and size of exhaled particles changes during the increase and decrease of bronchial constriction in subjects with mild intermittent asthma.
- Trial name
- NCT01095627
- Testing
- Metacholine challenge
- Volunteers
- 10 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Sleep Apnea, Obstructive, Asthma, Exercise-Induced
Pulmonary Disorders During Exercise in Patients With Obstructive Sleep Apnea
Purposes: 1. To investigate whether patients with severe obstructive sleep apnea syndrome (OSAS) are at higher risk for exercised-induced bronchoconstriction (EIB) due to baseline airway inflammation compared with age, gender…
- Trial name
- NCT00916773
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Asthma
AKL 1 Asthma Study
This study aims to provide scientific evidence of the efficacy and safety of this agent as 'add-on' therapy for adult patients whose asthma remains uncontrolled on standard medication.
- Trial name
- NCT00407524
- Testing
- AKL 1
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen
Asthma
Bi 671800 in Asthmatic Patients on Inhaled Corticosteroids
To investigate the effectiveness and safety of BI 671800 given in the morning (AM), evening (PM) or twice daily (b.i.d.) compared too placebo as add on therapy to inhaled corticosteroid in symptomatic asthma patients.
- Trial name
- NCT01090024
- Testing
- BI 671800
- Where
- 14 sites in United States
- Volunteers
- 108 people
- Sponsor
- Boehringer Ingelheim
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